Minocin for injection (minocycline intravenous) / Melinta Therap - LARVOL DELTA

Cost-Effectiveness of Minocycline Intravenous for the Treatment of Serious Infections Due to Multidrug-Resistant Acinetobacter baumannii in Jordan (ISPOR-EU 2025) - "This study assesses the cost-effectiveness of IV minocycline versus IV colistin in treating MDR A. baumannii infections in Jordan. A 28-day decision-tree model was developed to evaluate the cost-effectiveness of IV minocycline compared to IV colistin for the treatment of MDR Acinetobacter baumannii infections from a Jordanian payer perspective. IV minocycline is a dominant treatment option for MDR A. baumannii infections in Jordan. These findings may support clinicians and healthcare decision-makers in prescribing cost-effective therapies, contributing to more efficient allocation of healthcare resources."

Cost effectiveness • HEOR • Acute Kidney Injury • Infectious Disease • Renal Disease

THE CLEARANCE OF NEUTROPHIL EXTRACELLULAR TRAPS BY CONSTRAINT-INDUCED MOVEMENT THERAPY DEPENDS ON MICROGLIA (WSC 2025) - "The purpose of this study is to determine whether the clearance effect of CIMT on NETs is related to microglia and its specific mechanism. Administration of the Colony-stimulating factor 1 receptor inhibitor PLX3397 and intraperitoneal injection of minocycline were used to deplete and inactivate microglia, respectively. CIMT mediates the phagocytosis of NETs by microglia in ischemic cortex and is beneficial to maintain the balance of pro-inflammatory/anti-inflammatory microglia. The synaptic budding is at least partially attributed to the spatial location provided by microglial phagocytosis of NETs. IL-33/ST2 may be the target mediating this phagocytosis."

Cardiovascular • CD68 • CD86 • IL33 • ST2

ANTIMICROBIAL-RESISTANT GRAM-NEGATIVE INFECTIONS IN THE INTENSIVE CARE UNIT (CHEST 2025) - "He was treated with broad spectrum intravenous (IV) antibiotics with Vancomycin and Cefepime...He was started on IV ceftazidime-avibactam (Avycaz) and Infectious Disease (ID) was consulted...The patient was treated with high dose IV ampicillin-sulbactam 9 g every 8 hours along with IV Minocycline 200mg BID for 5 days... In patients with a history of colonization with MDRO, it is important to evaluate the patient thoroughly before treating the infection. Consequences to early treatment may be the rise of more resistant bugs whereas a delay or no treatment can lead to further deterioration of the patient."

Gram negative • Cardiovascular • CNS Disorders • Critical care • Epilepsy • Infectious Disease • Respiratory Diseases • Vascular Neurology

Scrub Typhus With an Unknown Source of Infection. (PubMed, Cureus) - "She was treated with intravenous minocycline for 14 days, following which the fever resolved and laboratory abnormalities improved...Her clinical course was favorable, and she was discharged in good condition. Although scrub typhus is traditionally associated with rural environments, urban transmission is becoming more recognized, possibly due to ecological changes such as urban heat islands, where temperatures are higher than in surrounding rural areas, potentially expanding the habitats of vector mites. This case highlights that scrub typhus should be considered in patients presenting with fever, rash, and eschar, even when no clear environmental exposure is identified."

Journal • Anorexia • Hematological Disorders • Infectious Disease • Pain • Thrombocytopenia • CRP

"Unmasking the Uncommon": A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates. (PubMed, F1000Res) - "Antibiotic susceptibility testing (AST) revealed resistance to Piperacillin/Tazobactam, but sensitivity to Vancomycin, Levofloxacin, and Minocycline...Intravenous Ciprofloxacin was initiated with clinical improvement and negative follow-up blood cultures...A combination of Levofloxacin and Colistin was added, and blood cultures were negative after seven days, with clinical improvement...Clinicians must have a high degree of suspicion of E. meningoseptica for gram-negative bacilli causing sepsis and meningitis in high-risk patients. Recent technological advances have enabled accurate speciation to guide therapy and reduce morbidity and mortality rates."

Journal • Acute Respiratory Distress Syndrome • CNS Disorders • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases • Septic Shock • CRP

Minocycline prevents monocrotaline-induced pulmonary hypertension through the attenuation of endothelial dysfunction and vascular wall thickening. (PubMed, J Pharmacol Sci) - "PH-preventing effect of minocycline does not seem to be mediated via the actions on matrix metalloproteinase, inflammatory cytokines, and mast cells migration in lung. In summary, we revealed for the first time that minocycline ameliorated the MCT-induced PH in rats, at least partly through preventing pulmonary artery endothelial dysfunction and wall thickening."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Intravenous Minocycline versus Oral Minocycline for the Treatment of CarbapenemResistant Acinetobacter baumannii and Stenotrophomonas maltophilia Infections (ASHP 2024) - No abstract available

Infectious Disease

New-generation tetracyclines for severe macrolide-resistant Mycoplasma pneumoniae pneumonia in children: a retrospective analysis. (PubMed, BMC Infect Dis) - "Doxycycline treatment resulted in a higher rate of defervescence than minocycline. Prompt treatment reduced the probability of pleural effusion, hypoxemia, pulmonary atelectasis, and D-dimer levels > 2 times the reference value."

Journal • Retrospective data • Cough • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Percutaneous injection of minocycline in postoperative sialocele following condylar fracture. (PubMed, Br J Oral Maxillofac Surg) - "After the injection, the buccal swelling completely disappeared without complications, including facial palsy. Percutaneous injection of minocycline might be the first choice for postoperative refractory sialocele following condylar fracture."

Journal • CNS Disorders • Musculoskeletal Diseases • Oncology • Orthopedics

Administration of Corticosteroids for Prompt Suppression of Cytokine Storm in Severe Cases of Japanese Spotted Fever. (PubMed, Cureus) - "Early treatment with tetracycline antibiotics is crucial to prevent severe complications, such as pneumonia, meningitis, disseminated intravascular coagulation (DIC), and systemic inflammatory response syndrome...Initial treatment with ceftriaxone was ineffective, leading to a switch to intravenous minocycline and levofloxacin. Considering the high levels of C-reactive protein, procalcitonin, ferritin, and soluble interleukin-2 receptor, intravenous hydrocortisone (200 mg/day) was administered to control the cytokine storm...Early administration of corticosteroids along with antibiotics effectively suppressed the cytokine storm in this case. Reports have shown mixed results, indicating the need for further research to determine the optimal type, dosage, and duration of corticosteroid treatment."

Cytokine storm • Journal • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Hypertension • Immunology • Infectious Disease • Nephrology • Oncology • Pneumonia • Renal Disease • Respiratory Diseases • Septic Shock • Systemic Inflammatory Response Syndrome • CRP • IL2 • IL6 • TNFA

IL-6 Inhibitor Tocilizumab Reduces Bone Resorption Around Implants with Bacterial Infection During Osseointegration: A Pilot Study in Rabbits. (PubMed, Int J Oral Maxillofac Implants) - "Tocilizumab, an inhibitor of IL-6, has a certain effect in preventing bone loss around implants caused by bacterial infection during the osseointegration period."

Journal • Preclinical • Infectious Disease • Osteoporosis • IL6

Neuroinflammation in the paraventricular nucleus of the hypothalamus precipitates visceral pain induced by pancreatic cancer in mice. (PubMed, J Gastrointest Oncol) - "Inhibition of microglial activity through minocycline microinjection into the PVN resulted in alleviation of visceral pain within 30 and 60 min...This study found that PVN microglia and astrocytes were involved in regulating PCVP. Our results suggest that targeting glia may be a potential approach for alleviating visceral pain in patients with pancreatic cancer."

Journal • Preclinical • Gastrointestinal Cancer • Hepatology • Oncology • Pain • Pancreatic Cancer • Solid Tumor

In vitro antimicrobial susceptibility data of global meropenem-resistant Acinetobacter baumannii isolates causing pneumonia: Data from the Antimicrobial Testing Leadership and Surveillance Program, 2014 - 2021, and re-estimations of susceptibility breakpoints and appropriate dosages of important antibiotics for pneumonia treatment. (PubMed, J Glob Antimicrob Resist) - "After deliberative estimations, dosages of 200 mg minocycline intravenously every 12 h (SBP, 8 mg/L), 100 mg tigecycline intravenously every 12 h (SBP, 1 mg/L), and 160 mg nebulized colistin methanesulfonate every 8 h (SBP, 2 mg/L) are needed for the effective treatment of pneumonia-causing MEM-R A. baumannii isolates."

Journal • Preclinical • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

A potential mechanism clue to the periodic storm from microglia activation and progressive neuron damage induced by paraquat exposure. (PubMed, Environ Toxicol) - "Surprisingly, the injection of minocycline before PQ for many hours not only can effectively improve the neurobehavioral symptoms of mice but inhibit the activation of microglia and the release of pro-inflammatory substances, even controlling the gradual damage and loss of neurons. A further mechanism of minocycline hampered the expression levels of key signaling proteins PI3K, PDK1, p-AKT, and CD11b (the receptor of microglia membrane recognition), while a large number of inflammatory factors. Our results suggested that the CD11b/PI3K/NOX2 pathway may be a clue that microglia-mediated inflammatory responses and neuronal damage in a PQ-induced abnormal behavior Parkinson-like mouse."

Journal • CNS Disorders • Inflammation • Movement Disorders • Parkinson's Disease • ITGAM

Priorities and Progress in Gram-negative Bacterial Infection Research by the Antibacterial Resistance Leadership Group. (PubMed, Clin Infect Dis) - "The ARLG has conducted a series of observational studies to define the clinical and molecular global epidemiology of carbapenem-resistant and ceftriaxone-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii, with the goal of optimizing the design and execution of interventional studies...The ARLG has conducted pharmacokinetic studies to inform the optimal dosing of antibiotics that are important in the treatment of drug-resistant gram-negative bacteria, including oral fosfomycin, intravenous minocycline, and a combination of intravenous ceftazidime-avibactam and aztreonam. In addition, randomized clinical trials have assessed the safety and efficacy of step-down oral fosfomycin for complicated urinary tract infections and single-dose intravenous phage therapy for adult patients with cystic fibrosis who are chronically colonized with P. aeruginosa in their respiratory tract. Thus, the focus of..."

Clinical • Gram negative • Journal • Cystic Fibrosis • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Nephrology • Pulmonary Disease • Respiratory Diseases

MINOCYCLINE-INDUCED PULMONARY INFILTRATES WITH EOSINOPHILIA (CHEST 2023) - "During the prior hospitalization, the patient was treated with IV minocycline for a 5-day course for superimposed pneumonia... Minocycline is a derivative of tetracycline which has been used for the treatment of pneumonia...Our patient was started on a prednisone 1 mg/kg/day taper with rapid symptom resolution and resolving infiltrates. Pulmonary infiltrates with peripheral eosinophilia following treatment of infections, such as pneumonia may suggest an adverse effect of minocycline and other drugs. Steroids may be required in addition to medication cessation if symptoms do not improve."

Cystic Fibrosis • Eosinophilia • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Novel Coronavirus Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • Transplantation

Safety and PK Trial Evaluating the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Minocin IV (clinicaltrials.gov) - P1 | N=0 | Withdrawn | Sponsor: Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company) | N=25 ➔ 0 | Unknown status ➔ Withdrawn

Enrollment change • Trial withdrawal

Treatment of inflammation with Minocycline in depressed patients Trattamento dell’infiammazione con Minociclina in pazienti depressi (clinicaltrialsregister.eu) - P2 | N=60 | Ongoing | Sponsor: IRCCS CENTRO SAN GIOVANNI DI DIO - FATEBENEFRATELLI AFFERENTE ALLA PROVINCIA LOMBARDO VENETA ORDINE OSPEDALIERO DI SAN G

Biomarker • New P2 trial • CNS Disorders • Depression • Inflammation • Mood Disorders • Psychiatry

Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). (PubMed, J Neuroinflammation) - "Our study shows that CSF1R deficiency results in aberrant microglial activation, characterized by a pro-inflammatory phenotype and enhanced phagocytosis of myelin. Our results also indicate that microglial inhibition by minocycline can ameliorate behavioral impairment and ALSP pathogenesis in CSF1R-deficient male mice, suggesting a potential therapeutic target for CSF1R-related leukoencephalopathy. Collectively, these data support that minocycline confers protective effects against CSF1R-related microgliopathy in male ALSP model mice."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Inflammation • CD68 • CSF1R

Allograft inflammatory factor-1 released from the cerebral microglia affect several organs in the body. (PubMed, J Mol Histol) - "Intraperitoneal injection of minocycline, a potent microglia inhibitor, reduced the number of Iba-1 cells suggesting microglia activation-dependent accumulation...Importantly, stimulation of the cells with recombinant AIF-1 induced the expression of AIF-1 mRNA. These results may suggest that increased AIF-1 production by microglia in cerebral ischemia regulate the AIF-1 mRNA expression at least in part by an autocrine manner."

Journal • Cardiovascular • AIF1

Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice. (PubMed, World J Gastroenterol) - "We describe a new model of cross-organ visceral sensitization between the bladder and the colon in mice. Intravesical injections of acetic acid induced a long-lasting colorectal hypersensitivity to distension, mediated by neuroglial interactions, MAPK-p38 phosphorylation and the NK1 receptor."

Journal • Preclinical • Anesthesia • Gastrointestinal Disorder • Immunology • Inflammation • Interstitial Cystitis • Musculoskeletal Pain • Pain • CX3CL1 • FOS • MPO

Spinal MCP-1 Contributes to Central Post-stroke Pain by Inducing Central Sensitization in Rats. (PubMed, Mol Neurobiol) - "Intrathecal injection of minocycline and fluorocitrate dramatically reverses the bilateral mechanical pain hypersensitivity...Intrathecal injection of anti-MCP-1 mAb was also able to reverse CPSP and reduce the expression of c-Fos, Iba-1, and GFAP in the lumbar spinal dorsal horn. These findings indicated that spinal MCP-1 contributes to CPSP by mediating the activation of spinal neurons and glial cells following thalamic hemorrhage stroke, which may provide insights into pharmacologic treatment for CPSP."

Journal • Preclinical • Cardiovascular • Central Neuropathic Pain • Cerebral Hemorrhage • Hematological Disorders • Immunology • Inflammation • Neuralgia • Pain • CCL2 • CCR2 • FOS • GFAP

Role of microglia in blood pressure and respiratory responses to acute hypoxic exposure in rats. (PubMed, J Physiol Sci) - "Here we investigated this issue by comparing cardiorespiratory responses to two levels of acute hypoxia (13% O for 4 min and 7% O for 5 min) in conscious unrestrained rats before and after systemic injection of minocycline (MINO), an inhibitor of microglia activation...We conclude that microglia differentially affect cardiorespiratory regulation depending on the level of blood oxygenation. Microglia suppressively contribute to blood pressure regulation in normoxia but help maintain ventilatory augmentation in hypoxia, which underscores the dichotomy of central regulatory pathways for both systems."

Journal • Preclinical

Microglial Engulfment of Spines in the Ventral Zona Incerta Regulates Anxiety-Like Behaviors in a Mouse Model of Acute Pain. (PubMed, Front Cell Neurosci) - "Furthermore, pain sensitization and anxiety-like behaviors were reversed when the ZI of CFA1D-treated mice were chemically inhibited by intra-ZI minocycline injection, accompanied by the recovery of decreased ZI excitability. Conclusively, our results provide novel insights that dysregulation of microglial engulfment capacity encodes maladaptation of ZI , thus promoting the development of anxiety-like behaviors in acute pain."

Journal • Preclinical • CNS Disorders • Mood Disorders • Pain • Psychiatry