Neutrofil (filgrastim biosimilar) / Pablo Cassara - LARVOL DELTA

Improvement of Survival By Use of New Tecniques of Manipulation after Haploidentical Hematopoietic Stem Cell Transplantation: Report of 230 Transplants in Paediatric Patients with Primary Immunodeficiencies and Oncological Diseases (ASH 2024) - "Median Neutrofil engraftment was 18 days, mean platelet engraftment was 23 days...In addition, no invasive bacterial, fungal and viral infections were reported, with no life-threating infections or organ damage. The continuous improvement of manipulation strategies has made excellent results possible not only in terms of GvHD control, but also in survival with an overall survival for the last transplanted patients almost 100%."

Clinical • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Infectious Disease • Pediatrics • Primary Immunodeficiency • Transplantation • CD34

The Effect of Hydroxytyrosol in Improving Neutrofil Limfosit Ratio, Monosit Limfosit Ratio, and Super Oxide Dismutase in Pregnant Woman With Hypertension (clinicaltrials.gov) - P=N/A | N=42 | Not yet recruiting | Sponsor: Dr Cipto Mangunkusumo General Hospital

New trial • Cardiovascular • Hypertension

High Neutrofil Count and Thrombocytopenia Are Associated with High Mortality in COVID 19 Patients (ISTH 2024) - "There was 1000 subjects, consisting of 488 males and 512 females, 66,2% of whom were under 60 years old. There was 23,8% of COVID-19 patients with a platelet count below 144.000 who died compare to 14.3% of COVID-19 patients with a platelet count above 144.000 (P < 0.05). There were 40.4% of COVID-19 patient with a neutrophil count above 10.000 who died compare to 11.4% of COVID-19 patients with a neutrophil count below 10.000 (P 0.000) Conclusion(s) : Neutrophilia and a low platelet count are associated with higher mortality in COVID-19 patients"

Clinical • Cardiovascular • Hematological Disorders • Infectious Disease • Inflammation • Novel Coronavirus Disease • Respiratory Diseases • Thrombocytopenia • Thrombosis

Defining Predicting Factors for In Hospital Mortality of COVID-19 Patients (ATS 2023) - "Laboratory data included haemoglobine, leucocyte, platelet, neutrofil,,C-reactive Protein (CRP), ALT, AST, ureum, creatinine, electrolyte, blood gas analysis and Brixiascore of chest x-ray.using logistic regression. Ethical issue was approved by ethical committeeUniversitas Indonesia.ResultThere were 271 subjects, 157 male and 114 femlaes, median age 49 (19-92) years old, andmedian length of stay 9 (1-66) days. We found fever (OR 5.39, CI95% 1.57-18.47), history ofdiabetes (OR 6.29 CI95% 2.30-17.23), respiratory rate (OR 3.58 CI 1.33-9.62), perifwer oxygensaturation (OR 3.22, CI95% 1.09-9.5), leucocyte (OR 3.27, CI95% 1.35-7.91), ALT (OR 4.74,CI95% 1.88- 11.94) and CRP (OR 6.85, CI 95% 2.77-16.94) as variable prognosis factors for inhospital mortality.ConclusionVariabel contributing as prognosis factor for in hosptial mortality among COVID-19 patientsinclude fever, diabetes, respiratory rate, oxygen saturation, leucocyte, ALT, and CRP."

Clinical • Cough • Diabetes • Fatigue • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Respiratory Diseases • CRP

ANGINA LUDWIG (ESPID 2023) - "Case Presentation Summary: 5 years old boy presented to the ED with history of fever 39-40 from 4 days,swelling of the submandibular,sublingual and submental regions in 12 hours,trismus,dysphagia,odynophagia,sialorrhea,halitosis,impetigo in perioral region The boy was pale and nourished.High temperature 39.5.In the submandibular region was noted a large bilateral swelling with pain in palpation, redness,difficulties and reduction in opening the mouth,keilitis.His parents refered that the boy has done extraction of the bilateral molar and premolar teeth of the mandibula.Laboratoric findings:WBC 26.7 x 10³ neutrofil 89%,PCR 45 mg/dl,ERS 35mm/h.Swab of the pus :mixed flora anaerob and aerob(streptococcus,staphylococcus aureus,epidermis,viridans) Neck ultrasound:inflamatory swelling of the subcutan connective tissues,increase vascularization,bilateral submandibular,sublingual limfonodules that suggested for celulits. Neck CT:through both the axial/coronal cuts was noted..."

Cardiovascular • Cognitive Disorders • Dental Disorders • Dermatology • Gastrointestinal Disorder • Infectious Disease • Inflammation • Pain • Pulmonary Disease

"Neutrofil ⬆️ Morphologycal irregular" (@asopa_atish)

Age-related macular degeneration and myeloproliferative neoplasms - A common pathway. (PubMed, Acta Ophthalmol) - "Vi fandt også at forekomst af druser var associeret med højere neutrofil-lymfocyt ratio, hvilket indikerer et højere niveau af kronisk inflammation i patienterne med druser sammenlignet med dem uden druser...We, therefore, propose an AMD model (Figure 18) where inflammation can initiate and accelerate the normal age-dependent accumulation of debris in the retina, which later evolve into drusen, resulting in increased local inflammation, and over time early- and intermediate AMD. This results in the increased risk of developing the late debilitating stages of AMD."

Journal • Age-related Macular Degeneration • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dry Age-related Macular Degeneration • Essential Thrombocythemia • Hematological Disorders • Hematological Malignancies • Immunology • Inflammation • Macular Degeneration • Myelofibrosis • Myeloproliferative Neoplasm • Oncology • Ophthalmology • Polycythemia Vera • Retinal Disorders • Thrombocytosis • Wet Age-related Macular Degeneration • CXCR3

Contribution of miRNAs and Other Inflammatory Biomarkers to the Differentiation of Inflammatory and Non-Inflammatory Joint Effusions. (PubMed, Acta Chir Orthop Traumatol Cech) - "The concentrations of miRNA were determined by enzyme-linked immunosorbent assays (ELISA), C-reactive protein, interleukin-6 and procalcitonin on automatic analyser, presepsin on POCT system, interleukin-1 and human neutrofil defensins 1-3 by ELISA...We have shown that miR-146a-5p, miR-223-3p and miR-23a-3p can be an important group of biomarkers for the detection and monitoring of various pathophysiological conditions in synovial fluid, including inflammatory conditions. Key words: miRNA, synovial fluid, inflammatory joint disease, enzyme-linked immunosorbent assay."

Biomarker • Journal • Immunology • Inflammation • Inflammatory Arthritis • Rheumatology • CRP • IL1B • IL6 • MIR146A • MIR223 • MIR23A

"neutrofilos" (@joaquinnieves55)

Epilobium angustifolium L. extract with high content in oenothein B on benign prostatic hyperplasia: A monocentric, randomized, double-blind, placebo-controlled clinical trial. (PubMed, Biomed Pharmacother) - "This study was conducted in 128 adult men, randomly assigned to receive either EAE food supplement (N = 70) or placebo (N = 58), who underwent four visits (baseline = t0, after 15 days = t1, after 2 months = t2 and after 6 months = t3) in an outpatient setting to evaluate post-void residual (PVR) and prostate volume (PV) by means of prostate ultrasound, prostate-specific antigen (PSA) and neutrofile/lymphocyte ratio (N/L), nocturia before the clinical visits and International Prostate Specific Score (IPSS) registered by the physicians...Moreover, EAE food supplement did not show hepatic or renal toxicity. In conclusion, EAE food supplements can be used in subjects with BPH, to improve their quality of life and general renal function."

Clinical • Journal • Benign Prostatic Hyperplasia

Subacute distal ileitis in a healthy young adult. (PubMed, Rev Esp Enferm Dig) - "He had an hematocrit of 39% and 14.300 leukocytes/mm3 (76% neutrofiles)...Stable patients can be managed conservatively. In cases of peritonitis or persistence or worsening of symptoms surgical exploration may be warranted to prevent delayed complications (4)."

