roxithromycin / Generic mfg. - LARVOL DELTA

An inner filter effect-based upconversion fluorescence sensor using TPPS-Co2+ complexes for rapid detection of roxithromycin in food. (PubMed, Talanta) - "The sensor showed a rapid response (10 min) and excellent selectivity. In honey samples, recoveries ranged from 98.29% to 102.59% with coefficients of variation of 1.15%-5.16%, demonstrating its potential for the rapid determination of ROX residues in food."

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Robust ultra-trace quantification of multi-class antibiotics in environmental waters using automated 96-well SPE and LC-HRMS. (PubMed, J Chromatogr A) - "The applicability of the workflow for high-throughput environmental monitoring was demonstrated by analyzing wastewater effluent and river water samples, revealing the widespread occurrence of sulfamethoxazole, trimethoprim, ciprofloxacin, levofloxacin, azithromycin, clarithromycin, erythromycin, and roxithromycin, ranging from ultra-trace levels in river water to substantially elevated concentrations in wastewater effluent. Thus, the developed workflow represents a robust and sensitive high-throughput approach for the analysis of antibiotic residues in environmental waters."

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Electrocatalytic Ozonation Roxithromycin in Aqueous Solution: Synergistic Effect and Mechanism. (PubMed, Water Environ Res) - "Radical quenching experiments and UPLC-QTOF/MS analysis confirmed •OH as primary oxidant, with •O2- and ozone contributions, and proposed three plausible degradation pathways involving oxidative attacks on nitrogen-containing heterocycles, glycosidic bonds, and macrolide ring leading to cleavages, rearrangements, and ultimate mineralization into CO2 and H2O. This research provides experimental and theoretical support for scaling up ECO systems in antibiotic-laden wastewater treatment."

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Current Practice in the Diagnosis and Management of Mycoplasma pneumoniae Infections: A Survey of Korean Physicians in 2024. (PubMed, J Korean Med Sci) - "This study reveals diverse practices and a need for standardized guidelines in managing M. pneumoniae infections, particularly in the context of rising MRMP prevalence. Clearer recommendations on diagnostic testing, antibiotic selection, and corticosteroid use are crucial to optimize patient care and mitigate the spread of resistance."

Journal • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Immobilized horseradish peroxidase hybrid biocatalysts for degradation of pharmaceuticals and other emerging micropollutants. (PubMed, PLoS One) - "For example, full degradation was achieved for MBT (100%), meloxicam (99.5%) and caffeic acid (98.6%). In contrast, prometryn and MCPA showed only partial degradation, reaching 19.2% and 20%, respectively, and no degradation was observed for fluometuron and atenolol...For instance, roxithromycin degradation increased from 0.5% to 58.2% with ZnO-HRP, and for cimetidine, TiO₂-HRP improved degradation from 0.3% to 60.1% without HOBT and from 9.0% to 66.7% with HOBT...Finally, an integrated HRP enzyme and chemical oxidation remediation strategy was applied to degrade two pollutants, trimethoprim and DEET. For trimethoprim, TiO2-HRP combined with H2O2 and UV achieved approximately 30% degradation, while for DEET, both TiO2-HRP + H2O2 + UV and ZnO-HRP + H2O2 + UV resulted in around 40% degradation, thereby highlighting a novel application for these hybrid peroxidase-photocatalysts."

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Macrolide-Induced Aldosterone Suppression as a Functional Marker of KCNJ5-Mutated Aldosterone-Producing Adenoma: A Proof-of-Concept Clinical and Experimental Study (MAPA Study). (PubMed, Eur J Endocrinol) - "The selective suppression of aldosterone secretion with roxithromycin in KCNJ5-mutated APA in vivo, which aligns with ex-vivo mechanistic data, can represent a functional marker of KCNJ5 mutations and could help guide precision subtyping of PA patients. Macrolides also exhibit an aldosterone-independent antihypertensive effect in non-PA patients, which involves nitric oxide-dependent vasodilation."

