nicorandil / Generic mfg. - LARVOL DELTA

Retraction Note: Ameliorative effect of nicorandil in ovarian ischemia-reperfusion-induced injury in rats: role of potassium channel. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - No abstract available

Journal • Preclinical • Cardiovascular • Reperfusion Injury

Nicorandil ameliorates neuropathic and inflammatory pain via TNF-α, IL6/MAPKERK1/2 and NO/cGMP signaling. (PubMed, Sci Rep) - "L-arginine (500 mg/kg, I.P), N(ω)-nitro-L-arginine methyl ester (L-NAME, 10 mg/kg, I.P), methylene blue (10 mg/kg, I.P), sildenafil (2.5 mg/kg, I.P) and glibenclamide (5 mg/kg, I.P) were tested 30 min before nicorandil. Taken together, these data demonstrate that nicorandil has an antiallodynic effect on neuropathic and inflammatory pain via inhibition of NO/cGMP pathways and reduction of oxidative stress and proinflammatory cytokines targeting ROS/TNF-α, IL6 /MAPKERK1/2 signaling pathways. These findings highlight nicorandil's potential as a promising multitarget therapeutic option for pain management through its anti-inflammatory and antioxidant properties."

Journal • Neuralgia • Pain • IL6 • TNFA • TRPV1

Optical Pumped Magnetometer Magnetocardiography in Left Main Disease With Coronary Microvascular Dysfunction. (PubMed, JACC Case Rep) - "This case demonstrates that CMD should be actively assessed in patients with hemodynamically significant stenosis, even after successful revascularization. OPM-MCG enables dynamic, noninvasive detection of ischemic changes, making it suitable for longitudinal follow-up and management in patients after percutaneous coronary intervention."

Journal • Cardiovascular • Coronary Artery Disease • Dyslipidemia • Hypertension

Telmisartan and Nicorandil Attenuate Polymyxin B-Induced Renal Injury by Modulating NrF2/NQO1, FAS/FASL Signaling, and Mitigation of P53, Cyt-C, and Caspase-3. (PubMed, Immunopharmacol Immunotoxicol) - "The renoprotective effects of telmisartan and nicorandil were mediated through modulation of the Nrf2/NQO1 antioxidant pathway and FAS/FASL apoptotic signaling, along with downregulation of renal expression of p53, cytochrome c, and caspase-3. These observations clearly indicate the protective role of both agents against PMB-induced nephrotoxicity."

Journal • Anesthesia • Infectious Disease • Metabolic Disorders • Renal Disease • CASP3 • FASLG • NQO1 • TP53

Sub-analysis of perfusion balloon predilatation with intracoronary nicorandil vs. distal protection for acute coronary syndrome: A comparative evaluation. (PubMed, Fujita Med J) - "PB predilatation with intracoronary nicorandil significantly reduced the number of slow-flow or no-reflow events, shortened procedure time, and reduced the volume of contrast used. This method could be at least as effective as DP."

Journal • Acute Coronary Syndrome • Cardiovascular • Thrombosis

Ferroptosis in heart failure: from molecular insights to therapeutic implications. (PubMed, Cardiovasc Res) - "It is an abundant form of regulated cell death in the myocardium of many heart failure animal models, including the chronic ischemic, pressure overload, diabetic, septic, obesity-related and doxorubicin-induced cardiomyopathy models...Although definitive causality between ferroptosis and heart failure has not yet been established, emerging evidence suggests that ferroptosis contributes to heart failure progression, supported by multi-layer rescue with classic inhibitors (ferrostatin-1, liproxstatin-1, iron chelators) and by cardiometabolic drugs with clinical efficacy in heart failure (Sodium-Glucose Cotransporter 2 inhibitors, sacubitril/valsartan, finerenone, levosimendan, nicorandil) as well as polyphenols, which restore systolic and/or diastolic indices and reverse remodelling...In this review, through critical synthesis of existing evidence, we analyse current literature, discuss translational barriers and propose a new conceptual mechanistic framework - "the..."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Genetic Disorders • Heart Failure • Obesity

Nicorandil ameliorates cardiac microcirculation in hypertensive myocardial infarction via LKB1/AMPK signaling activation. (PubMed, Pak J Pharm Sci) - "Nic exerts cardioprotective effects in HMI rats through multi-target mechanisms involving LKB1/AMPK pathway activation, which subsequently attenuates oxidative stress and inflammatory responses while facilitating microcirculatory reconstruction, ultimately leading to significant improvement in cardiac function."

