piroxicam / Generic mfg. - LARVOL DELTA

Counterpain PXM Versus Diclofenac Versus Piroxicam (clinicaltrials.gov) - P3 | N=180 | Completed | Sponsor: Taisho Pharmaceutical Indonesia

New P3 trial • Back Pain • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Osteoarthritis • Pain • Rheumatology

CARDIORENAL SAFETY OF NSAIDS IN PATIENTS WITH ARTHRITIS: A NETWORK METANALYSIS (ACC 2026) - " We included 23 studies (19 RCTs, 4 cohort) with 1245,108 patients,NSAIDs evaluated were Naproxen (n=69,209),Ibuprofen(n=535,651), Celecoxib(n=107,493),oral Diclofenac (n=335,154),Rofecoxib (n=105,102), Nabumetone (n=507),Valdecoxib (n=5,075), Meloxicam (n=27,713),Piroxicam (n=14,585),Mefenamic acid (n=13,856),Indomethacin (n=26,254),placebo (n=4192), Acetaminophen (n=287),and Amtolmetin guacil (n=30).Compared to placebo, Valdecoxib had highest odds of MACE [OR: 2.96 (95%CI:1.80-4.85)] and Rofecoxib highest odds of renal AEs [OR: 5.11 (95%CI: 2.58-10.10)].League tables showed no differences between different NSAIDs, SUCRA rankings identified Celecoxib with highest MACE and Rofecoxib with highest renal risk (Figure). Valdecoxib and Rofecoxib confer the highest cardiorenal risks. SUCRA rankings ranked Celecoxib as highest for MACE risk and Rofecoxib for renal risk, underscoring the importance of NSAID-specific safety profiles to guide arthritis treatment decisions."

Clinical • Cardiovascular • Immunology • Rheumatology

Arginine-linked solid basil polyphenol self-assembly stabilizes Pickering nanoemulsions: In vitro oxidative stress relief and early evidence of in vivo nephroprotection. (PubMed, Colloids Surf B Biointerfaces) - "Systemically, PEMA attenuated oxidative damage induced by gentamicin-piroxicam in vivo, as evidenced by a 37 % reduction in thiobarbituric acid reactive substances (TBARS) and an 88 % increase in cupric reducing antioxidant capacity (CUPRAC). Histological periodic acid-Schiff (PAS) staining confirmed that PEMA supports the structural integrity of the renal brush border membrane (BBM). Even though tubular recovery was incomplete compared to controls, PEMA demonstrate potential as a promising colloidal formulation for treating oxidative stress-related conditions."

Journal • Preclinical • Liver Failure • MUC5AC

Multicomponent Oxicam-Metformin Salts: Toward a Strategy for Enhancing Solubility and Stability. (PubMed, Cryst Growth Des) - "Here, we report the preparation and full characterization of a new family of oxicam-metformin (MTF) salts, involving the nonsteroidal anti-inflammatory drugs piroxicam (PRX), meloxicam (MLX), and tenoxicam (TNX). Significant modifications in fluorescence behavior were also observed, arising from interactions between functional groups involved in the fluorescence procedure within the frameworks. Overall, this study broadens the structural and functional landscape of oxicam-MTF salts and provides a rational framework for designing solid forms with improved stability and solubility."

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Predicting in vivo performance of piroxicam and apalutamide drug nanocrystals from in vitro flux measurements combined with in silico modelling. (PubMed, Int J Pharm) - "The in silico predictions reproduced key PK parameters, including area under the curve (AUC), time to maximum concentration (tmax), maximum concentration (Cmax), and captured formulation-specific differences in PK behaviour - in particular, the enhanced performance of APA and PRX nanocrystals over the reference products. Overall, these findings imply that this workflow potentially can identify formulation- and species-dependent rate-limiting factors governing bioavailability, indicating its potential as predictive tool for nanocrystal drug development and supporting further evaluation of the methods performance for other drugs."

Journal • Preclinical

Nonsteroidal Anti-Inflammatory Drug Use in Orthopaedic Surgery Practice is Increasing: A Review of Medicare Part D Claims from 2013 to 2021 (AAOS 2026) - "The use of ketorolac, meloxicam, diclofenac, celecoxib, and ibuprofen significantly increased with time while the use of naproxen, nabumetone, etodolac, sulindac, piroxicam, and indomethacin significantly decreased (Table 2). Outpatient NSAID prescriptions by orthopaedic surgery providers increased between 2013 and 2021and is likely underestimated by these data as the majority of NSAIDs are available as over the counter medications. Further study is needed to identify if these practice patterns represent rising use in the setting of fracture surgery as historically this has been the subspecialty where their use was most limited."