Journal • Cardiovascular • Endocrine Disorders • Hypertension

Isolation, Identification, Drug Sensitivity, Pathogenicity and Genomic Analysis of Vibrio mimicus from Pelteobagrus fulvidraco. (PubMed, Microorganisms) - "Antimicrobial susceptibility testing demonstrated that the isolate was highly susceptible to piperacillin, norfloxacin, roxithromycin, azithromycin, furazolidone, ceftriaxone and tetracycline, whereas it displayed high-level resistance to compound sulfamethoxazole and clindamycin. Collectively, this work lays a scientific foundation for the isolation, identification and comprehensive research of Vibrio mimicus-induced ulcerative disease in yellow catfish."

Journal • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Ulcerative Colitis

Tranilast/roxithromycin with topical tacrolimus in refractory atopic facial eczema: Case report. (PubMed, Int J Clin Pharmacol Ther) - "Within 3 weeks, his eczematous lesions on the face, as well as the severe itching, were completely cured. Addition of this combination therapy may be a promising therapeutic strategy for treating uncontrollable atopic dermatitis, particularly for facial eczema and itching."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pediatrics

Antibiotic Contamination in Groundwater Across Major Chinese Basins: Which Compounds Require Priority Control? (PubMed, Environ Res) - "Chlorotetracycline, enrofloxacin, roxithromycin, oxytetracycline, and ciprofloxacin were repeatedly identified as high-priority antibiotics in multiple basins (≥3). Six antibiotics requiring priority control were identified for the first time. Overall, this framework explicitly integrates antimicrobial resistance risks into groundwater antibiotic prioritization and provides a scientific basis for priority control, basin-specific management, and the protection of human health and ecological security."

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Antibiotic-induced photosynthetic dysfunction in wheat: Coupled inhibition of light reactions and carbon assimilation revealed by multi-omics. (PubMed, Environ Pollut) - "This study systematically investigated the phytotoxic effects of enrofloxacin (ENR), levofloxacin (LVX), and roxithromycin (ROX) on wheat (Triticum aestivum L.) seedlings. Significant alterations in fatty acid biosynthesis, pyrimidine metabolism, and GPI anchor biosynthesis pathways further confirmed antibiotic-induced metabolic reprogramming. This study provides new insights into the differential impacts of antibiotics on crop photosynthesis and cellular integrity, emphasizing the need for ecological risk assessment of antibiotic contamination in agricultural systems."

Journal • Targeted Protein Degradation

Migration and biotransformation mechanisms of risk-priority antibiotics in wastewater biotreatment: An integrated multi-omics and molecular dynamics perspective. (PubMed, Eco Environ Health) - "This study integrated metagenomics, metaproteomics, molecular dynamics (MD) simulations, and pathway analysis to elucidate the behavior of ciprofloxacin (CIP), sulfamethoxazole (SMX), and roxithromycin (ROX) under single- and mixed-antibiotic exposures in an activated sludge system. Under mixed-antibiotic stress, a confluence of reinforced resistance (e.g., Type IV secretion system K03205), altered EPS binding, and skewed energy allocation (e.g., downregulation of cofactor synthesis ko01240) led to incomplete degradation and widespread persistence. This study provides a multiscale theoretical framework for optimizing WWTPs to control antibiotic pollution."

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From gut lumen to extragut tissue: dysbiosis-induced gut bacterial translocation mediates antibiotic resistance gene enrichment in Eisenia fetida under polystyrene microplastic and roxithromycin exposure. (PubMed, Environ Pollut) - "Though co-exposure did not increase gut ARGs and MGEs abundance, the enrichment of gut-dominant MLSB resistance genes and MGEs extended to earthworm body tissue, notably driven by PS-MPs, while ROX increased intI-1 (clinic), the strongest contributor to overall variation. PLS-PM revealed that tissue ARGs and MGEs enrichment was associated with gut bacterial translocation driven by dysbiosis-induced activation of LPS-TLR signaling pathways, raising concerns about ARGs dissemination through earthworm-derived traditional medicine and food chains."

