Esclim (estradiol) / AbbVie - LARVOL DELTA

[VIRTUAL] Low-Grade Endometrial Endometrioid Adenocarcinomas with MELF Pattern Invasion Harbor ARID1A Mutations (USCAP 2021) - "In our cohort, truncating ARID1A variants were identified in 90% of EC with a MELF pattern of myometrial invasion. To our knowledge, this is the first study to characterize ARID1A at the molecular level in low-grade EC with MELF pattern invasion. These findings support molecular classification of EC as an emerging tool for better risk stratification and selection of molecularly informed therapies."

Endometrial Adenocarcinoma • Endometrial Cancer • Oncology • Solid Tumor • ARID1A • CTNNB1 • KRAS • MSH3 • PIK3CA • PIK3R1 • PTEN

Evaluation of NTRK immunohistochemistry as a screening method for NTRK gene fusion detection in non-small cell lung cancer. (PubMed, Lung Cancer) - "The presence of NTRK fusion genes in non-small cell lung cancer is exceedingly rare. The use of the immunohistochemical NTRK assay will result in a small number of false positive cases. This should be considered when the assay is applied as a screening tool in clinical diagnostics."

Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • NTRK

Determining microsatellite instability (MSI) status of colorectal cancers through next-generation sequencing (NGS) (AACR 2018) - "Collectively, this data indicates that NGS can be utilized for determining tumor MSI status using WES or the TST170 panel. In addition, a bioinformatics algorithm was developed that successfully categorized tumors according to their MSI status without requiring subject-matched normal DNA sequence data.For Research Use Only. Not for use in diagnostic procedures."

Biomarker • IO Biomarker • Microsatellite Instability • MSi-H Biomarker • Next-Generation Sequencing • Microsatellite Instability

[VIRTUAL] Whole exome sequencing vs. targeted panel sequencing – influence on diagnostic assessment for precision medicine in oncology (ECP 2020) - "We therefore evaluated results from three different sequencing approaches, WES, nNGM hotspot gene panel sequencing and TSO500/TST170 hybrid-capture based sequencing and compared their putative influence on decision making. As expected, known therapy-relevant variants such as EGFR or BRAF mutations were detected applying all assays."

Lung Cancer • Oncology • Solid Tumor • BRAF • EGFR • MSI

[VIRTUAL] Whole exome sequencing vs. targeted panel sequencing – influence on diagnostic assessment for precision medicine in oncology (ECP 2020) - "We therefore evaluated results from three different sequencing approaches, WES, nNGM hotspot gene panel sequencing and TSO500/TST170 hybrid-capture based sequencing and compared their putative influence on decision making. As expected, known therapy-relevant variants such as EGFR or BRAF mutations were detected applying all assays."

Lung Cancer • Oncology • Solid Tumor • BRAF • EGFR • MSI

[VIRTUAL] Whole exome sequencing vs. targeted panel sequencing – influence on diagnostic assessment for precision medicine in oncology (ECP 2020) - "We therefore evaluated results from three different sequencing approaches, WES, nNGM hotspot gene panel sequencing and TSO500/TST170 hybrid-capture based sequencing and compared their putative influence on decision making. As expected, known therapy-relevant variants such as EGFR or BRAF mutations were detected applying all assays."

Lung Cancer • Oncology • Solid Tumor • BRAF • EGFR • MSI

[VIRTUAL] GLANZMANN THROMBASTENIA: CASE REPORT (HEMO 2020) - "The patient was recently hospitalized with hematemesis - he received tranexamic acid, infusion of red blood cells and platelets, with rapid recovery...Diagnostic evaluation is characterized by: normal morphology and platelet count; TS prolongation, with normal TP and aPTT; platelet aggregation absent in the presence of agonists (Epinephrine, Collagen, Arachidonic acid, Adenosine diphosphate / ADP) and normal in response to ristocetin; with no expression of CD41 and CD61 (GPIIb / IIIa complex) at Flow Cytometry. Early diagnosis in cases of hemorrhagic syndromes is important to establish an adequate conduct for prophylaxis of abnormal bleeding in risky procedures, for correct treatment in the face of severe hemorrhages and maintenance prophylaxis to prevent bleeding."

Clinical • Cerebral Hemorrhage • Gastroenterology • Gastrointestinal Disorder • Gynecology • Hematological Disorders • Mood Disorders • Osteoarthritis • Peptic Ulcer • Thrombocytopenia • CD61

[VIRTUAL] Targeted Mutational Analysis of Predictive and Prognostic Biomarkers in Colorectal Carcinoma (AMP 2020) - "Although many of the detected gene variants would have been identified by our previous and smaller 50 gene panel, the expanded TST170 panel detected 34 potentially clinically actionable variants including 2 fusions and copy number variants not detected by the smaller panel."

