tacrolimus topical / Generic mfg. - LARVOL DELTA

Tacrolimus 0.1% Ophthalmic Suspension: Corneal and Intraocular Penetration Study. (PubMed, J Ocul Pharmacol Ther) - " Tacrolimus concentrations measured in the corneal tissues are significantly higher than that described as lower limit of efficacy in solid organ transplantation. Topical 0.1% tacrolimus could therefore become an alternative to corticosteroids for endothelial graft rejection prevention and endothelial inflammatory pathologies management."

Journal • Inflammation • Ocular Inflammation • Ophthalmology • Solid Organ Transplantation • Transplant Rejection • Transplantation

Management and outcome of microsporidia-induced stromal inflammatory keratitis - A long-term follow-up study. (PubMed, Indian J Ophthalmol) - "Microsporidia-associated ISK/IK is a novel condition having a chronic course with recurrences. It requires close follow-up for recurrences at least six months after discontinuing medications, and topical 0.03% tacrolimus ointment is an effective corticosteroid-sparing agent."

Journal • Keratitis • Ocular Inflammation • Ophthalmology

Management of folliculitis decalvans: The EADV task force on hair diseases position statement. (PubMed, J Eur Acad Dermatol Venereol) - "Oral isotretinoin should be considered as the first-line therapy in patients with mild active disease (perifollicular erythema and hyperkeratosis, no pustules or crusts)...Photodynamic therapy, biologics (preferably adalimumab), JAK inhibitors, oral dapsone, hydroxychloroquine or cyclosporine may also be effective...Topical tacrolimus 0.1% or dapsone 5% may be considered as second-line topical therapeutic options. In patients with folliculitis decalvans, surgical excision or laser therapy can be useful. Hair transplantation can be considered in patients with inactive disease."

Journal • Aesthetic Medicine • Alopecia • Dermatology • Immunology • Inflammation • Transplantation

Effectiveness and safety of rectal tacrolimus in patients with ulcerative colitis. TACRO-TOPIC study of GETECCU. (PubMed, J Crohns Colitis) - "Topical tacrolimus is an effective therapy and could be considered in distal UC patients before initiating other advance therapies when endoscopic activity remains."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

Topical tacrolimus for the amelioration of breast cancer-related lymphedema (TACLE Trial): a study protocol for a randomized, double-blind, placebo-controlled phase II/III trial. (PubMed, Trials) - P2/3 | "This trial will provide robust data on the efficacy of topical tacrolimus in reducing BCRL volume and improving patient quality of life. Positive results could establish tacrolimus as a standard treatment for BCRL, potentially enhancing clinical outcomes for affected patients. The findings will also contribute to understanding the role of immunomodulation in lymphedema management."

Clinical • Clinical protocol • Journal • P2/3 data • Breast Cancer • Fibrosis • Immunology • Oncology • Solid Tumor • CD4

A Comparative Clinical Trial Evaluating the Effect and Safety of Tacrolimus Versus Hydrocortisone (clinicaltrials.gov) - P2 | N=100 | Completed | Sponsor: Tanta University | Recruiting ➔ Completed

Trial completion • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy of topical tacrolimus 0.03% ointment in combination with microneedling versus topical phenytoin 2% cream in combination with microneedling for the treatment of non-segmental facial vitiligo. (PubMed, Arch Dermatol Res) - "Our results provide additional evidence for the potential positive role of phenytoin as a therapeutic option in patients with non segmental vitiligo. However, tacrolimus 0.03% ointment combined with microneedling was associated with a better response than phenytoin 2% cream combined with microneedling."

Clinical • Journal • Dermatology • Immunology • Vitiligo

Prospective clinical study of tacrolimus ointment combined with swellable microneedles in the treatment of psoriasis (ChiCTR) - P4 | N=60 | Not yet recruiting | Sponsor: Chu Hsien-I Memorial Hospital of Tianjin Medical University; Chu Hsien-I Memorial Hospital of Tianjin Medical University

New P4 trial • Dermatology • Immunology • Psoriasis

TERRITORY-WIDE RETROSPECTIVE REVIEW ON OUTCOMES OF ALLOGENEIC TRANSPLANTATION FOR HAEMOGLOBIN BART'S HYDROPS FETALIS SYNDROME IN HONG KONG (EBMT 2025) - "Apart from mild grade II acute graft-versus-host-disease (GVHD) of skin which resolved readily with topical steroid/tacrolimus and ruxolitinib, there were no features of severe acute GVHD or chronic GVHD... To conclude, local data demonstrated favorable outcome of allogeneic HSCT for BHFS patients. Non-directive approach in antenatal counseling and international collaboration is recommended. Haploidentical HSCT for BHFS patients using TCRab-depleted graft is a safe and feasible therapeutic option."

