BL0175 / Shanghai Best-Link Biosci - LARVOL DELTA

A Study of BL0175 Injection in Postmenopausal Female Adults With HR-positive, Locally Advanced or Metastatic Cancer (clinicaltrials.gov) - P1 | N=9 | Recruiting | Sponsor: Shanghai Best-Link Bioscience, LLC | Not yet recruiting ➔ Recruiting

Enrollment open • Breast Cancer • Endometrial Cancer • Hormone Receptor Positive Breast Cancer • Oncology • Ovarian Cancer • Solid Tumor

BL0175: An intramuscular nano-conjugate of fulvestrant, exhibits superior tumor distribution and antitumor efficacy compared to fulvestrant injection in MCF-7 xenograft mouse model (AACR 2025) - "BL0175 is a unique preclinical nano-drug candidate that exhibited remarkedly enhanced tumor retention and excellent pharmacokinetic properties compared to fulvestrant injection. Furthermore, BL0175 demonstrated superior anti-tumor efficacy against fulvestrant injection in breast cancer. The pre-clinical efficacy and safety studies supported its further development in the clinical stage for HR+ breast cancer therapy."

Preclinical • Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Oncology • Solid Tumor • ER