Pneumosil (10-valent pneumococcal conjugate vaccine) / Serum Institute of India, Ligand - LARVOL DELTA

Effectiveness of PCV10 and PCV13 against invasive pneumococcal disease in Vietnamese children: a multi-centre matched case–control study (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections

Nasopharyngeal pneumococcal carriage and serotype distribution among Ethiopian children under five years of age after PCV10 introduction: findings from a national multisite study (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections

Pneumococcal serotype epidemiology and resistance after PCV13 replacement with PCV10, Sweden. (PubMed, J Infect) - "Serotypes 19A and 3 re-emerged as predominant, indicating the need for continued surveillance. Our study emphasises the risk of rapid serotype resurgence when lower-valency vaccines are reintroduced."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Serotype-specific immunity and association with pneumococcal carriage following 3+1, 3+0 and 2+1 schedules of 10-valent pneumococcal conjugate vaccine. (PubMed, J Infect Dis) - P2/3 | "We found no substantive evidence linking Bmem, IgG and OPA with pneumococcal carriage. Larger studies are needed to identify associations between different immunological parameters and carriage."

Journal • Infectious Disease • Pneumococcal Infections

Implementation of India's largest sentinel surveillance for meningitis: an exploratory qualitative analysis of the facilitators and challenges in this sentinel site network. (PubMed, Front Public Health) - "The Pneumococcal Conjugate Vaccine (PCV) was introduced into India's Universal Immunization Program in 2017 with PCV-13 across five states and was later replaced by the indigenously manufactured PCV-10 in 2019...A decentralized sentinel laboratory network with integrated data management and strong central coordination is crucial for effective monitoring. Based on this experience, establishing similar surveillance systems is recommended for countries to track circulating pneumococcal serotypes and support evidence-based vaccine decisions."

Journal • CNS Disorders • Infectious Disease • Pneumococcal Infections • Pneumonia

BURDEN OF PCV10/13/20/21/24-UNIQUE PNEUMOCOCCAL SEROTYPES IN INVASIVE PNEUMOCOCCAL DISEASE IN CHILDREN UNDER FIVE YEARS OF AGE IN RURAL GAMBIA (ESPID 2026) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections

SEROTYPE-SPECIFIC PNEUMOCOCCAL COLONIZATION IN CHILDREN UNDER 5 YEARS, ONE YEAR AFTER TRANSITIONING TO A REDUCED 10-VALENT PCV (PCV10-SII) IN SOUTH AFRICA'S EXPANDED PROGRAM ON IMMUNISATION (ISPPD 2026) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections

LONG-TERM IMMUNOGENICITY OF A REDUCED 1+1 COMPARED WITH 2+1 SCHEDULE OF PCV10 AND PCV13 IN SOUTH AFRICAN CHILDREN UP TO 5 YEARS: A RANDOMIZED TRIAL (ISPPD 2026) - No abstract available

Clinical

SUSTAINED AND INDIRECT EFFECTS OF PCV10 REDUCED DOSE SCHEDULES ON PNEUMOCOCCAL CARRIAGE: A LONG-TERM FOLLOW-UP OF A CLUSTER RANDOMISED CONTROLLED TRIAL IN VIETNAM (ISPPD 2026) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections

PCV OPTIMISATION IN FIJI: ESTIMATED IMPACT OF A SWITCH FROM PCV10 3P+0 TO 1P+1 SCHEDULE: A MODELLING STUDY (ISPPD 2026) - No abstract available

EVALUATING THE SEROEFFICACY OF A NEW 10-VALENT PNEUMOCOCCAL CONJUGATE VACCINE (PNEUMOSIL®) AGAINST OTHER PNEUMOCOCCAL CONJUGATE VACCINES IN CHILDREN (ISPPD 2026) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections

SEROTYPE-SPECIFIC MEMORY B CELL RESPONSES FOLLOWING 1+1 SCHEDULES OF PCV10 AND PCV13 IN VIETNAM: RESULTS FROM A RANDOMISED CONTROLLED TRIAL (ISPPD 2026) - No abstract available

Clinical

Effectiveness of pneumococcal conjugate vaccines against invasive pneumococcal disease in Vietnamese children prior to national introduction: A matched case-control study. (PubMed, Vaccine) - "This first Vietnamese evidence demonstrates that PCV10 and PCV13 provide substantial protection against VT-IPD and overall IPD in young children despite low vaccine coverage. The predominance of serotype 19A and waning protection over time emphasize the importance of selecting 19A-containing formulations and booster schedules to inform timely national PCV introduction in Vietnam."

Journal • CNS Disorders • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Septic Shock

Streptococcus pneumoniae nasopharyngeal carriage in Vietnamese children during the first five years of life: a post hoc analysis. (PubMed, Lancet Reg Health West Pac) - "Serotype coverage was similar across products Pneumosil (68·6% [95% CI 65·5-71·7%], 595/867), Prevenar13 (70·0% [95% CI 67·0-73·1%], 607/867), and Vaxneuvance (70·0% [95% CI 67·0-73·1%], 607/867), and lower for Synflorix (41·5% [95% CI 38·2-44·8%], 360/867) p < 0·05 vs Pneumosil, Prevenar13 or Vaxneuvance...Serotype, lineage distribution, and prevalence of AMR genes across the sampled age groups remained consistent, indicating that these distributions are broadly representative of young unvaccinated children, helping to guide optimal approaches for pneumococcal surveillance in low- and middle-income countries. National Health and Medical Research Council, Bill & Melinda Gates Foundation, Murdoch Children's Research Institute."

