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May 15, 2024
Deubiquitinase UCHL1 stabilizes KDM4B to augment VEGF signaling and confer bevacizumab resistance in clear cell renal cell carcinoma.
(PubMed, Transl Oncol)
- "Overall, this study defined an epigenetic mechanism of UCHL1/KDM4B in activating VEGF signaling. The UCHL1-KDM4B axis represents a novel target for treating ccRCC and improving the efficacy of anti-angiogenesis therapy."
Journal • Clear Cell Renal Cell Carcinoma • Colorectal Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • Targeted Protein Degradation • EPAS1 • KDM4B • UCHL1
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