Clinical • Journal • Pain

"Jadni mi svi zajedno kad nas ovaj uci o mikrobiologiji i imunologiji... Dao bih se kladiti da ne razlikuje limfocit od neutrofila, a kamo li ista vise..." (@PetarTerze)

[VIRTUAL] KAWASAKI-LIKE PEDIATRIC MULTISYSTEM INFLAMMATORY SYNDROME ASSOCIATED WITH COVID-19 (HEMO 2020) - "Internada por 7 dias para receber ceftriaxone e azitromicina...No D12 desde o diagnóstico da COVID-19 internou com Hb 6,7g/dL, leucócitos 10.590/mm3, neutrofilia (80%), linfopenia (9%), plaquetas 557.400/mm3, TGO 37 U/L, TGP 53 U/L, DHL 138 UI/L, RNI 1,19, TTPA 1,09, fibrinogênio 711 mg/dL, PCR 16,7 mg/dL, VHS 94 mm, D-dímero 4,86 ug, troponina I < 5 ng/mL, procalcitonina 0,2 ng/mL, ferritina 394 ng/mL, liquor normal, CT tórax com mais de 10% de comprometimento pulmonar (imagem de consolidação e vidro fosco na base esquerda) e ecocardiograma com derrame pericárdico discreto...No 7° dia de tratamento teve melhora do ecocardiograma, reduzindo-se a dose de AAS para 3 mg/kg/dia e iniciada anticoagulação terapêutica com enoxaparina sódica...Conclusão: Embora a maioria das crianças apresentem quadro clínico brando de infecção pelo SARS-CoV-2, a SIM-P pode ocorrer após casos leves..."

Clinical • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Respiratory Diseases

Can gram-negative-like biomarker values in Streptococcus pyogenes sepsis negatively influence right choice of initial antibiotic therapy? (PubMed, Epidemiol Mikrobiol Imunol) - "Poměr neutrofilů a lymfocytů vykazoval stejné charakteristiky jako prokalcitonin...Vysoké hodnoty prokalcitoninu imitující gramnegativní zánětlivou odpověď přispěli k ovlivnění výběru iniciální antibiotické léčby (bez znalosti původce), což mohlo vést k vyšší mortalitě u této skupiny pacientů. Proto doporučujeme přehodnocení významu prokalcitoninu v diagnostice sepse pro zlepšení přežití i kvality života pacientů."

Biomarker • Journal • Infectious Disease • Septic Shock

[VIRTUAL] INFUSED TOTAL NUCLEATED CELL DOSE IS NOT ASSOCIATED WITH ENGRAFTMENT IN AUTOLOGOUS STEM CELL TRANSPLANTATION (EBMT 2020) - "Neutrophil engraftment was defined as the first day of an absolute neutrofil count > 500/µL on three consecutive measurements; platelet recovery was defined as the first day of two consecutive measurements of > 50,000/L... on the basis of our retrospective analysis it does not exist any correlation between infused total nucleated cell dose and time to engraftment in autologous stem cell transplanation. Clinical Trial Registry: None"

Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma • Oncology • Transplantation • CD34

[VIRTUAL] INFUSED TOTAL NUCLEATED CELL DOSE IS NOT ASSOCIATED WITH ENGRAFTMENT IN AUTOLOGOUS STEM CELL TRANSPLANTATION (EBMT 2020) - "Neutrophil engraftment was defined as the first day of an absolute neutrofil count > 500/µL on three consecutive measurements; platelet recovery was defined as the first day of two consecutive measurements of > 50,000/L... on the basis of our retrospective analysis it does not exist any correlation between infused total nucleated cell dose and time to engraftment in autologous stem cell transplanation. Clinical Trial Registry: None"

Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma • Oncology • Transplantation • CD34

[VIRTUAL] INFUSED TOTAL NUCLEATED CELL DOSE IS NOT ASSOCIATED WITH ENGRAFTMENT IN AUTOLOGOUS STEM CELL TRANSPLANTATION (EBMT 2020) - "Neutrophil engraftment was defined as the first day of an absolute neutrofil count > 500/µL on three consecutive measurements; platelet recovery was defined as the first day of two consecutive measurements of > 50,000/L... on the basis of our retrospective analysis it does not exist any correlation between infused total nucleated cell dose and time to engraftment in autologous stem cell transplanation. Clinical Trial Registry: None"

Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma • Oncology • Transplantation • CD34

[VIRTUAL] INFUSED TOTAL NUCLEATED CELL DOSE IS NOT ASSOCIATED WITH ENGRAFTMENT IN AUTOLOGOUS STEM CELL TRANSPLANTATION (EBMT 2020) - "Neutrophil engraftment was defined as the first day of an absolute neutrofil count > 500/µL on three consecutive measurements; platelet recovery was defined as the first day of two consecutive measurements of > 50,000/L... on the basis of our retrospective analysis it does not exist any correlation between infused total nucleated cell dose and time to engraftment in autologous stem cell transplanation. Clinical Trial Registry: None"

Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma • Oncology • Transplantation • CD34

[VIRTUAL] INVESTIGATION OF THE EFFECTS OF KYNURENIC ACID ANALOGS IN RHEUMATOID ARTHRITIS (EULAR 2020) - "The potential effect of KYNA analogs on further immune mediators including alarmins (S100A12=EN-RAGE and S100A8/9=calprotectin), and on human neutrofil peptide 1-3(α-defensin) production has not been investigated... TSG-6 expression could participate in the suppression of inflammatory cytokines, such as TNF-α, EN-RAGE, calprotectin and α-defensin. We suppose that the elevation of the TSG-6 expression by KYNA and especially by new KYNA analogs might be one of the mechanisms that are responsible for their suppressive effect on TNF-α production as a feedback mechanism in RA. KYNA and KYNA analogs have an important role in influencing TSG-6 expression, and there is a possible benefit with potential therapeutic consequence of targeting TSG-6 expression by kynurenines in inflammatory conditions in RA."

Immunology • Rheumatoid Arthritis • Rheumatology • AGER • TNFA

"fair question 👍 basically not much too see except for the ulceration, the neutrofil granulocytic infiltrate and the vasculitis...rather non-specific findings ...the diagnosis is based on clinical findings" (@kis_lorand)

Clinical • Immunology • Vasculitis

"@SoyUnNeutrofilo" (@quironvetemt)

SENSITIVITY COMPARISON OF THE NEUTROFIL LIMFOSITE RATIO VALUE OF PLEURA FLUID AND BLOOD SERUM IN PLEURAL EFFUSION PATIENTS AT HAJI ADAM MALIK GENERAL HOSPITAL, MEDAN (APSR 2019) - "The sensitivity of NLR of pleural fluid was greater than blood serum while the specificity of blood serum was greater than that of pleural fluid."

Clinical • Pleural Effusion

THE THICKNESS OF THE CRURAL DIAPHRAGM IS THINNER IN HELICOBACTER PYLORI INFECTED GERD PATIENTS (UEGW 2019) - "During the endoscopic procedure, biopsies of the antrum and gastric corpus (five different sites) were taken for blinded, four-points (0-3), hystologic analysis for each of the following items: inflammation, inflammatory activity (neutrofil infiltration), metaplasia, atrophy, and H. pylori infection... In GERD patients, the thickness of the RC and the strength of inspiratory muscles were associated with gastric inflammation due to the infection with H. Pylori . The esophageal acid exposure and the typical symptoms of the two groups of GERD patients did not differ. These results brings about new evidence that may help interpret the complex relationship between H. Pylori infection and GERD."

Clinical

Epididymis head abscess a rare complication in epididymo-orchitis ….a case report. (EUSEM 2019) - "Diffuse scrotal wall swelling on left side was noted.Blood test revealed WBC 24.50 with absolute neutrofil count 19.10, KFT within range, ALP 146, ALT 61, AST 44, Urine RBC 3+, Leu ve, Nit ve and Urine culture ve. Patient was admitted by Urology given the symptomatology and severe pain with final impression of acute epididymo-orchitis complicated by epididymal head abscess.Patient was managed conservatively with Ceftrioxone 2 gm daily and Ciprofloxcin 500mg twice and discharged after 3 days following improvement on Ciprofloxcin 500mg twice for 21 days plus Doxycycline 100mg twice for 14 days with follow up...Patients can be quickly examined by US Doppler without losing any precious time, in order to obtain valuable information. DOUS examination lasts less than 10 min, thus making it suitable in emergency situations."

Clinical

Enteritis-associated Acute Febrile Neutrophilic Dermatosis with Acute Monoarthritis. (PubMed, Folia Med (Plovdiv)) - "Febrile neutrofilic dermatosis is an uncommon entity with complex pathophysiology, usually secondary to an infection, a malignancy or an autoimmune disease. Extracutaneous manifestations of the disease are very rare as well. We report a patient with histologically confirmed acute febrile neutrophilic dermatosis caused by viral enteritis that was presented with painful rash along with acute monoarthritis and treated with oral corticosteroids."

Journal