Journal • Cardiovascular • Fibrosis • Hypertension • Immunology • Inflammation • Myocardial Infarction • Myocardial Ischemia • IL1B • IL6 • STK11 • TNFA

Study on the Efficacy of Shexiang Baoxin Pill in the Treatment of Coronary Microvascular Disease Based on TCM Syndrome Types (ChiCTR) - P4 | N=50 | Not yet recruiting | Sponsor: Dongzhimen Hospital, Beijing University of Chinese Medicine; Dongzhimen Hospital, Beijing University of Chinese Medicine

New P4 trial

Artificial Intelligence-Driven Medipixel Fractional Flow Reserve Versus Invasive Fractional Flow Reserve-Guided PCI Trial (AIM-FFR Trial) (clinicaltrials.gov) - P=N/A | N=2100 | Not yet recruiting | Sponsor: Samsung Medical Center

New trial • Acute Coronary Syndrome • Cardiovascular • Coronary Artery Disease

Effect and mechanism of Guizhi Tongluo Tablets in alleviating cardiac inflammation and improving myocardial ischemia-reperfusion injury in mice by activating PI3K/Akt signaling pathway (PubMed, Zhongguo Zhong Yao Za Zhi) - "Sixty healthy SPF-grade male C57BL/6J mice were randomly divided into sham group, model group, low-dose Guizhi Tongluo Tablets group, medium-dose Guizhi Tongluo Tablets group, high-dose Guizhi Tongluo Tablets group, and nicorandil group...Compared with the model group, mice in the Guizhi Tongluo Tablets groups showed significantly improved cardiac function, reduced inflammatory cell infiltration, partially restored cardiac structure, significantly decreased cardiomyocyte apoptosis and levels of IL-1β, IL-6, and TNF-α, along with significantly increased p-PI3K/PI3K and p-Akt/Akt levels. These findings suggest that Guizhi Tongluo Tablets can effectively prevent and treat MIRI, possibly by activating the PI3K/Akt signaling pathway and alleviating cardiac inflammation."

Journal • Preclinical • Cardiovascular • Inflammation • Myocardial Ischemia • Oncology • Reperfusion Injury • IL1B • IL6 • TNFA

Unlocking Neuroprotection: Potassium Channel Openers in Alzheimer's Disease. (PubMed, Curr Alzheimer Res) - "In this respect, ATP-sensitive potassium channel openers may have a potential role in prevention and protection. The present article focuses on several cellular mechanisms of this class, including the limitation of neuronal excitability, modulation of neurotransmitter release, prevention of aberrant protein buildup, reduction of excessive calcium influx, reduction of reactive oxygen species levels, and reduction of microglial activation."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Inflammation

Triglyceride-glucose-based predictive model for in-hospital mortality in older acute myocardial infarction patients with multimorbidity. (PubMed, Intern Emerg Med) - "Key predictors included the TyG index, occupation, ≥ 2 Killip classification, hepatic insufficiency, angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker, Nicorandil and white blood cell...Calibration plots demonstrated good model calibration, and DCA results indicated superior clinical applicability of the model. The predictive model based on the TyG index provides an effective tool for assessing in-hospital mortality risk in older AMI patients with multimorbidity, demonstrating strong predictive performance and significant clinical value."