Journal • Gastrointestinal Disorder • OCLN • TJP1

Occurrence of antibacterials, antivirals, and anti-inflammatory pharmaceuticals for COVID-19 treatment as emerging contaminants in the Chinese freshwater environment before, during and after the pandemic: the need for dynamic eco-pharmacovigilance. (PubMed, Environ Health Prev Med) - "Results revealed highly distinct regional and temporal variations in surface freshwater pollution by these COVID-19-associated PiE across the three periods, with no consistent regularity observed, thereby further highlighting the necessity of implementing EPV in a "dynamic" manner. Drawing on the framework of dynamic pharmacovigilance, the implementation of dynamic EPV can be promoted by establishing a dynamic watch-list mechanism, clarifying stakeholder roles, and advancing supportive policies and technological platforms, so as to enable adaptive interventions for the timely management of event-driven pharmaceutical pollution."

Adverse events • Journal • Review • Infectious Disease • Novel Coronavirus Disease

Isolation, prevalence, and antimicrobial resistance profiles of Ureaplasma spp. and Mycoplasma hominis in cervical secretions from pregnant and postpartum women in Hangzhou, China. (PubMed, BMC Pregnancy Childbirth) - "Ureaplasma spp. was the predominant genital mycoplasma colonizing pregnant and postpartum women in Hangzhou, with the highest rate observed among those under 20 years of age. There was high in vitro resistance to commonly used antibiotics such as ciprofloxacin and roxithromycin among the isolates. These findings provide local epidemiologic and antimicrobial susceptibility data for pregnant and postpartum women and highlight the need for further multi-center studies to confirm regional resistance patterns and clarify their clinical implications, including when genital mycoplasma colonization may warrant intervention."

Journal • Infectious Disease

From Correlation to Causality: Identifying Potential Environmental Drivers of Pathogenic Antibiotic-Resistant Bacteria in River Water Using Causal Machine Learning. (PubMed, Environ Pollut) - "Both Spearman correlation and explainable machine learning identified numerous potentially important factors, notably non-antibiotic pharmaceuticals such as carbamazepine and bezafibrate...Under predefined assumptions, this approach estimated potential causal effects for dissolved oxygen, the nitrate-to-ammonium ratio, specific antibiotics (roxithromycin, azithromycin), and non-antibiotic compounds (acenaphthene, 2-chloroanthracene)...Functional profiles suggested potential stress-adaptation mechanisms related to signal transduction and metabolic regulation pathways. By shifting from associative prediction to causal inference, this causal machine learning-guided framework provides a robust analytical basis for identifying environmental drivers and informing targeted management of PARB risks in aquatic ecosystems."

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Uniform annular cavitation field and superior mixing characteristics of a tube-in-tube continuous-flow ultrasonic reactor. (PubMed, Ultrasonics) - "In the continuous preparation, TIT-USR produced smaller, more uniform roxithromycin nanocrystals (9 nm, PDI 0.21 vs. ST-USR's 10.5 nm, PDI 0.42) and vitamin E nanoemulsions (150 nm, PDI 0.18 vs. ST-USR's 151 nm, PDI 0.26) under the same other conditions. These results prove that the uniform and effective annular cavitation field enables consistent nanoparticles and nanoemulsions."

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A comprehensive ecological risk assessment of pharmaceuticals in Japan with newly obtained chronic toxicity. (PubMed, Environ Toxicol Chem) - "The results showed that roxithromycin (a macrolide antibiotic) exhibited high toxicity to algae, whereas teprenone (antipeptic ulcer agent), ticlopidine (anticoagulant), and eperisone (muscle relaxant) showed high toxicity to daphnids...The sum of the toxic units indicated that the highest value for algae exceeded 1. This suggests that pharmaceutical contamination poses a significant risk to the aquatic environment in some locations in Japan."

Journal • Gastroenterology

Insights into the Interactions of Microalgae and Combined Macrolide Antibiotics: Removal Efficiency, Physiological-Biochemical Responses and Transcriptomic Analysis. (PubMed, Plants (Basel)) - "This study investigated the removal efficiency, physiological-biochemical responses, and molecular mechanisms of Chlorella pyrenoidosa under single and combined exposure to erythromycin (ERY) and roxithromycin (ROX) over 14 days. Key genes involved in stress signaling (e.g., MKK3, MPK3), detoxification (e.g., CYP97, GSTP), and photosynthesis (e.g., HemL) were differentially regulated, providing molecular evidence for the observed physiological responses and removal behaviors. These findings provide valuable insights for the ecological risk assessment of antibiotic mixtures and the development of microalgae-based wastewater treatment technologies."

