dobutamine / Generic mfg. - LARVOL DELTA

Navigating triple therapy in a high-risk cardiac patient with a covered stent and embolic stroke: A case report (ASH 2025) - "He was diagnosed with NSTEMI, and was initiated on aspirin, clopidogrel, enoxaparin, and nitroglycerin...Persistent cardiogenic shock necessitated Impella CP support, vasopressors (epinephrine, norepinephrine), and inotropes (dobutamine)...Following readmission, neurological evaluation revealed small subacute infarcts, following which anticoagulation with enoxaparin (later apixaban) was initiated alongside DAPT (aspirin, clopidogrel)...Repeat coronary angiography plays a major role here, allowing physicians to assess stent integrity and to make informed decision about de-escalation or continuation of therapy. Unfortunately, there are no current guidelines specifically addressing management strategies for patients with coronary artery aneurysms and recent embolic stroke, underscoring an urgent need for further research in this area."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Congestive Heart Failure • Depression • Heart Failure • Hematological Disorders • Ischemic stroke • Nephrology • Peripheral Arterial Disease • Pulmonary Disease • Renal Disease • Respiratory Diseases • Thrombosis

Diffusion Tensor CMR Assessment of the Microstructural Response to Dobutamine Stress in Health and Comparison With Patients With Recovered Dilated Cardiomyopathy. (PubMed, Circ Cardiovasc Imaging) - "Despite clinical recovery in patients with rDCM, microstructural function at rest and during dobutamine remains impaired. Further understanding of microstructural remodeling at rest and during stress may help refine risk stratification of patients with rDCM at risk of relapse."

Journal • Cardiomyopathy • Cardiovascular

Pharmacological Hypotensive Treatment in Very Preterm Newborns: Systematic Review and Meta-Analysis of Randomised Controlled Trials. (PubMed, Acta Paediatr) - "Pharmacological treatment of neonatal hypotension may improve blood pressure without positive effects on mortality and neurodevelopment in very preterm newborns. However, associated adverse effects such as intraventricular haemorrhage and hyperglycemia appear relevant."

Journal • Retrospective data • Review • Diabetes • Hypotension

Successful Substrate-Guided Ablation of Ventricular Tachycardia Storm in Acute Heart Failure Without Mechanical Circulatory Support. (PubMed, JACC Case Rep) - "Substrate-guided mapping with individualized hemodynamic support can achieve safe, effective VT ablation in resource-limited settings."

Journal • Anesthesia • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Ventricular Tachycardia

Dobutamine for Management of Surgical Patients With Septic Shock (clinicaltrials.gov) - P=N/A | N=584 | Completed | Sponsor: First Affiliated Hospital of Zhejiang University | Recruiting ➔ Completed | Trial completion date: Apr 2027 ➔ Nov 2025 | Trial primary completion date: Apr 2027 ➔ Nov 2025

Trial completion • Trial completion date • Trial primary completion date • Anesthesia • Critical care • Septic Shock

Automated cardiac MRI analysis for robust profiling of heart failure models in mice. (PubMed, Sci Rep) - "This time-efficiency allowed us to add additional sequences, including cine-Arterial Spin Labeling (ASL) for myocardial perfusion mapping and dobutamine stress testing, allowing for a comprehensive cardiac exam...The CNN demonstrated high accuracy and reproducibility, achieving a mean Dice similarity coefficient greater than 0.9 for segmentation and Intraclass Correlation Coefficients (ICC) exceeding 0.95 for key left ventricular functional parameters (volumes and mass) compared to expert consensus reads. This optimized protocol and automated analysis pipeline provides a valuable tool for preclinical cardiovascular research, enabling efficient and reliable assessment of cardiac remodeling and contributing to a deeper understanding of HFpEF progression."

Journal • Preclinical • Cardiovascular • Congestive Heart Failure • Genetic Disorders • Heart Failure • Obesity

ASAI-POL: AI Assessment of Low-Gradient Aortic Stenosis Severity Based on Echocardiography (clinicaltrials.gov) - P=N/A | N=300 | Recruiting | Sponsor: National Institute of Cardiology, Warsaw, Poland | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular

Hemodynamic effects of levosimendan in low cardiac output syndrome post-CABG refractory to standard inotropic therapy. (PubMed, Med Klin Intensivmed Notfmed) - "This retrospective single-center case series suggests that levosimendan may be associated with hemodynamic improvement in patients with LCOS after CABG who are unresponsive to standard therapy. However, due to the absence of a control group and the retrospective design, these findings should be considered exploratory and hypothesis-generating."

