tacrolimus topical / Generic mfg. - LARVOL DELTA

Systematic review: the use of tacrolimus in steroid-refractory ulcerative colitis. (PubMed, Ther Adv Chronic Dis) - "Subgroup analyses compared oral tacrolimus with anti-TNF therapy and evaluated topical tacrolimus in SR-UP. Further large-scale trials are needed to optimise treatment strategies and evaluate long-term safety. The review has been registered with PROSPERO (CRD42023432827), the international prospective register of systematic reviews."

Journal • Review • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Oncology • Ulcerative Colitis

Randomized controlled study of mometasone furoate and tacrolimus in the treatment of vulvar lichen sclerosus (ChiCTR) - P=N/A | N=120 | Recruiting | Sponsor: Obstetrics and Gynecology Hospital of Fudan University; Obstetrics and Gynecology Hospital of Fudan University

New trial • Dermatology

Vitiligo-Like Depigmentation Induced by Cyclin-Dependent Kinase 4/6 Inhibitors in the Treatment of Metastatic Breast Cancer: A Case Report and Literature Review. (PubMed, Cureus) - "Ribociclib was switched to palbociclib, which was subsequently stopped as the VLD continued to progress...She was started on topical tacrolimus and mometasone cream with minimal improvement. Our case, in conjunction with the 40 cases evaluated as part of our literature review, highlights the need to increase physician awareness of VLD as a rare but significant complication of CDK 4/6 inhibitor use. Given its expanding role in everyday practice, it would be useful to recognise its typical clinical course and morphology, understand its pathophysiology and explore potential treatment options."

Journal • Breast Cancer • Dermatology • HER2 Negative Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Immunology • Oncology • Pruritus • Solid Tumor • Vitiligo • HER-2

Topical Tacrolimus in the Management of High-Risk Keratoplasty: A Systematic Review and Meta-Analysis. (PubMed, Cureus) - "This study confirms that topical tacrolimus is both effective and the safest treatment for managing high-risk penetrating keratoplasty (PKP). However, future studies should focus on determining the appropriate dosage levels for the management of high-risk PKP."

Journal • Retrospective data • Review • Infectious Disease • Inflammation • Mood Disorders • Ocular Inflammation • Ophthalmology • Transplant Rejection • Transplantation

Needle radiofrequency ablation (RFA) and topical tacrolimus combination therapy for primary localised cutaneous nodular amyloidosis. (PubMed, Indian J Dermatol Venereol Leprol) - No abstract available

Journal • Amyloidosis

Efficacy and safety of calcineurin inhibitors in cutaneous lupus: a systematic review and brief meta-analysis of recommended concentration, type, and outcomes. (PubMed, Ann Med Surg (Lond)) - "Our systematic review findings support the effectiveness of these inhibitors, namely pimecrolimus cream and tacrolimus ointment in improving clinical manifestations and disease activity in various forms of CLE, such as discoid lupus and subacute CLE. While calcineurin inhibitors are generally safe, the most common side effect was skin burning sensation at application site in the first few days of treatment. Further research is needed to prove the effectiveness of these drugs, explore the comparative effectiveness between different calcineurin inhibitors and comparing their types and their concentration."

Journal • Retrospective data • Cutaneous Lupus Erythematosus • Discoid Lupus Erythematosus • Immunology • Inflammatory Arthritis • Lupus

Evaluating the Efficacy of Topical Tacrolimus Alone and in Combination with Prednisolone for Treating Subepithelial Infiltrates in Epidemic Keratoconjunctivitis. (PubMed, Biomedicines) - " Topical tacrolimus, both alone and in combination with topical prednisolone, was effective in treating subepithelial infiltrates secondary to EKC. Combination therapy may be applied early for faster recovery; however, close monitoring of IOP is necessary in individuals using topical prednisolone."

Journal • Conjunctivitis • Dry Eye Disease • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Plasma Cell Balanitis Unresponsive to Topical Corticosteroids: Combined Efficacy of Tacrolimus and Emerging Evidence for Underrecognized Intrinsic Resistance to Corticosteroids. (PubMed, Cureus) - "Combined treatment of a preceding topical corticosteroid with 0.1% tacrolimus ointment led to a dramatic clinical response within two weeks of treatment, followed by almost complete resolution after six weeks...We discuss the potential difficulty in managing PCB, with particular interest in the relatively high frequency of corticosteroid resistance in nearly half of the cases reported to date. This paper also updates the possible mechanisms of action and clinical benefits of topical calcineurin inhibitors in plasma cell biology."

Journal • Dermatology

Tacrolimus 0.1% Ophthalmic Suspension: Corneal and Intraocular Penetration Study. (PubMed, J Ocul Pharmacol Ther) - " Tacrolimus concentrations measured in the corneal tissues are significantly higher than that described as lower limit of efficacy in solid organ transplantation. Topical 0.1% tacrolimus could therefore become an alternative to corticosteroids for endothelial graft rejection prevention and endothelial inflammatory pathologies management."

