aspirin / Generic mfg. - LARVOL DELTA

Multi-Center Phase II Trial of Iberdomide and SQ Daratamumab as Post-ASCT Maintenance Therapy in Pts With Multiple Myeloma (the IBEX Trial): Initial Safety Analysis and Interim Efficacy Results. (IMS 2026) - "Lenalidomide (LEN) is standard maintenance therapy. Addition of an anti-CD38 antibody such as daratumumab (DARA) increases MRD(-) responses and further improves outcomes...All pts received aspirin unless anticoagulated... Post-ASCT maintenance with IBER plus DARA is feasible and safe. Neutropenia was manageable at the doses used in IBEX. Improvements in IMWG response and MRD conversion were observed despite pre-ASCT quadruplet induction."

Clinical • P2 data • Cardiovascular • Hematological Malignancies • Infectious Disease • Multiple Myeloma • Neutropenia • Respiratory Diseases • Targeted Protein Degradation • CRBN

Top 20 Research Studies of 2025 for Primary Care Physicians. (PubMed, Am Fam Physician) - "Women with normal bone density given zoledronic acid every 5 years have fewer fractures...For patients with provoked venous thromboembolism and at least one ongoing risk factor, 12 months of apixaban is better than 3 months. Clopidogrel is slightly more effective than aspirin for the secondary prevention of myocardial infarction and stroke over 3 years...Duloxetine, milnacipran, and pregabalin provide meaningful pain reduction in adults with fibromyalgia...A meta-analysis of platelet-rich plasma injections for knee osteoarthritis concluded that high-quality studies found no meaningful pain improvement. Using an oral challenge to rule out sulfonamide allergy is safe when used with a risk assessment tool."

Journal • Review • Allergy • Atherosclerosis • Atrial Fibrillation • Breast Cancer • Cardiovascular • CNS Disorders • Depression • Fibromyalgia • Hypotension • Immunology • Infectious Disease • Influenza • Long-acting Reversible Contraceptives • Musculoskeletal Diseases • Musculoskeletal Pain • Myocardial Infarction • Novel Coronavirus Disease • Oncology • Osteoarthritis • Pain • Psychiatry • Respiratory Diseases • Rheumatology • Solid Tumor • Vaginitis • Venous Thromboembolism

First-trimester urinary glycolic acid and methylsuccinic acid measurement for preeclampsia prediction: A Systematic review protocol. (PubMed, PLoS One) - "First-trimester screening for preeclampsia is vital for guiding preventative therapies like low dose aspirin...As a secondary analysis of peer reviewed articles, this review does not require ethical approval. Findings from the review will be disseminated through conference presentations and peer-reviewed publication."

Biomarker • Journal • Cardiovascular • Gynecology • Hypertension

Severe Myocardial Bridging Without Obstructive Coronary Artery Disease Presenting as Non-ST-Elevation Myocardial Infarction: A Management Challenge in Sinus Bradycardia. (PubMed, Cureus) - "He was given 324 mg of aspirin, a heparin drip was started, and pain improved after sublingual nitroglycerin. Treatment poses a challenge in patients with bradycardia. This case illustrates that cautious beta-blocker therapy may be a feasible option in selected patients."

Journal • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Dyslipidemia • Hypertension • Metabolic Disorders • Myocardial Infarction • Pain • Pulmonary Disease

Chronic Hypertension in Pregnancy: Risk Stratification, Management Strategies and Long-term Maternal-Fetal Outcomes. (PubMed, Curr Cardiol Rev) - "Chronic hypertension requires individualized multidisciplinary care from preconception through the postpartum period. Pregnancy acts as an early marker of future cardiovascular risk, underscoring the need for structured long-term follow-up and integration of obstetric and cardiovascular care."

Journal • Cardiovascular • Gynecology • Hypertension • Obstetrics

When neutrality misleads: shared decision-making and professional responsibility in perinatal medicine. (PubMed, J Perinat Med) - "Neutrality is inappropriate when the evidence clearly favors one course, as in vaccination in pregnancy or low-dose aspirin prophylaxis for preeclampsia, because presenting non-equipoise as equipoise misinforms the woman and can leave two patients unprotected. We examine the 2025 reclassification of US COVID-19 vaccination recommendations in pregnancy as a cautionary case."

Journal • Gynecology • Infectious Disease • Novel Coronavirus Disease • Obstetrics

Treatment of Antithrombotic-Associated Intracranial Hemorrhage in Adults: A Focused Guideline Update from the Neurocritical Care Society and the Society of Critical Care Medicine. (PubMed, Neurocrit Care) - "The guideline writing panel provided new conditional recommendations for the treatment of antithrombotic-associated acute ICH. These recommendations are intended for consideration along with the patient's clinical status and patient-specific factors."

