piroxicam / Generic mfg. - LARVOL DELTA

INHIBITION OF JAK/STAT SIGNALLING ATTENUATES NSAID-INDUCED INTESTINAL INFLAMMATION AND CELL DEATH (DDW 2025) - "Intestinal epithelial cell lines (HT29, DLD1), human colon organoids and JAK1, JAK2 deficient DLD1 cells were treated with IFNγ (10ng/ml) and piroxicam (400uM) and JAK-inhibitors (Tofacitinib, Baricitinib, Upadacitinib, 10mM) and caspase-8 inhibitor (Z-IETD-FMK, 20mM) followed by cell death (Sytox/CellTiterGlo), cytokine secretion (ELISA) and WB analysis. This results in inflammation and apoptosis, which exacerbate intestinal inflammation like IBD. The findings suggest that JAK inhibitors, such as Tofacitinib, may hold promise as a therapeutic option for patients with IBD who experience worsening symptoms due to NSAID use."

Gastroenterology • Gastrointestinal Disorder • Inflammation • Inflammatory Bowel Disease • CASP3 • CASP8 • IFNG • IL10 • IL1B • JAK1 • NLRP3 • STAT1

Effect of electron beam irradiated-piroxicam on the anti-inflammatory activities in LPS-stimulated BMDC and sepsis-induced mouse models (IMMUNOLOGY 2025) - "Although GOT and GPT levels increased with Piro treatment, no significant changes were observed with IR-Piro. Our findings indicate that IR-Piro offers strong anti-inflammatory benefits with reduced side effects, suggesting its promise as a new NSAID alternative.Keywords: Animals Other Animals; Cells Dendritic Cells; Molecules Cytokines; Processes Inflammation; Techniques/Approaches Molecular Biology"

Preclinical • Gastrointestinal Disorder • Infectious Disease • Inflammation • Septic Shock • IL10 • IL12A • IL6 • TNFA

The protective effects of garlic (Allium sativum var. Solo Garlic) extract mitigates piroxicam-induced liver damage and oxidative stress in rats. (PubMed, Open Vet J) - "SGE is a potent antioxidant that reduces oxidative stress in a piroxicam-induced IBD model and contributes to good health. Further studies are needed to explore the molecular mechanisms underlying these effects and to optimize the therapeutic potential of IBD."

Journal • Preclinical • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Piroxicam Versus Diclofenac for Post Caesarean Section Analgesia (clinicaltrials.gov) - P=N/A | N=108 | Completed | Sponsor: Federal Teaching Hospital Abakaliki

New trial • Pain

Ultrasonication-mediated Microbubbles Dressing for Hand Arthritis (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: National Taiwan University | Not yet recruiting ➔ Recruiting

Enrollment open • Immunology • Rheumatology

Preclinical Pharmacokinetic Assessment of a Promising Vasorelaxant, Analgesic, and Anti-Inflammatory Prototype 5-[1-(4-Fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole (LQFM020) Through Selective Bioanalytical HPLC-PDA-Based Method. (PubMed, Biomed Chromatogr) - "Detection of LQFM020 and the internal standard, piroxicam, was performed using a photodiode array detector...Additionally, LQFM020 showed no significant effect on the biotransformation of compounds mediated by the cytochrome P450 CYP3A4 enzyme. In conclusion, this new bioanalytical method supports preclinical studies and provides a basis for the utility of LQFM020 as a potential drug candidate."

Journal • PK/PD data • Preclinical • Pain • CYP3A4

Ultrasonication-mediated Microbubbles Dressing for Hand Arthritis (clinicaltrials.gov) - P=N/A | N=60 | Not yet recruiting | Sponsor: National Taiwan University

New trial • Immunology • Rheumatology

Efficacy of Lavender Oil as an Adjunctive Treatment for Patients with Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial. (PubMed, J Pain Palliat Care Pharmacother) - "To determine the clinical efficacy of lavender oil in comparison with Piroxicam gel (PG) for the treatment of knee OA...Altogether, Lavender oil has a similar effect as PG on pain severity and physical function in patients with knee OA. Lavender oil is recommended as an effective natural therapeutic agent and safe complementary treatment for knee OA."

Clinical • Journal • Immunology • Osteoarthritis • Pain • Rheumatology

Cross-Analytical Strategies to Tackle "Medicines in Disguise" Presented as Food Supplements, a New Threat for Human Health. (PubMed, Molecules) - "The samples contained active pharmaceutical ingredients, including diclofenac, piroxicam, dexamethasone 21-acetate, and sibutramine. We provided evidence of "medicines in disguise" presented as food supplements, which raises concerns about their quality and safety."

