tedalinab (GRC-10693) / Glenmark - LARVOL DELTA

Kinetic multiplex assay to assess biased signaling of clinical GPCR agonists. (PubMed, Pharmacol Res) - "Moreover, superagonists Tedalinab, Olorinab, PRS-211375 and ART-27.13 were characterized by fast k1 values. Altogether, this study accentuates the potential of multiplexing functional responses and performing kinetic analyses to provide an extensive preclinical profile for agonists that may better predict their in vivo pharmacological effects. Ultimately, providing full kinetic context for binding and signaling of GPCR agonists could advance drug discovery efforts."

Journal • Inflammation • ARRB1