lidocaine topical / Generic mfg. - LARVOL DELTA

Sedation-Free Transnasal Esophagogastroduodenoscopy (TN-EGD) With Biopsies Evaluates the Upper Gastrointestinal Tract in Adult Research Subjects Who Are Not Nothing Per Os (NPO) Status (ACG 2026) - "Prior to the procedure, topical 4% lidocaine (total dose 4 ml) was administered intranasally and orally... Fifty-six sedation-free TN-EGD were successfully performed on 17 subjects, ages 20-87 years, and biopsies were taken during all procedures (Table 1). Forty-nine procedures reached the second portion of the duodenum (Figure 1) and 7 reached the stomach. All per-protocol biopsies were obtained to the extent reached."

Biopsy • Clinical • Gastrointestinal Disorder

The Impact of Systemic Redistribution on Cutaneous Pharmacokinetic-Based Bioequivalence: An In vivo Dermal Open Flow Microperfusion Study for Lidocaine and Prilocaine. (PubMed, Eur J Pharm Sci) - P=N/A | "Systemic redistribution was negligible and did not alter the BE assessment. Under standardized conditions, dOFM and dMD showed comparable PK profile characteristics, supporting the potential utility of both dOFM and dMD for characterizing the dermal PK of moderately lipophilic, protein-bound topical drugs under standardized study conditions."

Journal • PK/PD data • Preclinical

Topical Lidocaine for Digital Nerve Block Pain (clinicaltrials.gov) - P4 | N=240 | Completed | Sponsor: Ankara City Hospital Bilkent

New P4 trial • Pain

Effects of Dexmedetomidine Combined With Lidocaine Topical Administration on Cough Reflex During Extubation in Thyroidectomy Patient. (clinicaltrials.gov) - P=N/A | N=120 | Active, not recruiting | Sponsor: Sohag University

New trial • Cough • Respiratory Diseases

Severe anaphylactic shock suspectedly induced by injection of recombinant humanized type III collagen lyophilized fiber for facial skin improvement: a case report. (PubMed, Front Allergy) - "We report a case of a 47-year-old woman with no prior history of allergy who received topical lidocaine to the face, followed by injection of recombinant humanized type III collagen lyophilized fibers for skin texture improvement...This case suggests that recombinant humanized collagen, as a macromolecular protein, inherently carries the risk of triggering immediate-type anaphylactic shock despite its favorable safety profile. Clinicians should perform rigorous preoperative assessment, adhere to standardized procedures, and be proficient in the emergency management of anaphylactic shock to minimize the risk of severe adverse reactions and ensure medical safety."

Journal • Allergy • Cardiovascular • Immunology

Robotic-assisted bronchoscopy with integrated cone-beam computed tomography under sedation: A proof-of-concept case series (ERS 2026) - "S&A was achieved via target-controlled infusion of 1% propofol and topical lidocaine...No serious adverse events occurred. Conclusion This case series provides a proof-of concept for performing RAB+CBCT under S&A in patients fit for S&A."

Clinical • Hypotension

Awake Fiberoptic Intubation for Segmental Mandibulectomy in a Patient with Follicular Ameloblastoma of the Anterior Mandible: A Case Report. (PubMed, Int Med Case Rep J) - "Topical anesthesia was achieved by combining nebulized 2% lidocaine (4 mL, 80 mg) with the spray-as-you-go technique (2-4 mL of 2% lidocaine)...Sedation was achieved with dexmedetomidine (loading dose 1 µg/kg over 10 minutes, then maintenance at 0.4 µg/kg/hour)...No episodes of desaturation occurred. This report highlights the practical adaptability of the DAS sTOP framework for AFOI when HFNO availability is limited, demonstrating that low-flow nasal oxygen combined with dual-method topicalization and a single sedative agent may serve as a feasible alternative."

Intubation • Journal • Anesthesia • Oncology

Pharmacological modulation of peripheral nerve excitability-a novel way to investigate sodium channel subtypes in humans. (PubMed, Pain) - "A novel electrical stimulation protocol-the Sodium channel Excitability Nociceptor Testing protocol-was used to identify alterations in Nav1.7, 1.8, and 1.9 after applying 3 (5% lidocaine, 10% phenytoin, and 2% mepyramine) topical pharmacological drugs. The Sodium channel Excitability Nociceptor Testing protocol can be used to investigate differential pharmacological alterations of specific Nav subtypes. This may lead to better insight of neurophysiological mechanisms of sensory afferents, forming the basis for targeted drug development, leading the way to stratified treatment regimens of peripheral pain."

Journal • Diabetic Neuropathy • Neuralgia • Pain • Peripheral Neuropathic Pain • NAV1

WarmLido: Studying Warmed Lidocaine for Increased Analgesic Effect During Intravitreal Injections (clinicaltrials.gov) - P=N/A | N=100 | Terminated | Sponsor: University of Missouri-Columbia | Trial completion date: May 2025 ➔ May 2026 | Enrolling by invitation ➔ Terminated | Trial primary completion date: May 2025 ➔ May 2026; IRB requesting termination.

