BMS-830216 / BMS - LARVOL DELTA

Computational prediction of analog compounds of the membrane protein MCHR1 antagonists ALB-127158 and KRX-104130. (PubMed, J Bioenerg Biomembr) - "Known MCHR1 antagonists include BMS-830216, GW-856464, NGD-4715, ALB-127158, and AMG 076, but many have failed phase-I clinical studies. In addition, all ligands remained stable in putative binding site. It has been suggested that PV-002757495233 and Z1922310273 compounds can be evaluated as MCHR1 antagonists when all these outputs are considered in melting pots."

Journal • Cardiovascular • Genetic Disorders • Metabolic Disorders • Obesity

Safety, pharmacokinetics and pharmacodynamics study to evaluate BMS-830216 in obese subjects (clinicaltrials.gov) - P1/2, N=113; Active, not recruiting → Completed

Trial completion • Diabetes

Some Observations on the Liquid Crystalline and Gel Behaviors of Aqueous Dispersions of a Prodrug. (PubMed, Drug Dev Ind Pharm) - "As indicated by SAXS, the lamellar phase formed seems to have two d-spacing values (∼5 nm and ∼10 nm (weak), which seems to correspond to two molecules connected tail by tail (5 nm). Further investigation is needed for phase identification, as their properties can affect the physical behavior of BMS-830216 in the development of pharmaceutical dosage forms."

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