Journal • Retrospective data • Infectious Disease • Pneumococcal Infections • Pneumonia

Comparative Whole Genome Sequencing of Seven Invasive Streptococcus pneumoniae Isolates from Malaysia Reveals Genetic Diversity, Recombination events, and Global Lineage Linkages. (PubMed, J Appl Microbiol) - "These findings underscore the critical role of recombination in shaping pneumococcal population structure, evolution, and adaptation."

Journal • CNS Disorders • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Septic Shock

Non-Vaccine Serotype Replacement and Subdominant Persistence of Vaccine Types in Nepalese Infants Following PCV10 Introduction. (PubMed, Vaccines (Basel)) - " While PCV10 reduced overall VT circulation, the persistence of VTs in subdominant niches creates a continuous reservoir for potential re-emergence and antibiotic resistance. This clear hierarchical shift in dominance towards NVTs underscores the urgent need for a public health strategy that includes the adoption of a higher-valent PCV to provide broader protection, and interventions targeting environmental risk factors are essential to sustain long-term reductions in pneumococcal colonization."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Genomic Surveillance Reveals Vaccine-Associated Shifts in Pediatric Invasive Streptococcus pneumoniae in Tunisia. (PubMed, Vaccines (Basel)) - " PCV10 introduction was associated with a marked reduction in vaccine-type IPD among young children, supporting its public health benefit. Ongoing genomic surveillance remains essential to monitor serotype replacement and antimicrobial resistance in Tunisia."

Journal • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia

Epidemiology, changing resistance trends and serotypes of Streptococcus pneumoniae in children in Chongqing, China, 2019-2024: a multicenter study. (PubMed, Front Cell Infect Microbiol) - "Except for vancomycin and linezolid...The resistance rates to trimethoprim/sulfamethoxazole, levofloxacin, and moxifloxacin were higher in non-IPD group than in IPD group, whereas chloramphenicol resistance was lower...PCV7, PCV10, and PCV13 covered 388 (64.6%), 440 (73.3%), and 501 (83.5%) strains, respectively. The resistance rates of S. pneumoniae to penicillin, trimethoprim/sulfamethoxazole, erythromycin, clindamycin, cefotaxime, and cefepime show significant downward trends over the six-year study period. The pneumococcal conjugate vaccine PCV13 can effectively cover the major drug-resistant serotypes in China, and PCV 13 is therefore recommended for the prevention of S. pneumoniae infection. These findings contribute to informed and clinical policy decisions for prevention and treatment."

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia

Effectiveness of 10-valent pneumococcal conjugate vaccine against radiologically confirmed pneumonia and invasive pneumococcal disease among young children in Mozambique. (PubMed, Vaccine) - "PCV10 offers substantial protection against RCP in young children in a high burden setting, highlighting its importance for reducing child pneumonia globally."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Antibiogram profiles and genetic characteristics of Streptococcus pneumoniae clinical isolates from Pakistan. (PubMed, Pak J Pharm Sci) - "These findings underscore the growing prevalence of antibiotic-resistant S. pneumoniae in Pakistan and highlight the urgent need for enhanced antimicrobial stewardship, improved surveillance systems and preventive measures to address the rising threat of resistant strains and shifting serotype distribution."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Whole genome sequencing analysis of Streptococcus pneumoniae populations of serotypes 10A, 11A, 12F, 15B, and 33F involved in invasive pneumococcal disease in the Czech Republic in 2013-2023. (PubMed, Epidemiol Mikrobiol Imunol) - "Both Czech and European populations of S. pneumoniae of different serotypes show considerable heterogeneity. They include serotypes in which related isolates of a single ST (11A) predominate, as well as serotypes that consist of several completely unrelated clusters (12F, 15B). The structures of these individual populations are continually changing over time and also differ within individual European countries. It is important to monitor S. pneumoniae populations as closely as possible and to use the data obtained to evaluate the possibilities for introducing new PCVs in the Czech Republic."

Journal • Infectious Disease • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia

Determining the dose-response relationship for pneumococcal conjugate vaccines: a nested analysis of the fractional dose PCV trial. (PubMed, Vaccine) - P4 | "Our findings suggest that available PCV10/13 could be reformulated to optimize protective responses."

Clinical • Journal • Infectious Disease • Pneumococcal Infections

Nasopharyngeal pneumococcal carriage in Indian children following 10-valent PCV (PNEUMOSIL®) introduction through India's universal immunization program: A post licensure cross-sectional study. (PubMed, Vaccine) - "The observed reduction in VT-carriage amongst Indian children was comparable to that observed with other PCVs that have demonstrated marked declines in disease transmission. These results suggest PNEUMOSIL® could be an effective public health tool in decreasing pneumococcal disease."

Journal • Observational data • Infectious Disease • Pneumococcal Infections • Pneumonia

Long-Term Impact of Pneumococcal Conjugate Vaccines on the Burden of Pneumococcal Meningitis in Mozambique, 2013-2023. (PubMed, Vaccines (Basel)) - "Since the introduction of PCVs in Mozambique, the burden of pneumococcal meningitis and deaths in children under 5 years of age has substantially decreased, as well as the prevalence of PCV13-serotypes. Higher valency PCVs are needed due to the increased prevalence of non-PCV10/13-serotypes."

Journal • CNS Disorders • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

OPTIMAL: Opportunistic Pneumococcal Immunisation Trial in MALnutrition (clinicaltrials.gov) - P4 | N=214 | Not yet recruiting | Sponsor: Nick Fancourt | Initiation date: Apr 2025 ➔ Jan 2026 | Trial primary completion date: Dec 2027 ➔ Mar 2028

Trial initiation date • Trial primary completion date • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases