torasemide / Generic mfg. - LARVOL DELTA

Permanent pacemaker implantation with high pacing rate for treating refractory right heart failure: a case report. (PubMed, Eur Heart J Case Rep) - "At the 12-month follow-up, the patient was classified as New York Heart Association Class I and did not experience recurrence of oedema, even while taking low-dose diuretics (torasemide, 5 mg once daily, and spironolactone, 20 mg once daily). In addition, patients who undergo Fontan surgery can remain asymptomatic for decades, suggesting that left ventricular pump function may be sufficient to sustain both systemic and pulmonary circulation. Therefore, increasing HR can increase cardiac output, promote forward flow from the right atrium and vena cava into the pulmonary circulation, and reduce venous and right atrium pressures in patients with RHF and normal left-sided heart function."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fatigue • Heart Failure

Loop Diuretic Therapy in Severe Aortic Stenosis: Marker of Organ Congestion, Unfavorable Hemodynamics, and Increased Post-Valve Replacement Mortality. (PubMed, Clin Cardiol) - "LDT identifies AS patients with more advanced cardiac remodeling, more severe congestion, unfavorable hemodynamics, impaired post-AVR status, and increased post-AVR long-term mortality."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure

The use of predictive, preventive, and personalized medical approaches to optimize hypertension management. (PubMed, EPMA J) - "The 3PM framework leverages AI-driven integration of multi-omics, retinal imaging like ViT models, and hemodynamic profiling for risk prediction and treatment response forecasting; genetic profiling such as MTHFR, UMOD variants, urinary proteomics (CKD273 classifier), and microbiome-guided nutrition for early intervention; and pharmacogenomics, digital phenotyping like smartphone-guided dosing, and novel therapies such as aprocitentan and finerenone for personalized efficacy. Specific findings include aprocitentan reducing systolic BP by -15.3 mmHg in resistant hypertension, UMOD-guided torasemide use lowering BP by 8.5 mmHg in carriers, and microbiome-based nutrition reducing systolic BP by 14% in hyperglycemic patients...3PM transforms hypertension management by enabling proactive, individualized care. However, rigorous validation, affordable diagnostics, pragmatic trials, and equitable access are essential to bridge translational gaps and..."

Journal • Review • Cardiovascular • Diabetes • Hypertension • MTHFR

Predicting Pharmacokinetics of Drugs in Patients with Heart Failure and Optimizing Their Dosing Strategies Using a Physiologically Based Pharmacokinetic Model. (PubMed, Pharmaceutics) - "Eight commonly used drugs (digoxin, furosemide, bumetanide, torasemide, captopril, valsartan, felodipine and midazolam) for treating HF and its comorbidities were selected. A PBPK model was successfully developed to predict the plasma concentration-time profiles of the eight tested drugs in both healthy subjects and HF patients. Furthermore, this model may also be applied to guide digoxin dose optimization for HF patients."

Journal • PK/PD data • Cardiovascular • Congestive Heart Failure • Heart Failure

Ozempic, Travel, and Troublesome Diarrhoea: Lessons from a Transplant Case (EUSEM 2025) - "Current medications included apixaban, allopurinol, doxazosin, torasemide, flecainide, bisoprolol, methylprednisolone, ciclosporin, mycophenolic acid, and sodium hydrogen carbonate.On examination, he was afebrile (36.1°C), normotensive (BP 120/70 mmHg), tachycardic (HR 123 bpm), and had normal oxygen saturation (SpO₂ 98%). This suggests that an otherwise self-limiting episode of traveller's diarrhoea may have been exacerbated by cumulative burden of chronic immunosuppression and previous gastrointestinal insults by Ozempic.Following nephrology consultation, recommendations included withholding mycophenolic acid and torasemide, and initiating ciprofloxacin and ornidazole. Despite advice, patient declined hospital admission for rehydrationThis case highlights the importance of careful medication review—including consideration of newer agents such as semaglutide—and vigilance for complications in transplant recipients presenting with gastrointestinal..."

Clinical • Acute Kidney Injury • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypertension • Immunology • Metabolic Dysfunction-Associated Steatotic Liver Disease • Nephrology • Renal Disease • Transplantation

A Comparative Bioavailability Study of Two Torasemide 10 mg Tablets Formulations in Healthy Adult Participants Under Fasting Conditions: (clinicaltrials.gov) - P1 | N=26 | Recruiting | Sponsor: Berlin-Chemie AG Menarini Group

New P1 trial

Fast and sustainable active pharmaceutical ingredient (API) screening in over-the-counter and prescription drug products by surface-assisted plasma-based desorption/ionization high-resolution mass spectrometry. (PubMed, Anal Methods) - "Typically, the protonated molecular ion ([M + H]+) was the most abundant species, while some compounds (codeine, metamizole, phenoxymethylpenicillin, and torasemide) did show some degree of fragmentation. Here, SA-FAPA-HRMS with a CN-HPTLC sample substrate yielded the best performance (20.02 ± 0.52 μg mL-1, RSD = 2.6%, and deviation of -1.9% from the theoretical value) compared to RP2-TLC (18.97 ± 1.37 μg mL-1 and RSD = 7.2%, -7.0%), and HPLC-UV (18.51 ± 0.03 μg mL-1 and RSD = 0.2%, -9.3%) results. In conclusion, SA-FAPA-HRMS is considered attractive for rapid and sustainable analysis of pharmaceuticals with potential in non-invasive patient monitoring."

Journal • Anesthesia • Pain

Progress achieved in EURAMET project 21GRD09 MetroPOEM: Metrology for the harmonisation of measurements of environmental pollutants in Europe. (PubMed, Appl Radiat Isot) - "Low level radioactive standard solutions (90Sr, 237Np, 234U, 236U, natural uranium (Unat), 239Pu, 240Pu, 241Am, 239,240Pu) were distributed to 18 partner laboratories for measurement by mass spectrometric and decay counting techniques...These materials were characterised in accordance with ISO 17034 by interlaboratory studies between project partners, using techniques developed in the project. Two Good Practice Guides, on (i) measurement of radioactivity by mass spectrometry, and (ii) sample treatment, uncertainties, and mass bias quantification, are in draft."

Harmonization • Journal

No Correlation Between Chronic Cough and Radiographic Signs of Bronchial Narrowing in Dogs with Cardiomegaly and Left Atrial Dilation Secondary to Primary Mitral Valve Regurgitation. (PubMed, Animals (Basel)) - "Bronchial compression by an enlarged heart and left atrium is an unlikely cause of chronic cough in dogs with severe primary mitral valve regurgitation."

Journal • Cardiovascular • Chronic Cough • Cough • Pulmonary Disease • Respiratory Diseases

The comparative antihypertensive efficacy of torasemide and mineralocorticoid receptor antagonists in patients with resistant hypertension (ESC-WCC 2025) - "Objective: To compare the antihypertensive efficacy of antagonists of mineralocorticoid receptor (AMR) (spironolactone (SPR) or eplerenone (EPL)) and torasemide (TOR) as an add-on therapy in true resistant hypertensive (RH) patients. AMRs were more effective than TOR in lowering SBP and achieving target BP. The efficacy of AMRs was directly related to PA and USE levels and inversely related to ARC, while only PA level was a predictor of TOR's BP reduction. TOR can be recommended for RH patients with AMR intolerance, including high serum potassium levels, with monitoring of eGFR."

Clinical • Cardiovascular • Hypertension

Risk factors associated with high-dose methotrexate induced toxicities in primary central nervous system lymphoma. (PubMed, Front Pharmacol) - "Higher ALB level, female, ABCB1 rs1045642, MTHFR rs1801131, and MTHFD1 rs2236225 were associated with lower risk of anemia, while the combination of furosemide, torasemide, bumetanide, and levetiracetam associating with higher risk...In conclusion, higher ALB levels had a lower risk of HDMTX toxicities; loop diuretics and levetiracetam generally accelerated the occurrence of toxicities. Rs1801133 GG, rs1128503 GG + AG, rs2231142 AA+ AC, rs717620 TT + GT were associated with increased risk of toxicity; rs1045642 TT and rs1801394 GG + AG were less likely to develop toxicity."

Journal • CNS Lymphoma • Hematological Disorders • Hematological Malignancies • Leukopenia • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Primary Central Nervous System Lymphoma • Thrombocytopenia • ABCB1 • ABCC2 • ABCG2 • MTHFR

A Dose-finding Study of JMKX003142 in Treatment of Renal Edema (clinicaltrials.gov) - P2 | N=216 | Recruiting | Sponsor: Jemincare | Not yet recruiting ➔ Recruiting

Enrollment open

Effects of bisoprolol combined with torasemide on cardiac electrophysiology in patients with acute myocardial infarction and heart failure. (PubMed, Front Physiol) - "No significant differences were observed between groups in cardiovascular or all-cause mortality (P > 0.05). Bisoprolol combined with torasemide improves cardiac electrophysiological parameters, cardiac function, symptoms, and hemodynamics in AMI-HF patients as early as 2 weeks into treatment."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction • Pulmonary Disease

The impact of high-salt diet and diuretics on the development of the aestival phenomenon in patients with chronic heart failure. (PubMed, Front Nutr) - "The diuretic group received average daily doses of furosemide 39.1 ± 22.1 mg, torasemide 7.4 ± 3 mg, and spironolactone 42 ± 12.4 mg. Early identification of these changes may guide adjustments in diuretic regimens, as well as prompt nutritional and physical interventions to mitigate sarcopenia and functional decline. These findings support a personalized approach to diuretic therapy in CHF, emphasizing the role of dietary sodium in shaping metabolic responses and highlighting metabolic aestivation as a potential contributor to fatigue and weakness in this population."

