tacrolimus topical / Generic mfg. - LARVOL DELTA

A bilayered microneedle patch loaded with methotrexate and dexamethasone for transdermal treatment of psoriasis. (PubMed, Sci Rep) - "The patch successfully traversed imiquimod (IMQ)-induced thickened epidermis in murine models to achieve intralesional drug delivery and effectively alleviate psoriasis-like skin inflammation. Versus tacrolimus ointment (positive control), MTX@DXM-MNs markedly alleviated the manifestations of stratum corneum thickening, erythema, and scaling in a mouse model and attenuated the levels of inflammatory mediators in skin tissues and peripheral blood as well as splenic indices. In conclusion, the MTX@DXM-MN bilayered microneedle patch provides a new strategy for the efficient and safe treatment of psoriasis through the temporal and spatial synergistic effects of an outer layer for the immediate release of a hormone and an inner layer for the slow release of an immunosuppressant. Thus, this patch has potential as a future clinical alternative for the treatment of psoriasis."

Journal • Dermatitis • Dermatology • Immunology • Inflammation • Psoriasis

Long-Term Clinical Outcomes of 0.015% Tacrolimus HPβCD Eye Drops in Ocular Surface Inflammatory Disorders. (PubMed, Eur J Pharm Sci) - "The 0.015% tacrolimus/HPβCD formulation proves efficacy, and safety over 12 months for the treatment of diverse ocular inflammatory conditions, delivering sustained clinical stability and patient-reported benefits with reduced steroid reliance."

Clinical data • Journal • Inflammation • Ocular Inflammation • Ophthalmology

Efficacy and safety of treatments for atopic dermatitis: a model based meta-analysis of randomized controlled trials. (PubMed, Eur J Clin Pharmacol) - "MBMA was conducted for the time courses of several efficacy index. In conclusion, results showed that there is still a lack of treatment methods that balance efficacy, safety and speed of onset. The results of this MBMA can be used as a reference for optimizing clinical medication and provide a basis for decision-making in the future development of new AD drugs."

Clinical • Journal • Retrospective data • Review • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pruritus

A preclinical study of device dependent therapeutic effects of cold atmospheric plasmas on atopic dermatitis induced by DNCB. (PubMed, Sci Rep) - "Mice were treated with cold plasma and tacrolimus ointment (TAC)...Additionally, helium and argon plasma treatment enhanced cell adhesion protein E-cadherin and modulated CD31 protein, a marker of angiogenesis. Together, these findings suggest that CAP may be a promising candidate for the research and development of therapeutic modalities for AD."

Journal • Preclinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • CD31 • CDH1 • IL12A • IL13 • PECAM1

Comparative Study of Crisaborole vs. Tacrolimus in Atopic Dermatitis (clinicaltrials.gov) - P4 | N=30 | Not yet recruiting | Sponsor: Cairo University

New P4 trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Successful Treatment of Cutaneous Lupus Erythematosus in a Horse With Tacrolimus Ointment. (PubMed, Vet Dermatol) - "A 9-year-old gelding Quarter Horse with a lesion on the right upper eyelid was diagnosed with cutaneous lupus erythematosus. Clinical resolution and control of UV-induced flares were achieved with topical tacrolimus and a UV-blocking mask without adverse effects over the following 3 years."

Journal • Cutaneous Lupus Erythematosus • Dermatology • Immunology • Inflammatory Arthritis • Lupus

Prospective Comparative Study of Topical Tacrolimus and Sirolimus for the Treatment of Pigmentary Keratitis in Pug Dogs. (PubMed, Vet Sci) - "Further long-term studies are warranted to clarify safety considerations and to optimize immunomodulatory strategies for this breed-specific condition. These findings suggest tacrolimus may be considered a first-line immunomodulatory therapy for PK in Pug dogs."

Journal • CNS Disorders • Immunology • Keratitis • Ocular Inflammation • Ophthalmology

Topical Cyclosporine Vs Tacrolimus for Ocular GVHD Prophylaxis after Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I–II Trial (TCT-ASTCT-CIBMTR 2026) - P1/2 | "This study evaluated the safety, tolerability, and early efficacy of topical tacrolimus (Tac) versus cyclosporine (Cys) for oGVHD prevention in the outpatient alloHCT setting...Systemic GVHD prophylaxis included post-transplant cyclophosphamide, a calcineurin inhibitor, and mycophenolate... Both topical Tac and Cys were safe, well tolerated, and associated with high adherence in outpatient alloHCT. Tac showed a trend toward fewer dry eye symptoms and lower ocular toxicity, though not statistically significant. Ocular QoL remained preserved in both groups, supporting the feasibility of topical immunomodulator prophylaxis for oGVHD."

P1/2 data • Acute Graft versus Host Disease • Bone Marrow Transplantation • Dermatology • Dry Eye Disease • Graft versus Host Disease • Immunology • Infectious Disease • Ocular Infections • Ophthalmology • Pruritus • Transplantation

Treatments for actinic prurigo: A case report with upadacitinib and systematic review. (PubMed, SAGE Open Med Case Rep) - "A systematic review including 334 actinic prurigo patients from 38 studies found the highest complete resolution rates with Janus kinase inhibitors (100%), hydroxychloroquine (100%), and topical tacrolimus (100%). Treatment recurrence was common with thalidomide (34%), highlighting limitations of traditional therapies. Janus kinase inhibitors, targeting cytokine-driven inflammation, appear particularly promising. Although further large-scale studies are needed, our findings suggest Janus kinase inhibitors such as upadacitinib offer effective and safe treatment alternatives for refractory actinic prurigo, significantly enhancing patient outcomes and quality of life."

Journal • Dermatology • Inflammation

Adjunctive tacrolimus in the treatment of fungal keratitis requiring therapeutic penetrating keratoplasty. (PubMed, Am J Ophthalmol Case Rep) - P3 | "Adjunctive topical tacrolimus after therapeutic penetrating keratoplasty may reduce post operative complications and improve the chances of subsequent successful optical penetrating keratoplasty. NCT05110001."

Journal • Glaucoma • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

An Unusual Presentation of Lichen Planus Pigmentosus Inversus Responsive to Topical Tacrolimus: A Case Report. (PubMed, HCA Healthc J Med) - "Initial treatments with triamcinolone were ineffective, and hydroquinone was discontinued after 2 weeks due to irritation. Given the possible impact of LPPI on quality of life, timely diagnosis and appropriate management are crucial. Due to the absence of established treatment protocols for LPPI, further studies are necessary to better understand treatment responses and guide therapeutic strategies, particularly for individuals with darker skin tones."

Journal • Dermatology • Dermatopathology • Diabetes • Dyslipidemia • Hepatitis C • Infectious Disease • Inflammation • Lichen Planus • Metabolic Disorders • Nephrology • Rheumatology

Vitiligo associated with ribociclib therapy: a rare case report. (PubMed, Front Oncol) - "A 59-year-old woman with ER/PR (90% strong+), HER2-negative metastatic breast cancer developed pruritic hypopigmented patches on her forearms 16 months after initiating ribociclib/letrozole...Topical 0.1% mometasone cream and 0.1% tacrolimus ointment were initiated, with stabilization of existing lesions and no new depigmentation at 2-month follow-up...Combined with prior reports, it suggests a link between ribociclib and vitiligo. Further clinical observations and studies are needed to confirm causality, and pre-use risk explanations to patients are advisable."

Journal • Breast Cancer • Dermatology • Hematological Disorders • HER2 Breast Cancer • HER2 Negative Breast Cancer • Hormone Receptor Positive Breast Cancer • Immunology • Oncology • Solid Tumor • Vitiligo • HER-2

Outcomes of stem cell transplantation in pediatric and adolescent/young adult patients with trisomy 21: A single-center experience (ASH 2025) - "All patients received a myeloablative conditioning with post-transplant cyclophosphamide for graft-versus-host disease (GVHD) prophylaxis...One patient developed steroid refractory grade III skin GvHD requiring prednisone, ruxolitinib, and topical tacrolimus, and experienced eventual improvement with extracorporeal photopheresis... Here we describe three patients with T21 who underwent HSCT for relapsed/refractory leukemia. Two patients are surviving, including one with multiply relapsed disease who had initial graft failure, and remains disease free 2 years and 7 months following HSCT. Toxicities following HSCT were manageable and did not significantly impact engraftment."

Clinical • Acute Kidney Injury • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Bone Marrow Transplantation • CNS Disorders • Developmental Disorders • Endocrine Disorders • Epilepsy • Genetic Disorders • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Mucositis • Nephrology • Pediatrics • Transplantation • TP53

Hiding beneath the surface: Paraneoplastic pemphigus as a rare presentation of follicular lymphoma (ASH 2025) - "He initiated treatment with bendamustine and obinutuzumab and tolerated three of six planned cycles...The observed rapid improvement with topical tacrolimus supports a T cell–mediated pathogenesis... PNP is an exceptionally rare autoimmune manifestation of follicular lymphoma and should be considered in patients with refractory erosive mucositis and new lymphoproliferative diagnoses, even when conventional diagnostic tests are inconclusive. Prompt recognition, interdisciplinary management, and consideration of T cell–targeted therapy are essential, especially in cases with respiratory involvement. Further research into immunosuppressive strategies for lichenoid PNP is needed."

Cognitive Disorders • Dermatology • Dermatopathology • Follicular Lymphoma • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Lichen Planus • Lymphoma • Mucositis • Non-Hodgkin’s Lymphoma • Pneumonia • Pulmonary Disease • Respiratory Diseases • CD8

Topical cyclosporine vs tacrolimus for ocular GVHD prophylaxis after outpatient allogeneic hematopoietic stem cell transplantation: A Phase I–II trial (ASH 2025) - P1/2 | "This study evaluated the safety,tolerability and early efficacy of topical tacrolimus (Tac) vs cyclosporine (Cys) for oGVHD prevention in theoutpatient alloHCT setting.MethodsNon-blinded phase I–II trial (NCT06348602) in patients >18 years undergoing outpatient peripheral bloodalloHCT from matched sibling or haploidentical donors...Systemic GVHD prophylaxis included post-transplant cyclophosphamide, a calcineurin inhibitor, and mycophenolate mofetil.Ophthalmologic evaluations were performed every 3 months using NIH and ICCGVHD criteria.Tolerability was defined as relative (with adverse effects but no discontinuation) or absolute (treatmentwithdrawal)...These findings support the feasibility ofusing topical immunomodulators for oGVHD prophylaxis in outpatient alloHCT. Longer follow-up isneeded to assess sustained efficacy."

Clinical • P1/2 data • Acute Graft versus Host Disease • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Anemia • Aplastic Anemia • Bone Marrow Transplantation • Chronic Graft versus Host Disease • CNS Disorders • Depression • Dermatology • Dry Eye Disease • Gastrointestinal Disorder • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Leukemia • Myeloproliferative Neoplasm • Ocular Infections • Ophthalmology • Pruritus • Psychiatry • Transplantation • CD34

BI24 A case of refractory pyoderma gangrenosum successfully treated with upadacitinib. (PubMed, Br J Dermatol) - "The patient also had enteropathic arthritis, initially controlled with infliximab and azathioprine...Initial treatments were unsuccessful, including wound dressings, topical and systemic corticosteroids (intravenous methylprednisolone), topical tacrolimus and antibiotics. Ciclosporin was introduced when she did not respond to escalated doses of infliximab...This case highlights the importance of collaborating with other specialties regarding alternative treatments that are not available for dermatology conditions. Further studies are needed to evaluate the efficacy of Janus kinase inhibitors in PG."

Journal • Crohn's disease • Dermatology • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Immunology • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Pain • Pyoderma Gangrenosum • Rheumatoid Arthritis • Rheumatology

Exploratory Evaluation of Topical Tacrolimus for Prevention of Breast Cancer-Related Arm Lymphedema: A Multicenter Non-Randomized Pilot Study. (PubMed, Cancers (Basel)) - "Adverse events were mild and manageable, with no serious events reported. While topical tacrolimus did not significantly reduce the incidence of lymphedema, exploratory patterns in symptom onset and quality-of-life measures indicate that further investigation in larger randomized trials may be warranted."

Journal • Breast Cancer • Oncology • Solid Tumor

Case series of mycosis fungoides with marked clinical resemblance to seborrheic dermatitis (ISDS 2025) - "Six months later, the lesion had progressed into a dry, cracked plaque with thick scale that was refractory to topical hydrocortisone, clobetasol, and ketoconazole...Seven months later, the lesion proved refractory to tacrolimus, topical hydrocortisone, and bexarotene (75 mg) that had been prescribed for another MF lesion...Taken together, these three cases highlight key clinical features that help distinguish SD-like MF from SD: unilateral presentation, asymmetry, poor response to standard SD therapies, and history of MF; histopathology may be diagnostic, as in cases 1 and 2, or equivocal, as in case 3. For patients with MF and new lesions or rashes, we thus recommend a combination of total body skin exams, repeat biopsies, and molecular analysis for clonality."

