lidocaine topical / Generic mfg. - LARVOL DELTA

Efficacy of lidocaine-prilocaine combined with amitriptyline or Acmella oleracea in a liposomal cream for topical anesthesia: a randomized crossover clinical trial. (PubMed, J Dent Anesth Pain Med) - "Pentravan®-based formulations did not exhibit clinical superiority. Future studies should focus on optimizing these combined formulations to enhance the efficacy of topical anesthesia in dentistry."

Journal • Anesthesia • Pain

Management of a difficult airway for multispace infection of the floor of the mouth: A case report. (PubMed, Medicine (Baltimore)) - "This is the first reported case of diabetic ketoacidosis with severe trismus and multispace infection managed by ATI using an epidural catheter fixed to a channel-less fiberoptic bronchoscope for sequential topical anesthesia. The technique offers an alternative when standard devices are impossible or contraindicated."

Journal • Anesthesia • Diabetes • Infectious Disease • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Type 1 Diabetes Mellitus

Management of Small Fiber Neuropathy: A Clinical Perspective. (PubMed, Muscle Nerve) - "First-line medications include amitriptyline, nortriptyline, gabapentin, and pregabalin. Second-line treatments can include serotonin-norepinephrine reuptake inhibitors and selective serotonin reuptake inhibitors such as duloxetine and venlafaxine, as well as lidocaine patches and capsaicin."

Journal • Diabetes • Immunology • Infectious Disease • Metabolic Disorders • Neuralgia • Pain

Dramatic Response to Lidocaine Infusion Therapy for Chronic Generalized Pain Secondary to Multiple Large Keloids. (PubMed, Cureus) - "Conventional treatments, including surgical excision with intralesional corticosteroids, duloxetine, meloxicam, amitriptyline, and acupuncture, provided only transient relief. Moderate pain relief was achieved with pregabalin, nortriptyline, topical lidocaine, and medical marijuana, resulting in a visual analog scale (VAS) score of 8/10. The subsequent addition of intravenous (IV) lidocaine infusions (5 mg/kg administered over one hour) produced significant pain reduction (VAS 3/10) and notable improvements in quality of life and functional capacity, enabling her to maintain employment. The interval between infusions was later extended to every four months while maintaining pain relief, without neuroexcitatory or cardiac complications. This case suggests that periodic IV lidocaine infusions may offer a safe and effective therapeutic option for sustained analgesia in patients with chronic keloid-related pain."

Journal • Fibrosis • Infectious Disease • Mood Disorders • Musculoskeletal Pain • Neuralgia • Pain • Varicella Zoster

Pain Control for Cervical Ripening Balloon (clinicaltrials.gov) - P2 | N=110 | Not yet recruiting | Sponsor: Beth Israel Deaconess Medical Center

New P2 trial • Pain

Anesthetic Management in a Patient with Dandy-Walker Syndrome Undergoing Supraglottoplasty and Adenotonsillectomy: A Case Report. (PubMed, Cureus) - "Anesthetic management prioritized spontaneous ventilation using inhalational induction with sevoflurane followed by propofol infusion. Airway topicalization with lidocaine and adjunctive dexmedetomidine facilitated atraumatic airway manipulation...Given the extensive airway instrumentation and severe OSA, the patient remained intubated postoperatively and was extubated uneventfully in the pediatric intensive care unit after 24 hours. This case highlights the challenges of anesthetic management in children with complex syndromic airways and emphasizes the importance of strategies that maintain spontaneous ventilation, attenuate airway reflexes, and allow for safe postoperative monitoring."

Journal • Anesthesia • CNS Disorders • Critical care • Epilepsy • Infectious Disease • Obstructive Sleep Apnea • Pediatrics • Pneumonia • Respiratory Diseases • Sleep Disorder

A Novel Nebulization-Assisted Topicalization Device for Flexible Bronchoscopic-Guided Awake Nasotracheal Intubation: A Case Report. (PubMed, A A Pract) - "This device integrates a nasal trumpet with a nebulization chamber to deliver 4% lidocaine, effectively anesthetizing the nasal cavity, nasopharynx, and the vocal cords. This technique was successfully used in 2 patients, ensuring smooth and efficient awake FB-guided nasotracheal intubation while minimizing adverse effects such as epistaxis, coughing, or discomfort."

Intubation • Journal • Anesthesia

Detecting Local Myocardial Spatiotemporal Repolarization Gradients With Clinical Mapping Arrays. (PubMed, Circ Arrhythm Electrophysiol) - "Repolarization changes were created using global infusion of ibutilide or pinacidil, or topical application of lidocaine. Although ARI only correlates with uniformly distributed changes in repolarization in the entire myocardium, RepolLoc also provided accurate regional gradient assessment and duration alternans of repolarization. These findings suggest ARI has significant far-field contamination and RepolLoc may provide a better clinical mapping tool for spatiotemporal repolarization gradient mapping."

