LT102 / Chengdu IncTAC Biotechnology - LARVOL DELTA

Positive allosteric modulators of AMPA receptors: advances and emerging trends. (PubMed, Expert Opin Ther Pat) - "Key chemotypes covered include benzamides, benzothiadiazines, benzoxathiazines such as TAK-653 and LT-102, constrained sulfonamides such as PF-04958242, PF-4778574 and MDI-222, and newer heterocyclic and bivalent ligands. AMPA receptor potentiation remains a promising strategy, but future candidates will need to combine potency, finely tuned efficacy, favorable pharmacokinetics, and circuit-level selectivity. The most successful next-generation PAMs will likely be those that maximize therapeutic window while minimizing seizure liability."

Journal • CNS Disorders • Epilepsy