LYT-210 / PureTech - LARVOL DELTA

PureTech Provides End of Year Report on Key Progress (Businesswire) - "Based on these and other compelling preclinical data generated with LYT-200 in blood cancers, PureTech initiated a clinical trial to evaluate LYT-200 as a single agent for the treatment of AML, with results expected in 2023....Given the expansion of the clinical evaluation of LYT-200, the Company has deprioritized preclinical development of LYT-210."

Clinical data • Pipeline update • Acute Myelogenous Leukemia • Hematological Malignancies • Oncology

[VIRTUAL] Efficacy and characterization of a specific and potent monoclonal antibody, LYT-210, against immunosuppressive gd1 T cell in cancer (AACR 2021) - "We have developed a novel, therapeutic immuno-oncology strategy specifically targeting imunosuppressive γδ1cells. Our data support that this therapeutic approach may have the potential to be transformative for the treatment of cancers where γδ1T cells drive a pro-tumorigenic, immunosuppressive environment."

Clinical • Breast Cancer • Colorectal Cancer • Gastrointestinal Cancer • Glioblastoma • Liver Cancer • Melanoma • Oncology • Ovarian Cancer • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • CEACAM5

PureTech Presents Promising Preclinical Data from LYT-210 Immuno-Oncology Program at American Association for Cancer Research (AACR) Annual Meeting (Businesswire) - "PureTech announced the presentation of a scientific poster detailing additional promising preclinical results for its LYT-210 antibody at the 2021 AACR Annual Virtual Meeting. The new research demonstrates that LYT-210 is both highly specific and highly potent, rapidly inducing cell death of immune-suppressive gamma delta-1 T cells, while sparing other T cells that play important roles in a healthy immune response....The research was conducted in vitro using both patient blood and cancer tissue. LYT-210 has potential as either a single agent or in combination with checkpoint inhibitors and other anti-cancer treatments."

Preclinical • Colorectal Cancer • Gastrointestinal Cancer • Liver Cancer • Oncology • Solid Tumor