Minocin for injection (minocycline intravenous) / Melinta Therap - LARVOL DELTA

Sequential Onset of Japanese Spotted Fever in a Parent-Child Household: A Familial Cluster of Two Cases. (PubMed, Cureus) - "Intravenous minocycline, followed by oral therapy, resulted in clinical improvement...Clinicians should consider JSF in patients presenting with fever and rash when a cohabiting family member is diagnosed with JSF, even in the absence of clear outdoor exposure. Early antimicrobial therapy is essential to prevent severe complications."

Journal • Dermatology • Fatigue • Hematological Disorders • Hepatology • Infectious Disease • Liver Failure • Thrombocytopenia

Minocycline inhibits somatic hyperalgesia induced by malocclusion through up-regulating spinal IL-10 expression in female rats. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Repeated intrathecal injection of minocycline for 5 days dose-dependently inhibited UAC-induced mechanical allodynia and thermal hyperalgesia in hindpaws, down-regulated Iba-1 expression, and up-regulated IL-10 expression in the spinal dorsal horn. These findings indicate that minocycline attenuates UAC-induced somatic hyperalgesia by upregulating IL-10 expression and inhibiting microglial activation in the spinal cord. Therefore, minocycline may be a novel candidate analgesic for treating pain associated with TMD and FMS comorbidity."

Journal • Preclinical • Fibromyalgia • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Pain • Rheumatology • IL10

The role of microglia in hyperalgesia priming and electroacupuncture intervention for pain transition (PubMed, Zhen Ci Yan Jiu) - "Microglia activation is critical in pain transition. EA can alleviate hyperalgesia in HP mice by inhibiting microglia activation."

Journal • Pain • CSF1 • GFAP

Effects of minocycline on acrylamide-induced neurotoxicity in Wistar rats. (PubMed, Iran J Basic Med Sci) - "Furthermore, intraperitoneal injection of minocycline (40 mg/kg) with ACR reduced the levels of MDA, IL-1β, and caspase-3-cleaved proteins in the cerebral cortex. Administration of minocycline exhibits both prophylactic and therapeutic properties against ACR-induced neurotoxicity primarily through anti-oxidant, anti-apoptotic, and anti-inflammatory properties."

Journal • Preclinical • Movement Disorders • Oncology • CASP3 • IL1B • TNFA

Drug repurposing for disease-modifying effects in multiple system atrophy. (PubMed, Transl Neurodegener) - "We focus on agents targeting key pathogenic mechanisms in MSA-including α-synuclein aggregation (e.g., sirolimus/rapamycin, rifampicin, lithium, nilotinib, epigallocatechin gallate), neuroinflammation (e.g., minocycline, intravenous immunoglobulin), mitochondrial dysfunction and excitotoxicity (e.g., ubiquinol, rasagiline, safinamide, riluzole), and impaired neurotrophic support (e.g., fluoxetine/selective serotonin reuptake inhibitors, insulin, exendin-4). Nonetheless, ongoing studies and emerging approaches such as combination therapies hold promise. Continued exploration of repurposed therapies, along with improved trial design and biomarker development, is warranted to finally achieve a disease-modifying treatment for MSA."

Journal • Review • CNS Disorders • Inflammation • Metabolic Disorders • Movement Disorders • Multiple System Atrophy

Efficacy of Minocycline in Acute Traumatic Spinal Cord Injury. (PubMed, J Neurotrauma) - "Minocycline, a tetracycline antibiotic with anti-inflammatory and neuroprotective properties, has been proposed as a therapeutic candidate...In humans, intravenous minocycline (200-400 mg daily for 7 days) achieved cerebrospinal fluid concentrations of ∼2.3 µg/mL, below the therapeutic range suggested by preclinical models (35-75 µg/mL)...Overall, minocycline exerts robust neuroprotective effects in preclinical SCI but limited functional benefit in humans, largely due to subtherapeutic central nervous system penetration at tolerated systemic doses. Future trials should explore optimized delivery strategies, include demographic stratification, and employ standardized functional endpoints to better define translational potential."

