torasemide / Generic mfg. - LARVOL DELTA

Long-Term Control of Refractory Cardiogenic Pleural Effusion in a Cat Treated with Sacubitril/Valsartan and Hydrochlorothiazide: A Case Report. (PubMed, Animals (Basel)) - "Hydrochlorothiazide is a thiazide diuretic that acts at a more distal segment of the nephron than furosemide...Despite conventional treatment, which included pimobendan, torasemide, and antithrombotic medications, the cat experienced multiple episodes of pleural effusion over the following months, requiring repeated thoracocentesis...Nonetheless, the duration and completeness of the response observed here warrant prospective evaluation of combination of ARNI therapy and hydrochlorothiazide in cats with refractory congestive heart failure. Further studies are needed to assess the safety and effectiveness of this approach in feline cardiomyopathy."

Journal • Pleural effusion • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Respiratory Diseases

Comparing Ibuprofen and Loop Diuretics for Protein-Bound Uremic Toxins Clearance During Hemodialysis. (PubMed, Kidney Int Rep) - "The experimental arms included the following: (i) Standard postdilutional HDF (control), (ii) High-flux hemodialysis (HF-HD) (iii) Oral furosemide 1h predialysis, (iv) Oral torasemide 1h predialysis, (v) 1h arterial infusion of furosemide, and (vi) 1h arterial infusion of ibuprofen. The lack of efficacy observed with furosemide suggests a ceiling effect in high-volume HDF, where only high-affinity competitors can further displace PBUTs from albumin-binding sites. Pharmacological displacement represents a promising adjunct to convective therapies to optimize protein-bound uremic toxin removal."

Journal • Cardiovascular

Long-Term Hemodynamic Stabilization With TTR-Stabilizing Therapy and Pressure-Guided Management in ATTR Cardiomyopathy. (PubMed, JACC Case Rep) - "Remote PAP-guided management may support disease-modifying treatment in selected patients with ATTR-CM."

Journal • Amyloidosis • Cardiac Amyloidosis • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure

Pharmacotherapeutic Optimization in a Polymedicated Patient Through Coordinated Pharmaceutical Intervention: A Community Pharmacy Case Report. (PubMed, Farm Comunitarios) - "Case study and evaluation: During the initial interview, several Drug-Related Problems (DRPs) were identified: inappropriate dosage of olmesartan/hydrochlorothiazide, combination of diuretics with kaliuretic effect (torasemide and hydrochlorothiazide), prolonged use of omeprazole without current indication, lack of recent laboratory monitoring in the management of hypercholesterolemia, untreated cognitive impairment, and unnecessary prescription of paracetamol...Intervention: From the community pharmacy, and in coordination with the family and the primary care team, the dosage regimen of olmesartan/hydrochlorothiazide was adjusted, torasemide and paracetamol were discontinued, the atorvastatin dose was modified according to recent laboratory results, and, following specialist recommendation, memantine 10 mg/day together with cognitive stimulation measures was initiated... Coordinated intervention between community pharmacy, family environment, and primary care allowed..."

Journal • Alzheimer's Disease • Cardiovascular • Cognitive Disorders • Dyslipidemia • Fatigue • Hypertension • Metabolic Disorders • Pain

Clinical findings and survival time in dogs with myxomatous mitral valve disease at the American College of Veterinary Internal Medicine stage D. (PubMed, J Vet Cardiol) - "This study provides novel data on the clinical characteristics and survival expectations of dogs with MMVD at the ACVIM stage D."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

NT-proBNP reference and cut-off values should be adjusted to patient's age in clinical practice - results of national representative survey POLSENIOR 2. (PubMed, Kardiol Pol) - "The level of NT-proBNP increases significantly with age and the assessment of NT-proBNP level should be age adjusted. Using NT-proBNP cut-off points among elderly patients may lead to unnecessary diagnostics and treatment."

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Endocrine Disorders • Heart Failure • Inflammation • Nephrology • Renal Disease

Weight loss and clinical decongestion across heart failure phenotypes: a post-hoc analysis of a multicentre randomised trial (duel-hf) (HEART FAILURE 2026) - "Torasemide has pharmacokinetic properties that may differ from furosemide; however, comparative data across HF phenotypes remain limited. Although torasemide was associated with greater weight reduction, improvement in congestion severity was comparable between diuretics. These findings indicate that changes in body weight alone do not fully reflect clinical decongestion and support the use of multidimensional congestion assessment in acute HF."