Journal • Cerebral Hemorrhage • CNS Disorders • Critical care • Hematological Disorders • Subarachnoid Hemorrhage • Vascular Neurology

Beneath the Ulcer: Uncovering Gastrointestinal AL Amyloidosis (ACG 2026) - "Case Description/ 50 year-old woman with kappa light-chain multiple myeloma and heart failure with reduced ejection fraction presented with epigastric and substernal pain.No NSAID use expect aspirin 81mg was reported. Multiple myeloma was well controlled on daratumumab and pomalidomide with stable serial bone marrow biopsies...She was started on pantoprazole 40 mg twice daily...(b) Surveillance endoscopy demonstrating a single large deep ulcer with a flat pigmented spot (Forrest IIC), with no interval healing despite prolonged high-dose proton pump inhibitor therapy. (c) Subsequent endoscopy with endoscopic ultrasound (EUS) showing interval improvement of the previously non-healing ulcer, now appearing as a 10 mm linear erosion."

Amyloidosis • Cardiovascular • Congestive Heart Failure • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Hematological Malignancies • Multiple Myeloma • Peptic Ulcer

Overt Gastrointestinal Bleeding From Proximal Gastric Hyperplastic Polyps: A Two-Case Series (ACG 2026) - "A 53-year-old woman with a history of renal transplant on aspirin presented with hematemesis and hemoglobin decline from 10 to 7.5 g/dL...(C) Post-polypectomy site following hot snare resection with hemostatic clip placement achieving complete hemostasis. Histopathology confirmed a gastric hyperplastic polyp without dysplasia; Helicobacter pylori staining was negative."

Clinical • Fibrosis • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Solid Tumor • Thrombosis

Obscure Gastrointestinal Bleeding: A Rare Convergence of Small Bowel Lymphangiectasia and Chylous Cysts in a Milky Way of Lymphatic Malformations (ACG 2026) - "Case Description/ An 83-year-old male with chronic iron deficiency anemia and prior cerebrovascular accident on aspirin and ticagrelor presented with worsening anemia on routine labs. Figure: Large, polypoid jejunal lymphangiectasia with surrounding small chylous cysts on deep enteroscopy. Figure: Drill biopsy of the polypoid jejunal lesion yielded mixed milky white fluid and blood on deep enteroscopy."

Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Rare Diseases

Suspected Isolated SMA Arteritis: A Rare Vascular Cause of Postprandial Epigastric Pain (ACG 2026) - "He was managed conservatively with aspirin and surveillance imaging...In improving patients with noncritical stenosis, conservative management with close vascular follow-up may be appropriate. Figure: CT image of SMA Figure: CT image of SMA"

Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Hypertension • Inflammation • Musculoskeletal Pain • Pain • Pulmonary Disease • Vasculitis

Autoimmune Hepatitis With Acute Liver Injury: An Uncommon Presentation (ACG 2026) - "His only prescription medication was metformin. He reported chronic use of Goodyâs ® powder (aspirin, acetaminophen, and caffeine), but no other over-the-counter supplements...The patient was started on prednisone with improvement in liver enzymes (total bilirubin 1.6 mg/dL, AST 34 U/L, ALT 104 U/L)...The recommended treatment is steroids to induce remission and azathioprine or mycophenolate to maintain remission. This case highlights the importance of maintaining a high index of suspicion for AIH in a patient with unexplained acute liver injury, even without classic risk factors, to facilitate timely diagnosis and treatment."

Autoimmune Hepatitis • Cardiovascular • Coronary Artery Disease • Diabetes • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Metabolic Disorders • Type 2 Diabetes Mellitus

Drug-Induced Liver Injury Superimposed on EBV Infection Presenting as Cholestatic Hepatitis With Hyperferritinemia: A Case Report (ACG 2026) - "Case Description/ A 25-year-old female with a history of asthma presented with a five-day history of intractable nausea, vomiting, abdominal pain, and headache, which she self-medicated with frequent doses of acetaminophen and Excedrin (acetaminophen/aspirin/caffeine)...N-acetylcysteine (NAC) was initiated on hospital day 3, resulting in a reduction of hepatic inflammation and down-trending of bilirubin and ALP...(A) AST and ALT, (B) total and direct bilirubin, and (C) ferritin levels. Figure: Table 1 - Serial Hepatic Function Tests: Complete Laboratory Data from Hospital Admission through Discharge"

Case report • Clinical • Asthma • Cardiovascular • Epstein-Barr Virus Infections • Gastroenterology • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Respiratory Diseases • Septic Shock

When Shear Stress Extends Beyond the Valve: Heyde-Like Syndrome in HOCM (ACG 2026) - "Risk factors included increased low-dose aspirin and intermittent NSAID use...Figure: Figure 2. Duodenal angioectasia status post successful argon plasma coagulation treatment."