Medicare • Reimbursement • Review • Surgery • US reimbursement • Musculoskeletal Diseases • Orthopedics

RAPPEL: Rct Assessing Pregnancy - Piroxicam for Ec With Levonorgestrel (clinicaltrials.gov) - P3 | N=1458 | Not yet recruiting | Sponsor: University of Utah

New P3 trial

Case Report: Endoscopic-guided electrochemotherapy combined with metronomic chemotherapy for the treatment of nasal tumors in dogs. (PubMed, Front Vet Sci) - "Under general anesthesia and endoscopic guidance, bleomycin (20,000 IU/m2) was administered intravenously, followed by bipolar electroporation via a new single needle electrode. Palliative metronomic chemotherapy (piroxicam, thalidomide, and cyclophosphamide) was also administered as an adjuvant to the local treatment...Endoscopic-guided ECT combined with metronomic chemotherapy appears to be a promising palliative approach for canine endonasal tumors, providing tumor cytoreduction and improvement of clinical signs. Further studies with larger sample sizes and longer follow-up periods are needed to confirm the safety and efficacy of this approach, either alone or in combination with other surgical or medical treatments."

Journal • Anesthesia • CNS Disorders • Oncology • Skin Cancer

Microwave-Assisted Wet Granulation for Engineering Rice Starch-Mannitol Co-Processed Excipients for Direct Compression of Orally Disintegrating Tablets. (PubMed, Pharmaceutics) - "The optimized excipient was further evaluated in ODT formulations containing chlorpheniramine maleate and piroxicam and benchmarked against a commercial co-processed excipient (Starlac®). Microwave-assisted wet granulation provides an efficient, scalable, and environmentally friendly strategy for engineering starch-based co-processed excipients with enhanced functionality for direct compression ODT applications. The developed excipient demonstrates strong potential for solid dosage form manufacturing."

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Drugs in paradise: caffeine, cocaine, and painkillers detected in sharks from The Bahamas. (PubMed, Environ Pollut) - "This study provides the first investigation into the occurrence of selected CECs (acetaminophen, benzoylecgonine, caffeine, carbamazepine, ciprofloxacin, citalopram, clindamycin, cocaine, diclofenac, fipronil, fluoxetine, nimesulide, piroxicam, sertraline, sulfamethoxazole, triclosan, trimethoprim, and tramadol) and their potential associations with physiological systemic health markers (triglycerides, total cholesterol, urea, phosphorus, and lactate) in the serum of five shark species sampled from nearshore habitats in Eleuthera Island, namely Galeocerdo cuvier (Tiger Shark), Carcharhinus limbatus (Blacktip Shark), Carcharhinus perezi (Caribbean Reef Shark), Ginglymostoma cirratum (Atlantic Nurse Shark), and Negaprion brevirostris (Lemon Shark). Furthermore, sharks with detectable CECs exhibited triglyceride, urea, and lactate alterations in comparison to those where these contaminants were not detected. This represents the first report concerning CECs and potentially..."

Journal • Pain

Development and validation of a HILIC-ESI/MS method for quantitation of three oxicams and 5-hydroxypiroxicam in human breast milk. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "This study reports the development and validation of a rapid and sensitive hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry (HILIC-ESI/MS) method for the simultaneous quantitation of tenoxicam, meloxicam, piroxicam, and the metabolite 5'-hydroxypiroxicam in human breast milk. The validated HILIC-ESI/MS method was subsequently applied to screen breast milk samples collected from ten lactating women donating to a hospital milk bank. Although oxicam NSAIDs were not detected in this cohort, the method is well-suited for targeted screening of human milk in clinical or surveillance settings, including milk banks and pharmacovigilance studies."

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Unveiling the metabolic profile and anti-inflammatory potential of apple of Sodom (Calotropis procera (Aiton) W.T.) by UPLC-MS/MS chemometric analysis. (PubMed, Sci Rep) - "Results indicate that the extracts from flowers and fruits significantly downregulated IL-1β expression to levels lower than those exhibited by piroxicam, indicating their proficient inflammation inhibitory efficacy...This research underscores C. procera's pharmacological significance, providing a scientific foundation for its traditional medicinal applications. The findings highlight the necessity for further investigations into the mechanistic pathways of its bioactive compounds and their implications for developing novel anti-inflammatory therapies."