Journal

Synthesis and characterization of piroxicam and M (M= Pd (II), Ag (I)) complex nanoconjugates with orange quantum dots for enhanced antimicrobial and anticancer activity. (PubMed, Nanotechnology) - "The in vitro antiproliferative activity depicted that all synthesized conjugates showed better Cytotoxic effect than piroxicam, specifically Pd conjugate which had IC50 values with by 2-fold lower than piroxicam on human liver cancer cell line HepG2. While Pd and Ag conjugates showed 2.3 and 1.9-fold higher effect on human colon cancer cell line HT-29 compared to piroxicam."

Journal • Colon Cancer • Colorectal Cancer • Hepatology • Liver Cancer • Oncology • Solid Tumor • PD-L2

Nonsteroidal anti-inflammatory drugs (NSAIDs) for acute renal colic. (PubMed, Cochrane Database Syst Rev) - "NSAIDs may reduce pain in adult patients with renal colic compared to placebo. Comparing one NSAID against another, IV ketorolac may be less effective than IV ibuprofen, and pirprofen may result in less need for rescue medication than indomethacin. The intravenous route of administration is probably similar to the intramuscular route but may be better than the rectal route. The evidence is uncertain regarding the potential harms of NSAIDs. We were not able to perform subgroup analysis based on our predefined criteria because there were no eligible studies."

Clinical • Journal • Review • Inflammation • Pain • Renal Calculi • Urolithiasis

Pure and Doped Brushite Cements Loaded with Piroxicam for Prolonged and Constant Drug Release. (PubMed, Materials (Basel)) - "Both the compressive strength and the elastic modulus decreased for the samples immersed in solution compared to the non-immersed samples, with stabilisation as the number of days increased. After 7 days, the whole drug amount was released, with a slower and constant kinetic for the Ba-doped cements compared to the pure and Si-doped ones."

Journal • Musculoskeletal Diseases

Enhanced Transdermal Delivery of Piroxicam via Nanocarriers, Formulation, Optimization, Characterization, Animal Studies and Randomized Double-Blind Clinical Trial. (PubMed, AAPS PharmSciTech) - "The clinical trial indicated that the painkilling efficiency of the niosomal piroxicam emulgel was 37.30-fold and 3.16-fold greater compared to the placebo and the positive control groups, respectively. In conclusion, the niosomal piroxicam emulgel which may enable the drug to permeate through the skin and accumulate in synovial tissue more efficiently, showed a promising performance in lowering pain and inflammation based on the animal studies and the human clinical trial."

Clinical • Journal • Immunology • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatoid Arthritis • Rheumatology

Enhancing Process Control and Quality in Amorphous Solid Dispersions Using In-Line UV-Vis Monitoring of L* as a Real-Time Response. (PubMed, Pharmaceutics) - " An in-line UV-Vis process analytical technology (PAT) system was successfully employed to monitor critical quality attributes (CQAs) of piroxicam amorphous solid dispersion (ASD) extrusion products, specifically lightness (L*)...By adopting this strategy, manufacturers can minimize variability, reduce waste, and ensure adherence to quality target product profiles (QTPPs). Overall, this study highlights the value of in-line UV-Vis spectroscopy as a PAT tool in hot melt extrusion, enhancing CQA assessment and advancing the efficiency and reliability of ASD manufacturing."

Journal

miRNA-503 inhibition exerts anticancer effects and reduces tumor growth in mesothelioma. (PubMed, J Exp Clin Cancer Res) - "Our study is the first reporting an oncomiR role for miR-503 in MM and suggests that its inactivation could have a clinical value in MM patients. This study reveals that miRNA-503 acts as an oncomiR in MM suggesting that its inhibition, through LNP delivery, has the potential to be considered as a novel therapeutic strategy in MM."

Journal • Mesothelioma • Oncology • Solid Tumor • CCNG1 • CXCL8 • MIR503 • S1PR1 • SERPINE1 • SPP1 • TIMP2

Comparative analysis of piroxicam and post-isometric exercises in knee osteoarthritis in school teachers. (PubMed, Work) - "These findings suggest that post-isometric exercises could be a more beneficial treatment option than piroxicam for knee osteoarthritis. The practical implications of this research are significant, as it demonstrates that post-isometric exercises not only enhance functional results but also reduce pain severity, offering a promising alternative to traditional medication."

Clinical • Journal • Immunology • Osteoarthritis • Pain • Rheumatology

A comprehensive metabolomic study of three Egyptian Salsola species revealed their potential anti-inflammatory activity. (PubMed, Sci Rep) - "Concerning the anti-inflammatory activity of the tested extracts, the safety margin of all the tested extracts was higher than that of the standard drug piroxicam...The shoot extract of S. tetrandra was the most biologically active fraction. The obtained results revealed the shoots of the three Salosla species to be promising anti-inflammatory drug candidates of high safety and efficacy that could be used in the pharmaceutical industry."