Journal • Inflammation • Ocular Inflammation • Ophthalmology • Solid Organ Transplantation • Transplant Rejection • Transplantation

Management and outcome of microsporidia-induced stromal inflammatory keratitis - A long-term follow-up study. (PubMed, Indian J Ophthalmol) - "Microsporidia-associated ISK/IK is a novel condition having a chronic course with recurrences. It requires close follow-up for recurrences at least six months after discontinuing medications, and topical 0.03% tacrolimus ointment is an effective corticosteroid-sparing agent."

Journal • Keratitis • Ocular Inflammation • Ophthalmology

Management of folliculitis decalvans: The EADV task force on hair diseases position statement. (PubMed, J Eur Acad Dermatol Venereol) - "Oral isotretinoin should be considered as the first-line therapy in patients with mild active disease (perifollicular erythema and hyperkeratosis, no pustules or crusts)...Photodynamic therapy, biologics (preferably adalimumab), JAK inhibitors, oral dapsone, hydroxychloroquine or cyclosporine may also be effective...Topical tacrolimus 0.1% or dapsone 5% may be considered as second-line topical therapeutic options. In patients with folliculitis decalvans, surgical excision or laser therapy can be useful. Hair transplantation can be considered in patients with inactive disease."

Journal • Aesthetic Medicine • Alopecia • Dermatology • Immunology • Inflammation • Transplantation

Effectiveness and safety of rectal tacrolimus in patients with ulcerative colitis. TACRO-TOPIC study of GETECCU. (PubMed, J Crohns Colitis) - "Topical tacrolimus is an effective therapy and could be considered in distal UC patients before initiating other advance therapies when endoscopic activity remains."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

Topical tacrolimus for the amelioration of breast cancer-related lymphedema (TACLE Trial): a study protocol for a randomized, double-blind, placebo-controlled phase II/III trial. (PubMed, Trials) - P2/3 | "This trial will provide robust data on the efficacy of topical tacrolimus in reducing BCRL volume and improving patient quality of life. Positive results could establish tacrolimus as a standard treatment for BCRL, potentially enhancing clinical outcomes for affected patients. The findings will also contribute to understanding the role of immunomodulation in lymphedema management."

Clinical • Clinical protocol • Journal • P2/3 data • Breast Cancer • Fibrosis • Immunology • Oncology • Solid Tumor • CD4

A Comparative Clinical Trial Evaluating the Effect and Safety of Tacrolimus Versus Hydrocortisone (clinicaltrials.gov) - P2 | N=100 | Completed | Sponsor: Tanta University | Recruiting ➔ Completed

Trial completion • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy of topical tacrolimus 0.03% ointment in combination with microneedling versus topical phenytoin 2% cream in combination with microneedling for the treatment of non-segmental facial vitiligo. (PubMed, Arch Dermatol Res) - "Our results provide additional evidence for the potential positive role of phenytoin as a therapeutic option in patients with non segmental vitiligo. However, tacrolimus 0.03% ointment combined with microneedling was associated with a better response than phenytoin 2% cream combined with microneedling."

Clinical • Journal • Dermatology • Immunology • Vitiligo

Prospective clinical study of tacrolimus ointment combined with swellable microneedles in the treatment of psoriasis (ChiCTR) - P4 | N=60 | Not yet recruiting | Sponsor: Chu Hsien-I Memorial Hospital of Tianjin Medical University; Chu Hsien-I Memorial Hospital of Tianjin Medical University

New P4 trial • Dermatology • Immunology • Psoriasis

TERRITORY-WIDE RETROSPECTIVE REVIEW ON OUTCOMES OF ALLOGENEIC TRANSPLANTATION FOR HAEMOGLOBIN BART'S HYDROPS FETALIS SYNDROME IN HONG KONG (EBMT 2025) - "Apart from mild grade II acute graft-versus-host-disease (GVHD) of skin which resolved readily with topical steroid/tacrolimus and ruxolitinib, there were no features of severe acute GVHD or chronic GVHD... To conclude, local data demonstrated favorable outcome of allogeneic HSCT for BHFS patients. Non-directive approach in antenatal counseling and international collaboration is recommended. Haploidentical HSCT for BHFS patients using TCRab-depleted graft is a safe and feasible therapeutic option."

Retrospective data • Review • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Pediatrics • Transplantation

TERRITORY-WIDE RETROSPECTIVE REVIEW ON OUTCOMES OF ALLOGENEIC TRANSPLANTATION FOR HAEMOGLOBIN BART'S HYDROPS FETALIS SYNDROME IN HONG KONG (EBMT 2025) - "Apart from mild grade II acute graft-versus-host-disease (GVHD) of skin which resolved readily with topical steroid/tacrolimus and ruxolitinib, there were no features of severe acute GVHD or chronic GVHD... To conclude, local data demonstrated favorable outcome of allogeneic HSCT for BHFS patients. Non-directive approach in antenatal counseling and international collaboration is recommended. Haploidentical HSCT for BHFS patients using TCRab-depleted graft is a safe and feasible therapeutic option."

