IMD5 / Daewoong Pharma - LARVOL DELTA

P147 Exploring the impact of age and deprivation on malignant melanoma diagnoses during the COVID-19 pandemic in England: a national retrospective cohort study. (PubMed, Br J Dermatol) - "Deprivation was recorded by means of the Index of Multiple Deprivation (IMD), with quintiles ranging from IMD1 (most deprived) to IMD5 (least deprived)...The lack of a clear pattern highlights the complexity of pandemic-related disruptions to healthcare services. Future research should explore interactions between geographies, ethnicity and gender, alongside age and deprivation, by MM stage at presentation and survival, to fully understand the long-term consequences of service interruptions and inform future national emergency strategies."

Journal • Retrospective data • Infectious Disease • Melanoma • Novel Coronavirus Disease • Oncology • Solid Tumor

Social deprivation and morbidity and mortality after surgery: a UK national observational cohort study. (PubMed, Br J Anaesth) - "Socioeconomic deprivation is associated with short-term postoperative morbidity and mortality. This association might relate to poorer baseline fitness among people living in socioeconomically deprived areas, highlighting opportunities for targeted preoperative optimisation."

Journal • Observational data • Anesthesia • Cardiovascular • Critical care

Frailty and Social Deprivation Affect Real-world Outcomes in Multiple Myeloma (MM) – an England-wide Cohort Study from the UNCOVER Study Group and UKMRA Frailty Group (IMS 2025) - "Adjusted IRRs increased with age and were lower for females [0.62 (p< 0.001)], less deprived areas [0.95 (p=0.006) for IMD5 vs 1), and all provincial regions vs London [e.g. 0.63 (p< 0.001) for North West]... Deprivation is associated with a higher probability of MM diagnosis and shorter survival once diagnosed in MV analysis. Living in the capital is associated with a higher probability of MM diagnosis but longer survival once diagnosed. Frailty adds to the effect of deprivation and region and is associated with shorter survival."

Clinical • Real-world • Real-world evidence • Hematological Malignancies • Multiple Myeloma

Time, treatment and inequality: Socioeconomic disparities and temporal changes in the surgical and medical management of Crohn's disease (ESCP 2025) - "Lower SES (IMD5 aHR 1.23 (95% CI 1.09-1.38) cf IMD1) and smoking (aHR 1.39 (95% CI 1.29-1.50) were associated with increased risk...Deprivation is a risk factor for surgery and biologic use suggesting discrepancies in accessing healthcare and timely intervention. Further work would serve to understand this complex association."

Crohn's disease • Gastroenterology • Immunology • Inflammatory Bowel Disease

INCIDENCE AND SURVIVAL OF MULTIPLE MYELOMA IN ENGLAND: AN UNSELECTED COHORT STUDY FROM THE UNCOVER STUDY GROUP AND UKMRA FRAILTY GROUP. (EHA 2025) - "Adjusted IRRs increased with age and were lower in females (0.62, p<0.001), the two least deprived IMD quintiles vs the most deprived (IMD4 0.94, p<0.001; IMD5 0.95, p=0.006), and all 8 provincial regions vs London (IRR for North West 0.63, p<0.001)... Our analysis provides a detailed description of MM epidemiology in England over the period 2014-2021. Incidence was independently associated with age, sex, ethnicity, deprivation and geography and fell significantly during the COVID-19 pandemic. Survival was independently associated with age, sex, ethnicity, deprivation, geography and year of diagnosis, with a year-on-year improvement in outcome for cohorts diagnosed in successive calendar years until the onset of the COVID-19 pandemic."

Hematological Malignancies • Infectious Disease • Multiple Myeloma • Oncology

Hospitalisation after paediatric kidney transplant: a U.K. multicentre retrospective review. (UKKW 2025) - "• Patients in the IMD 5 quintile (least deprived) were the least likely to need any of the three presentation types, as a proportion of patients within that quintile... This study highlights significant variations in healthcare utilisation during the first year following PKT, with notable differences based on gender, ethnicity, and socio-economic factors. Understanding the reasons for re-hospitalisation in this population is crucial for identifying strategies to reduce hospital admissions, mitigate associated healthcare costs, and address healthcare inequities. Our findings suggest that targeted interventions may be needed to improve outcomes for patients, particularly those from disadvantaged socio-economic backgrounds."

Retrospective data • Review • Nephrology • Pediatrics • Transplantation

The science of performance: Driving quality improvement in radiation oncology (ESTRO 2025) - "The NPCA provided the patient list with comorbidity scores (Charlston index) and deprivation (IMD5) scores... We included 802 patients; 39 had bowel toxicity (4.9%). Baseline characteristics were similar. Prostate pelvic node patients (25/300) were more likely to develop bowel toxicity (RR: 3.15, 95% CI: 1.58-5.66), compared to prostate only group (13/492)."

Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor

Socioeconomic status and older adult's experiences of weight loss: a qualitative secondary analysis. (PubMed, PLoS One) - "This study demonstrates that there is structural and individual inequity in individual views, identification, and clinical management of weight loss. The consequences of this disproportionately affect the most deprived, further confounding the inequalities that already exist."