Clinical • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure

Discover Oncology: The Interplay Between the Food/Drug Related Nitrosogenesis Based on ROS/Nitric Oxide (NO) Interaction: Two Powerful Factors possibly Responsible for the Photo Nitroso Carcinogenicity Concerning the Skin Cancers Pathogenesis (EADV-Sp 2026) - "In this context, we report a patient, who developed a high-risk tumor near the eye under systemic treatment with : (nitroso-) metoprolol, (nitroso-) torasemide, (nitroso-) rosuvastatin, (nitroso-) ezetinib, Nitroso acetylsalicylic acid (NO-ASA), (nitroso-) piroxicam , (nitroso-) dapaglifozin and (nitroso-) clopidogrel. Correction of this type of adverse drug reactions, namely skin cancer in high-risk areas, could be successfully treated using severe reconstructive surgical techniques such as island flap. Possible links of each and every drug in relation to Nitrosogenesis has been presented !"

Addiction (Opioid and Alcohol) • Basal Cell Carcinoma • Gastrointestinal Disorder • Genetic Disorders • Non-melanoma Skin Cancer • Oncology • Skin Cancer

Differential pulse anoding voltammetric determination of torasemide using carbon paste electrode. (PubMed, Acta Chim Slov) - "The responses of differential pulse were linear over the torasemide concentration range of 0.35-4.13 µg/mL, with detection and quantification limits of 0.110 and 0.367 µg/mL, respectively. The suggested voltammetric method was successful in detecting torasemide in its pharmaceutical preparation (Torsamolex 20 mg tablets) as well as in spiked urine matrix, demonstrating its suitability for pharmaceutical quality control and potential applications in clinical analysis."

Journal

Analysis of a serious adverse reaction of rhabdomyolysis precipitated by a possible interaction of methylprednisolone with atorvastatin: a case report. (PubMed, Eur J Hosp Pharm) - "Due to the recurrence of nephrotic syndrome, methylprednisolone, torasemide, benidipine and atorvastatin were prescribed after admission to hospital. The temporal correlation between the drug combination and symptom onset, coupled with rapid clinical and biochemical improvement after atorvastatin discontinuation, supported a diagnosis of rhabdomyolysis due to a potential drug-drug interaction between atorvastatin and methylprednisolone, likely exacerbated by hypoproteinaemia. This case highlights the need for clinicians and pharmacists to be vigilant for such drug-drug interactions, particularly in patients with predisposing conditions like hypoproteinaemia."

Journal • Dyslipidemia • Glomerulonephritis • Musculoskeletal Pain • Nephrology • Pulmonary Disease • Renal Disease • MB

ASSOCIATION BETWEEN URINARY BIOMARKERS AND DIURETIC RESPONSE IN ACUTE HEART FAILURE: A COHORT ANALYSIS (ISN-WCN 2026) - "Dose conversion was standardized: azosemide 60 mg = furosemide 40 mg, torasemide 8 mg = furosemide 40 mg; oral doses were adjusted using a bioavailability factor 0.5.Urinary biomarkers (L-FABP, NGAL, and tAM) were collected within 3 days of admission, normalized to urinary creatinine, log10-transformed, and standardized (z-scores) using JMP software. Spearman correlation coefficients were weak: L-FABP (r = −0.0142, p = 0.8796), NGAL (r = 0.0203, p = 0.8703), tAM (r = −0.0189, p = 0.8395).Multivariable regression results were as follows:Model 1: L-FABP = 0.044 (95% CI −0.256 to 0.344), NGAL = −0.005 (−0.303 to 0.292), tAM = 0.057 (−0.206 to 0.319)Model 2: L-FABP = 0.054 (−0.274 to 0.381), NGAL = −0.036 (−0.360 to 0.288), tAM = 0.105 (−0.195 to 0.405), LVEF = 0.074 (−0.235 to 0.382), TRPG = 0.179 (−0.179 to 0.537)Model 3: L-FABP = 0.135 (−0.224 to 0.494), NGAL = 0.026 (−0.303 to 0.356), tAM = −0.109 (−0.491 to 0.409), TRPG = 0.247 (−0.115 to 0.609), BNP = −0.183 (−0.570 to..."

Biomarker • Cardiovascular • Congestive Heart Failure • Heart Failure • ADM • FABP1

Adverse events associated with drug-related thiamine deficiency: A pharmacovigilance study. (PubMed, JPEN J Parenter Enteral Nutr) - "This pharmacovigilance analysis identifies safety signals linking specific medications with thiamine deficiency, potentially mediated by mechanisms such as transport inhibition and metabolic interference. These findings highlight the importance of clinical vigilance and the consideration of thiamine monitoring in high-risk patients to mitigate the risk of neurological complications."

