nicorandil / Generic mfg. - LARVOL DELTA

Ethyl Pyruvate Promotes Wound Healing in Elastase-Induced Lung Injury in Mice as Assessed by Hyperpolarized 129Xe Magnetic Resonance Imaging. (PubMed, Mol Imaging Biol) - "In the present study, we provide some insight into the role of the MAPK pathway in wound healing in elastase-induced lung injury, as assessed using the HP 129Xe MRI protocol."

Journal • Preclinical • Pulmonary Disease • Respiratory Diseases • ELANE

Huanglian Jiedu Decoction Alleviates Myocardial Ischemia-Reperfusion Injury via AKT-Mediated Regulation of Endoplasmic Reticulum Stress. (PubMed, J Inflamm Res) - "In vivo studies employed a rat model of MIRI with three HLJDD dosage groups and a nicorandil control group...HLJDD may serve as a potential therapeutic candidate for ischemia-induced cardiomyocyte apoptosis during MIRI. HLJDD exerts its effects by inhibiting the AKT-mediated PERK/eIF2α/CHOP signaling pathway, attenuating ERS and thereby reducing MIRI-induced apoptosis."

Journal • Cardiovascular • Myocardial Ischemia • Reperfusion Injury

Nicorandil attenuates thioacetamide induced liver fibrosis via AMPK, SIRT1 and HIF1α mediated cellular energy homeostasis. (PubMed, Sci Rep) - "In conclusion, both NIC doses showed therapeutic potential, with the 15 mg dose demonstrating superior efficacy. These findings highlight NIC's promise as an effective treatment for liver fibrosis by mediating the AMPK/SIRT-1/HIF-1α pathway and modulating key molecular and cellular processes."

Journal • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Liver Failure • AMPK • HIF1A • IL10 • IL1B • IL6 • SIRT1 • STAT3 • TGFB1 • TNFA

Intracoronary adjunctive therapies for ST-elevation myocardial infarction: a network meta-analysis of trials. (PubMed, Eur Heart J Cardiovasc Pharmacother) - "Adjunctive IC treatments during primary PCI do not influence hard clinical outcomes compared to conventional therapy within a mean 8-month follow-up, although several of them lead to an improvement in surrogate endpoints of CMVO."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction • Thrombosis • Ventricular Tachycardia

Effects of nicorandil on inflammatory response, oxidative stress and myocardial fibrosis after myocardial infarction. (PubMed, BMC Cardiovasc Disord) - "Nicorandil attenuates myocardial inflammation, oxidative stress and myocardial fibrosis levels by activating ATP-sensitive potassium channels (K-ATP), thereby improving post-MI cardiac remodeling and preserving cardiac function."

Journal • Cardiovascular • Fibrosis • Immunology • Inflammation • Myocardial Infarction • IL1B • IL6 • TNFA

The protective effects of Nicorandil on renal function in patients undergoing coronary interventions: a systematic review and meta-analysis. (PubMed, BMC Nephrol) - "Nicorandil had an effective role in reducing the incidence of CIN, lower rise in creatinine, and a good safety profile in patients undergoing coronary interventions."

Journal • Retrospective data • Cardiovascular • Chronic Kidney Disease • Myocardial Infarction • Nephrology • Renal Disease

Nicorandil Attenuates Global Myocardial Ischemia-Reperfusion Injury and Systemic Inflammation Through Inhibition of TLR-4 Signaling in a Neonatal Piglet Model of Cardiopulmonary Bypass and Cardioplegic Arrest. (PubMed, Pediatr Cardiol) - "Nicorandil also upregulates the HIF-1α/PI3K pro-survival signaling pathway. These results suggest that nicorandil should be studied further to assess its potential therapeutic effects after CPB in children."

IO biomarker • Journal • Cardiovascular • Immunology • Inflammation • Myocardial Ischemia • Pediatrics • Reperfusion Injury • Systemic Inflammatory Response Syndrome • HIF1A • IL6

'The monthly curse': menstrual-associated coronary artery vasospasm in a premenopausal woman-a case report. (PubMed, Eur Heart J Case Rep) - "Sublingual administration of nitroglycerin resulted in the prompt relief of symptoms and resolution of ST-segment changes...She was closely monitored in an outpatient setting and was prescribed a combination of benidipine and nicorandil...In recent years, oestrogen replacement therapy has been reported to confer therapeutic benefits in this patient population. Early multidisciplinary collaboration involving gynaecologists and timely initiation of hormonal therapy may alter the clinical course and prevent fatal outcomes in such patients."