Journal • Cardiovascular • Hepatitis C • Liver Failure • Myocardial Infarction

Phenome-wide screening of the putative causal determinants of bipolar affective disorder using genetic data. (PubMed, PLoS One) - "On the other hand, we found that genetic variants influencing the use of certain supplements and medications, such as glucosamine/chondroitin, multivitamin mineral preparations, vitamin D, clopidogrel, and nicorandil, as well as the exposure to gas or solid fuel cooking/heating, decreased BPAD risk. Additionally, we detected that genetic variants affecting some mental, work, living, dietary, and physical health factors also increased BPAD risk. Our study provides novel insights into the potential causal determinants of BPAD and suggests new avenues for future research to elucidate the biological mechanisms and pathways involved in this disorder."

Journal • Bipolar Disorder • CNS Disorders • Depression • Psychiatry

Nicorandil attenuates thioacetamide induced liver fibrosis via AMPK, SIRT1 and HIF1α mediated cellular energy homeostasis. (PubMed, Sci Rep) - "In conclusion, both NIC doses showed therapeutic potential, with the 15 mg dose demonstrating superior efficacy. These findings highlight NIC's promise as an effective treatment for liver fibrosis by mediating the AMPK/SIRT-1/HIF-1α pathway and modulating key molecular and cellular processes."

Journal • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Liver Failure • AMPK • HIF1A • IL10 • IL1B • IL6 • SIRT1 • STAT3 • TGFB1 • TNFA

Ethyl Pyruvate Promotes Wound Healing in Elastase-Induced Lung Injury in Mice as Assessed by Hyperpolarized 129Xe Magnetic Resonance Imaging. (PubMed, Mol Imaging Biol) - "In the present study, we provide some insight into the role of the MAPK pathway in wound healing in elastase-induced lung injury, as assessed using the HP 129Xe MRI protocol."

Journal • Preclinical • Pulmonary Disease • Respiratory Diseases • ELANE

Huanglian Jiedu Decoction Alleviates Myocardial Ischemia-Reperfusion Injury via AKT-Mediated Regulation of Endoplasmic Reticulum Stress. (PubMed, J Inflamm Res) - "In vivo studies employed a rat model of MIRI with three HLJDD dosage groups and a nicorandil control group...HLJDD may serve as a potential therapeutic candidate for ischemia-induced cardiomyocyte apoptosis during MIRI. HLJDD exerts its effects by inhibiting the AKT-mediated PERK/eIF2α/CHOP signaling pathway, attenuating ERS and thereby reducing MIRI-induced apoptosis."

Journal • Cardiovascular • Myocardial Ischemia • Reperfusion Injury

Intracoronary adjunctive therapies for ST-elevation myocardial infarction: a network meta-analysis of trials. (PubMed, Eur Heart J Cardiovasc Pharmacother) - "Adjunctive IC treatments during primary PCI do not influence hard clinical outcomes compared to conventional therapy within a mean 8-month follow-up, although several of them lead to an improvement in surrogate endpoints of CMVO."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction • Thrombosis • Ventricular Tachycardia

Effects of nicorandil on inflammatory response, oxidative stress and myocardial fibrosis after myocardial infarction. (PubMed, BMC Cardiovasc Disord) - "Nicorandil attenuates myocardial inflammation, oxidative stress and myocardial fibrosis levels by activating ATP-sensitive potassium channels (K-ATP), thereby improving post-MI cardiac remodeling and preserving cardiac function."

Journal • Cardiovascular • Fibrosis • Immunology • Inflammation • Myocardial Infarction • IL1B • IL6 • TNFA

The protective effects of Nicorandil on renal function in patients undergoing coronary interventions: a systematic review and meta-analysis. (PubMed, BMC Nephrol) - "Nicorandil had an effective role in reducing the incidence of CIN, lower rise in creatinine, and a good safety profile in patients undergoing coronary interventions."

Journal • Retrospective data • Cardiovascular • Chronic Kidney Disease • Myocardial Infarction • Nephrology • Renal Disease

Nicorandil Attenuates Global Myocardial Ischemia-Reperfusion Injury and Systemic Inflammation Through Inhibition of TLR-4 Signaling in a Neonatal Piglet Model of Cardiopulmonary Bypass and Cardioplegic Arrest. (PubMed, Pediatr Cardiol) - "Nicorandil also upregulates the HIF-1α/PI3K pro-survival signaling pathway. These results suggest that nicorandil should be studied further to assess its potential therapeutic effects after CPB in children."

IO biomarker • Journal • Cardiovascular • Immunology • Inflammation • Myocardial Ischemia • Pediatrics • Reperfusion Injury • Systemic Inflammatory Response Syndrome • HIF1A • IL6

'The monthly curse': menstrual-associated coronary artery vasospasm in a premenopausal woman-a case report. (PubMed, Eur Heart J Case Rep) - "Sublingual administration of nitroglycerin resulted in the prompt relief of symptoms and resolution of ST-segment changes...She was closely monitored in an outpatient setting and was prescribed a combination of benidipine and nicorandil...In recent years, oestrogen replacement therapy has been reported to confer therapeutic benefits in this patient population. Early multidisciplinary collaboration involving gynaecologists and timely initiation of hormonal therapy may alter the clinical course and prevent fatal outcomes in such patients."

Journal • Cardiovascular • Critical care • Myocardial Infarction • Pain

Trials evaluating nicorandil renoprotection against contrast-induced nephropathy after coronary angiography or percutaneous coronary intervention: a systematic review and meta-analysis. (PubMed, Egypt Heart J) - "This study demonstrated the renoprotective effects of nicorandil in preventing CIN in patients undergoing coronary angioplasty, and this relationship was also evident from the double-dose response. Further larger size randomised controlled trials are recommended to assess the efficacy of nicorandil in preventing CIN in patients undergoing coronary angioplasty."

Journal • Retrospective data • Review • Cardiovascular • Coronary Artery Disease • Heart Failure • Renal Disease

Intra-Arterial Vasodilators for Radial Artery Spasm and Occlusion Prevention in Trans-radial Coronary Procedures: A Network Meta-Analysis of Randomized Control Trials (AHA 2025) - "A random-effects model was used for outcomes with high heterogeneity. In the network meta-analysis, 21 clinical trials with 11010 patients comparing 10 treatments for the prevention of spasm (Placebo, Verapamil, Diltiazem, Molsidomine, Nitroglycerin, Nicorandil, ISDN, Labetalol, Magnesium, and Phentolamine) were included, forming a network centered on Verapamil and Placebo with multiple direct connections. Patients undergoing radial artery catheterization for coronary interventions, verapamil and molsidomine significantly reduced the risk of RAS relative to placebo."

Retrospective data

Mitochondrial Transplantation During Ongoing Ischemia May Preserve Neuronal Viability (AHA 2025) - "Additionally, nicorandil (NIC), a mitochondrial KATP channel opener, can improve metabolic tolerance during IR injury.Hypothesis/Aims: This study aimed to evaluate whether MTx during ongoing ischemia preserves neuronal viability and mitochondrial function in an in vitro oxygen-glucose deprivation (OGD) model, and whether NIC co-treatment provides a synergistic effect. The study included two main groups: normoxic control and OGD; each had 9 subgroups: no treatment, 10 or 0.1µg/mL mitochondria (Mito), 100 or 500µM NIC, and their combinations... Skeletal muscle-derived MTx effectively preserved mitochondrial function and viability of HT-22 cells when given during ongoing OGD, suggesting a potentially new therapeutic window prior to reperfusion. NIC co-treatment further improved metabolic tolerance, indicating a possible synergistic effect. Overall, MTx has neuroprotective potential for stroke in aortic surgery."

Cardiovascular • Reperfusion Injury • Transplantation

Spectroscopic and Thermodynamic Studies on the Binding Interaction of Nicorandil to Bovine Serum Albumin, Supported by Molecular Docking Analysis. (PubMed, Luminescence) - "In addition, synchronous fluorescence spectroscopy, FTIR, and ligand-protein docking studies have deduced the conformational alteration in the BSA secondary structure when it interacts with NCL. Docking results were in accordance with experimental results."

Journal