Adverse events • Journal • Addiction (Opioid and Alcohol) • CNS Disorders

Negative Anion Gap in Critically Ill Patients: A Case Study of Metabolic Alkalosis and Clinical Strategies. (PubMed, Am J Case Rep) - "Six months before admission, torasemide was added to her regimen in combination with spironolactone. The application of targeted next-generation sequencing (t-NGS) successfully identified the infectious pathogen responsible for the patient's clinical deterioration, thereby guiding appropriate antimicrobial therapy. CONCLUSIONS This case illustrates the diagnostic and educational value of recognizing a negative anion gap as a rare but physiologically predictable artifact of severe chloride-depletion alkalosis, underscoring the importance of mechanism-based interpretation in complex acid-base disorders."

Journal • Cardiovascular • Coronary Artery Disease • Heart Failure • Immunology • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases

A Clinical Study Using FAPI-PET Imaging to Assess the Postoperative Effects of TAVI in Patients With Aortic Stenosis (clinicaltrials.gov) - P=N/A | N=25 | Recruiting | Sponsor: RenJi Hospital

New trial • Cardiovascular

Research on drug-drug interaction prediction using capsule neural network based on self-attention mechanism. (PubMed, BMC Bioinformatics) - "Experimental results on two benchmark datasets show that the ACaps-DDI model outperforms six other classification models across seven evaluation metrics, demonstrating its strong predictive performance and generalization ability. Ablation studies further confirm the effectiveness of individual components within the ACaps-DDI architecture. Finally, case studies involving three drugs (cannabidiol, torasemide, and cyclophosphamide) validate the model's ability to predict previously unknown drug interactions. In conclusion, the ACaps-DDI model exhibits high predictive accuracy for known drugs and demonstrates promising predictive capability for unseen drugs, highlighting its practical significance for clinical research on drug interactions."

Journal

Permanent pacemaker implantation with high pacing rate for treating refractory right heart failure: a case report. (PubMed, Eur Heart J Case Rep) - "At the 12-month follow-up, the patient was classified as New York Heart Association Class I and did not experience recurrence of oedema, even while taking low-dose diuretics (torasemide, 5 mg once daily, and spironolactone, 20 mg once daily). In addition, patients who undergo Fontan surgery can remain asymptomatic for decades, suggesting that left ventricular pump function may be sufficient to sustain both systemic and pulmonary circulation. Therefore, increasing HR can increase cardiac output, promote forward flow from the right atrium and vena cava into the pulmonary circulation, and reduce venous and right atrium pressures in patients with RHF and normal left-sided heart function."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fatigue • Heart Failure

Loop Diuretic Therapy in Severe Aortic Stenosis: Marker of Organ Congestion, Unfavorable Hemodynamics, and Increased Post-Valve Replacement Mortality. (PubMed, Clin Cardiol) - "LDT identifies AS patients with more advanced cardiac remodeling, more severe congestion, unfavorable hemodynamics, impaired post-AVR status, and increased post-AVR long-term mortality."

Journal • Retrospective data • Cardiovascular • Congestive Heart Failure • Heart Failure

The use of predictive, preventive, and personalized medical approaches to optimize hypertension management. (PubMed, EPMA J) - "The 3PM framework leverages AI-driven integration of multi-omics, retinal imaging like ViT models, and hemodynamic profiling for risk prediction and treatment response forecasting; genetic profiling such as MTHFR, UMOD variants, urinary proteomics (CKD273 classifier), and microbiome-guided nutrition for early intervention; and pharmacogenomics, digital phenotyping like smartphone-guided dosing, and novel therapies such as aprocitentan and finerenone for personalized efficacy. Specific findings include aprocitentan reducing systolic BP by -15.3 mmHg in resistant hypertension, UMOD-guided torasemide use lowering BP by 8.5 mmHg in carriers, and microbiome-based nutrition reducing systolic BP by 14% in hyperglycemic patients...3PM transforms hypertension management by enabling proactive, individualized care. However, rigorous validation, affordable diagnostics, pragmatic trials, and equitable access are essential to bridge translational gaps and..."

Journal • Review • Cardiovascular • Diabetes • Hypertension • MTHFR

Predicting Pharmacokinetics of Drugs in Patients with Heart Failure and Optimizing Their Dosing Strategies Using a Physiologically Based Pharmacokinetic Model. (PubMed, Pharmaceutics) - "Eight commonly used drugs (digoxin, furosemide, bumetanide, torasemide, captopril, valsartan, felodipine and midazolam) for treating HF and its comorbidities were selected. A PBPK model was successfully developed to predict the plasma concentration-time profiles of the eight tested drugs in both healthy subjects and HF patients. Furthermore, this model may also be applied to guide digoxin dose optimization for HF patients."