Journal • Cardiovascular • Critical care • Myocardial Infarction • Pain

Trials evaluating nicorandil renoprotection against contrast-induced nephropathy after coronary angiography or percutaneous coronary intervention: a systematic review and meta-analysis. (PubMed, Egypt Heart J) - "This study demonstrated the renoprotective effects of nicorandil in preventing CIN in patients undergoing coronary angioplasty, and this relationship was also evident from the double-dose response. Further larger size randomised controlled trials are recommended to assess the efficacy of nicorandil in preventing CIN in patients undergoing coronary angioplasty."

Journal • Retrospective data • Review • Cardiovascular • Coronary Artery Disease • Heart Failure • Renal Disease

Intra-Arterial Vasodilators for Radial Artery Spasm and Occlusion Prevention in Trans-radial Coronary Procedures: A Network Meta-Analysis of Randomized Control Trials (AHA 2025) - "A random-effects model was used for outcomes with high heterogeneity. In the network meta-analysis, 21 clinical trials with 11010 patients comparing 10 treatments for the prevention of spasm (Placebo, Verapamil, Diltiazem, Molsidomine, Nitroglycerin, Nicorandil, ISDN, Labetalol, Magnesium, and Phentolamine) were included, forming a network centered on Verapamil and Placebo with multiple direct connections. Patients undergoing radial artery catheterization for coronary interventions, verapamil and molsidomine significantly reduced the risk of RAS relative to placebo."

Retrospective data

Mitochondrial Transplantation During Ongoing Ischemia May Preserve Neuronal Viability (AHA 2025) - "Additionally, nicorandil (NIC), a mitochondrial KATP channel opener, can improve metabolic tolerance during IR injury.Hypothesis/Aims: This study aimed to evaluate whether MTx during ongoing ischemia preserves neuronal viability and mitochondrial function in an in vitro oxygen-glucose deprivation (OGD) model, and whether NIC co-treatment provides a synergistic effect. The study included two main groups: normoxic control and OGD; each had 9 subgroups: no treatment, 10 or 0.1µg/mL mitochondria (Mito), 100 or 500µM NIC, and their combinations... Skeletal muscle-derived MTx effectively preserved mitochondrial function and viability of HT-22 cells when given during ongoing OGD, suggesting a potentially new therapeutic window prior to reperfusion. NIC co-treatment further improved metabolic tolerance, indicating a possible synergistic effect. Overall, MTx has neuroprotective potential for stroke in aortic surgery."

Cardiovascular • Reperfusion Injury • Transplantation

Spectroscopic and Thermodynamic Studies on the Binding Interaction of Nicorandil to Bovine Serum Albumin, Supported by Molecular Docking Analysis. (PubMed, Luminescence) - "In addition, synchronous fluorescence spectroscopy, FTIR, and ligand-protein docking studies have deduced the conformational alteration in the BSA secondary structure when it interacts with NCL. Docking results were in accordance with experimental results."

Journal

Recurrent acute coronary syndrome caused by refractory vasospastic angina in a patient with essential thrombocythemia: a case report. (PubMed, Eur Heart J Case Rep) - "Her ET medication was switched from anagrelide to hydroxyurea and vasodilatory therapy was intensified with benidipine, diltiazem, and nicorandil. A multidisciplinary diagnostic approach, including OCT and histopathological evaluation and spasm provocation, can help to identify the underlying pathophysiology of ACS. Tailored therapy, verified through invasive provocation tests under vasodilation, successfully controlled the symptoms and prevented recurrence."

Journal • Acute Coronary Syndrome • Cardiovascular • Essential Thrombocythemia • Hematological Disorders • Myeloproliferative Neoplasm • Thrombocytosis

UNI-494 treatment improves measures of renal dysfunction and cardiac pathology in male rats receiving L-NAME and angiotensin II. (PubMed, Physiol Rep) - "Nicorandil, a nicotinamide nitrate derivative, has been used for years as a cardioprotective agent...Treatment with UNI-494 significantly reduced L-NAME/AngII-induced albuminuria, KIM-1 levels, and cardiac injury, with no significant effect on blood pressure. Our data suggest that cardiorenal damage can be prevented by treatment with UNI-494."

Journal • Preclinical • Cardiovascular • Chronic Kidney Disease • Metabolic Disorders • Nephrology • Renal Disease • KIM1

Letter to editor: Nicorandil: a word of caution on growing long-term risks versus benefits. (PubMed, Int Urol Nephrol) - No abstract available

Journal • Cardiovascular • Renal Disease

The Role of Medications in Enhancing Patients' Overall Well-being and Quality of Life in Coronary Slow Flow syndrome: A Randomized Controlled Trial. (PubMed, Med J Islam Repub Iran) - "They were randomly divided into two groups, with one receiving a three-drug treatment with 80 mg of aspirin, 20 mg of atorvastatin daily, and 2.6 mg of nitroglycerin every 12 hours (26 patients) and in the second group plus nicorandil 10 mg every 12 hours (26 patients). A combination therapy of aspirin, atorvastatin, and nitrates has been demonstrated to significantly improve the quality of life in patients with Coronary Slow Flow Phenomenon (CSFP). However, the addition of nicorandil to this regimen does not provide significant further improvement, according to present findings."