Biomarker • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • ALK • AXL • BRAF • FBXW7 • HER-2 • KRAS • MLH1 • MSH2 • NRAS • PIK3CA • PTEN • STRN • TP53

[VIRTUAL] Somatic Variant Analysis Using a Pan-Solid Tumor Expanded Gene Panel (AMP 2020) - "Implementation of an expanded panel was well received by our institution and resulted in testing of more tumor types, detection of variants not covered by the prior assay and decreased send out testing."

Biliary Cancer • Colorectal Cancer • Gastrointestinal Cancer • Gastrointestinal Disorder • Genito-urinary Cancer • Hepatology • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pancreatic Cancer • Prostate Cancer • Solid Tumor • BRCA1 • BRCA2 • EGFR • TERT

[VIRTUAL] Presumed Germline Pathogenic Variants in Tumor-Only Sequencing: Frequency and Follow-Up (AMP 2020) - "PGVs were identified in 3.6% of our patients using a tumor-only sequencing assay. Special consideration and a coordinated effort should be taken to identify PGVs, and get appropriate referrals and subsequent confirmatory testing."

Biliary Cancer • Cholangiocarcinoma • Colon Cancer • Colorectal Cancer • Gastrointestinal Cancer • Glioblastoma • Oncology • Ovarian Cancer • Solid Tumor • BRCA1 • BRCA2 • MSH2 • MSH6 • RAD51C

[VIRTUAL] An RNA Sequencing Panel for Detection of Fusions and Splice Site Variants in Solid Tumors (AMP 2020) - "Implementation of a RNA sequencing panel has resulted in the detection of clinically significant fusion events and splice site variants in a variety of tumor types opening up more therapeutic options for these patients."

Colorectal Cancer • Genito-urinary Cancer • Glioblastoma • Lung Cancer • Melanoma • Oncology • Prostate Cancer • Solid Tumor • ABL1 • ALK • EGFR • ER • ETV1 • FGFR1 • NTRK • NTRK1 • NTRK3 • RAF1 • ROS1 • STAT2 • TMPRSS2

[VIRTUAL] Identifying Prognostic and Predictive Gene Alterations in Metastatic Prostate Cancer (AMP 2020) - "In our initial cohort, 9/16 samples showed fusions involving ETS transcription factors. Five cases showed alterations in AR (splice variants, amplification and SNV). In addition, we identified mismatch repair deficient/MSH-H, BRCA2 homozygous deletion and biallelic CDK12 loss which all may have specific treatment implications."

IO Biomarker • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • AR • BRCA1 • BRCA2 • CDK12 • CTNNB1 • ETV1 • MLL • MSH2 • MSH6 • MSI • PTEN • STAT3 • TMPRSS2 • TP53

[VIRTUAL] Aberrant PAX3 (Paired Box Gene 3) RNA Splicing Is a Potential Marker for Diagnosis of Melanoma (AMP 2020) - "PAX3 intron 4 splice variant occurs frequently and is specific to patients with melanomas. This recurrent aberrant splicing alteration can serve as a helpful genomic signature to resolve the classification of immunohistological challenging cases such as cancers of unknown primary."

Cutaneous Melanoma • Melanoma • Oncology • Solid Tumor

Testing NTRK testing: wet-lab and in silico comparison of RNA-based targeted sequencing assays. (PubMed, Genes Chromosomes Cancer) - "A test algorithm that reflects assay methodology is provided. This data will support implementation of targeted RNA sequencing in routine diagnostics and inform screening and testing strategies that have been brought forward."

Journal • Oncology • Solid Tumor

Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome. (PubMed, Dis Model Mech) - "The inconsistent phenotypes in Ts65Dn mice highlight specific cautions and caveats for use of this model. We outline important steps for ensuring responsible use of Ts65Dn in future research."

Journal • Preclinical • CNS Disorders • Developmental Disorders • Genetic Disorders • Mental Retardation • Psychiatry • Solid Tumor

[VIRTUAL] Fast pyrolysis bio-oils FPBO for co-refining in – quality determination (ACS-Fall 2020) - "727531) and Waste2Road (GA No. 818120), data to allow a further standardization for the use of bio-liquids in refining processes are generated.This paper discusses the need and obstacles on standardization of bio-liquids, with emphasis on the typical constraints associated with the use of fast pyrolysis oils in co-refining."

[VIRTUAL] Vitamin D3supplementation affects the morphology and MTHFR and caspase 3 p12 expression in the olfactory bulb of a mouse model for Down syndrome (ESHG 2020) - "Ts mice show morphological and molecular changes in the OB and VD 3 can attenuate and reverse these abnormalities indicating its neuroprotective function. Grants: Capes (Code 001); CNPq (310806/2018-6) and FAPESP (2018/09126-0)."