Journal • CNS Disorders • Orthopedics

Spinal lncRNA_RT1-CE10 attenuates chronic visceral hypersensitivity in rats with irritable bowel syndrome via inhibiting microglial activation (PubMed, Sheng Li Xue Bao) - "After intrathecal injection of minocycline (an inhibitor of microglia), the expression of Iba-1, MHCII and the visceral hypersensitivity were determined by Western blot and EMG, respectively...Over-expression of lncRNA_RT1-CE10 decreased the Iba-1 and MHCⅡ levels in IBS rats, while knockdown of lncRNA_RT1-CE10 increased the Iba-1 and MHCⅡ levels in control rats. Collectively, these results demonstrate that lncRNA_RT1-CE10 attenuates visceral hypersensitivity by inhibiting microglial activation in IBS rats."

Journal • Preclinical • Gastrointestinal Disorder • Immunology • Pain

Mutant KRAS in brain endothelial cells promotes vascular inflammation and impairs vascular integrity in brain arteriovenous malformation. (PubMed, J Cereb Blood Flow Metab) - "In our bAVM mouse model that uses AAV-BR1-KRASG12V injection to produce EC expression of KRASG12V in the brain, minocycline injection reduced production of inflammatory cytokines by bAVM nidus, reduced leakage of BSA-647, and restored VE-cadherin expression on malformed vessels. Our findings suggest that KRAS-G12V-EC can activate local MG/Mφ that causes vascular inflammation and instability of malformed vessels in bAVM."

Journal • Cardiovascular • CNS Disorders • Inflammation • CDH5 • KRAS

A Daily Injection Paradigm Disrupts the Environmental-Enrichment-Induced Pruning of Miswired Axonal Projections in Developing Mice. (PubMed, Dev Neurobiol) - "Aiming to confirm a causal role for microglial-mediated engulfment in this process, we assessed the effect of daily injections of minocycline or vehicle saline from P18 to P24 (inclusive) on measures of microglial reactivity and anatomical corrective pruning in P25 Ten-m3 KO mice...This suggests that the injection procedure itself disrupted the experience-induced microglial-mediated circuit repair. These results underscore the highly sensitive nature of EE-driven corrective pruning actions of microglia and the critical importance of considering and controlling for all aspects of experience."

Journal • Preclinical

Geographic shift of Japanese spotted fever and diagnostic overshadowing by COVID-19 testing: A genetically confirmed northernmost case. (PubMed, IDCases) - "Physical examination revealed a diffuse rash and an eschar on the lower leg. Rickettsial infection was suspected, and intravenous minocycline was initiated. Rickettsia japonica was later confirmed by PCR and serology. This case represents the northernmost genetically confirmed JSF in Japan and emphasizes the importance of maintaining a broad differential diagnosis, particularly when COVID-19 test results conflict with clinical findings."

Journal • Critical care • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • Septic Shock

Refractory chronic seroma following latissimus dorsi flap breast reconstruction successfully treated by surgical excision: A case report. (PubMed, JPRAS Open) - "We report a case of a refractory seroma that developed in the early postoperative period and persisted for over four years despite 79 aspirations (including 37 combined with corticosteroid injections and 5 minocycline sclerotherapy sessions)...This case highlights the importance of early recognition and surgical consideration in managing chronic seromas unresponsive to conservative therapy. Surgical excision combined with compression may achieve excellent long-term outcomes and improve patient quality of life."

Journal • Infectious Disease • Oncology

Antimicrobial Stewardship Medication Use Evaluation of Intravenous Minocycline at a Large Academic Medical Center (ASHP 2025) - No abstract available

Cost-Effectiveness of Minocycline Intravenous for the Treatment of Serious Infections Due to Multidrug-Resistant Acinetobacter baumannii in Jordan (ISPOR-EU 2025) - "This study assesses the cost-effectiveness of IV minocycline versus IV colistin in treating MDR A. baumannii infections in Jordan. A 28-day decision-tree model was developed to evaluate the cost-effectiveness of IV minocycline compared to IV colistin for the treatment of MDR Acinetobacter baumannii infections from a Jordanian payer perspective. IV minocycline is a dominant treatment option for MDR A. baumannii infections in Jordan. These findings may support clinicians and healthcare decision-makers in prescribing cost-effective therapies, contributing to more efficient allocation of healthcare resources."