Trial completion date • Trial primary completion date • Trial termination • Anesthesia • Pain

Efficacy of lidocaine spray for pain reduction during rabies immunoglobulin infiltration: a double-blind, randomized, placebo-controlled trial. (PubMed, Vaccine) - "Topical 10% lidocaine spray achieved statistically and clinically significant reductions in pain intensity during needle penetration and RIG infiltration compared with placebo. The intervention was well tolerated and associated with higher participant satisfaction. These findings support its use as a simple and efficacious option for procedural pain control in adults aged 18-65 years with the eligible small-to-moderate wound types evaluated in this study."

Clinical • Journal • Pain

Intralesional Corticosteroid Therapy for Refractory Hyperkeratotic Vulvar Lichen Sclerosus: A Case Series. (PubMed, J Low Genit Tract Dis) - "Intralesional triamcinolone may be a useful rescue therapy for selected patients with persistent or refractory hyperkeratotic vulvar lichen sclerosus, provided that neoplasia is excluded and long-term surveillance is maintained."

Journal • Dermatology • Oncology • Squamous Cell Carcinoma

Blunting the Needle: A Quality Improvement Project to Reduce Needle Phobia (NACFC 2026) - "With the decreasing age of approval of CFTR modulator medications and need for frequent laboratory testing, having potential interventions to address needle phobia and create a more peaceful experience for pwCF is crucial. In this quality improvement project, we saw a significant decrease in concern through targeted interventions, with a high level of caregiver comfort and satisfaction. Notable issues with the intervention were lack of consistent laboratory staff, timing of topical lidocaine placement versus wait times for lab."

Cystic Fibrosis • Genetic Disorders • Immunology • Mood Disorders • Respiratory Diseases

Effect of Lidocaine Spray on the Sedative Dose of Remimazolam During Gastroscopy in Adults: A Prospective, Randomized Dose-Response Trial Using an Up-Down Sequential Allocation Method. (PubMed, Drug Des Devel Ther) - "At the start of sedation, alfentanil was intravenously injected at a dose of 3 μg/kg, followed by remimazolam administration using a sequential method. In addition, no statistically significant differences were observed in hemodynamic changes or related adverse events between the two groups (P > 0.05). Lidocaine spray can be used in combination with remimazolam for gastroscopic examination to reduce the sedative dose of remimazolam during gastroscopy in adults."

Clinical • Journal • Anesthesia • Pain

Topical Therapy of Otitis Externa: Potential Use of Combined Preparations (PubMed, Vestn Otorinolaringol) - "Combined topical therapy with an ear drop preparation demonstrated high efficacy and a favorable safety profile in the treatment of acute otitis externa in children older than 6 years and adult patients, providing positive clinical dynamics in 96.4% of patients."

Journal • Retrospective data • Dermatopathology • Inflammation • Otorhinolaryngology

Current advances in the epidemiology, risk factors, prevention, management, and long-term outcomes of herpes zoster and post-herpetic neuralgia. (PubMed, Front Microbiol) - "Evidence supports the use of gabapentinoids, tricyclic antidepressants, topical lidocaine, and capsaicin for PHN management, while multidisciplinary approaches incorporating non-pharmacologic interventions may further improve outcomes...PHN remains a substantial source of long-term morbidity following HZ, particularly in aging populations. Early recognition of high-risk patients, prompt antiviral treatment, evidence-based pain management, and wider uptake of recombinant zoster vaccination are key strategies for reducing disease burden and improving patient outcomes."

Journal • Review • Herpes Zoster • Infectious Disease • Neuralgia • Pain • Varicella Zoster

Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy (clinicaltrials.gov) - P4 | N=80 | Not yet recruiting | Sponsor: Wah Medical college , POF hospital

New P4 trial • Diabetes • Diabetic Neuropathy • Metabolic Disorders • Peripheral Neuropathic Pain • Type 2 Diabetes Mellitus

The Effect of Topical Anesthesia on the Phonation Process During High-Speed Digital Imaging Laryngoscopy in Patients with Laryngopharyngeal Reflux: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial. (PubMed, Medicina (Kaunas)) - "All subjects were recorded in two modalities, with TA application (lidocaine spray 100 mg/mL) and without it, on two consecutive days... TA application during HSDI in subjects with LPR was not associated with significant changes in the analyzed phonation process parameters. Further research is needed to determine the benefit of TA in reducing pain and discomfort during examination, weighed against the risk of potentially life-threatening side effects, in order to individualize the approach to each patient."

Clinical • Journal • Anesthesia • Otorhinolaryngology • Pain

Procedural Optimization of Capsaicin 8% Patch Therapy Using Ultrasound-Guided Bilateral Ankle Nerve Block in Painful Diabetic Peripheral Neuropathy: A Retrospective Comparative Cohort Study. (PubMed, Healthcare (Basel)) - "This study evaluated whether ultrasound-guided bilateral ankle nerve block (UGBANB) was associated with better procedural outcomes than topical eutectic mixture of lidocaine/prilocaine (EMLA) pretreatment or no pretreatment. These findings relate specifically to procedural optimization and should not be interpreted as evidence that UGBANB enhances the intrinsic or long-term analgesic efficacy of capsaicin. Prospective multicenter randomized controlled trials are needed to confirm these associations and determine whether improved procedural tolerability translates into better long-term treatment adherence, clinical outcomes, health-related quality of life, safety, and cost-effectiveness."