Alzheimer's Disease • CNS Disorders • Developmental Disorders • Genetic Disorders • CASP3 • MTHFR

Probiotic Role of Salt Pan Bacteria in Enhancing the Growth of Whiteleg Shrimp, Litopenaeus vannamei. (PubMed, Probiotics Antimicrob Proteins) - "Safety evaluation by antibiotic susceptibility test and hemolytic activity test indicated that the bacteria are safe as bioinoculants. The increased enzyme activity by colonisation of the isolates in the shrimp gut, along with improved growth and feed utilisation efficiency, strongly confirms that these salt pan bacteria are prospective probiotics in shrimp aquaculture."

Journal

[VIRTUAL] Clinical utility of comprehensive genomic pathway and integrated network analyses in personalized oncology. (ASCO 2020) - "We discovered that the integrated WfG pathway analyses tool is ideal for visualization of the variants with levels of evidence from clinical literature and FDA drug databases that can help inform treatment options and provides a holistic understanding of a specific tumor profile allowing the treating clinician to select personalized targeted therapy. Research Funding: None"

Clinical • Acute Myelogenous Leukemia • Brain Cancer • Breast Cancer • Genito-urinary Cancer • Glioma • Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • Thyroid Cancer • BRAF • BRCA1 • BRCA2 • CDKN2A • HRAS • MAPK1 • PARP1 • PTEN • RAF1 • TP53

Utility of a Comprehensive and Cost-effective DNA/RNA Panel (170 Genes) for Single Nucleotide Variants (SNV’s), Small Insertions or Deletions (Indels), Copy Number Variations (CNV’s) Splice Variations, and Gene Fusions on an NGS in Evaluation of Colon Cancer (AMP 2018) - "...Libraries for were prepared using the Illumina TruSight Tumor 170 (TST170) kit and sequenced on NextSeq 550... DNA and RNA libraries are prepared, sequenced, and analyzed simultaneously for efficient assessment of numerous types of somatic variants. We anticipate that this approach of obtaining high-resolution data from formalin-fixed, paraffinembedded (FFPE) samples at reduced sequencing cost, will facilitate testing in different malignances which was not previously possible."

HEOR • Next-Generation Sequencing • Biosimilar • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Phytoplankton growth rate modelling: can spectroscopic cell chemotyping be superior to physiological predictors? (PubMed) - Proc Biol Sci - "The high predictive power of both sets of cellular traits for growth rate is of great importance for applied phycological studies. Our approach may find application as a quality control tool for the monitoring of phytoplankton populations in natural communities or in photobioreactors."

Journal • Biosimilar

Clinical Validation of a Comprehensive DNA/RNA Panel (170 Genes) for Single Nucleotide Variants (SNVs), Small Insertions/Deletions (Indels), Copy Number Variations (CNVs) Splice Variations (SVs), and Gene Fusions (GF) on an NGS Platform in a CLIA Setting. (AMP 2018) - "...Libraries for were prepared using the Illumina TruSight Tumor 170 (TST170) kit and sequenced on NextSeq 550... DNA and RNA libraries are prepared, sequenced, and analyzed simultaneously for efficient assessment of numerous types of somatic variants. We anticipate that this approach of obtaining high-resolution data from an FFPE samples at reduced sequencing cost will facilitate testing in different malignances which was not previously possible."

Clinical • Next-Generation Sequencing • Biosimilar • Brain Cancer • Colorectal Cancer • Gastrointestinal Cancer • Gynecologic Cancers • Lung Cancer • Melanoma • Oncology • Ovarian Cancer • Solid Tumor • Thoracic Cancer • Uterine Cancer

Impact of Soil Warming on the Plant Metabolome of Icelandic Grasslands. (PubMed, Metabolites) - "The metabolomes of A. capillaris and R. acris shifted abruptly and nonlinearly to soil warming >5 °C above the control temperature for the coming decades. These results thus suggest that a slight warming increase may not imply substantial changes in plant function, but if the temperature rises more than 5 °C, warming may end up triggering metabolic pathways associated with heat stress in some plant species currently dominant in this region."

Journal • Biosimilar

Clinical implementation of personalised medicine for 6 high priority WA cancers (COSA 2018) - "... The laboratory and bioinformatics workflow has been established using the Illumina TST170 gene NGS panel on the NextSeq instrument and Pierian Dx Clinical Genomics Workspace software... This pilot study has successfully commenced. Initial results will be presented."

Clinical • Melanoma • Oncology • Sarcoma • Solid Tumor

Old World megadroughts and pluvials during the Common Era. (PubMed) - Sci Adv - "In addition, megadroughts reconstructed over north-central Europe in the 11th and mid-15th centuries reinforce other evidence from North America and Asia that droughts were more severe, extensive, and prolonged over Northern Hemisphere land areas before the 20th century, with an inadequate understanding of their causes. The OWDA provides new data to determine the causes of Old World drought and wetness and attribute past climate variability to forced and/or internal variability."

Journal • Biosimilar