Cardiomyopathy • Cardiovascular • Gastroenterology • Hematological Disorders • Hypertrophic Cardiomyopathy • Obstructive Hypertrophic Cardiomyopathy • Pulmonary Disease • Targeted Protein Degradation

Melena Unmasking Undifferentiated Carcinoma of the Pancreas With Osteoclast-Like Giant Cells (ACG 2026) - "Case Description/ A 77-year-old male, with ulcerative colitis (well controlled on sulfasalazine), mild aortic stenosis, and recently diagnosed Type 1 diabetes mellitus presented with melena for 1 week and subacute generalized weakness and lightheadedness. He recently started aspirin, but denied NSAIDs, anticoagulants, steroids, smoking, and alcohol use...He was started on FOLFIRINOX with pembrolizumab and completed palliative radiation...Figure B: CT abdomen and pelvis with 4.4 cm cystic and solid pancreatic head mass with upstream pancreatic atrophy and dilatation of main pancreatic duct. Figure C: Pathology with poorly differentiated carcinoma with osteoclast-like giant cells."

Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Metabolic Disorders • Oncology • Pancreatic Cancer • Pancreatic Ductal Adenocarcinoma • Solid Tumor • Type 1 Diabetes Mellitus • Ulcerative Colitis • VIM

Antithrombotic Therapy Is Not Associated With Increased Recurrent Bleeding After Peptic Ulcer-Related Upper Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction and Atrial Fibrillation (ACG 2026) - "We aimed to compare 30-day rebleeding outcomes between triple therapy (oral anticoagulant + aspirin + P2Y12 inhibitor) and dual therapy (oral anticoagulant + single antiplatelet agent) in patients with MI, AF, and recent peptic ulcer-related UGIB... After matching, 16,708 patients were included in each cohort. Baseline characteristics were well balanced, with a mean age of 71.1 ± 10.9 years and 41.5% females. Triple antithrombotic therapy was not associated with an increased risk of recurrent GI bleeding compared with dual therapy (aHR 0.97, 95% CI 0.92â1.02; P = .19; Figure 1)."

Clinical • Atrial Fibrillation • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Myocardial Infarction • Peptic Ulcer

Test Before You Try - Helicobacter pylori Testing in Patients Starting Dual Anti-Platelet Therapy: A Quality Improvement Project (ACG 2026) - "Twenty residents completed the pre-presentation questionnaire, and 19 completed the post-presentation version. Recognition of H. pylori testing before initiating aspirin for primary or secondary prevention rose from 35% to 52.6%. For non-aspirin APT in patients with prior peptic ulcer disease, recognition increased from 30% to 52.6%."

Clinical • Cardiovascular • CNS Disorders • Cognitive Disorders • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Peptic Ulcer • Vascular Neurology

Concurrent Aspirin Use in Anticoagulated Patients and Risk of Gastrointestinal Bleeding: A Propensity-Score-Matched Cohort Analysis (ACG 2026) - "Cohort 1 comprised adults on chronic anticoagulation (apixaban, rivaroxaban, dabigatran, edoxaban, or warfarin) with concurrent aspirin use; Cohort 2 comprised anticoagulated adults without aspirin. Post-PSM cohorts were well-balanced (all SMDs < 0.003). Aspirin use was associated with significantly higher rates of upper GI bleed (1.51% vs. 1.26%; HR 1.34, 95% CI 1.20â1.48; p< 0.001), unspecified GI hemorrhage (1.39% vs."

Clinical • Cardiovascular • Chronic Kidney Disease • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Renal Disease • Thrombocytopenia

Antithrombotic Agents and Post-Polypectomy Bleeding Risk in Patients With Polyps â¤20mm: Systematic Review and Meta-Analysis (ACG 2026) - "Fifty studies including 25,205 patients were included in the proportion meta-analysis. The pooled incidence of delayed PPB was 2.14% (95% CI 1.43â3.20), myocardial infarction was 0.18% (95% CI 0.05â0.72), stroke was 0.27% (95% CI 0.20â0.37), and composite TE events was 0.15% (95% CI 0.05â0.48). Delayed bleeding rates varied by antithrombotic class: aspirin 1.21%, P2Y12 inhibitors 1.43%, DOACs 2.01%, and warfarin 2.40%."