HEOR • Journal • Cardiovascular • Coronary Artery Disease • Myocardial Ischemia

Nicorandil reduces the antimicrobial effectiveness of polymyxin E against Klebsiella pneumoniae by decreasing reactive oxygen species accumulation. (PubMed, Front Cell Infect Microbiol) - "Our study further elucidated that nicorandil treatment mitigates the bactericidal efficacy of polymyxin E against K. pneumoniae. These findings highlight the significant risk of increased bacterial infections associated with the concurrent administration of nicorandil and polymyxin E."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases

Risk of mucocutaneous ulcerations associated with nicorandil: Recent data of the French Pharmacovigilance DataBase and Toulouse Hospital Discharge DataBase (NICORUC) (PubMed, Therapie) - "Despite a decline in nicorandil sales since 2017 and several communications from the health authorities, our findings indicate the persistence of serious adverse reactions with nicorandil. Delayed discontinuation of the drug results in unnecessary investigations and potentially fatal outcomes. This study has shown that the PMSI and then the Clinical Data Warehouse (CDW), operational at the Toulouse Universitary Hospital Center since 18 June 2025, is a data source that contributes to reducing the under-reporting rate of unknown, albeit "expected" AE and to confirming the persistence of a validated pharmacovigilance signal."

Adverse events • Journal • Infectious Disease • Septic Shock

Nicorandil Use and Health Status Outcomes in Patients with Angina Pectoris: A Prospective, Multicenter, Cohort Study (GREAT). (PubMed, Drug Des Devel Ther) - P=N/A | "A substantial proportion of patients using nicorandil exhibited noteworthy improvements in health status outcomes at one year. ClinicalTrials.gov, NCT05050773."

Journal • Cardiovascular • Coronary Artery Disease

Prospective Study of End Stage Renal Disease Patients With Coronary Artery Disease Treated by Oral Nicorandil (clinicaltrials.gov) - P4 | N=268 | Active, not recruiting | Sponsor: Kumamoto University | Trial completion date: Dec 2024 ➔ Mar 2026

Trial completion date • Cardiovascular • Chronic Kidney Disease • Coronary Artery Disease • Nephrology • Renal Disease

Myocardial infarction with nonobstructive coronary arteries associated with blood transfusion in a young woman: A case report. (PubMed, Medicine (Baltimore)) - "The delicate balance between hemorrhage and hemostasis was emphasized. Treatment strategies for blood transfusion-induced MINOCA remain limited, and our therapeutic approach may provide an effective option for clinical practice."

Journal • Acute Coronary Syndrome • Cardiovascular • Coronary Artery Disease • Hematological Disorders • Myocardial Infarction

Nicorandil in preventing contrast-induced nephropathy in patients undergoing cardiac catheterization procedures: a systematic review and meta-analysis. (PubMed, Ann Med Surg (Lond)) - "Nicorandil administration reduces CIN incidence and improves renal biomarker profiles in patients undergoing CAG and PCI. Further large-scale trials are necessary to validate its renoprotective properties."

Journal • Retrospective data • Renal Disease • CST3

Intravenous nicorandil during primary percutaneous coronary intervention for acute myocardial infarction (ESC-WCC 2025) - No abstract available

Cardiovascular • Myocardial Infarction

Sex differences in health status trajectories among Chinese patients with angina pectoris: insights from the GREAT registry study (ESC-WCC 2025) - "Subgroup analyses showed that women experienced greater clinically meaningful improvements in SAQ-SS across several groups, including those aged < 65 years, with hypertension, without diabetes, with unstable angina, not undergoing coronary revascularisation, and not using nitrates or nicorandil (all P < 0.05) (Figure 2). Significant sex differences exist in health status trajectories among Chinese patients with AP, with women showing greater improvements over time in the natural course of treatment. These findings suggest that women may benefit more from proactive treatment strategies."

Clinical • Cardiovascular • Hypertension

Oral Nicorandil for Prevention of No Reflow Phenomenon in Anterior STEMI Patients Undergoing PPCI (clinicaltrials.gov) - P1/2 | N=300 | Completed | Sponsor: Ain Shams University

New P1/2 trial