EZM8266
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April 13, 2023
Antitumoral activity of the G9a inhibitor EZM8266 in hepatocellular carcinoma: potential for combination with immune checkpoint inhibitors
(EASL-ILC 2023)
- "G9a is confirmed as an effective druggable target in HCC. Pharmacological inhibition of G9a with EZM8266 antagonizes HCC cells growth and leverages the efficacy of ICIs. Our findings provide strong support for the combination immunotherapy with epigenetic drugs such as EZM8266 for HCC treatment."
Checkpoint inhibition • IO biomarker • Gastrointestinal Cancer • Hepatocellular Cancer • Hepatology • Immune Modulation • Oncology • Solid Tumor • CXCL10 • CXCL9
February 20, 2023
Antitumoral activity of the G9a inhibitor EZM8266 in hepatocellular carcinoma: potential for combination with immune checkpoint inhibitors
(AEEH 2023)
- No abstract available
Checkpoint inhibition • Gastrointestinal Cancer • Hepatocellular Cancer • Immune Modulation • Oncology • Solid Tumor
February 20, 2023
Antitumoral activity of the G9a inhibitor EZM8266 in hepatocellular carcinoma: potential for combination with immune checkpoint inhibitors
(AEEH 2023)
- No abstract available
Checkpoint inhibition • Gastrointestinal Cancer • Hepatocellular Cancer • Immune Modulation • Oncology • Solid Tumor
October 30, 2019
Epizyme announces positive pre-NDA meeting for tazemetostat for follicular lymphoma, pipeline updates and third quarter 2019 results
(Businesswire)
- "Epizyme has decided to refocus its preclinical program targeting G9a on other potential development candidates and discontinue development of EZM-8266. This decision was made after a review of development path implications of a preclinical toxicology finding of EZM-8266. The company is evaluating next steps for its G9a program to develop an oral, disease-modifying approach to treating a variety of hemoglobinopathies, including sickle cell disease."
Discontinued
August 15, 2019
Epizyme (EPZM) focuses on developing lead drug tazemetostat
(Yahoo Finance)
- "Epizyme also aims at completing IND-enabling studies on EZM8266, its G9a inhibitor designed to treat patients with sickle cell disease (SCD). It is on track to begin clinical development of the candidate in the second half of 2019 with a dose-finding and safety study."
New trial
August 09, 2019
Epizyme reports business progress and second quarter 2019 results
(BioSpace)
- "EZM8266 for Sickle Cell Disease: Epizyme anticipates beginning clinical development of EZM8266, a novel, first-in-class G9a inhibitor, with a Phase 1 clinical trial in the second half of 2019."
New P1 trial
May 06, 2019
Epizyme provides business update and reports first quarter 2019 financial results
(Businesswire)
- "Upon approval of an Investigational New Application (IND) for EZM8266 for the treatment of patients with sickle cell disease, Epizyme anticipates beginning clinical development in the second half of 2019 with a Phase 1 trial of EZM8266, a novel, first-in-class G9a inhibitor."
New P1 trial
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