piroxicam / Generic mfg. - LARVOL DELTA

Sorafenib/piroxicam therapy with biomarker-defined survival benefit in canine muscle-invasive urothelial carcinoma. (PubMed, Sci Rep) - "Biomarker analyses revealed that treatment-induced hypertension and high tumor CX3CL1 mRNA expression were independently associated with improved overall survival, suggesting that effective VEGFR pathway inhibition and modulation of the tumor immune microenvironment contribute to clinical benefit. These findings support sorafenib-based therapy as a promising strategy for canine urothelial carcinoma and highlight the translational potential of biomarker-driven VEGFR-targeted approaches in precision oncology."

Biomarker • Journal • Bladder Cancer • Cardiovascular • Genito-urinary Cancer • Hypertension • Oncology • Solid Tumor • Urothelial Cancer • BRAF • CX3CL1 • PDGFRB

A Model of Piroxicam-Accelerated Enterocolitis in Interleukin-10 Knockout Mice for Studying Inflammation-Induced Metabolic Alterations. (PubMed, J Vis Exp) - "The protocol is efficient and reproducible, inducing enterocolitis simultaneously in multiple mice, and allows assessment of metabolic dysregulation in an inflammatory bowel disease model. Further studies using this protocol may investigate the effects of enterocolitis on other components of metabolic dysregulation, such as energy expenditure and body composition, revealing broader connections between inflammatory bowel disease and host metabolism."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Mucositis • IL10

Evaluation of anti-arthritic activity of aripiprazole through multi models: new potential of an old drug. (PubMed, Inflammopharmacology) - "Above stated results strongly claims that aripiprazole is an effective anti-arthritic therapy as verified through molecular docking, in-vitro and in-vivo assessment and via down regulating pro-inflammatory markers and up regulation of anti-inflammatory cytokines and can be thought to be an appropriate option to repurpose the drug as anti-arthritic agent."

Journal • CNS Disorders • Immunology • Oncology • Rheumatology • Targeted Protein Degradation • IL10 • IL1B • IL4 • IL6 • TNFA

Comparing the Effect of Subcutaneous and Intradermal Mesotherapy on Pain and Function in Knee Osteoarthritis: A Randomized Clinical Trial : Short title: Subcutaneous vs. Intradermal Mesotherapy in Knee Osteoarthritis. (PubMed, Galen Med J) - "Each patient received six sessions of intradermal or subcutaneous piroxicam-lidocaine mesotherapy at six acupuncture points over three weeks (two sessions per week)...Both subcutaneous and intradermal mesotherapy appeared to be effective short-term treatments for patients with KOA. However, intradermal mesotherapy demonstrated greater effectiveness at the one-month follow-up, with superior pain reduction and functional improvement compared with subcutaneous mesotherapy."

Clinical • Journal • Immunology • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology

Sabinene attenuates inflammation and oxidative stress in CFA-induced arthritis: In vivo and in silico evidence implicating TLR4/NLRP3/NF-κB signaling. (PubMed, Biomol Biomed) - "Rats were allocated to vehicle control, arthritic control, piroxicam, or sabinene groups (15, 30, or 60 mg/kg; n = 6/group); sabinene was administered orally beginning 30 minutes before CFA injection and continued for 28 days...These findings support a prophylactic protective effect of sabinene against CFA-induced arthritis associated with reduced inflammation, improved antioxidant status, and modulation of inflammasome-related gene expression. Further protein-level, functional, and post-induction studies are required to confirm the proposed mechanisms and therapeutic relevance."

IO biomarker • Journal • Preclinical • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Oncology • Rheumatoid Arthritis • Rheumatology • IFNG • IL10 • IL4 • IL6 • NLRP3 • STAT3 • TLR4 • TNFA

Comparative effects of topically applied diclofenac, ketoprofen, and piroxicam on interleukin-17, signal transducer and activator of transcription 3, and prostaglandin E2 levels in a rat model of collagen-induced arthritis. (PubMed, Med Glas (Zenica)) - "Topical NSAIDs demonstrated selective anti-inflammatory effects, primarily through significant suppression of tissue PGE₂, confirming effective local COX pathway inhibition. The absence of significant changes in IL-17 and STAT3 suggests that short-term topical therapy mainly targets prostaglandin-mediated inflammation rather than upstream cytokine or transcriptional pathways involved in rheumatoid arthritis pathogenesis, warranting further investigation into their long-term therapeutic benefits."