Journal • MAP2K3

Ameliorative effect of roxithromycin against prostate inflammation-induced chronic pelvic pain in a preclinical model. (PubMed, Can J Physiol Pharmacol) - "The beneficial effect of roxithromycin was also evident from the dose-dependent restoration of markers of inflammation and oxidative stress. This study shows that by alleviating pain and suppressing inflammation and oxidative stress, roxithromycin has a potential to provide relief in prostatitis."

Journal • Preclinical • Gynecology • Inflammation • Musculoskeletal Pain • Pain • TNFA

Toxic effects of carboxyl/amino polystyrene microplastics and macrolide antibiotics on Chlorella pyrenoidosa: Insights based on physiological level, microstructure, and toxicity prediction. (PubMed, Environ Pollut) - "This study investigates the toxic effects and mechanisms of carboxyl-modified and amino-modified polystyrene microplastics (PS-COOH, PS-NH2) combined with macrolide antibiotics (Erythromycin, Roxithromycin, Azithromycin) to support ecological risk assessment of co-exposure. Mechanistically, the pollutants inhibited synthesis of photosynthetic pigments (Chla, Chlb, Car) , disrupted TP metabolism, and induced oxidative stress-evidenced by increased MDA levels and a "low-promotion, high-inhibition" pattern in SOD and CAT activities. This study underscores the importance of microplastic surface functionality in modulating combined toxicity with antibiotics, offering a theoretical basis for risk control of co-pollution in aquatic environments."

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Antimicrobial resistance in commensal skin bacteria among individuals without prior exposure to acne therapy. (PubMed, J Glob Antimicrob Resist) - "The results of this study suggest that the use of antimicrobials for the treatment of acne may substantially contribute to the development of AMR in skin bacteria. Therefore, it is crucial to use antimicrobial agents appropriately when treating acne to prevent the emergence of AMR in commensal skin bacteria."

Journal • Acne Vulgaris • Dermatology

Prospects for solving difficulties in steroid withdrawal and management supplementing tranilast and roxithromycin in corticosteroid-dependent atopic dermatitis. (PubMed, Int J Clin Pharmacol Ther) - "One approach involves combining the anti-allergic drug tranilast, which inhibits mast cell degranulation, with the unique macrolide antibiotic roxithromycin, known for its T helper type 2 (Th2) suppressive effect. Moreover, we examine the methods for managing steroid-dependent atopic dermatitis, a condition that poses significant challenges in terms of withdrawal."

Journal • Atopic Dermatitis • CNS Disorders • Dermatitis • Dermatology • Immunology • Psychiatry

Doxycycline in the treatment of outpatient mild community-acquired pneumonia: a propensity matched retrospective cohort study. (PubMed, Clin Microbiol Infect) - "The findings of this study support the potential non-inferiority of empiric doxycycline compared with other alternatives for outpatient mild CAP."

Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort. (PubMed, Environ Health (Wash)) - "In couple-based analyses, sulfaclozine, roxithromycin, sulfamonomethoxine, erythromycin, and penicillin V were positively related to several early IVF reproductive outcomes, while sulfamethoxazole, penicillin G, chlorotetracycline, norfloxacin, florfenicol amine (FFA), sulfadiazine, cyadox, and sulfachloropyridazine were negatively related to early IVF outcomes. The association between parental antibiotic exposure and IVF outcomes requires further validation in a larger cohort of couples. Additionally, the extrapolation of our results to the general childbearing-aged couples requires caution as infertile couples may be more susceptible to antibiotics."

Journal • Preclinical • Gynecology • Infertility

Target-Induced DNA Nanodevice as Efficient Signal Amplification Strategy Coupled with a Regenerable SERS Substrate HOF@Au for Ultrasensitive Detection of Roxithromycin. (PubMed, Anal Chem) - "Moreover, modulation of pH induced reversible folding and unfolding of the triplex structure to facilitate regeneration of the SERS substrate, which simplified operational procedures and reduced detection costs. As a result, this work presents a novel, regenerable SERS biosensor and offers valuable insights into the design of multifunctional sensing platforms for analytical applications."

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