Journal • PK/PD data • Cardiovascular • Congestive Heart Failure • Heart Failure

Ozempic, Travel, and Troublesome Diarrhoea: Lessons from a Transplant Case (EUSEM 2025) - "Current medications included apixaban, allopurinol, doxazosin, torasemide, flecainide, bisoprolol, methylprednisolone, ciclosporin, mycophenolic acid, and sodium hydrogen carbonate.On examination, he was afebrile (36.1°C), normotensive (BP 120/70 mmHg), tachycardic (HR 123 bpm), and had normal oxygen saturation (SpO₂ 98%). This suggests that an otherwise self-limiting episode of traveller's diarrhoea may have been exacerbated by cumulative burden of chronic immunosuppression and previous gastrointestinal insults by Ozempic.Following nephrology consultation, recommendations included withholding mycophenolic acid and torasemide, and initiating ciprofloxacin and ornidazole. Despite advice, patient declined hospital admission for rehydrationThis case highlights the importance of careful medication review—including consideration of newer agents such as semaglutide—and vigilance for complications in transplant recipients presenting with gastrointestinal..."

Clinical • Acute Kidney Injury • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypertension • Immunology • Metabolic Dysfunction-Associated Steatotic Liver Disease • Nephrology • Renal Disease • Transplantation

A Comparative Bioavailability Study of Two Torasemide 10 mg Tablets Formulations in Healthy Adult Participants Under Fasting Conditions: (clinicaltrials.gov) - P1 | N=26 | Recruiting | Sponsor: Berlin-Chemie AG Menarini Group

New P1 trial

Fast and sustainable active pharmaceutical ingredient (API) screening in over-the-counter and prescription drug products by surface-assisted plasma-based desorption/ionization high-resolution mass spectrometry. (PubMed, Anal Methods) - "Typically, the protonated molecular ion ([M + H]+) was the most abundant species, while some compounds (codeine, metamizole, phenoxymethylpenicillin, and torasemide) did show some degree of fragmentation. Here, SA-FAPA-HRMS with a CN-HPTLC sample substrate yielded the best performance (20.02 ± 0.52 μg mL-1, RSD = 2.6%, and deviation of -1.9% from the theoretical value) compared to RP2-TLC (18.97 ± 1.37 μg mL-1 and RSD = 7.2%, -7.0%), and HPLC-UV (18.51 ± 0.03 μg mL-1 and RSD = 0.2%, -9.3%) results. In conclusion, SA-FAPA-HRMS is considered attractive for rapid and sustainable analysis of pharmaceuticals with potential in non-invasive patient monitoring."

Journal • Anesthesia • Pain

Progress achieved in EURAMET project 21GRD09 MetroPOEM: Metrology for the harmonisation of measurements of environmental pollutants in Europe. (PubMed, Appl Radiat Isot) - "Low level radioactive standard solutions (90Sr, 237Np, 234U, 236U, natural uranium (Unat), 239Pu, 240Pu, 241Am, 239,240Pu) were distributed to 18 partner laboratories for measurement by mass spectrometric and decay counting techniques...These materials were characterised in accordance with ISO 17034 by interlaboratory studies between project partners, using techniques developed in the project. Two Good Practice Guides, on (i) measurement of radioactivity by mass spectrometry, and (ii) sample treatment, uncertainties, and mass bias quantification, are in draft."

Harmonization • Journal

No Correlation Between Chronic Cough and Radiographic Signs of Bronchial Narrowing in Dogs with Cardiomegaly and Left Atrial Dilation Secondary to Primary Mitral Valve Regurgitation. (PubMed, Animals (Basel)) - "Bronchial compression by an enlarged heart and left atrium is an unlikely cause of chronic cough in dogs with severe primary mitral valve regurgitation."

Journal • Cardiovascular • Chronic Cough • Cough • Pulmonary Disease • Respiratory Diseases

The comparative antihypertensive efficacy of torasemide and mineralocorticoid receptor antagonists in patients with resistant hypertension (ESC-WCC 2025) - "Objective: To compare the antihypertensive efficacy of antagonists of mineralocorticoid receptor (AMR) (spironolactone (SPR) or eplerenone (EPL)) and torasemide (TOR) as an add-on therapy in true resistant hypertensive (RH) patients. AMRs were more effective than TOR in lowering SBP and achieving target BP. The efficacy of AMRs was directly related to PA and USE levels and inversely related to ARC, while only PA level was a predictor of TOR's BP reduction. TOR can be recommended for RH patients with AMR intolerance, including high serum potassium levels, with monitoring of eGFR."

Clinical • Cardiovascular • Hypertension