dobutamine / Generic mfg. - LARVOL DELTA

Stellate Ganglion Nrf2 Modulates Oxidative Stress and Heart Rate Responses in Mice and Rats with Heart Failure. (PubMed, Antioxidants (Basel)) - "The increase in plasma norepinephrine levels was reduced following stellate stimulation in CHF rats that overexpressed Nrf2, while β1-adrenergic responsiveness to dobutamine was unchanged...Nrf2 overexpression significantly modulated sympathetic regulation, altering heart rate responses and reducing plasma norepinephrine in CHF rats. These findings support the concept that impaired Nrf2 signaling contributes to ganglionic redox imbalance and dysregulated sympathetic nerve activity in CHF."

Journal • Preclinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction • NFE2L2

Impaired mitochondrial proteostasis underlies cardiomyocyte bioenergetic dysfunction in a murine 3-hit model of heart failure with preserved ejection fraction. (PubMed, Am J Physiol Heart Circ Physiol) - "Notably, mitochondrial chaperones and proteases for protein quality control were reduced, leading to increased accumulation of ubiquitinated mitochondrial proteins and impaired mitochondrial proteostasis. Together, these findings indicate that mitochondrial dysfunction in a 3-hit HFpEF model is characterized by reduced respiratory capacity and impaired mitochondrial proteostasis, rather than defective biogenesis, suggesting that impaired mitochondrial protein quality control may contribute to reduced cardiac reserve in HFpEF."

Journal • Preclinical • Cardiovascular • Congestive Heart Failure • Genetic Disorders • Heart Failure • Hypertension • Metabolic Disorders • Targeted Protein Degradation

Comparison of arterial blood pressure and quality of induction and recovery in horses anesthetized with diazepam or guaifenesin co-induction combined with xylazine and ketamine and maintained on isoflurane. (PubMed, Can J Vet Res) - "Requirements for dobutamine and/or phenylephrine for arterial blood pressure support were recorded. Induction scores were good to excellent [both groups: 0.5 (0, 2); median (range)]. In conclusion, guaifenesin and diazepam at the doses used in this study produced similar effects on arterial blood pressure and on the quality of induction and recovery."

Journal • Anesthesia

Novel Transvalvular Flow Criteria Reduce Indeterminate Stress Echocardiography and Refine Risk Stratification in Low-Gradient Aortic Stenosis. (PubMed, Circ Cardiovasc Imaging) - "Guidelines advocate the use of dobutamine stress echocardiography (DSE) in low-gradient aortic stenosis (aortic valve area [AVA] <1 cm2 with aortic valve mean gradient <40 mm Hg) with reduced left ventricular ejection fraction (<50%) for subsequent patient management...In this real-world study, the transvalvular flow-based criteria for severe AS markedly reduced the number of indeterminate DSE. Within the indeterminate AS group, patients with reclassified severe AS derived benefit from aortic valve intervention."

Journal • Atrial Fibrillation • Cardiovascular

Effects of sympathomimetic agents on heart rate variability during general anesthesia in Thoroughbred horses. (PubMed, J Equine Sci) - "Five healthy Thoroughbred horses were anesthetized with sevoflurane in oxygen...Two doses (µg·kg-1·min-1) of epinephrine (0.1 and 0.5), norepinephrine (0.5 and 1), dobutamine (1 and 5), dopamine (5 and 15), and saline (as a control) were infused for 7 min each...Increases in LF power and the LF/HF ratio may reflect enhanced sympathetic modulation; however, these indices should be interpreted in the context of baroreflex-mediated autonomic regulation. Understanding the differential autonomic effects of sympathomimetic agents may aid in optimizing cardiovascular support during equine anesthesia."

Journal • Anesthesia • Cardiovascular

Clinical Outcomes of Levosimendan Versus Dobutamine Versus Milrinone in Cases With Acute Decompensated Heart Failure With Impaired Renal Function (clinicaltrials.gov) - P4 | N=60 | Completed | Sponsor: Ain Shams University | Phase classification: P ➔ P4

Phase classification • Cardiovascular • Congestive Heart Failure • Heart Failure • Nephrology

Community Pharmacist Support for Complex Palliative Pharmacotherapy and Home Infusion in Advanced Heart Failure: A Case Report. (PubMed, J Pain Palliat Care Pharmacother) - "During home care, the pharmacist coordinated cassette preparation and exchange, proposed a lightweight disposable pump for high-dose continuous furosemide infusion, implemented light protection for furosemide, supported lumen separation to avoid incompatibility with dobutamine, and prepared a morphine cassette for continuous subcutaneous infusion. Home infusion was continued until the patient died peacefully at home on Day 45. This case highlights the multifaceted role of community pharmacists in supporting complex palliative pharmacotherapy and home infusion for advanced HF."

