LOAd732
/ Lokon
- LARVOL DELTA
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July 28, 2023
Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models.
(PubMed, J Transl Med)
- "LOAd732 is a novel immunostimulatory gene therapy based on an oncolytic adenovirus that expresses three transgenes, which are essential for mediating an anti-tumor immune response by activating DCs and stimulating T and NK cells even under imunosuppressive conditions commonly present in the TME. These qualities make LOAd732 an appealing new immunotherapy approach."
Gene therapy • IO biomarker • Journal • Gene Therapies • Immune Modulation • Infectious Disease • Melanoma • Oncology • Solid Tumor • CD40 • CD40LG • IL10 • IL2 • IL2RA • TGFB1
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