R 1541 / Roche - LARVOL DELTA

Peripartum cardiomyopathy: An analysis of clinical profiles and outcomes from a tertiary care centre in southern India. (PubMed, Obstet Med) - "The incidence of peripartum cardiomyopathy was one case per 1541 live births...Peripartum cardiomyopathy with poor left ventricular ejection fraction and shock is associated with adverse maternal outcomes, while non-severe maternal anaemia predisposes to adverse fetal outcomes. Significant left ventricular ejection fraction recovery occurred on follow-up."

Clinical • Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Disorders

Three GLI2 mutations combined potentially underlie non-syndromic cleft lip with or without cleft palate in a Chinese pedigree. (PubMed, Mol Genet Genomic Med) - "Our results further demonstrate that GLI2 variants play a role in the pathogenesis of NSCL/P, and the three rare missense mutations combined are probably the potential disease-causing variants in this family."

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Exosomes Derived from the Human Primary Colorectal Cancer Cell Line SW480 Orchestrate Fibroblast-Led Cancer Invasion. (PubMed, Proteomics) - "Mass spectrometry-based protein profiling revealed that cancer exosomes upregulated CRL1541 proteins implicated in focal adhesion (ITGA2/A6/AV, ITGB1/B4/B5, EGFR, CRK), regulators of actin cytoskeleton (RAC1,ARF1, ARPC3, CYFIP1,NCKAP1, ICAM1, ERM complex) and signalling pathways (MAPK, Rap1, RAC1, Ras) important in pro-invasive remodelling of the extracellular matrix...Mass spectrometry-based protein profiling revealed that cancer exosomes upregulated CRL1541 proteins implicated in focal adhesion (ITGA2/A6/AV, ITGB1/B4/B5, EGFR, CRK), regulators of actin cytoskeleton (RAC1,ARF1, ARPC3, CYFIP1,NCKAP1, ICAM1, ERM complex) and signalling pathways (MAPK, Rap1, RAC1, Ras) important in pro-invasive remodelling of the extracellular matrix. Blocking tumour exosome-mediated signalling to stromal fibroblasts could therefore represent an attractive therapeutic strategy in restraining tumours by perturbing stroma-driven invasive outgrowth."

Journal • Preclinical • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor • EGFR • ICAM1 • RAC1

Attention-deficit/hyperactivity disorder associated with KChIP1 rs1541665 in Kv channels accessory proteins. (PubMed, PLoS One) - "Moreover, we also found rs1541665 involvement in ADHD-I subtype (OR (95% CI) = 2.341(1.713, 3.282), and Hyperactive index score (P = 0.005) in combined samples.Intriguingly, gene-environmental interactions analysis consistently revealed the potential interactionsof rs1541665 collaboratingwith maternal stress pregnancy (Pmul = 0.021) and blood lead (Padd = 0.017) to modify ADHD risk. In conclusion, the current study provides evidence that genetic variants of Kv accessory proteins may contribute to the susceptibility of ADHD.Further studies with different ethnicitiesare warranted to produce definitive conclusions."

Journal • Attention Deficit Hyperactivity Disorder • Biosimilar • CNS Disorders

High peak-power and narrow-linewidth all-fiber Raman nanosecond laser in 1.65 µm waveband. (PubMed, Opt Express) - "A homemade high peak-power 1541 nm pulsed laser is employed to modulate and amplify a 1653.7 nm distributed feedback laser (DFB) seed synchronously in a segment of the 52-meter-long highly germania-doped fiber (HGDF). The repetition-rate and the pulse-width of the 1653.7 nm pulsed laser are 100 kHz and 31 ns, respectively. The peak power is estimated to be as high as about 30.85 W, and a 3-dB linewidth as narrow as less than 0.08 nm is achieved when the average power of 1541 nm pump is 3.1 W. The wavelength of Raman pulsed laser can be tuned from 1652.0 nm to 1654.0 nm continuously with an optical signal-to-noise ratio (OSNR) of more than 35 dB."

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An exploratory study by DMET array identifies a germline signature associated with imatinib response in gastrointestinal stromal tumor. (PubMed, Pharmacogenomics J) - "We further confirmed the genotype of selected variants in an extended cohort of 49 patients (the original cohort and 15 new cases, all with exon 11 primary mutation), identifying 6 SNPs- ABCB4 rs1202283, ABCC2 rs2273697, ABCG1 rs1541290, CYP11B1 rs7003319, CYP7B1 rs6987861, and NQO1 rs10517-significantly associated with response to imatinib. We confirmed that these SNPs could stratify the cohort of 49 patients according to the risk of developing progression under imatinib treatment. In conclusion, we identified a genetic signature of response to imatinib therapy in GIST patients able to stratify patients at low and high risk to progress, according to their genotype."

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Mediator Complex (MED) 7 is Downregulated in High Grade Ductal Carcinoma in Situ (DCIS) (USCAP 2020) - "Design: MED7 immunostaining was performed with a rabbit monoclonal antibody (EPR15410, Abcam- Ab187146, Cambridge, UK)... Our results suggest that MED7 expression is significantly down regulated in high grade and ER-negative DCIS cases, thus implying a significant biological role of MED7 in the progression of DCIS. Taken together, our data establishes MED7 H-score as a tangible tool for evaluating high grade DCIS. Further studies are underway to establish a practical cut-off value for the MED7 H-Score for high grade DCIS."

Benchmark and integration of resources for the estimation of human transcription factor activities. (PubMed, Genome Res) - "We assembled a collection of TF-target interactions for 1541 human TFs and evaluated how different molecular and regulatory properties of the TFs, such as the DNA-binding domain, specificities, or mode of interaction with the chromatin, affect the predictions of TF activity. We assessed their coverage and found little overlap on the regulons derived from each strategy and better performance by literature-curated information followed by ChIP-seq data. We provide an integrated resource of all TF-target interactions derived through these strategies, with confidence scores, as a resource for enhanced prediction of TF activities."

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Reproducibility of pharmacogenetics findings for paclitaxel in a heterogeneous population of patients with lung cancer. (PubMed, PLoS One) - "Of these, seven variants in ABCB11 (rs4148768), ABCC3 (rs1051640), ABCG1 (rs1541290), CYP8B1 (rs735320), NR3C1 (rs6169), FMO6P (rs7889839), and GSTM3 (rs7483) were associated with paclitaxel PFS in a multivariate analysis accounting for clinical covariates. With the exception of a variant in VKORC1, the present study did not find the same genetic outcome associations of other published research on pharmacogenetics variants that affect paclitaxel outcomes. This finding suggests that prior pharmacogenomics research findings may not be reproduced in the most frequently-diagnosed malignancy, lung cancer."

Biomarker • Clinical • Heterogeneity • Journal