Journal • Cardiovascular • Congestive Heart Failure • Fatigue • Heart Failure • Nephrology • Renal Disease • Sarcopenia

Clomipramine potentially induced fatal torsades de pointes in a patient with acute decompensated heart failure: a case report. (PubMed, Front Psychiatry) - "The patient was admitted for acute decompensated heart failure and treated with torasemide intravenously while continuing clomipramine (25 mg daily) for depression. Despite corrective measures, including potassium and magnesium supplementation, the patient developed ventricular fibrillation and cardiac arrest, leading to death. This case highlights the potential risk of clomipramine-induced QT prolongation and TdP, particularly in patients with acute heart failure and electrolyte imbalances, underscoring the need for careful risk assessment and monitoring in such populations."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Congestive Heart Failure • Depression • Heart Failure • Hypertension • Psychiatry

Loop diuretics in anuric hemodialysis patients for the clearance of protein-bound uremic toxins. (PubMed, Clin Kidney J) - "This study hypothesizes that loop diuretics, particularly torasemide and furosemide, can displace PBUTs from their albumin-binding sites, increasing their free fraction and enhancing their removal during hemodialysis. Their use mobilizes PBUTs from tissue stores and increases their dialyzability. These findings warrant further investigation in larger, long-term studies to validate the efficacy and clinical benefits of this approach."

Journal • Chronic Kidney Disease • Nephrology • Renal Disease

DEVELOPMENT OF UNMET NEEDS ASSESSMENT TOOL IN ADVANCED CANCER PATIENTS (MASCC-ISOO 2025) - "The UNAT demonstrated both validity and reliability. Conclusions UNAT is a reliable and valid tool for assessing unmet needs in advanced cancer patients, and can contribute to improving patients' quality of life by enabling healthcare providers to apply tailored care plans based on individual needs in clinical settings."

Clinical • Metastases • Oncology

Identification of potentially effective drugs for metabolic dysfunction-associated steatotic liver disease against liver cirrhosis: In-silico drug repositioning-based retrospective cohort study. (PubMed, PLoS One) - "This study is limited to drugs registered in the Korean NHIS, potentially excluding other relevant candidates. Additionally, the absence of dietary and genetic data in the NHIS database may introduce residual confounding. Lastly, as the study population consists solely of Korean adults, the findings may not be generalizable to other populations."

Journal • Retrospective data • Fibrosis • Gastroenterology • Hepatology • Immunology • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease

Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials. (PubMed, Eur Geriatr Med) - "Our umbrella review offers a comprehensive and up-to-date evaluation of the benefits and harms of diuretics. However, further research is needed to establish their efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty."

Journal • Review • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Heart Failure • Hypertension • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

The impact of the high doses of loop diuretics on nutritional status in patients with heart failure with reduced ejection fraction (HEART FAILURE 2025) - "The daily doses of loop diuretics were defined as furosemide equivalent = 1x dose of furosemide and 2x dose of torasemide. Intake of high-dose diuretics independent of NYHA and LVEF classifications, as well as patient age and sex, may indicate an elevated risk of malnutrition. Patients receiving high-dose diuretics should be screened and provided with nutritional support, including dietetic care."

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure

Neonatal metabolic alkalosis and mild diuresis resulting from torasemide self-medication by the mother: a case report. (PubMed, J Pharm Health Care Sci) - "This case suggests close counseling and monitoring of pregnant women before childbirth regarding their past and present use of drugs, particularly in those with mental illness."

Journal • Bulimia • CNS Disorders • Long-acting Reversible Contraceptives • Metabolic Disorders

Rapid resolution of severe rheumatic mitral regurgitation following dapagliflozin and torasemide treatment. (PubMed, Kardiol Pol) - No abstract available

Journal

Genotyping by sequencing reveals the genetic diversity and population structure of Peruvian highland maize races. (PubMed, Front Plant Sci) - "Here, we used genotyping-by-sequencing (GBS) to obtain single nucleotide polymorphisms (SNPs) that allow inferring the genetic structure and diversity of 423 maize accessions from the genebank of Universidad Nacional Agraria la Molina (UNALM) and Universidad Nacional Autónoma de Tayacaja (UNAT)...Peruvian maize germplasm needs further investigation with modern technologies to better use them massively in breeding programs that favor agriculture mainly in the South American highlands. We also expect this work will pave a path for establishing more accurate conservation strategies for this precious crop genetic resource."

Journal

Subcutaneous Furosemide Therapy for Chronic Management of Refractory Congestive Heart Failure in Dogs and Cats. (PubMed, Animals (Basel)) - "Following administration of SC furosemide, the median survival time was 106 (95% CI: 22-154) days in dogs and 89 (95% CI: 35 to 749) days in cats. This study showed that furosemide administered subcutaneously appears to be an efficacious and feasible therapeutic option for providing control of the signs of cardiac congestion in both dogs and cats with a previous unsatisfactory response to oral diuresis."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Diagnosis of Turner syndrome after presenting with ischemic cardiomyopathy: A case report. (PubMed, SAGE Open Med Case Rep) - "Because she refused coronary artery bypass grafting, she received aspirin, torasemide, atorvastatin, bisoprolol, sacubitril/valsartan, empagliflozin, spironolactone, and complex packing estradiol tablets/estradiol and dydrogesterone tablets (1-10 mg). Prompt diagnosis and comprehensive management through a multidisciplinary approach can improve patient outcomes. Further evidence is needed to establish a secondary prevention strategy for Turner syndrome with ischemic cardiomyopathy."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Genetic Disorders • Heart Failure • Turners Syndrome • Women's Health • NPPB