Journal

ENHANCED ANTIOXIDANT SIGNALING BY MITOCHONDRIAL-TARGETED DRUG AUPHOS DRIVES ATTENUATION OF COLITIS (CCCongress 2025) - "We postulate that AuPhos-induced mitochondrial function enhances anti-oxidant levels and improves tissue inflammation in IBD. Effects of AuPhos on cellular antioxidant defense system were evaluated in normal human colonic epithelial cells (NCM460), piroxicam (Px)-accelerated Il10-/- colitis mice and human ulcerative colitis (UC) biopsies... Increased AuPhos-induced Nrf2 signaling enhances anti-oxidant enzymes and attenuates oxidant injury in UC tissue biopsies raising the possibility that enhanced mitochondrial function limits oxidant injury, a major mechanism for mucosal repair. This suggests the potential of AuPhos in treating IBD by attenuating oxidative injury."

Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis • CAT • GPX4 • IL10 • PRDX3 • SOD2

A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic. (PubMed, Front Immunol) - "In this series of observational, retrospective, case-control, pharmacovigilance analyses of the FDA Adverse Event Reporting System, the odds of reporting the adverse event pemphigus were significantly elevated among individuals exposed to 11/36 previously reported trigger drugs namely, gold sodium thiomalate, penicillamine, piroxicam, rifampin, hydroxychloroquine, imiquimod, hydrochlorothiazide, irbesartan, lisinopril, nivolumab, and nifedipine. Our findings reinforce the need for larger, more definitive studies to confirm these associations and to explore the mechanisms by which these drugs may contribute to PV development. Finally, these findings underscore the importance of considering environmental factors in the development and course of PV in genetically susceptible individuals."

Journal • Observational data • Retrospective data • Dermatology • Immunology • Pemphigus Vulgaris

Breaking the Phalanx: Overcoming Bacterial Drug Resistance with Quorum Sensing Inhibitors that Enhance Therapeutic Activity of Antibiotics. (PubMed, bioRxiv) - "Amongst explored drug combinations, 31 exhibited a synergistic effect, including mixtures involving naldemedine and telotristat, two drugs predicted by our model with previously undescribed QSI activity. Although no mixture inhibiting all the strains was found, piperacillin combined with curcumin, ketoprofen, indomethacin, and piroxicam demonstrated the broadest antimicrobial action. We anticipate that further preclinical investigation of these combinations of novel repurposed QSIs with a known antibiotic may lead to novel clinical candidates."

Journal • Infectious Disease

Fabrication of novel multifunctional copper-functionalized hemp fibers to remove anionic dye and non-steroidal anti-inflammatory drugs from wastewaters. (PubMed, Chemosphere) - "It was demonstrated the multifunctional properties of the produced adsorbent since it showed a great selectivity in removing two anti-inflammatory drugs (91% for piroxicam and 34% for diclofenc sodium salt). Finally, the selective removal of different anionic dyes in a mixed solution was proved, following the order methyl orange>congo red>acid yellow 17. The reported approach presents a sustainable, low-cost option for the preparation of novel and effective adsorbents with interesting properties to achieve remarkable adsorption of anionic dyes and anti-inflammatory drugs with a great reusability."

Journal

Equilibrium of monomers, dimers, and polymeric aggregates in the α-aryl-propionic acid-type analgesics naproxen, ketoprofen, and ibuprofen: Comparative study with oxicam-type meloxicam and piroxicam. (PubMed, Int J Pharm) - "Their dissolution behaviors are dominated by phenomenological processes, generating a type of dissipative structure that is adaptive to the features of individual solutes. The results of this study suggest that the apparent hydrophobicity of organic solutes is reflected in the dissolved state."

Clinical • Journal • Pain

The potency of ethyl acetate fraction of cempedak (Artocarpus champeden) leaves in attenuating the nephrotoxic effect in gentamicin-piroxicam-induced rat models. (PubMed, J Ayurveda Integr Med) - "The ethyl acetate fraction of A. champeden leaves demonstrated nephroprotective activity and has potential as a therapeutic agent for kidney damage and hypertension from natural sources."

Journal • Preclinical • Cardiovascular • Hypertension

Exploring the anti-biofilm and gene regulatory effects of anti-inflammatory drugs on Candida albicans. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Betamethasone and dexamethasone markedly inhibited C. albicans biofilm formation by up to 80% at a concentration of 2 mg/mL. Moreover, the inhibition of C. albicans biofilm formation was significant at concentrations ranging from 0.6 to 10 mg/mL for piroxicam and from 0.75 to 12 mg/mL for diclofenac...Our novel findings indicate the downregulation of several Candida genes that are crucial for morphogenesis, pathogenesis, and biofilm formation. However, further research is necessary to fully elucidate the clinical applications and effectiveness of anti-inflammatory drugs as alternative or adjunctive therapies for Candida infections."

Journal • Candidiasis • Infectious Disease

Levonorgestrel-piroxicam Versus Ulipristal Acetate for Emergency Contraception (clinicaltrials.gov) - P3 | N=980 | Not yet recruiting | Sponsor: The University of Hong Kong

New P3 trial