Cost effectiveness • HEOR • Acute Kidney Injury • Infectious Disease • Renal Disease

THE CLEARANCE OF NEUTROPHIL EXTRACELLULAR TRAPS BY CONSTRAINT-INDUCED MOVEMENT THERAPY DEPENDS ON MICROGLIA (WSC 2025) - "The purpose of this study is to determine whether the clearance effect of CIMT on NETs is related to microglia and its specific mechanism. Administration of the Colony-stimulating factor 1 receptor inhibitor PLX3397 and intraperitoneal injection of minocycline were used to deplete and inactivate microglia, respectively. CIMT mediates the phagocytosis of NETs by microglia in ischemic cortex and is beneficial to maintain the balance of pro-inflammatory/anti-inflammatory microglia. The synaptic budding is at least partially attributed to the spatial location provided by microglial phagocytosis of NETs. IL-33/ST2 may be the target mediating this phagocytosis."

Cardiovascular • CD68 • CD86 • IL33 • ST2

ANTIMICROBIAL-RESISTANT GRAM-NEGATIVE INFECTIONS IN THE INTENSIVE CARE UNIT (CHEST 2025) - "He was treated with broad spectrum intravenous (IV) antibiotics with Vancomycin and Cefepime...He was started on IV ceftazidime-avibactam (Avycaz) and Infectious Disease (ID) was consulted...The patient was treated with high dose IV ampicillin-sulbactam 9 g every 8 hours along with IV Minocycline 200mg BID for 5 days... In patients with a history of colonization with MDRO, it is important to evaluate the patient thoroughly before treating the infection. Consequences to early treatment may be the rise of more resistant bugs whereas a delay or no treatment can lead to further deterioration of the patient."

Gram negative • Cardiovascular • CNS Disorders • Critical care • Epilepsy • Infectious Disease • Respiratory Diseases • Vascular Neurology

Scrub Typhus With an Unknown Source of Infection. (PubMed, Cureus) - "She was treated with intravenous minocycline for 14 days, following which the fever resolved and laboratory abnormalities improved...Her clinical course was favorable, and she was discharged in good condition. Although scrub typhus is traditionally associated with rural environments, urban transmission is becoming more recognized, possibly due to ecological changes such as urban heat islands, where temperatures are higher than in surrounding rural areas, potentially expanding the habitats of vector mites. This case highlights that scrub typhus should be considered in patients presenting with fever, rash, and eschar, even when no clear environmental exposure is identified."

Journal • Anorexia • Hematological Disorders • Infectious Disease • Pain • Thrombocytopenia • CRP

"Unmasking the Uncommon": A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates. (PubMed, F1000Res) - "Antibiotic susceptibility testing (AST) revealed resistance to Piperacillin/Tazobactam, but sensitivity to Vancomycin, Levofloxacin, and Minocycline...Intravenous Ciprofloxacin was initiated with clinical improvement and negative follow-up blood cultures...A combination of Levofloxacin and Colistin was added, and blood cultures were negative after seven days, with clinical improvement...Clinicians must have a high degree of suspicion of E. meningoseptica for gram-negative bacilli causing sepsis and meningitis in high-risk patients. Recent technological advances have enabled accurate speciation to guide therapy and reduce morbidity and mortality rates."