Journal

Regulatory science-aligned development and pre-clinical evaluation of Novel Lidocaine-loaded nanoemulgel for psoriasis management (ISDS 2025) - "In the imiquimod-induced psoriasis in male BALB/c mice and histopathological studies, the nanoemulgel-treated groups confirmed the improvement of psoriatic conditions compared to untreated, plain gel, and marketed formulation. LID nanoemulgels have shown satisfactory results in improving psoriatic conditions in the mice and may serve as an attractive approach compared to other topical formulations. This first reported LID nanoemulgel to date may become a suitable translational strategy for the management of psoriasis."

Preclinical • Anesthesia • Dermatology • Immunology • Inflammation • Pruritus • Psoriasis

Clinical Studies on Topical Anesthesia in Dentistry: A Bibliometric Analysis. (PubMed, Pharmaceuticals (Basel)) - "Journals focusing on periodontics, general dentistry, and oral surgery published the majority of these articles, with lidocaine being the most studied anesthetic...Our findings suggest a research preference for studies with immediate clinical impact over those focusing on pain management, particularly in the field of topical dental anesthesia. This highlights the need for further research and progress in this important field."

Journal • Review • Anesthesia • Pain

Hell's Itch: A Case Series of a Debilitating Post-Sunburn Pruritic Syndrome in a Healthy Young Adult. (PubMed, Reports (MDPI)) - "The patients did not achieve symptom relief from standard treatments which included oral antihistamines and topical lidocaine, NSAIDs, aloe vera, and cold compresses...While anecdotal, further study is needed to elucidate the mechanism of action of β-alanine in relieving symptoms of Hell's Itch, as well as assess safety and efficacy in controlled settings. Increased clinical awareness of Hell's Itch may reduce patient distress and improve management strategies."

Journal • Dermatology • Inflammation • Pain • Pruritus

No need: EFFECTS OF TOPICAL LIDOCAINE AND BENZOCAINE ON PAIN LEVEL AND INJECTION SATISFACTION (clinicaltrials.gov) - P3 | N=60 | Completed | Sponsor: TC Erciyes University

New P3 trial • Cardiovascular • Pain

Evaluation of Over-the-Counter Cutaneous Lidocaine Cream for Temporary Deafferentation in Upper Limb Rehabilitation: A Cross-Sectional Study. (PubMed, Cureus) - "Our results suggest that the use of OTC lidocaine can be used to achieve TD in as little as 60 minutes. While demographic factors were found to influence the level of TD, this approach offers a practical and economical solution for studies seeking to utilize TD outside of traditional healthcare or research facilities."

Journal • Observational data • Anesthesia • CNS Disorders

Topical Lidocaine During Airway Manipulation in Pediatric Anesthesia: A Systematic Review and Meta-Analysis. (PubMed, Paediatr Anaesth) - "Our findings suggest that topical lidocaine may reduce the incidence of undesirable airway reflexes such as laryngospasm, desaturation, and sore throat in children undergoing airway management. However, its benefit for other perioperative respiratory adverse events requires further investigation, especially in high-risk populations."

Journal • Retrospective data • Review • Anesthesia • Cough • Otorhinolaryngology • Pediatrics • Respiratory Diseases

Turning Down the Heat: Lumbar Sympathetic Block for Autoimmune-Associated Erythromelalgia (ASRA-FALL 2025) - "• She had been treated with pregabalin, duloxetine, capsaicin, and mexiletine, with partial relief but eventually returned three years later with intolerable side effects...On oblique view skin infiltration with 1% lidocaine was performed at the needle entry site...of 0.25% Bupivacaine with epinephrine 1:200000 was injected as a test dose, there was no change in the heart rate...CONCLUSION This case underscores the potential utility of LSB in patients with erythromelalgia who have failed or cannot tolerate pharmacologic therapies. While evidence remains limited, existing literature supports sympathetic blocks as a therapeutic option in select cases of both primary and secondary erythromelalgia, including those associated with autoimmune disease."

Dermatology • Fibromyalgia • Immunology • Inflammatory Arthritis • Lupus • Musculoskeletal Pain • Rheumatology • Systemic Lupus Erythematosus

"Gasserian Ganglion Block as a Novel Approach for Refractory Burning Mouth Syndrome in Complex Regional Pain Syndrome" (ASRA-FALL 2025) - "Materials and Methods Failed treatments: Gabapentin 900 mg TID, pregabalin 150 mg BID, nortriptyline, baclofen (diarrhea), naltrexone, tramadol, opioids (fentanyl, hydrocodone), topical lidocaine, capsaicin rinses...* Bilateral diagnostic gasserian ganglion block: Performed under fluoroscopy using 0.5% ropivacaine + dexamethasone, with sedation...BMS pathophysiology includes reduced intraepithelial nerve fiber density, overexpression of TRPV1/P2X3/Nav1.7 channels, dopaminergic hypofunction, impaired descending pain modulation, and postmenopausal estrogen decline. The patient’s improvement with sphenopalatine and gasserian ganglion blocks highlights the trigeminal pathway’s role and suggests gasserian ganglion interventions, traditionally used for trigeminal neuralgia, as promising options in refractory BMS."