Journal • Cardiovascular • Coronary Artery Disease • Hypotension

Postoperative hemodynamic stability of patients treated with the sacubritil-valsartan combination in cardiac surgery. (PubMed, Anaesth Crit Care Pain Med) - "In this exploratory study in cardiac surgery, preoperative treatment with SVC was not associated with increased vasoplegia and vasoactive drug consumption."

Journal • Acute Coronary Syndrome • Acute Kidney Injury • Cardiovascular • Congestive Heart Failure • Critical care • Heart Failure • Renal Disease

Successful Replication of the Transconal Repair Technique for Anomalous Aortic Origin of the Left Main Coronary Artery. (PubMed, JACC Case Rep) - "Transconal unroofing for AAOLCA with extended transseptal course is safe, reproducible, and provides favorable early outcomes."

Journal • Cardiovascular • Myocardial Ischemia • Pain

Evaluation of Hemodynamic Changes in Normovolemic Hypotensive Dogs Treated With Fluids Alone or in Combination With Ephedrine or Dobutamine. (PubMed, Vet Med Sci) - "While ephedrine and dobutamine improved hemodynamic variables, crystalloid fluid therapy alone was ineffective in managing normovolemic hypotension in dogs. Future studies with larger samples must assess the combined promising effects of fluid therapy and ephedrine."

Journal • Anesthesia • Hypotension • Metabolic Disorders

Utilization patterns and determinants of guideline-recommended therapies for acute heart failure in Denmark. (PubMed, Eur Heart J Acute Cardiovasc Care) - "Loop diuretics were widely used, while vasodilators, inotropes, and vasopressors had lower utilization. The observed variation in treatment reflects complexity of inpatient AHF management, warranting further studies to assess treatment outcomes."

Journal • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Nephrology • Renal Disease

Personalised treatment strategies in heart failure: A literature review and new proposed algorithm for device therapy selection. (PubMed, Biomed Pap Med Fac Univ Palacky Olomouc Czech Repu) - "In addition, it discusses novel prognostic and monitoring methods such as impedance cardiography and dobutamine stress echocardiography, which enable more precise patient assessment. Based on the available clinical data, we propose a new four-step decision algorithm for personalised device therapy selection in heart failure, integrating etiology-specific risk stratification, electrical and functional evaluation, and prognostic modifiers. The integration of evidence-based interventions and phenotype-driven decision-making supports a proactive and individualized approach to improving outcomes and quality of life in patients with heart failure."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Prognostic value of cardiac biomarkers and Phoenix criteria in pediatric sepsis: a retrospective cohort study. (PubMed, BMC Pediatr) - "Laboratory parameters such as pro-BNP obtained in the early stages of the disease could serve as good guides for in determining the timing of initiation of vasoactive drug therapy. Furthermore, the fact that children who died did not meet the Phoenix sepsis criteria raises concerns about the ability of these criteria to detect sepsis at an early stage."

Biomarker • Journal • Retrospective data • Infectious Disease • Pediatrics • Septic Shock

ADAPT: Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion (clinicaltrials.gov) - P3 | N=136 | Completed | Sponsor: University Hospital, Limoges | Recruiting ➔ Completed | N=270 ➔ 136 | Trial completion date: Dec 2025 ➔ Jul 2025 | Trial primary completion date: Dec 2025 ➔ Jul 2025

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Cardiomyopathy • Cardiovascular • Infectious Disease • Septic Shock

Association of noradrenaline dose with mortality in critically ill patients: a systematic review and dose-response meta-analysis. (PubMed, Crit Care) - "In critically ill patients, escalating doses of noradrenaline correlate with an exponentially rising relative risk of mortality. This dose-dependent pattern reinforces the role of noradrenaline dose as a marker of cardiovascular failure severity."

Clinical • Journal • Retrospective data • Review • Cardiovascular • Critical care

Analysis of prognostic risk factors in critically ill elderly patients with sepsis-associated acute kidney injury. (PubMed, BMC Nephrol) - "Elderly SA-AKI patients have a high short-term mortality. Advanced age, renal impairment, liver disease, renal replacement therapy, and the use of several vasoactive drugs were associated with poor outcomes, while the potential benefit of epinephrine requires further validation."

Journal • Retrospective data • Acute Kidney Injury • Critical care • Hepatology • Infectious Disease • Nephrology • Renal Disease • Septic Shock

Impairment of local metabolic coronary control involves perfusion-contraction matching not supply-demand imbalance. (PubMed, Basic Res Cardiol) - "To address this question we performed experiments in a cannulated coronary preparation in swine to precisely control flow as myocardial oxygen consumption (MVO2) and contractile function were modulated by dobutamine (1-10 μg/kg/min, iv), reductions in coronary perfusion pressure (CPP), and the inhibition of voltage-gated K+ channels with 4-aminopyridine (4-AP; 1 mM, ic). Wall thickening progressively decreased as coronary flow was reduced below ~ 5.0-7.5 μL/g/beat regardless of whether the decrease was due to diminished "supply" (CPP, 4-AP) or limitations during increased "demand" (flow clamp or restriction with dobutamine). These findings demonstrate that impairments in local metabolic control of coronary flow are reliably demonstrated by decreases in contractile function as a consequence of reductions in the volume of myocardial perfusion per beat."

Journal

Relationship between external jugular and central venous oxygen saturation in anesthetized dogs under varying hemodynamic conditions. (PubMed, Am J Vet Res) - "Six sequential hemodynamic states were induced: baseline, controlled hemorrhage, isotonic crystalloid resuscitation, autotransfusion, continuous rate infusion of dobutamine, and administration of high-concentration isoflurane. However, it demonstrated moderate ability to track directional changes under different hemodynamic conditions. SejvO2 may serve as a less invasive option for serial monitoring of oxygen balance when direct ScvO2 measurement is not feasible, supporting its potential role in critical care monitoring."

Journal • Anesthesia • Critical care • Hematological Disorders

Effect of sevoflurane on hemodynamic response during cardiopulmonary bypass in cardiac surgery patients: A randomized controlled trial. (PubMed, J Cardiovasc Thorac Res) - "In addition, the proportion of patients using dobutamine and noradrenaline during CPB was also lower in group S-CPB. In conclusion, in patients undergoing cardiac surgery under CPB, the use of sevoflurane for anesthesia during CPB results in hemodynamic stability with less need for inotropes and vasopressors during CPB but morbidity and mortality within 30 days after surgery were not significantly different when compared with the control group."

Journal • Anesthesia • Cardiovascular

Clinical Assessment of Arterial Dynamic Elastance in ICU Patients, Dependent on Inotropic or Vasopressor Drugs. (clinicaltrials.gov) - P=N/A | N=0 | Withdrawn | Sponsor: Universitair Ziekenhuis Brussel | N=30 ➔ 0 | Unknown status ➔ Withdrawn

Enrollment change • Trial withdrawal • Cardiovascular • Heart Failure • Infectious Disease • Septic Shock

Targeted metabolomic profiling reveals inflammation-associated longitudinal changes in plasma metabolites following on-pump coronary bypass surgery. (PubMed, Front Med (Lausanne)) - "We assessed correlations with parameters of intra-operative course (cardiopulmonary bypass time and aortic cross-clamping time), intensive care unit (ICU) care, (length of ICU stay, duration of mechanical ventilation, duration of epinephrine/dobutamine or norepinephrine therapy), and systemic inflammation. Of note, neither C-reactive protein (CRP) nor leukocyte count correlated significantly with an intra-operative or ICU parameter. These results reveal pronounced changes in plasma metabolite populations after CABG, which likely result from the combined effects of surgical and post-operative stress, systemic inflammation, reduced dietary intake, and possibly changes in gut microflora."

Journal • Cardiovascular • Coronary Artery Disease • Critical care • Inflammation • CRP

Improved accuracy for myocardial blood flow mapping with deep learning-enabled CMR arterial spin labeling (DeepMASL): validation by microsphere in vivo. (PubMed, J Cardiovasc Magn Reson) - "The novel DeepMASL demonstrates much improved accuracy in the quantification of regional MBF at varying levels of coronary artery stenosis, which is correlated strongly with microsphere MBF values. The validated data indicates the potential for this DeepMASL technique to be translated for noncontrast diagnosis of myocardial perfusion deficit in a clinical setting."

Journal • Preclinical • Cardiovascular • Coronary Artery Disease

Utilizing a real-world data set to assess titration practices for high-alert medications delivered via continuous infusions with smart infusion pumps. (PubMed, Am J Health Syst Pharm) - "This first-of-its-kind data analysis identified safety gaps that can help establish greater standardization of appropriate titration parameters for high-alert medications. These standards can further optimize drug libraries and enhance DERS to increase medication safety in the use of smart infusion pumps."

Journal • Real-world evidence

Anomalous Right Coronary Artery: A Case of Exertional Angina and Sinus Node Ischemia. (PubMed, JACC Case Rep) - "Nondominant anomalous RCA may present with angina and chronotropic limitation. SA nodal ischemia can be an ischemic equivalent when regional wall motion abnormalities are absent."

Journal • Cardiovascular • Pain