Retrospective data • Review • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Pediatrics • Transplantation

TERRITORY-WIDE RETROSPECTIVE REVIEW ON OUTCOMES OF ALLOGENEIC TRANSPLANTATION FOR HAEMOGLOBIN BART'S HYDROPS FETALIS SYNDROME IN HONG KONG (EBMT 2025) - "Apart from mild grade II acute graft-versus-host-disease (GVHD) of skin which resolved readily with topical steroid/tacrolimus and ruxolitinib, there were no features of severe acute GVHD or chronic GVHD... To conclude, local data demonstrated favorable outcome of allogeneic HSCT for BHFS patients. Non-directive approach in antenatal counseling and international collaboration is recommended. Haploidentical HSCT for BHFS patients using TCRab-depleted graft is a safe and feasible therapeutic option."

Retrospective data • Review • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Pediatrics • Transplantation

EXCELLENT OUTCOMES OF HAEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN WITH SEVERE APLASTIC ANEMIA, A SINGLE CENTRE EXPERIENCE; 15 YEARS RESULTS (EBMT 2025) - "We concluded that the HSCT program for children with SAA in Singapore has been robust and successful, yielding excellent long-term outcomes and overall survival."

Clinical • Acute Graft versus Host Disease • Acute Respiratory Distress Syndrome • Anemia • Aplastic Anemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Pediatrics • Pneumonia • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections • Transplantation

Limbal Stem Cell Deficiency Induced by Prolonged Use of Topical 0.03% Tacrolimus Ointment in a Patient With Atopic Keratoconjunctivitis. (PubMed, Eye Contact Lens) - "This case suggests that LSCD is possible after prolonged use of topical tacrolimus ointment 0.03%. In this context, it is imperative to monitor patients continuously to evaluate the safety of its chronic use."

Journal • Conjunctivitis • Dry Eye Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Focal Hypertrichosis during Topical Tacrolimus Therapy for Vitiligo: A Case Report. (PubMed, Case Rep Dermatol) - "Drug-induced hypertrichosis is a well-known side effect of cyclosporine. It is reported that tacrolimus directly stimulates mouse whiskers in vitro and prolongs the anagen phase of hair growth when it is applied topically in mice. We believe that a greater awareness of this rare side effect of tacrolimus is warranted as tacrolimus is widely used in treating vitiligo."

Journal • Dermatology • Immunology • Vitiligo

Adverse effects of topical tacrolimus compounded ophthalmic preparations. (PubMed, Cutan Ocul Toxicol) - "It is imperative to understand the potential side effects associated with topical tacrolimus ophthalmic preparations to optimize the treatment outcomes and guarantee patient safety. Routine ophthalmic examinations should be conducted to detect these side effects early and address them appropriately."

Adverse events • Journal • Review • Cataract • Glaucoma • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Dupilumab-Associated Ocular Surface Disease in Paediatric Atopic Dermatitis Patients: Results From the BioDay Registry. (PubMed, Clin Exp Allergy) - "This prospective, long-term, real-world study shows that 34.6% of paediatric AD patients treated with dupilumab develop DAOSD. Elevated baseline serum IgE (≥ 3000 kU/L) may predict the development of DAOSD. The high incidence of DAOSD underscores the importance of awareness of ocular symptoms during dupilumab treatment, especially in (young) paediatric patients, where reporting ocular symptoms can be challenging and may lead to delayed diagnosis."

Journal • Atopic Dermatitis • Conjunctivitis • Dermatitis • Dermatology • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pediatrics • Pruritus

Comparison of Safety and Efficacy of Topical Mometasone 0.1% Ointment, Calcipotriol 0.005% Ointment, and Tacrolimus 0.1% Ointment in Patients with Localized Alopecia Areata: A Triple-Arm Randomized Clinical Study. (PubMed, Indian Dermatol Online J) - "Treatment consists of corticosteroids, calcineurin inhibitors, prostaglandin analogs, minoxidil, anthralin, vitamin D analogs, and JAK STAT inhibitors. The lack of long-term follow-up is also a limitation of this study. Both mometasone and calcipotriol formulations were found to be effective in the treatment of localized stable AA; however, calcipotriol preparation was associated with minimal side effects."

Journal • Alopecia • Dermatology • Immunology

Effect of needle cauterization on vitiligo with deficiency cold and blood stasis: a randomized controlled trial (PubMed, Zhongguo Zhen Jiu) - "A total of 62 patients of vitiligo with deficiency cold and blood stasis were randomly divided into an observation group and a control group, 31 cases each group.On the basis of 308 nm excimer light irradiation combined with ironing with Chinese medicine, the control group was treated with tacrolimus ointment for external use, twice a day; the observation group was treated with needle cauterization at vitiligo spots, once a week.Both groups were treated for 10 weeks...The total effective rate in the observation group was 93.5% (29/31), which was higher than 77.4% (24/31) in the control group (P<0.05). Needle cauterization could reduce the areas of vitiligo spot in patients of vitiligo with deficiency cold and blood stasis, improve the clinical symptoms, its mechanism may be related to the reduction of serum levels of inflammatory indexes."