Journal • Obesity • Oncology

Surgical and transcatheter aortic valve interventions for aortic stenosis in England: sociodemographic variations in treatment trends and outcome over 20 years. (PubMed, Heart) - "There are differences in intervention rates for AS in England, with lower rates in female patients and to a lesser extent, those from the most deprived areas and ethnic minority groups. These variations have widened over time. Post-intervention cardiovascular mortality is lower in women and with decreasing deprivation. Public health measures and research are needed to identify the true prevalence of AS in different populations, and the reasons for potential inequalities."

Journal • Cardiovascular • Infectious Disease • Novel Coronavirus Disease

Predictors and barriers to accepting smoking cessation support within targeted lung health screening programmes: a mixed method approach. (ERS 2024) - "Of 152 smokers randomised to smoking cessation support (Age 61.3 years 58%±4.8 male), 72 accepted the offer, 15 of whom dropped out, and 80 declined the offer. The 57 treated were more likely to be female [53% vs 40% AOR: 3.30, 95%CI 1.47-7.48] and younger [AOR: 0.90, 95%CI 0.80-0.98]. Compared to smokers living in areas with high deprivation, smokers who accepted support were more likely to live in areas of medium or low deprivation, [IMDQ3: 26% vs 14% AOR: 3.79, 95%CI 1.17-13.47], [IMDQ5: 17%vs 9%, AOR: 4.26, 95% CI 1.11-16.33]."

Lung Cancer • Oncology • Solid Tumor • Tobacco Cessation

Disparities in Clinical Trial Enrolment and Survival Outcomes by Socio-economic Class in Multiple Myeloma (IMW 2023) - "There were significantly less patients enrolled into clinical trials (both EPT and LPT) from deprived areas compared to the expected social demographic of MM patients in England (7% (trials) vs 14% (England) for IMD 5, p= < 0.001). Patients enrolled into clinical trials were from less socially deprived areas than expected from the distribution of MM in England with referrals favouring higher socio-economic class. As lower socio-economic class impacts overall survival independently of racial group, it is vital that clinical trials enrol from a diverse but balanced socio-economic population. Enrolment should be monitored according to socioeconomic deprivation to ensure there is adequate representation of the geographical population served."

Clinical • Hematological Malignancies • Multiple Myeloma • Oncology

Socio-economic status in patients with juvenile idiopathic arthritis in the United Kingdom (BSR 2022) - "However, amongst cases there was an association between older age at diagnosis and higher SES [ß(95%CI)0.15 years (0.01-0.29)] such that CYP in the IMD 5 quintile (highest SES) were on average 8 months older at their first JIA code compared to CYP in IMD 1. This study found CYP from higher socio-economic groups appeared to be diagnosed at an older age than those from the least deprived backgrounds. This study found CYP from higher socio-economic groups appeared to be diagnosed at an older age than those from the least deprived backgrounds. Factors such as later presentation to healthcare after disease onset, delays in referrals to specialist care, delays in diagnosis by specialist care or differences in population demographics across IMD quantiles may all contribute to the older age of diagnosis in high SES group. Further research is required to explore these factors."

Clinical • Idiopathic Arthritis • Immunology • Rheumatoid Arthritis • Rheumatology

Advances in CD247. (PubMed, Scand J Immunol) - "CD247, which is also known as CD3ζ, CD3H, CD3Q, CD3Z, IMD25, T3Z, and TCRZ, encodes CD3ζ protein, which is expressed primarily in natural killer (NK) and T cells. Since the discovery of the ζ peptide in 1986, it has been continuously investigated. In this paper, we review the composition, molecular mechanisms and regulatory factors of CD247 expression in T cells; and review the autoimmune diseases, tumors and inflammatory diseases associated with CD247, providing a detailed and comprehensive reference for further research on the mechanism of CD247 and related diseases."

Journal • Review • Immunology • Infectious Disease • Inflammation • Oncology • CD47

Socioeconomic deprivation and long-term outcomes after elective surgery: analysis of prospective data from two observational studies. (PubMed, Br J Anaesth) - "Socioeconomic deprivation is associated with worse long-term outcomes after elective surgery. This risk factor should be considered when planning perioperative care for patients from deprived areas."

Clinical • Journal • Observational data

Unintentional injury in England: an analysis of the emergency care data set pilot in Oxfordshire from 2012 to 2014. (PubMed, J Epidemiol Community Health) - "This pilot has demonstrated both the feasibility and importance of prioritising the collection of a national injury data set."

Journal

Causes of death among homeless people: a population-based cross-sectional study of linked hospitalisation and mortality data in England. (PubMed, Wellcome Open Res) - "...We compared our results to a sample of people living in areas of high social deprivation (IMD5 group)... Nearly one in three homeless deaths were due to causes amenable to timely and effective health care. The high burden of amenable deaths highlights the extreme health harms of homelessness and the need for greater emphasis on prevention of homelessness and early healthcare interventions."

Clinical • Journal • Observational data