Journal • Retrospective data • Anesthesia • Diabetic Neuropathy • Pain • Peripheral Neuropathic Pain

Toxic Anterior Segment Syndrome following XEN Gel Stent Implantation: A Rare Complication in Minimally Invasive Glaucoma Surgery - Case Report. (PubMed, Case Rep Ophthalmol) - "Potential causative factors included intracameral agents (lidocaine, acetylcholine, cefuroxime, viscoelastic material), possible migration of mitomycin C through the XEN stent lumen, or an inflammatory response to the gelatin-based device itself. This case demonstrates that TASS can occur following minimally invasive glaucoma surgery, including XEN Gel Stent implantation, and may result in severe and irreversible ocular sequelae. It underscores the importance of heightened postoperative vigilance and strict preventive protocols even in procedures perceived as low risk."

Journal • Cataract • Glaucoma • Inflammation • Ophthalmology • Pain

Enhanced Pain Management With Combined EMLA Patch and Local Anesthetic Infiltration in Transradial Angiography. (PubMed, Clin Cardiol) - "Combined EMLA patch plus local lidocaine infiltration was associated with superior analgesia during and after transradial coronary angiography compared with either method alone. An EMLA application time of 100-300 min may optimize analgesic effectiveness, while patients with obesity may benefit from tailored pain-management strategies."

Clinical • Journal • Retrospective data • Anesthesia • Genetic Disorders • Obesity • Pain

Durable, Anatomically Confined Clearance of Scalp Psoriasis and Associated Pruritus After Single Bilateral Greater Occipital Nerve Block. (PubMed, Cureus) - "Psoriasis is a chronic, immune-mediated inflammatory skin disease that frequently involves the scalp, presenting as well-demarcated, erythematous plaques with silvery scale, pruritus, and impaired quality of life. Emerging evidence supports the role of sensory nerves in psoriatic inflammation through neuroimmune signaling involving the calcitonin gene-related peptide (CGRP) and interleukin-23/interleukin-17 (IL-23/IL-17) axis. Here, we report a case of severe, recalcitrant, markedly pruritic scalp psoriasis in a patient who failed multiple topical therapies and had only temporary improvement with apremilast before denial by her insurance, requiring discontinuation. Given the proposed neuroimmune pathophysiology of psoriasis, the patient underwent bilateral greater occipital nerve block utilizing lidocaine. At 169 days post-procedure, she demonstrated complete resolution of itch and clearance of plaques..."

Journal • Dermatology • Immunology • Inflammation • Pruritus • Psoriasis • IL17A • IL23A

Comparison of 4 ml of 1% Lignocaine Versus 2 ml of 2% Lignocaine for Landmark-Guided Superior Laryngeal Nerve Block During Awake Fiberoptic Intubation. (PubMed, Cureus) - "For landmark-guided superior laryngeal nerve block, 4 mL of 1% lignocaine per side was associated with more completely relaxed vocal cords and shorter fiberoptic intubation time than 2 mL of 2% lignocaine per side. The findings support further multicenter confirmation using validated airway-anesthesia scales and fully blinded injectate preparation where feasible."

Intubation • Journal • Anesthesia

Intraoperative Management of a Large Mediastinal Mass Complicated by Bronchoesophageal Fistula and Pericardial Effusion with Concern for Cardiac Tamponade (ASA 2026) - "Echocardiogram demonstrated right-sided diastolic collapse and pulsus paradoxus on exam, concerning for cardiac tamponade.She underwent biopsy and esophageal stent placement for fistula closure using topical 4% lidocaine, ketamine, and dexmedetomidine to maintain spontaneous ventilation and hemodynamic stability in lieu of standard general endotracheal anesthesia. This case emphasizes the importance of modifying the anesthetic approach, considering the pathophysiology of complex anterior mediastinal masses to maintain cardiopulmonary function."

Cardiovascular • Gastrointestinal Disorder

Awake Fiberoptic Double-Lumen Tube Placement in a Difficult Airway (ASA 2026) - "Dexmedetomidine and ketamine were used for sedation while maintaining spontaneous ventilation in a seated position. After airway topicalization with lidocaine, a flexible bronchoscope was used to place a 37 Fr left-sided DLT. After tracheal cuff inflation and end-tidal confirmation, anesthesia was deepened with propofol and rocuronium. DLT placement was rechecked after lateral positioning. The procedure proceeded without complication."

Head and Neck Cancer • Oral Cancer • Solid Tumor

Ludwig's Angina in a Pacemaker‑Dependent Patient: Airway Management Without an OR Magnet (ASA 2026) - "A combined airway strategy was planned: awake intubation with videolaryngoscopy, topical lidocaine, and a fiberoptic bronchoscope available...The procedure was uneventful. This case highlights expert difficult airway management in Ludwig's angina and the critical adaptation required in a life-threatening emergency."

Clinical • Cardiovascular • CNS Disorders • Congestive Heart Failure • Heart Failure