Journal • Acute Respiratory Distress Syndrome • CNS Disorders • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock • CRP

Minocycline prevents monocrotaline-induced pulmonary hypertension through the attenuation of endothelial dysfunction and vascular wall thickening. (PubMed, J Pharmacol Sci) - "PH-preventing effect of minocycline does not seem to be mediated via the actions on matrix metalloproteinase, inflammatory cytokines, and mast cells migration in lung. In summary, we revealed for the first time that minocycline ameliorated the MCT-induced PH in rats, at least partly through preventing pulmonary artery endothelial dysfunction and wall thickening."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Intravenous Minocycline versus Oral Minocycline for the Treatment of CarbapenemResistant Acinetobacter baumannii and Stenotrophomonas maltophilia Infections (ASHP 2024) - No abstract available

Infectious Disease

New-generation tetracyclines for severe macrolide-resistant Mycoplasma pneumoniae pneumonia in children: a retrospective analysis. (PubMed, BMC Infect Dis) - "Doxycycline treatment resulted in a higher rate of defervescence than minocycline. Prompt treatment reduced the probability of pleural effusion, hypoxemia, pulmonary atelectasis, and D-dimer levels > 2 times the reference value."

Journal • Retrospective data • Cough • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Percutaneous injection of minocycline in postoperative sialocele following condylar fracture. (PubMed, Br J Oral Maxillofac Surg) - "After the injection, the buccal swelling completely disappeared without complications, including facial palsy. Percutaneous injection of minocycline might be the first choice for postoperative refractory sialocele following condylar fracture."

Journal • CNS Disorders • Musculoskeletal Diseases • Oncology • Orthopedics

Administration of Corticosteroids for Prompt Suppression of Cytokine Storm in Severe Cases of Japanese Spotted Fever. (PubMed, Cureus) - "Early treatment with tetracycline antibiotics is crucial to prevent severe complications, such as pneumonia, meningitis, disseminated intravascular coagulation (DIC), and systemic inflammatory response syndrome...Initial treatment with ceftriaxone was ineffective, leading to a switch to intravenous minocycline and levofloxacin. Considering the high levels of C-reactive protein, procalcitonin, ferritin, and soluble interleukin-2 receptor, intravenous hydrocortisone (200 mg/day) was administered to control the cytokine storm...Early administration of corticosteroids along with antibiotics effectively suppressed the cytokine storm in this case. Reports have shown mixed results, indicating the need for further research to determine the optimal type, dosage, and duration of corticosteroid treatment."

Cytokine storm • Journal • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Hypertension • Immunology • Infectious Disease • Nephrology • Oncology • Pneumonia • Renal Disease • Respiratory Diseases • Septic Shock • Systemic Inflammatory Response Syndrome • CRP • IL2 • IL6 • TNFA

IL-6 Inhibitor Tocilizumab Reduces Bone Resorption Around Implants with Bacterial Infection During Osseointegration: A Pilot Study in Rabbits. (PubMed, Int J Oral Maxillofac Implants) - "Tocilizumab, an inhibitor of IL-6, has a certain effect in preventing bone loss around implants caused by bacterial infection during the osseointegration period."

Journal • Preclinical • Infectious Disease • Osteoporosis • IL6

Neuroinflammation in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice. (PubMed, J Gastrointest Oncol) - "Inhibition of microglial activity through minocycline microinjection into the PVN resulted in alleviation of visceral pain within 30 and 60 min...This study found that PVN microglia and astrocytes were involved in regulating PCVP. Our results suggest that targeting glia may be a potential approach for alleviating visceral pain in patients with pancreatic cancer."

Journal • Preclinical • Gastrointestinal Cancer • Hepatology • Oncology • Pain • Pancreatic Cancer • Solid Tumor

In vitro antimicrobial susceptibility data of global meropenem-resistant Acinetobacter baumannii isolates causing pneumonia: Data from the Antimicrobial Testing Leadership and Surveillance Program, 2014 - 2021, and re-estimations of susceptibility breakpoints and appropriate dosages of important antibiotics for pneumonia treatment. (PubMed, J Glob Antimicrob Resist) - "After deliberative estimations, dosages of 200 mg minocycline intravenously every 12 h (SBP, 8 mg/L), 100 mg tigecycline intravenously every 12 h (SBP, 1 mg/L), and 160 mg nebulized colistin methanesulfonate every 8 h (SBP, 2 mg/L) are needed for the effective treatment of pneumonia-causing MEM-R A. baumannii isolates."

Journal • Preclinical • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases