piroxicam / Generic mfg. - LARVOL DELTA

First-line treatment with low-dose ruxolitinib, pirfenidone, and low-dose calcineurin inhibitors leads to significant improvement in patients with bronchiolitis obliterans syndrome after allogeneic transplantation (ASH 2025) - "Traditional treatments for BOS rely on glucocorticoids combined with FAM regimens ( fluticasone + azithromycin + montelukast ) and calmodulin phosphatase inhibitors ( CNIs ), but they have limited efficacy with an even lower overall remission rate ( ORR ) and poor prognosis once progression to steroid-refractory cGVHD (SR-cGVHD) is achieved...Methods A retrospective analysis of 14 patients, 11 males and 3 females, with a median age of 19 years (7-54 years), who underwent hematopoietic stem cell transplantation combined with BOS at Henan Cancer Hospital from 2018 to 2025, including 6 cases of mild BOS, 3 cases of moderate BOS, 5 cases of severe BOS, Among them, 6 cases of mild, 3 cases of moderate, and 5 cases of severe BOS were treated with low-dose rucotinib ( 5 mg qd po) combined with piroxicam (200 mg tid po), small-dose CNI (half of the effective therapeutic concentration), and FAM first-line treatment...Conclusions In conclusion, the first-line treatment of BOS..."

Clinical • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Transplantation

Curcumin impacts on cisplatin sensitivity determining apoptotic boost in mesothelioma. (PubMed, Biomed Pharmacother) - "The effect of combined treatment was evaluated in 2D and 3D cultures by using two MM cell lines, MSTO-211H and Ist-Mes2, that are sensitive or less responsive to the piroxicam/cisplatin combined treatment respectively. Results indicate that this treatment determines a dramatic apoptotic increase linked to a concomitant inactivation of Nrf2, a transcription factor with a key role in carcinogenesis, and of NUPR1, a transcriptional regulator involved in drug chemoresistance."

Journal • Mesothelioma • Oncology • Solid Tumor

Asiatic acid inhibits NF-κB signaling and ameliorates experimental acute and chronic colitis in mice. (PubMed, Int J Immunopathol Pharmacol) - "AA alleviates intestinal inflammation by suppressing NF-κB signaling in vitro and exhibits therapeutic efficacy in both acute and chronic colitis models, suggesting its potential as a therapeutic candidate for inflammatory bowel disease."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Oncology • IL10 • IL6 • NFKBIA • TNFA

Chemically tuned radiolabeling and membrane affinity in Drug-Functionalized carbon nanotube nanocarriers. (PubMed, Sci Rep) - "Four clinically relevant drugs-methotrexate, diclofenac, ketotifen, and piroxicam-were conjugated to a single-walled CNT (SWCNT) via a bifunctional chelating group. Free energy landscapes reconstructed from metadynamics simulations further confirmed the high thermodynamic stability of this configuration. These findings suggest that rational drug selection can effectively tune the physicochemical behavior of CNT-based radiopharmaceuticals, providing a mechanistic foundation for designing multifunctional nanocarriers with improved performance for nuclear imaging and site-specific drug delivery."

Journal • Oncology

Drug Repurposing in Veterinary Oncology: Myth or Reality? (PubMed, Vet Sci) - "The therapeutic agents discussed include non-steroidal anti-inflammatory drugs (e.g., piroxicam), metabolic modulators (e.g., metformin), anti-parasitic drugs (e.g., fenbendazole), immunomodulators (e.g., thalidomide, oclacitinib), cardiovascular agents (e.g., propranolol, statins, losartan), and other compounds such as auranofin and disulfiram. Challenges to clinical implementation, including limited funding, regulatory and ethical considerations, and the need for well-designed, multi-institutional clinical trials, are discussed. Ultimately, drug repurposing represents a practical and translationally valuable approach to broaden therapeutic options, improve quality of life in companion animals, and advance comparative oncology by promoting progress that benefits both veterinary and human patients."

Journal • Review • Cardiovascular • Oncology

Primary Prostatic Carcinoma with Metastasis to Epaxial Muscles and Myocardium in a Dog. (PubMed, Vet Sci) - "This report describes an 11-year-old intact male Maltese dog with a two-month history of anorexia and lethargy, referred for further evaluation after failing to respond to piroxicam therapy...To the best of our knowledge, this is the first documented case of canine prostatic carcinoma with exclusive myotropic and myocardial metastases. These findings suggest a possible hematogenous metastatic route and highlight the importance of including muscle and cardiac tissues in staging protocols for canine prostatic carcinoma, even when lymphadenopathy or pulmonary lesions are absent."

Journal • Anorexia • Oncology • Prostate Cancer • UPK3

In vivo and in silico assays demonstrate that the hydroalcoholic extract of Aloysia polystachya and carvone promote anti-ulcer effects. (PubMed, J Ethnopharmacol) - "The findings of this study demonstrate that the hydroalcoholic extract of A. polystachya (HEAp) and its bioactive compound carvone possess significant gastroprotective and gastric healing properties. These effects are likely mediated through the modulation of sulfhydryl compounds, anti-inflammatory and antioxidant defenses, and antisecretory mechanisms. The identification of phenolic constituents, combined with in silico analyses, further supports the potential therapeutic relevance of HEAp and carvone. Collectively, these results highlight that the phytoconstituents from A. polystachya corroborate the traditional use of the plant and are promising candidates for the investigation of anti-ulcer gastric agents."

Journal • Preclinical • Peptic Ulcer • MPO

Efficacy and Potential Mechanisms of Yi-Ping Lin Circum-Knee Acupuncture in the Treatment of Knee Osteoarthritis. (PubMed, J Pain Res) - "Female SD rats were randomly divided into 4 groups: Sham, Model, CKA-L treatment (Treatment), and positive control (Piroxicam)...The PPI analysis of DEGs designated five hub genes: Bgn, Ctsb, Lum, Serpine1, and Tnfaip6, which demonstrated consistent transcriptional and translational expression levels. CKA-L promotes chondrocyte proliferation and provides effective treatment for KOA, with the advantages of low price, low side effects, and convenient operation."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology • BGN • IL1B • SERPINE1 • TNFA • TNFAIP6

A real-world data analysis of piroxicam in the FDA Adverse Event Reporting System (FAERS) database. (PubMed, Front Med (Lausanne)) - "This real-world study reinforces established safety concerns related to piroxicam while identifying potentially less well-known safety signals. These findings offer valuable insights for clinicians aiming to optimize patient safety during piroxicam therapy."

Adverse events • Journal • Real-world evidence • Dermatology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Pain • Peptic Ulcer • Urticaria

Mechanistic investigation of polymorphic transformation and solubilization in piroxicam multicomponent delivery systems via experimental and multiscale simulation approaches. (PubMed, Int J Pharm) - "These interactions synergistically increased PRX conformational flexibility, inhibited crystallization, and promoted amorphization. This study uncovers the molecular mechanisms of excipient-mediated polymorphic transformation and provides theoretical insights for the rational design of multicomponent solubilization systems."

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Systematic review and meta-analysis of analgesic treatment options in patients with rheumatoid arthritis related pain. (PubMed, Adv Rheumatol) - "Several therapies demonstrated substantial pain relief, but heterogeneity, publication bias, and varying study quality limit generalizability. High-quality, long-term trials with standardized pain assessments are needed to guide personalized rheumatoid arthritis pain management."

Clinical • Journal • Retrospective data • Review • Immunology • Inflammation • Inflammatory Arthritis • Musculoskeletal Pain • Pain • Rheumatoid Arthritis • Rheumatology

Altered expressions of CGRP, SULT1A1, HMGB1, and HIF-1α in the trigeminal ganglion in medication overuse headache in female rats. (PubMed, J Headache Pain) - "Our study showed for the first time that NSAID overuse headache is associated with a robust increase in CGRP, HMGB1, and HIF-1α and reduced SULT1A1 expression in the trigeminal ganglion. Increased nociceptive, inflammatory, and mitochondrial stress signaling in the trigeminal ganglion cells may drive sustained trigeminal nociceptive activity in MOH. Besides, reduced SULT1A1 expression in the trigeminal ganglion suggests reduced capacity of detoxification and catecholamine metabolism in MOH. The role of lipopolysaccharide leakage and systemic nociceptive drive on trigeminal neurons remains to be clarified."

Journal • Preclinical • CNS Disorders • Inflammation • Migraine • Pain • HIF1A • HMGB1 • SULT1A1

Repurposing piroxicam as an SLC7A5 antagonist to ameliorate prothrombotic state in Diane-35-treated polycystic ovary syndrome patients. (PubMed, Comput Biol Med) - "This study elucidate a novel genetically informed mechanism for Diane-35-associated thrombosis and propose targeted SLC7A5 inhibition as a promising therapeutic strategy. Piroxicam emerges as a mechanistically grounded repurposing candidate for mitigating thrombotic risk in PCOS, effectively bridging genomic discovery with clinical intervention."

Journal • Cardiovascular • Hematological Disorders • Polycystic Ovary Syndrome • Thrombosis • SLC7A5

Anti-arthritic and anti-inflammatory effects of BMZD-2CPE in a CFA and carrageenan-induced animal model. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Treatment with BMZD-2CPE and piroxicam was started on the 7th day of arthritic induction and continued for 20 days...Creatinine, urea, alanine transaminase, and aspartate aminotransferase levels were found to be non-significantly different indicating safety of the compound. BMZD-2CPE in various doses (more potentially in higher dose) showed anti-inflammatory and immunomodulatory properties."

Journal • Preclinical • Immunology • Inflammation • Rheumatology • IL6 • TNFA

Lipid Raft Membrane Interactivity Correlating with Cyclooxygenase-2 Selectivity of Non-Steroidal Anti-Inflammatory Drugs. (PubMed, Membranes (Basel)) - "Conventional NSAIDs (diclofenac, ibuprofen, indomethacin, aspirin, and flurbiprofen) and Coxibs (lumiracoxib, etoricoxib, celecoxib, valdecoxib, and rofecoxib) decreased membrane fluidity, whereas Oxicams (meloxicam, piroxicam, tenoxicam, and lornoxicam) increased. Under inflammatory acidic conditions, the lipid raft membrane interactivity of NSAIDs was more likely to correlate with cyclooxygenase-2 selectivity than the reference membrane interactivity. It is hypothesized that NSAIDs may interact with lipid raft membranes to induce membrane fluidity changes with the potency corresponding to cyclooxygenase-2 inhibition, disrupting the structural and functional integrity of lipid rafts to affect the activity of cyclooxygenase-2 localized in lipid rafts, resulting in cyclooxygenase-2 selective inhibition."

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Bioinformatics Analysis Reveals the Oncogenic Role and Therapeutic Potential of lncRNA SNHG25 in Colon Adenocarcinoma. (PubMed, Int J Genomics) - "ZMYND8 was identified as a key downstream mRNA target (AUC = 0.811), and three potential therapeutic drugs-demecolcine, piroxicam, and vorinostat-were predicted based on DSigDB screening and validated by molecular docking, with binding energies of -6.48, -7.15, and -5.39 kcal/mol, respectively. Finally, in vitro cellular assays confirmed that SNHG25 expression was elevated in COAD cell lines (p < 0.0001), and its knockdown significantly suppressed cell proliferation, migration, and invasion. This study highlights that SNHG25 is highly expressed in COAD and promotes tumor progression through multiple mechanisms, advancing research and treatment strategies for this malignancy."

IO biomarker • Journal • Colon Adenocarcinoma • Colon Cancer • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Oncology • SNHG5 • ZMYND8

Nonsteroidal Anti-Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis. (PubMed, Clin Pharmacol Ther) - "Among non-selective NSAIDs, ibuprofen had the lowest significant risk (OR 2.28, 95% CI: 1.71-3.03), while ketorolac showed the highest risk (OR 20.67, 95% CI: 14.56-29.34). Other agents, such as piroxicam and meloxicam, also demonstrated significantly elevated risks...Celecoxib appears to have the lowest GI risk, though cardiovascular safety must also be considered. These findings highlight the need for personalized NSAID selection and suggest that NSAIDs should not be treated as a uniform class when assessing bleeding risk."

Journal • Retrospective data • Review • Cardiovascular • Gastroenterology • Inflammation • Pain

Drug-Induced Toxic Epidermal Necrolysis: A Case Report. (PubMed, Cureus) - "The medications most frequently associated with TEN include antibiotics such as sulfamethoxazole-trimethoprim (sulfonamides), penicillins, cephalosporins, and quinolones (e.g., ciprofloxacin); anticonvulsants such as phenytoin, carbamazepine, and lamotrigine; nonsteroidal anti-inflammatory drugs (NSAIDs), especially oxicam derivatives (e.g., piroxicam), and, less commonly, ibuprofen; allopurinol; nevirapine; and other agents such as paracetamol, celecoxib, tyrosine kinase inhibitors, and immunobiological therapies like infliximab...However, the use of immunomodulatory therapies, such as corticosteroids, cyclosporine, and biologics, remains a subject of ongoing debate, with inconsistent evidence regarding their efficacy...The prognosis in TEN is heavily influenced by factors such as advanced age, existing comorbidities, and the extent of skin involvement. Given the high fatality rates associated with TEN, especially in older adults, clinicians should maintain a high index..."