Clinical • Journal • Preclinical • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • IL17A • STAT3

Oral Retinol, Alone or Combined with Medical Photoprotection, in Patients with Actinic Keratosis: A Randomized, Open-Label, Prospective, Multicentric Study. (PubMed, Dermatol Ther (Heidelb)) - "Oral retinol combined with medical photoprotection was associated with earlier and greater improvements than oral retinol alone or standard photoprotection recommendations. These findings support further controlled studies to confirm efficacy and clarify the contribution of each intervention."

Journal • Actinic Keratosis • Dermatology • Oncology • Squamous Cell Carcinoma

Piroxicam accelerates diabetic foot ulcer healing via ERα-dependent mitochondrial protection and oxidative stress relief. (PubMed, Front Pharmacol) - "Piroxicam's protection of mitochondrial function and suppression of oxidative stress was also abolished upon blocking ERα by tamoxifen. In conclusion, piroxicam alleviates mitochondrial dysfunction and suppresses inflammatory responses by binding to ERα, which ultimately promotes DFU healing at low doses."

Journal • Diabetes • Fibrosis • Immunology • Inflammation • Metabolic Disorders • STING

Preclinical evaluation of 3,4-dimethoxybenzoic acid alone and in combination for adjuvant-induced arthritis in Wistar rats. (PubMed, Immunopharmacol Immunotoxicol) - "The VA was given at doses of 20, 40, and 80 mg/kg, with Piroxicam (10mg/kg) as standard drug. For anti-arthritic action, 0.1 ml of Complete Freund's adjuvant was intradermally inoculated in left posterior paw on first day while treatment with VA at 20, 40, 80, and VA 80 mg/kg + methotrexate and methotrexate (1 mg/kg) as standard drug were given orally on the 8th day for 21 days...In acute toxicity study, LD50 of VA was greater than 2000 mg/kg. It can be inferenced from data that VA can be safely used to treat arthritis especially in combination with MTX but it should be further evaluated in combination for long term use."

Journal • Preclinical • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • IL10 • IL4 • IL6 • TNFA

ORAL AND INTRA - LIGAMENTARY PIROXICAM for Post Endodontic Pain Management (clinicaltrials.gov) - P4 | N=50 | Completed | Sponsor: Pakistan Institute of Medical Sciences

New P4 trial • Pain

Protective Effects of Geraniol in Rheumatoid Arthritis Through Attenuation of Inflammation and Oxidative Stress. (PubMed, Endocr Metab Immune Disord Drug Targets) - "Geraniol pretreatment was associated with reduced severity of arthritis, lower inflammatory cytokine mRNA expression, and improved oxidative stress markers in an FCA-induced rat model. These findings reflect effects on disease development in a pretreatment (pre-induction) experimental model and do not represent therapeutic efficacy in established rheumatoid arthritis. Further studies using post-induction treatment designs are required to evaluate potential therapeutic relevance."

Journal • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Oncology • Rheumatoid Arthritis • Rheumatology • HIF1A • IL1B • IL6 • TNFA

Exposomic fingerprints of emerging contaminants in a mediterranean multi-by‑product dietary supplement: a preliminary study. (PubMed, Sci Rep) - "Pesticides represented the dominant contaminant class, with phosmet, fluazinam, and chlorantraniliprole contributing most to the overall burden, while piroxicam and diclofenac were the principal pharmaceutical residues...Because the study was conducted on a single supplement formulation, the results should be interpreted as a proof-of-concept dataset rather than as representative of plant-based supplements in general. To our knowledge, this is the first study reporting the concurrent occurrence of pharmaceuticals, pesticides, cyanotoxins, and a lifestyle-related chemical marker in a Mediterranean agro-industrial by-product dietary supplement, providing a baseline for future exposomic investigations and the development of monitoring strategies within a One Health framework."

Journal

A standardized fecal microbiota transplantation protocol enables consistent, microbiota-driven colitis in IL-10-deficient mice. (PubMed, Front Microbiol) - "To overcome this limitation, pharmacologic approaches such as piroxicam administration have been widely used to synchronize disease, but these methods introduce epithelial injury and non-microbiota-dependent inflammatory pathways that confound mechanistic interpretation...Importantly, this approach preserves microbiota-driven disease mechanisms while improving experimental consistency compared with conventional spontaneous Il10-/- models and avoids the confounding effects of pharmacologic synchronization. The protocol is compatible with downstream histological, immunological, and microbiome analyses and provides a practical platform for investigating host-microbiota interactions and microbiome-targeted therapeutic strategies in IBD."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Transplantation • IL10

