CG-105-12 / Cells & Genes Biotech (Shanghai) - LARVOL DELTA

Epigenome-wide association study of BMI and waist-to-hip ratio and their associations with dietary patterns in Korean adults. (PubMed, Sci Rep) - "The most significant associations were at cg10323433 and cg10501210 in serotonin receptor 2 A (HTR2A) for abdominal obesity (Δβ = -0.023) and BMI-defined obesity (Δβ = -0.021), respectively...Sites with hypomethylation in obesity consistently demonstrated positive correlations with fat intake but negative correlations with carbohydrates. The distinct associations between methylation patterns and dietary components suggest that different foods may influence epigenetic modifications that are specific to overall adiposity or fat distribution, providing potential targets for nutritional interventions to modify obesity-related epigenetic signatures."

Journal • Genetic Disorders • Obesity • HTR2A

A Study to Evaluate CG-105-12 in Patients With Relapsed/Refractory Multiple Myeloma (clinicaltrials.gov) - P1 | N=12 | Recruiting | Sponsor: The First Affiliated Hospital of Nanchang University

New P1 trial • Hematological Malignancies • Multiple Myeloma • Oncology