Journal • Inflammation • IL1B • IL6 • TNFA

Evaluating adverse events reported for non-steroidal anti-inflammatory drugs in osteoarthritis: a real-world pharmacovigilance study. (PubMed, Inflammopharmacology) - "This study complementing evidence from clinical trials and epidemiological research, by detecting potential adverse reaction signals not fully captured or reflected in approved product information, thus providing a pharmacovigilance perspective grounded in real-world data."

Adverse events • Journal • Real-world evidence • Cardiovascular • CNS Disorders • Depression • Dermatology • Dyspepsia • Gastrointestinal Disorder • Hematological Disorders • Immunology • Inflammation • Ischemic stroke • Musculoskeletal Diseases • Musculoskeletal Pain • Osteoarthritis • Pain • Peptic Ulcer • Psychiatry • Respiratory Diseases • Rheumatology • Vascular Neurology

Microstructural Insights into Solid Dispersions: A Combined Small-Angle Neutron Scattering and Molecular Dynamics Approach. (PubMed, Mol Pharm) - "The combined results from SANS and molecular dynamics simulations indicated the "sandwich-like" structure of PXM-PEG solid dispersions. The outcomes of this innovative approach have the potential to advance the development of solid dispersion formulations, enhance research and development efficiency, and pave the way for the industrial production of solid dispersions."

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Evaluation of the analgesic effect of sublingual administration of wheatgrass (Triticum aestivum) extract for dental pain management in irreversible pulpitis: a randomized clinical trial. (PubMed, Odontology) - "The purpose of this randomized clinical trial was to compare the analgesic effectiveness of sublingual administration of wheatgrass (WG) and piroxicam, a non-steroidal anti-inflammatory drug (NSAID), for patients with symptomatic irreversible pulpitis, with or without apical periodontitis...These findings suggest that WG may offer a rapid and effective analgesic response when administered sublingually. Given its natural origin, WG may serve as a promising adjunct or alternative to conventional NSAIDs for the short-term management of acute dental pain associated with symptomatic irreversible pulpitis.Trial registration: This clinical trial was prospectively registered in Clinical Trial Registry of India under the registration number of CTRI/2024/12/078719 dated on 30/12/2024 ( https://www.ctri.nic.in/ )."

Clinical • Journal • Dental Disorders • Pain • Periodontitis

Analytical Determination of Piroxicam and Its Metabolites: A Comprehensive Insight. (PubMed, Crit Rev Anal Chem) - "In contrast, electrochemical and voltammetric approaches, particularly those employing nanomaterial-modified electrodes, offer excellent sensitivity, portability, and operational simplicity, making them promising candidates for real-time and on-site applications. Looking ahead, progress is expected to be driven by greener analytical technologies, miniaturized and automated platforms, and the growing role of artificial intelligence (AI) and machine learning (ML) in data processing, pattern recognition, and method optimization, ultimately improving the sustainability, accessibility, and regulatory relevance of PX analysis."

Journal • Review

Ethnopharmacological Validation of Terminalia superba (Combretaceae) as an Anti-inflammatory Agent: An Integrated In Vitro and In Vivo Assessment. (PubMed, J Ethnopharmacol) - "This study validates the ethnopharmacological use of T. superba, particularly its n-hexane-rich fraction (HFTs), as a potent anti-inflammatory agent with consistent effects in mechanistic and animal models. HFTs merit further isolation, mechanistic elucidation, and development toward phytopharmaceutical use."

Journal • Preclinical • Hematological Disorders • Inflammation

Comparison of the Pain Levels of Single-Dose Premedication With Piroxicam and Prednisolone on Post-Endodontic Pain in Single-Visit Root Canal Treatment of Premolars (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: RANA AHMAD

New P4 trial • Dental Disorders • Pain • Periodontitis

First-line treatment with low-dose ruxolitinib, pirfenidone, and low-dose calcineurin inhibitors leads to significant improvement in patients with bronchiolitis obliterans syndrome after allogeneic transplantation (ASH 2025) - "Traditional treatments for BOS rely on glucocorticoids combined with FAM regimens ( fluticasone + azithromycin + montelukast ) and calmodulin phosphatase inhibitors ( CNIs ), but they have limited efficacy with an even lower overall remission rate ( ORR ) and poor prognosis once progression to steroid-refractory cGVHD (SR-cGVHD) is achieved...Methods A retrospective analysis of 14 patients, 11 males and 3 females, with a median age of 19 years (7-54 years), who underwent hematopoietic stem cell transplantation combined with BOS at Henan Cancer Hospital from 2018 to 2025, including 6 cases of mild BOS, 3 cases of moderate BOS, 5 cases of severe BOS, Among them, 6 cases of mild, 3 cases of moderate, and 5 cases of severe BOS were treated with low-dose rucotinib ( 5 mg qd po) combined with piroxicam (200 mg tid po), small-dose CNI (half of the effective therapeutic concentration), and FAM first-line treatment...Conclusions In conclusion, the first-line treatment of BOS..."