Effect of electron beam irradiation of piroxicam on inhibiting the inflammatory response in LPS-stimulated BMDCs and sepsis-induced mouse models. (PubMed, Biomed Pharmacother) - "In a lipopolysaccharide-induced sepsis model, PX-EB showed mediator-specific systemic anti-inflammatory activity and a relatively favorable hepatic biochemical profile, compared with PX. Collectively, these findings suggest that e-beam irradiation generates structurally distinct PX-derived radiolytic products with selective immunomodulatory activities, supporting further investigation of irradiation-based structural modification as a strategy to expand the pharmacological utility of existing NSAID."

Journal • Preclinical • Infectious Disease • Inflammation • Oncology • Septic Shock • IL12A • IL6 • TNFA

Clinical Remission of an Unresectable Presumptive Haemangiosarcoma in a Dog Treated With Toceranib, Piroxicam, and Propranolol: A Case Report. (PubMed, Vet Med Sci) - "Haemangiosarcoma (HSA) is a highly aggressive vascular tumour in dogs, characterised by rapid growth, early metastasis, and poor prognosis despite conventional treatment with surgery and doxorubicin-based chemotherapy. This case demonstrates that combined therapy with toceranib, propranolol, and piroxicam achieved radiographic and clinically sustained remission of unresectable canine presumptive HSA while preserving quality of life. These findings suggest that multimodal therapy targeting angiogenesis and tumour growth pathways may represent a promising alternative strategy for managing this malignancy and warrant further clinical evaluation."

Journal • Angiosarcoma • Anorexia • Hematological Disorders • Oncology • Sarcoma • Solid Tumor

Multi-class contaminants of emerging concern in threatened coastal elasmobranchs: Novel evidence of early-life exposure in southeastern Brazil. (PubMed, Mar Pollut Bull) - "Gymnura altavela showed the greatest diversity of compounds, including benzoylecgonine, cocaine, diclofenac, sulfamethoxazole, fipronil, and piroxicam, with liver presenting a broader profile than muscle...All detections occurred in juveniles, indicating early-life exposure. These findings highlight the occurrence of multiple classes of CEC in coastal elasmobranchs from southeastern Brazil and reinforce the need for continued monitoring to clarify exposure routes, tissue distribution, and potential consequences for the health and conservation of threatened marine predators."

Journal

The impact of ubrogepant on the use of other migraine acute treatments, opioid discontinuation, and healthcare utilization: Results from a pre-post opioid subcohort analysis (AHS 2026) - "Acute medications other than ubrogepant included acetaminophen, almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan, dihydroergotamine, ergotamine, amobarbital, aprobarbital, butabarbital, butalbital, mephobarbital, metharbital, pentobarbital, phenobarbital, secobarbital, talbutal, barbital, codeine, hydrocodone, meperidine, morphine, oxycodone, propoxyphene, tramadol, aspirin, bromfenac, celecoxib, diclofenac, diflunisal, esomeprazole, etodolac, famotidine, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, piroxicam, sulindac, tolmetin, lasmiditan, Zavegepant, and Rimegepant (<15 pills). Opioid use included acetaminophen/tramadol, oxymorphone, levorphanol, buprenorphine/naloxone, meperidine, morphine, oxycodone, codeine, methadone, oxycodone, hydromorphone, butorphanol, and tapentadol... In patients with a history of opioid use,..."

HEOR • CNS Disorders • Migraine • Pain

The hybrid drug delivery system of TCPP-Co, β-cyclodextrin and piroxicam: Spectroscopic characterization, morphological reorganization and controlled release dynamics. (PubMed, Pak J Pharm Sci) - "The TCPP-Co/β-cyclodextrin/piroxicam hybrid system demonstrates enhanced solubility, disrupted crystallinity and controlled release dynamics. This supramolecular assembly validates the potential of metalloporphyrin-cyclodextrin hybrids as advanced NSAID delivery platforms with improved therapeutic performance."

Journal

Engineering piroxicam crystals with targeted morphologies and polymorphs using organic additives: A comprehensive study of tablet performance and molecular mechanisms. (PubMed, Eur J Pharm Sci) - "In addition, the mechanism of crystal form and morphology regulation was explained using molecular dynamics calculations. This study not only provides an effective approach for the co-regulation of crystal form and morphology in piroxicam, but also offers experimental evidence and process guidance for the production of high-performance tablet formulations."

Journal • Inflammation • Pain

Preemptive Analgesia With Steroidal and Nonsteroidal Anti-Inflammatory Drugs in Dental Implant Surgeries: A Systematic Review. (PubMed, J Oral Implantol) - "Seven RCTs (n = 589 patients) evaluated aceclofenac 100 mg (in combination with acetaminophen), dexamethasone 4 mg, dexketoprofen 25 mg, etoricoxib 90 mg, ibuprofen 600 mg, ketorolac 10 mg, meloxicam 15 mg, nimesulide 100 mg, piroxicam 40 mg, and tenoxicam 20 mg. Owing to the heterogeneity in protocols, drug regimens, and outcome measures, definitive conclusions regarding the most effective and safest preemptive agents could not be drawn. Future trials should emphasize methodological standardization and focus on widely used drugs to support evidence-based decisions in implant dentistry."

Clinical • Journal • Review • Pain

A Case of Urothelial Carcinoma in Situ of the Bladder in Local Dog in Bali, Indonesia. (PubMed, Arch Razi Inst) - "Prior to release the histopathological results, post-cystotomy the dog was treated with cefadroxil as antibiotics at 20 mg/kg BW b.i.d for 14 days, carprofen as anti-inflammatory at 2 mg/kg BW s.i.d. for 5 days, and tramadol as analgesics at 2 mg/kg BW b.i.d...The patient was managed palliatively with the administration of piroxicam at 0.3 mg/kg BW s.i.d as monotherapy. Until day 190, the dog showing a stable disease. To the best of the authors' knowledge, this is the first documented case of canine urothelial carcinoma in Indonesi."

Journal • Bladder Cancer • Genito-urinary Cancer • Hematological Disorders • Infectious Disease • Nephrology • Oncology • Pain • Palliative care • Solid Tumor • Urothelial Cancer

Effect of Intra-Socket Delivery of Piroxicam on Post-Extraction Dental Pain: A Crossover Randomized Clinical Trial. (PubMed, J Maxillofac Oral Surg) - "NSAIDs like ibuprofen and diclofenac are standard treatments but have limitations, including short half-lives necessitating frequent dosing. A single dose of 20 mg piroxicam administered intra-socket effectively manages post-extraction pain with fewer systemic adverse effects compared to conventional NSAIDs. This method provides a viable alternative for enhancing patient comfort and recovery post-dental extraction."

Clinical • Journal • Pain

Crosslinking-Dependent Design of Hyaluronic Acid Matrices for Enhanced Bioadhesion and Cellular Response. (PubMed, Pharmaceutics) - "Piroxicam (Px) was included as a model drug to evaluate the drug delivery potential of the resulting systems... This study provides a comparative analysis of physical and covalent crosslinking strategies within a HA platform and highlights how formulation variables influence key physicochemical and biological properties. These findings contribute to the rational design of HA-based hydrogels, although further studies are required to establish their performance in more complex biological environments."

Journal • Addiction (Opioid and Alcohol)

Piroxicam Adsorption over Graphene OXIDE Nanosheets: A DFT-ONIOM Study. (PubMed, ACS Omega) - "All these results indicated a favored chemisorption process and allowed us to confirm that GO-sheets could be a good adsorbent for this drug. The G-sheet also showed a good behavior as an adsorbent material."

Journal

Epidemiological and Clinical Profile of Cutaneous Adverse Drug Reactions: A Series of 110Cases (EADV-Sp 2026) - "The most frequently incriminated drugs were paracetamol (n=10), piroxicam (n=7), griseofulvin, tetracyclines, and allopurinol (n=6 each); pristinamycin, anticonvulsants, acetylsalicylic acid, and cephalosporins (n=4 each); hydroxychloroquine (n=3), antidepressants, and diclofenac (n=2 each). Imatinib caused a lichenoid eruption in one case; sorafenib and capecitabine were responsible for hand-foot syndrome... One hundred and ten files were identified (61 females and 49 males) with a sex ratio (M/F) of 0.8. The mean age at diagnosis was 68.7 years. A pharmacovigilance survey was performed in 100 cases (90.9%); causality was considered probable in 19 cases, likely in 35 cases, and very likely in 46 cases."

Adverse drug reaction • Clinical • Acne Vulgaris • Atopic Dermatitis • Dermatopathology • Immunology • Infectious Disease • Lichen Planus • Novel Coronavirus Disease • Psoriasis • Respiratory Diseases • Steven-Johnson Syndrome • Urticaria