Journal • Geriatric Disorders • Immunology • Infectious Disease • Pain • Steven-Johnson Syndrome • HLA-B

Investigation of antibacterial and wound healing activities of the extract of Rhodotorula mucilaginosa endophyte isolated from cucumber leaves. (PubMed, Sci Rep) - "The in vitro anti-inflammatory activity of ERM was supported by the marked decrease in TNF-α gene expression in the cells treated with either ERM or piroxicam compared to the control cells...The histological investigation of the wound showed a remarkable improvement in the group treated with ERM. Therefore, further investigation is required to explore the possible application of ERM as a potential antibacterial agent, which could aid in our fight against pathogenic microbes that have become resistant."

Journal • Infectious Disease • TNFA

A comprehensive DFT study on piroxicam transition metal complexes (Mn, Fe, Co, Ni, and Zn): implications for computational drug design. (PubMed, J Mol Model) - "Solvent effects (water, ethanol, and DMSO) were modeled using the SMD continuum model as implemented in the Gaussian 16. Key descriptors such as HOMO-LUMO energies, their energy gaps, molecular electrostatic potential (ESP), and thermodynamics metrics were computed by Multiwf, Jmol, and SHERMO, respectively."

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Prescription Trends by Orthopedic Surgery Provider: Review of the Medicare Part D Prescribers - by Provider and Drug, 2013-2021. (PubMed, Orthopedics) - "In line with national guidelines, claims for NSAIDs are increasing and claims for opioid pain medications and AOMs are decreasing. Claims for outpatient antibiotics are increasing, which is of significant concern, given renewed focus on antibiotic stewardship."

Journal • Medicare • Reimbursement • Review • US reimbursement • Orthopedics • Pain

Citrus aurantifolia essential oil: antiaging potential through integrated in vitro and in silico studies. (PubMed, Front Chem) - "In vitro analysis revealed good inhibition of elastase and collagenase enzymes by fresh key lime essential oil, with IC50 values of 145.02 and 63.97 μg/mL, respectively, compared to positive controls (daidzein for collagenase, piroxicam for elastase), in comparison to dry key lime oil (IC50 = 223.14 and 109.57 μg/mL, respectively)...The anti-aging potential of fresh key lime essential oil may be attributed to its major compounds. These findings suggest that key lime essential oil could be a promising natural ingredient for anti-aging skincare formulations."

Journal • Preclinical • ELANE

From prescription patterns to drug safety: a closer look at non-steroidal anti-inflammatory drugs and analgesics in outpatient pharmacy. (PubMed, Front Pharmacol) - "A significant association was found between the prescribed NSAID and its co-prescription with gastroprotective agents, specifically ibuprofen, celecoxib, piroxicam, meloxicam (P < 0.001), diclofenac (P = 0.007), and aspirin (P = 0.001). The study examines NSAID prescribing trends and emphasizes the potential for drug-related issues, particularly in light of polypharmacy, which calls for careful monitoring and prescribing practices. Healthcare providers should routinely conduct medication reviews and team up with clinical pharmacists to ensure rational NSAID use, reduce drug interactions, and enhance patient safety by thus mitigating this risks."

Journal • Cardiovascular • Diabetes • Inflammation • Metabolic Disorders • Pain

Repurposing piroxicam enhances the antineoplastic effects of docetaxel and enzalutamide in prostate cancer cells using 2D and 3D in vitro culture models. (PubMed, Front Cell Dev Biol) - "Importantly, PXM treatment in combination with Doc or Enz resulted in more pronounced antineoplastic effects compared to single-drug exposure. Our work suggests PXM as a potential adjunctive therapy to enhance the efficacy of conventional treatments in PCa patients."

Journal • Preclinical • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Molecular imprinted polymer-based metal complex potentiometric sensor doped with carbon nanotubes for sensitive determination of piroxicam in spiked human plasma. (PubMed, RSC Adv) - "The obtained Nernstian slope was 28.97 mV/decade with linearity range of 9.7 × 10-7-1 × 10-3 M and LOD of 5.2 × 10-7 M. The sensor was successfully applied into spiked human plasma. This would offer an alternative sensing platform for therapeutic monitoring of piroxicam in biological fluids."

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