Clinical • Journal • Dermatology • Immunology • Vitiligo • IL17A • IL6

Dupilumab for Atopic Dermatitis-like Chronic Graft-versus-Host Disease in Three Pediatric Hematopoietic Cell Transplant Recipients. (PubMed, J Pediatr Hematol Oncol) - "Three patients received tacrolimus and topical corticosteroids for GVHD treatment, and 1 also received sirolimus and ruxolitinib...DUP was efficacious and safe for treating AD-like cGVHD in our 3 pediatric patients. Further investigations are warranted to determine the appropriate placement in therapy."

Journal • Atopic Dermatitis • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Dermatitis • Dermatology • Graft versus Host Disease • Immunology • Infectious Disease • Pediatrics • Pruritus • Transplantation

Value of tacrolimus 0.1% in the treatment of vitiligo in the era of targeted therapy. (PubMed, Ann Dermatol Venereol) - "Notwithstanding the market access of topical ruxolitinib, tacrolimus remains a viable treatment option for vitiligo, as substantiated by extant efficacy and safety in the literature. A recent decision of the French National Agency for the Safety of Medicines and Health Products (ANSM) authorized the compassionate prescription of tacrolimus and its reimbursement for patients."

Journal • Dermatology • Immunology • Vitiligo

Topical tacrolimus versus dexamethasone in managing shield ulcer of vernal keratoconjunctivitis. (PubMed, Med Hypothesis Discov Innov Ophthalmol) - "We compared the efficacies and safeties of 1% tacrolimus eye drops and 1% dexamethasone eye drops in managing unilateral shield ulcers and corneal epitheliopathy secondary to VKC. This suggests that tacrolimus could be administered as monotherapy for managing this debilitating ocular inflammatory condition. Further studies are required to determine the long-term safety and efficacy of this promising treatment modality."

Journal • Conjunctivitis • Dry Eye Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology

Erosive Pustular Dermatosis of the scalp after Herpes Zoster with recalcitrant Post Herpetic Neuralgia: A long term follow up. (AAD 2025) - "eventually topical Tacrolimus and Fluticasone healed EPDS with an atrophic scar. This case report may spark the need for better understanding of these chronic unrelenting inflammatory conditions which can potentially increase the morbidity especially when they coexist. Larger epidemiological studies about the association between EPDS and PHN are essential to establish pathogenesis and therapeutic guidelines in such chronic debilitating conditions."

Alopecia • Dermatology • Herpes Zoster • Immunology • Mood Disorders • Musculoskeletal Pain • Neuralgia • Pain • Varicella Zoster

Effectiveness of Combination Therapy with Topical Tacrolimus and Narrowband UVB in Treating Vitiligo: A Systematic Review and Meta-analysis (AAD 2025) - "Combination therapy with topical tacrolimus and NB-UVB appears to be more effective than monotherapy in treating vitiligo, with a favorable safety profile. This approach may be considered as a first-line treatment for vitiligo, particularly in patients with limited disease extent."

Combination therapy • Retrospective data • Review • Dermatology • Immunology • Vitiligo

Comparative evaluation of the efficacy and safety of crisaborole ointment versus tacrolimus ointment for the topical treatment of atopic dermatitis-A randomized controlled trial (AAD 2025) - "Localized burning sensation was seen in both groups, with tacrolimus showing more incidence of the adverse event. Conclusion The study demonstrated that crisaborole and tacrolimus ointment have comparable efficacy in treating atopic dermatitis; however, crisaborole has a superior safety profile."

Clinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pruritus

An algorithmic multimodality approach to the treatment of acquired dermal macular hyperpigmentation (AAD 2025) - "Treatment instituted was cyclosporine at 4-4mg/Kg/day in 2 divided doses for 3.5-5 months for rapidly spreading ADMH and colchicine 0.5mg Q12H for a period of 6-12 months for indolent disease...Topical tacrolimus and sunscreens were given along with gentle non-fragranced cleansers and moisturisers... The combination of picolaser, isotretinoin and colchicine/cyclosprorine proved to be safe and effective for ADMH and led to excellent patient outcomes and satisfaction."

Anesthesia • Dermatology

Lichen planus pigmentosus inversus: case report and systematic review. (PubMed, Dermatol Reports) - "Topical tacrolimus 0.1% ointment was administered with moderate improvement at five weeks. A review of the literature showed no significant differences in involved sites and age distribution among genders, with a slightly longer duration of manifestations in females. The most administered therapeutic agents were topical corticosteroids, alone or in combination with other agents, and tacrolimus."

Journal • Dermatitis • Dermatology • Dermatopathology • Immunology • Lichen Planus