Late-breaking abstract • Anesthesia • Musculoskeletal Pain • Neuralgia • Pain • NAV1 • TRPM8 • TRPV1

Local Anesthetic Systemic Toxicity Caused by Non-Anesthesiologists: A Narrative Review of Case Reports. (PubMed, J Korean Med Sci) - "These findings suggest that subcutaneous infiltration or topical administration of lidocaine overdoses by non-anesthesiologists, particularly in patients with or without risk factors for LAST, significantly contributes to LAST. Preventive strategies, including education on maximum recommended doses of local anesthetics, identification of patient risk factors for LAST, utilization of ultrasound-guided nerve blocks, and ensuring the availability of lipid emulsion treatment, should be emphasized. Lipid emulsions ought to be readily accessible for the management of LAST in all locations where local anesthetics are used."

Journal • Review • Anesthesia • Cardiovascular • CNS Disorders • Epilepsy • Pain

Effects of Different Local Medications on Sore Throat After Endotracheal Intubation: A Single-Center Randomized Controlled Trial (ChiCTR) - P=N/A | N=108 | Completed | Sponsor: General Hospital of Eastern Theater Command; General Hospital of Eastern Theater Command

Intubation • New trial • Otorhinolaryngology

Patient Reported Experiences and Comfort Associated with Intravitreal Injection Technique: A Cross-Sectional Survey Approach. (PubMed, J Vitreoretin Dis) - "Lidocaine pledgets were associated with the most discomfort (P < .05). Surveyed patients preferred topical gel or subconjunctival injections, manual lid retraction, and Betadine-soaked cotton tips. Future studies may consider the safety associated with each technique."

Journal • Age-related Macular Degeneration • Anesthesia • Diabetic Macular Edema • Diabetic Retinopathy • Hematological Disorders • Ophthalmology • Retinal Disorders • Wet Age-related Macular Degeneration

Effects of topical lidocaine infusion through endotracheal tube and target controlled infusion of remifentanil on stress response during emergence from general anesthesia in patients undergoing interventional surgery for intracranial aneurysms (ChiCTR) - P=N/A | N=50 | Completed | Sponsor: Huadong Hospital affiliated to Fudan University; Huadong Hospital affiliated to Fudan University

New trial • Anesthesia • Cardiovascular • Vascular Neurology

Predictors of Same Day Discharge Following Peroral Endoscopic Myotomy in a Tertiary Care Center (ACG 2025) - "Eighty patients were included in the study (mean age 58.3, 57.5% male). Baseline characteristics were similar (Table 1). Procedure duration was significantly shorter (32 vs."

Anesthesia • Gastrointestinal Disorder • Infectious Disease • Pneumonia • Rare Diseases • Respiratory Diseases

High dose topical capsaicin in the treatment of meralgia paresthetica: a case report. (PubMed, Pain Manag) - "She had previously tried lidocaine 5% patch, capsaicin 0.1% patch, gabapentin, and oxycodone, with minimal relief. This off-label use of capsaicin 8% patch showed promise for pain management for MP. However, prospective studies are needed to determine the long-term efficacy, safety, and optimal dosing.High-Dose Capsaicin Patch Relieved Thigh Nerve Pain in a Complex Patient - Plain Language Summary."

Journal • Fibrosis • Hematological Disorders • Immunology • Infectious Disease • Neuralgia • Pain • Thrombocytopenia

Exploring the Role of Amitriptyline in Modulating Gag Reflex Sensitivity. (PubMed, Iran J Pharm Res) - "Amitriptyline can be considered a potential alternative to lidocaine spray in gag reflex management, particularly in lidocaine-intolerant patients. Further studies are needed to confirm long-term safety and determine the local versus systemic pharmacological effects."

Journal • Anesthesia

Topical Lidocaine or not for laser follicle ablation in pilonidal disease: a prospective, randomized, double-blinded trial. (PubMed, J Pediatr Surg) - "Application of topical anesthetic cream prior to laser follicle ablation adds significant time to a patient's clinic visit and does not appear to improve pain control when compared to placebo for gluteal laser follicle ablation for pilonidal disease."

Clinical • Journal • Anesthesia • Pain

DYSHEMOGLOBINEMIA: WHEN SULFUR MET HEMOGLOBIN (CHEST 2025) - "Here we discuss a case of presumed methemoglobinemia later revealed to be predominantly sulfhemoglobinemia after recent initiation of over-the-counter topical lidocaine patches and phenazopyridine (AZO)... Dyshemoglobinemia should be considered when a patient presents with symptoms of cyanosis associated with hypoxia refractory to supplemental oxygen administration. Sulfhemoglobinemia presents similarly to methemoglobinemia requiring prompt recognition and subsequent discontinuation of known precipitants as these disorders can be life-threatening. Methylene blue should be considered in acute toxic methemoglobinemia with levels >30% or in those who are symptomatic with methemoglobin levels between 20-30%."

Anemia • Anesthesia • CNS Disorders • Hematological Disorders • Multiple Sclerosis • Peripheral Neuropathic Pain