Retrospective data • Review • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Pediatrics • Transplantation

EXCELLENT OUTCOMES OF HAEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN WITH SEVERE APLASTIC ANEMIA, A SINGLE CENTRE EXPERIENCE; 15 YEARS RESULTS (EBMT 2025) - "We concluded that the HSCT program for children with SAA in Singapore has been robust and successful, yielding excellent long-term outcomes and overall survival."

Clinical • Acute Graft versus Host Disease • Acute Respiratory Distress Syndrome • Anemia • Aplastic Anemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Pediatrics • Pneumonia • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections • Transplantation

Limbal Stem Cell Deficiency Induced by Prolonged Use of Topical 0.03% Tacrolimus Ointment in a Patient With Atopic Keratoconjunctivitis. (PubMed, Eye Contact Lens) - "This case suggests that LSCD is possible after prolonged use of topical tacrolimus ointment 0.03%. In this context, it is imperative to monitor patients continuously to evaluate the safety of its chronic use."

Journal • Conjunctivitis • Dry Eye Disease • Ocular Infections • Ocular Inflammation • Ophthalmology

Focal Hypertrichosis during Topical Tacrolimus Therapy for Vitiligo: A Case Report. (PubMed, Case Rep Dermatol) - "Drug-induced hypertrichosis is a well-known side effect of cyclosporine. It is reported that tacrolimus directly stimulates mouse whiskers in vitro and prolongs the anagen phase of hair growth when it is applied topically in mice. We believe that a greater awareness of this rare side effect of tacrolimus is warranted as tacrolimus is widely used in treating vitiligo."

Journal • Dermatology • Immunology • Vitiligo

Adverse effects of topical tacrolimus compounded ophthalmic preparations. (PubMed, Cutan Ocul Toxicol) - "It is imperative to understand the potential side effects associated with topical tacrolimus ophthalmic preparations to optimize the treatment outcomes and guarantee patient safety. Routine ophthalmic examinations should be conducted to detect these side effects early and address them appropriately."

Adverse events • Journal • Review • Cataract • Glaucoma • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Dupilumab-Associated Ocular Surface Disease in Paediatric Atopic Dermatitis Patients: Results From the BioDay Registry. (PubMed, Clin Exp Allergy) - "This prospective, long-term, real-world study shows that 34.6% of paediatric AD patients treated with dupilumab develop DAOSD. Elevated baseline serum IgE (≥ 3000 kU/L) may predict the development of DAOSD. The high incidence of DAOSD underscores the importance of awareness of ocular symptoms during dupilumab treatment, especially in (young) paediatric patients, where reporting ocular symptoms can be challenging and may lead to delayed diagnosis."

Journal • Atopic Dermatitis • Conjunctivitis • Dermatitis • Dermatology • Immunology • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pediatrics • Pruritus

Comparison of Safety and Efficacy of Topical Mometasone 0.1% Ointment, Calcipotriol 0.005% Ointment, and Tacrolimus 0.1% Ointment in Patients with Localized Alopecia Areata: A Triple-Arm Randomized Clinical Study. (PubMed, Indian Dermatol Online J) - "Treatment consists of corticosteroids, calcineurin inhibitors, prostaglandin analogs, minoxidil, anthralin, vitamin D analogs, and JAK STAT inhibitors. The lack of long-term follow-up is also a limitation of this study. Both mometasone and calcipotriol formulations were found to be effective in the treatment of localized stable AA; however, calcipotriol preparation was associated with minimal side effects."

Journal • Alopecia • Dermatology • Immunology

Effect of needle cauterization on vitiligo with deficiency cold and blood stasis: a randomized controlled trial (PubMed, Zhongguo Zhen Jiu) - "A total of 62 patients of vitiligo with deficiency cold and blood stasis were randomly divided into an observation group and a control group, 31 cases each group.On the basis of 308 nm excimer light irradiation combined with ironing with Chinese medicine, the control group was treated with tacrolimus ointment for external use, twice a day; the observation group was treated with needle cauterization at vitiligo spots, once a week.Both groups were treated for 10 weeks...The total effective rate in the observation group was 93.5% (29/31), which was higher than 77.4% (24/31) in the control group (P<0.05). Needle cauterization could reduce the areas of vitiligo spot in patients of vitiligo with deficiency cold and blood stasis, improve the clinical symptoms, its mechanism may be related to the reduction of serum levels of inflammatory indexes."

Clinical • Journal • Dermatology • Immunology • Vitiligo • IL17A • IL6