Retrospective data • Review • Cardiovascular • Myocardial Infarction

Neutrophilic Esophagitis: A New Endoscopic Pathological Esophagitis (ACG 2026) - "Medications included omeprazole 20 mg daily, oral potassium chloride pills, and BC powder (845 mg aspirin/65 mg caffeine) that she took every other day over the past five years. Figure 1C: Ballon dilation with moderate mucosal disruption with improvement of the esophageal webs (red arrows) Figure: Pathology findings of Neutrophilic Esophagitis with neutrophils in dark purple indicated by the arrow on 400x magnification (Figure 1A and 1B) and 600x magnification (Figure 1C). Gomori's Methenamine Silver (GMS) stain for Candida indicated by the red arrow (Figure 1D)"

Cardiovascular • Eosinophilic Esophagitis • Gastrointestinal Disorder • Hypertension • Immunology • Infectious Disease • Inflammation

Premature Detachment of Wireless pH Capsule Limits 4-Day Reflux Monitoring in Nearly One Quarter of Patients (ACG 2026) - "A total of 352 patients met the study eligibility criteria, of whom 85 (24.1%) experienced early capsule detachment ( Table 1 ). Of the 85 with early capsule detachment, 7 (8.2%) had capsule detachment on day 1, 6 (7.1%) on day 2, 19 (22.4%) on day 3, and 53 (62.4%) on day 4. Patients in both groups were similar in age, sex, race, ethnicity, body mass index, comorbidities, prior proton pump inhibitor use, current NSAID use, aspirin use, GLP-1 receptor agonist use, anesthesia/sedation type, ASA classification, presence and size of hiatal hernia, capsule deployment site, and baseline esophageal pH."

Clinical • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder

Antiplatelet Therapy Does Not Increase Advanced Neoplasia Detection Following Positive Multitarget Stool DNA Testing (ACG 2026) - "Antiplatelet therapy included aspirin and/or P2Y12 inhibitor use... A total of 580 mt-sDNA-positive patients underwent diagnostic colonoscopy, including 125 on antiplatelets and 455 not on antiplatelets. Advanced neoplasia was detected in 31.2% of antiplatelet users compared with 39.6% of non-users. Antiplatelet therapy showed a nonsignificant trend toward lower advanced neoplasia detection (OR 0.69, 95% CI 0.45â1.06; p = 0.085), with similar findings on multivariable adjustment (aOR 0.68, 95% CI 0.43â1.07; p = 0.099)."

Metastases • Stool DNA • Colorectal Adenocarcinoma • Colorectal Cancer • Gastroenterology • Solid Tumor

GLP-1 Receptor Agonists and Metachronous Adenoma Recurrence After Colonoscopic Polypectomy: A Propensity-Matched Real-World Analysis of 12,152 Patients (ACG 2026) - "Exposed patients initiated GLP-1 RA (tirzepatide, liraglutide, dulaglutide, exenatide, semaglutide) 1-180 days post-polypectomy; unexposed never received one. 1:1 propensity matching used 22 covariates, including age, sex, race, ethnicity, diabetes, obesity, hypertension, hyperlipidemia, tobacco, alcohol, family history of GI cancer, IBD, aspirin, metformin, BMI, and HbA1c... 6,076 matched pairs were analyzed; 21 of 22 covariates achieved SMD< 0.10. The mean follow-up was 1,411 vs 1,507 days. Metachronous adenoma occurred in 31.1% exposed vs 36.5% unexposed (HR 0.82, 0.77-0.87; p< 0.0001)."

Clinical • Real-world • Real-world evidence • Colorectal Cancer • Diabetes • Dyslipidemia • Gastrointestinal Cancer • Genetic Disorders • Hypertension • Metabolic Disorders • Obesity • Skin Cancer • Solid Tumor

Esophagogastric Intramucosal Carcinoma Following Chronic Laparoscopic Gastric Band Erosion (ACG 2026) - "His history was notable for LAGB in 2010 and PCI with stenting of the SVG-RPDA in September 2025, after which he was started on aspirin and prasugrel. Endoscopic image of mass extending into esophagus Figure: Figure 2. Endoscopic appearance of tumor"

Cardiovascular • Coronary Artery Disease • Esophageal Cancer • Gastric Cancer • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Genetic Disorders • Obesity • Oncology • Solid Tumor • Venous Ulcer

An Unusual Case: DAPT Revealing Meckelâs Diverticulum in an Adult (ACG 2026) - "One month after starting aspirin and Plavix, he presented to the emergency department with presyncope and several concurrent episodes of hematochezia. It emphasizes the importance of a broad differential and considering Md as a cause of lower GI bleeding in adults. Figure: Technetium-99m scan positive for Meckelâs diverticulum"

Clinical • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Ischemic stroke