Journal • Addiction (Opioid and Alcohol) • Cardiovascular • Congestive Heart Failure • Heart Failure

Comparison of chiral separation performance of （2-hydroxyethyl-β）-cyclodextrin bonded superficially porous and fully porous particle chiral stationary phases in supercritical fluid chromatography and reversed-phase liquid chromatography (PubMed, Se Pu) - "The evaluation was performed using ten chiral molecular probes： zopiclone， equol， 2-phenylpropionic acid， dobutamine， flutriafol， miconazole， folic acid， catechin， valacyclovir， and chlorphenamine. Polar organic solvent mode was not investigated either. Additionally， peak symmetry and theoretical plate numbers on the SPP-CSP were generally inferior to those observed on the commercial Hp-β-CD chiral column across both chromatographic modes."

Journal • Addiction (Opioid and Alcohol)

Preoperative vasoactive-inotropic score predicts early mortality after deceased donor liver transplantation (TTS 2026) - "Preoperative vasopressor requirement was quantified using the vasoactive-inotropic score (VIS), calculated as: dopamine (μg/kg/min) + dobutamine (μg/kg/min) + 100 × norepinephrine (μg/kg/min) + 10,000 × vasopressin (U/kg/min)... Higher preoperative vasopressor requirement quantified by VIS is independently associated with early mortality after DDLT. VIS may provide additional prognostic information beyond conventional surgical risk factors when evaluating liver transplantation candidates."

Hepatology • Solid Organ Transplantation • Transplantation

1406: Sepsis-Induced Cardiogenic Shock (CHEST 2026) - "The Surviving Sepsis Campaign guidelines recommend using dobutamine with norepinephrine or epinephrine alone for patients with septic shock with cardiac dysfunction and persistent hypoperfusion despite adequate fluid resuscitation and stable BP...4. Learn the role of mechanical circulatory support for sepsis-induced cardiogenic shock."

Cardiovascular • Infectious Disease • Septic Shock

Altered Neurovascular Coupling Dynamics During Dobutamine-Induced Acute Stress. (PubMed, Brain Behav) - "Acute cardiovascular stress induced by dobutamine altered neurovascular coupling dynamics, and individuals with lower resting diastolic pressure and greater systolic responses showed stronger stress-related NVC enhancement."

Journal • Cardiovascular • Solid Tumor

Computed Tomographic Findings and Clinical Manifestations of Acute Severe Hypersensitivity to a Non-Ionic Iodinated Contrast Agent in a Castrated Male Dog: A Case Report. (PubMed, Animals (Basel)) - "Following immediate intervention with cardiopulmonary resuscitation, epinephrine, and dexamethasone, the patient temporarily exhibited facial edema, hematochezia, diarrhea, and transient ataxia. However, dobutamine administration successfully restored systemic blood pressure and tissue perfusion, returning the patient to a normal clinical status. Consequently, this case highlights potential pathophysiological mechanisms, key CT findings, and emergency management considerations for contrast-induced hypersensitivity. Notably, sequential CT imaging documented evolving shock-related changes before the onset of overt clinical deterioration, suggesting that these findings may represent early imaging indicators of contrast-induced hypersensitivity."

Journal • Anesthesia • Ataxia • Hypotension • Immunology • Movement Disorders • Oncology • Respiratory Diseases

ROGAR: Renal Oxygenation-Guided AKI Reduction Trial (clinicaltrials.gov) - P=N/A | N=1200 | Not yet recruiting | Sponsor: Chinese PLA General Hospital

Head-to-Head • New trial • Acute Kidney Injury • Nephrology • Renal Disease

Clinical significance of resting and dobutamine stress myocardial work in cirrhotic cardiomyopathy. (PubMed, Echo Res Pract) - "MW was decreased in patients with CCM. Neither MW indices nor a diagnosis of CCM was predictive of the study outcome. Liver disease severity measured by MELD-Na score and E/e' were independent predictors of the study outcome. Although MW is a load-independent measure, in this study, it did not add to the diagnosis CCM more than GLS. Further large-scale studies are required to establish the role of MW in evaluation of patients with liver cirrhosis."

Journal • Acute Kidney Injury • Addiction (Opioid and Alcohol) • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Gastroenterology • Heart Failure • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Nephrology • Renal Disease • Transplantation

Sensitivity and specificity of speckle tracking echocardiography for coronary artery disease: a systematic review and meta-analysis. (PubMed, Front Cardiovasc Med) - "Exercise stress STE demonstrated higher sensitivity than dobutamine stress or no stress protocols, and recovery-phase measurements showed promising but imprecise results...Future research should focus on standardizing methodologies, validating strain thresholds, and integrating STE into multidisciplinary diagnostic pathways. https://www.crd.york.ac.uk/PROSPERO/view/CRD420251207466."

Journal • Retrospective data • Review • Cardiovascular • Coronary Artery Disease

Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST) (clinicaltrials.gov) - P=N/A | N=48 | Terminated | Sponsor: CAMC Health System | N=196 ➔ 48 | Unknown status ➔ Terminated; Lack of research personnel

Enrollment change • Trial termination • Mood Disorders

Ea/Ees and oscillatory power fraction capture complementary but distinct components of ventriculoarterial coupling: a porcine study. (PubMed, Front Physiol) - "In 14 juvenile pigs challenged with vasoactive (phenylephrine, nitroprusside) and cardioactive drugs (dobutamine, esmolol) titrated toward protocolized targets (± 40% MAP, ± 50% dP/dt), we obtained a comprehensive dataset using intracardiac conductance catheters, intraaortic pressure probes, and ascending aortic flow probes. This is consistent with the two indices reflecting predominantly steady and pulsatile aspects of arterial load, although the present data do not demonstrate that separation directly. While OPF cannot replace Ea/Ees, power-derived indices offer practical adjuncts for characterizing ventriculoarterial interactions and the effects of selected drugs at the intensive care bedside."

Journal • Preclinical • Critical care

Vasoactive intensity predicts mortality beyond SCAI staging in cardiogenic shock. (PubMed, Eur Heart J Open) - "In stage C, dobutamine alone was associated with lower mortality than norepinephrine alone [OR = 0.25 (0.09-0.74); P = 0.009]; in stage E, dobutamine plus norepinephrine was associated with higher mortality [OR = 2.39 (1.07-5.36); P = 0.028]...Adding SCAI stage minimally improved discrimination (R 2 = 0.222-0.226; Δ = +0.004), whereas VIS substantially improved model performance (R 2 = 0.286; Δ = +0.060; P < 0.001). Vasoactive intensity quantified by the VIS improved 90-day mortality prediction beyond SCAI staging and the simple count of vasoactive drugs, providing incremental prognostic information beyond SCAI staging."

Journal • Cardiovascular • CNS Disorders • Psychiatry

REsting FLOW rate to determine true Aortic valve Severity (REFLOW-AS). (PubMed, Int J Cardiol) - "TFR is an easily applied echo measurement. In situations with discordant echo data, TFR ≥220 ml/s supports the diagnosis of severe aortic stenosis and negates the need for further diagnostic imaging."

Journal • Cardiovascular

Dobutamine-induced Myoclonus: A Case Following Continuous Dobutamine Administration In A Patient With Decompensated Heart Failure And Chronic Kidney Disease [Poster no. 727] (HFSA 2026) - No abstract available

Clinical • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Movement Disorders • Nephrology • Renal Disease

Levosimendan versus Dobutamine in Hospitalized Heart Failure With and Without Beta-Blocker Therapy: A Multinational Propensity-Matched Real-World Analysis (AHA 2026) - "Abstract is embargoed at this time."

Clinical • Real-world • Real-world evidence • Cardiovascular • Congestive Heart Failure • Heart Failure

Outcomes of Milrinone vs. Dobutamine in Cardiogenic Shock with Acute Kidney Injury (AHA 2026) - "Abstract is embargoed at this time."

Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease

Dobutamine Stress Echocardiography Prior to Liver Transplantation: Comparative Analysis of Transplant and Cardiovascular Outcomes (AHA 2026) - "Abstract is embargoed at this time."

Cardiovascular • Transplantation

Impact of levosimendan versus dobutamine on 30-day mortality and hospital stay in acute decompensated heart failure: a systematic review and meta-analysis (ESC 2026) - "Conclusion In adults with ADHF and low cardiac output, levosimendan was associated with lower short-term mortality and shorter hospital stay compared with dobutamine, with signals of renal benefit. Larger contemporary trials are needed to confirm these findings and to define the optimal use of levosimendan in this high-risk population."

Retrospective data • Review • Cardiovascular • Congestive Heart Failure • Heart Failure

Levosimendan administration and survival in patients receiving mechanical circulatory support: insights from an unselected real-world cohort (ESC 2026) - "While norepinephrine, epinephrine, and dobutamine represent standard treatment, the prognostic relevance of levosimendan administration in this setting remains uncertain. In this retrospective real-world MCS cohort, levosimendan administration was independently associated with reduced short-term mortality and improved long-term survival, including in resuscitated patients. While residual confounding inherent to the observational design cannot be excluded, these findings support prospective evaluation of levosimendan as adjunctive therapy in advanced cardiogenic shock."

Clinical • Real-world • Real-world evidence • Cardiovascular