Clinical • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatitis • Dermatology • Immunology • Mycosis Fungoides • Oncology • Psoriasis • Seborrheic Dermatitis

Roflumilast as an Emerging Treatment for Oral Lichen Planus: A Case Series (ISDS 2025) - "Management typically relies on off-label medications such as topical corticosteroids (TCS), systemic corticosteroids, calcineurin inhibitors (TCI), oral retinoids, and cyclosporine. Phosphodiesterase-4 (PDE-4) inhibitors, including apremilast and roflumilast, have recently been explored for OLP...Case Series: We present three cases of OLP in patients aged 65, 66, and 69, each with recurrent flares after multiple prior therapies, including TCS, TCI, hydroxychloroquine, and minoxidil...Adjunctive therapy included isotretinoin in two cases and topical tacrolimus swish and spit in the third case... This case series suggests that OR may be an effective treatment option for OLP. Further studies are warranted, as only one prior investigation of OR in OLP exists."

Clinical • Anorexia • Dermatitis • Dermatology • Dermatopathology • Gastrointestinal Disorder • Immunology • Inflammation • Lichen Planus • Movement Disorders • Mucositis • Pruritus • CD8

Lichen Aureus in a Patient with Prior Methotrexate Therapy: Successful Management with Topical Tacrolimus and Adjunctive Rutin/Vitamin C (ISDS 2025) - "She was started on betamethasone dipropionate 0.05% cream twice daily. While lichen aureus is typically idiopathic, the patient's prior methotrexate use raises the possibility that immune modulation may have contributed to lesion development, though a direct causal link cannot be established. Notably, this case demonstrates successful management using topical tacrolimus as a steroid-sparing agent, combined with adjunctive oral rutin and vitamin C to support vascular integrity, an approach rarely reported in the literature that may provide a useful strategy for persistent or refractory lesions."

Clinical • Dermatitis • Dermatology • Immune Modulation • Immunology • Infectious Disease • Pruritus • Respiratory Diseases • Tuberculosis

Lymphocytoma cutis treated with topical tacrolimus (ISDS 2025) - "Identified triggers include acupuncture, piercings, tattoos, medications (e.g., phenytoin), vaccinations, viral infections, insect bites, and Borrelia burgdorferi, though many cases are idiopathic...Current treatments—including systemic corticosteroids, intralesional injections, superficial radiotherapy, PUVA, photodynamic therapy, cryosurgery, and hydroxychloroquine—show variable efficacy, with no consensus on optimal management... This case highlights the potential utility of topical tacrolimus in LC, expanding therapeutic options for this challenging condition. Given the limited data on tacrolimus use in LC, further studies are warranted to establish efficacy and safety, particularly for lesions in cosmetically sensitive areas."

CNS Disorders • Dermatology • Hematological Malignancies • Infectious Disease • Lyme Disease • Lymphoma • Pruritus

A humanized xenotransplant model reveals IgG4 and HSP70 as co-drivers of vitiligo and predicts clinical drug responses (ISDS 2025) - "Therapeutically, topical tacrolimus and ruxolitinib cream produced repigmentation in ∼30% and ∼70% of lesions respectively, consistent with clinical experience; however, epidermal TRM persisted after ruxolitinib, retaining cytokine competence. Senescence and mitochondrial dysfunction are early, supportive features that increase model relevance to human disease. The platform therefore provides a translationally relevant tool for dissecting mechanisms and testing therapies that target humoral-cellular cooperation, danger signaling, and cellular senescence in vitiligo."

Clinical • Dermatology • Immunology • Metabolic Disorders • Transplantation • Vitiligo • CAT • CD8 • IFNA1 • IFNG • IL15 • IL18 • ITGAX • MICA • NKG2D • SIRT1 • Tyrosinase

Anti-Cytokine Drugs in the Treatment of Canine Atopic Dermatitis. (PubMed, Int J Mol Sci) - "Ciclosporin, a calcineurin inhibitor, remains a valuable immunosuppressant for long-term cAD management, while topical tacrolimus provides localized benefits...Consequently, they enable improved quality of life for affected dogs and their owners. Future strategies will likely focus on patient stratification and personalized approaches based on immunological endotypes."

Journal • Review • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Pruritus

The mouth as a window: A multi-center retrospective study of oral extraintestinal manifestations of IBD and their management. (PubMed, Med Oral Patol Oral Cir Bucal) - "OEIMs are common in IBD and can influence treatment decisions. Colchicine and topical agents demonstrated benefit in selected cases. These findings support multidisciplinary care and inform a therapeutic algorithm for OEIM management in IBD."

Journal • Retrospective data • Anesthesia • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Photobiomodulation in Combination With Topical Cyclosporine A or Tacrolimus (clinicaltrials.gov) - P1 | N=160 | Completed | Sponsor: University of Seville

New P1 trial • Dry Eye Disease • Ophthalmology