Clinical • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Transplantation

Curcumin impacts on cisplatin sensitivity determining apoptotic boost in mesothelioma. (PubMed, Biomed Pharmacother) - "The effect of combined treatment was evaluated in 2D and 3D cultures by using two MM cell lines, MSTO-211H and Ist-Mes2, that are sensitive or less responsive to the piroxicam/cisplatin combined treatment respectively. Results indicate that this treatment determines a dramatic apoptotic increase linked to a concomitant inactivation of Nrf2, a transcription factor with a key role in carcinogenesis, and of NUPR1, a transcriptional regulator involved in drug chemoresistance."

Journal • Mesothelioma • Oncology • Solid Tumor

Asiatic acid inhibits NF-κB signaling and ameliorates experimental acute and chronic colitis in mice. (PubMed, Int J Immunopathol Pharmacol) - "AA alleviates intestinal inflammation by suppressing NF-κB signaling in vitro and exhibits therapeutic efficacy in both acute and chronic colitis models, suggesting its potential as a therapeutic candidate for inflammatory bowel disease."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Oncology • IL10 • IL6 • NFKBIA • TNFA

Chemically tuned radiolabeling and membrane affinity in Drug-Functionalized carbon nanotube nanocarriers. (PubMed, Sci Rep) - "Four clinically relevant drugs-methotrexate, diclofenac, ketotifen, and piroxicam-were conjugated to a single-walled CNT (SWCNT) via a bifunctional chelating group. Free energy landscapes reconstructed from metadynamics simulations further confirmed the high thermodynamic stability of this configuration. These findings suggest that rational drug selection can effectively tune the physicochemical behavior of CNT-based radiopharmaceuticals, providing a mechanistic foundation for designing multifunctional nanocarriers with improved performance for nuclear imaging and site-specific drug delivery."

Journal • Oncology

Drug Repurposing in Veterinary Oncology: Myth or Reality? (PubMed, Vet Sci) - "The therapeutic agents discussed include non-steroidal anti-inflammatory drugs (e.g., piroxicam), metabolic modulators (e.g., metformin), anti-parasitic drugs (e.g., fenbendazole), immunomodulators (e.g., thalidomide, oclacitinib), cardiovascular agents (e.g., propranolol, statins, losartan), and other compounds such as auranofin and disulfiram. Challenges to clinical implementation, including limited funding, regulatory and ethical considerations, and the need for well-designed, multi-institutional clinical trials, are discussed. Ultimately, drug repurposing represents a practical and translationally valuable approach to broaden therapeutic options, improve quality of life in companion animals, and advance comparative oncology by promoting progress that benefits both veterinary and human patients."

Journal • Review • Cardiovascular • Oncology

Primary Prostatic Carcinoma with Metastasis to Epaxial Muscles and Myocardium in a Dog. (PubMed, Vet Sci) - "This report describes an 11-year-old intact male Maltese dog with a two-month history of anorexia and lethargy, referred for further evaluation after failing to respond to piroxicam therapy...To the best of our knowledge, this is the first documented case of canine prostatic carcinoma with exclusive myotropic and myocardial metastases. These findings suggest a possible hematogenous metastatic route and highlight the importance of including muscle and cardiac tissues in staging protocols for canine prostatic carcinoma, even when lymphadenopathy or pulmonary lesions are absent."

Journal • Anorexia • Oncology • Prostate Cancer • UPK3

In vivo and in silico assays demonstrate that the hydroalcoholic extract of Aloysia polystachya and carvone promote anti-ulcer effects. (PubMed, J Ethnopharmacol) - "The findings of this study demonstrate that the hydroalcoholic extract of A. polystachya (HEAp) and its bioactive compound carvone possess significant gastroprotective and gastric healing properties. These effects are likely mediated through the modulation of sulfhydryl compounds, anti-inflammatory and antioxidant defenses, and antisecretory mechanisms. The identification of phenolic constituents, combined with in silico analyses, further supports the potential therapeutic relevance of HEAp and carvone. Collectively, these results highlight that the phytoconstituents from A. polystachya corroborate the traditional use of the plant and are promising candidates for the investigation of anti-ulcer gastric agents."

Journal • Preclinical • Peptic Ulcer • MPO