Pneumosil (10-valent pneumococcal conjugate vaccine) / Serum Institute of India, Ligand - LARVOL DELTA

Effectiveness of PCV10 and PCV13 against invasive pneumococcal disease in Vietnamese children: a multi-centre matched case–control study (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections

Nasopharyngeal pneumococcal carriage and serotype distribution among Ethiopian children under five years of age after PCV10 introduction: findings from a national multisite study (ESCMID Global 2026) - No abstract available

Clinical • Infectious Disease • Pneumococcal Infections

Non-Vaccine Serotype Replacement and Subdominant Persistence of Vaccine Types in Nepalese Infants Following PCV10 Introduction. (PubMed, Vaccines (Basel)) - " While PCV10 reduced overall VT circulation, the persistence of VTs in subdominant niches creates a continuous reservoir for potential re-emergence and antibiotic resistance. This clear hierarchical shift in dominance towards NVTs underscores the urgent need for a public health strategy that includes the adoption of a higher-valent PCV to provide broader protection, and interventions targeting environmental risk factors are essential to sustain long-term reductions in pneumococcal colonization."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Genomic Surveillance Reveals Vaccine-Associated Shifts in Pediatric Invasive Streptococcus pneumoniae in Tunisia. (PubMed, Vaccines (Basel)) - " PCV10 introduction was associated with a marked reduction in vaccine-type IPD among young children, supporting its public health benefit. Ongoing genomic surveillance remains essential to monitor serotype replacement and antimicrobial resistance in Tunisia."

Journal • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia

Epidemiology, changing resistance trends and serotypes of Streptococcus pneumoniae in children in Chongqing, China, 2019-2024: a multicenter study. (PubMed, Front Cell Infect Microbiol) - "Except for vancomycin and linezolid...The resistance rates to trimethoprim/sulfamethoxazole, levofloxacin, and moxifloxacin were higher in non-IPD group than in IPD group, whereas chloramphenicol resistance was lower...PCV7, PCV10, and PCV13 covered 388 (64.6%), 440 (73.3%), and 501 (83.5%) strains, respectively. The resistance rates of S. pneumoniae to penicillin, trimethoprim/sulfamethoxazole, erythromycin, clindamycin, cefotaxime, and cefepime show significant downward trends over the six-year study period. The pneumococcal conjugate vaccine PCV13 can effectively cover the major drug-resistant serotypes in China, and PCV 13 is therefore recommended for the prevention of S. pneumoniae infection. These findings contribute to informed and clinical policy decisions for prevention and treatment."

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia

Effectiveness of 10-valent pneumococcal conjugate vaccine against radiologically confirmed pneumonia and invasive pneumococcal disease among young children in Mozambique. (PubMed, Vaccine) - "PCV10 offers substantial protection against RCP in young children in a high burden setting, highlighting its importance for reducing child pneumonia globally."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Antibiogram profiles and genetic characteristics of Streptococcus pneumoniae clinical isolates from Pakistan. (PubMed, Pak J Pharm Sci) - "These findings underscore the growing prevalence of antibiotic-resistant S. pneumoniae in Pakistan and highlight the urgent need for enhanced antimicrobial stewardship, improved surveillance systems and preventive measures to address the rising threat of resistant strains and shifting serotype distribution."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Whole genome sequencing analysis of Streptococcus pneumoniae populations of serotypes 10A, 11A, 12F, 15B, and 33F involved in invasive pneumococcal disease in the Czech Republic in 2013-2023. (PubMed, Epidemiol Mikrobiol Imunol) - "Both Czech and European populations of S. pneumoniae of different serotypes show considerable heterogeneity. They include serotypes in which related isolates of a single ST (11A) predominate, as well as serotypes that consist of several completely unrelated clusters (12F, 15B). The structures of these individual populations are continually changing over time and also differ within individual European countries. It is important to monitor S. pneumoniae populations as closely as possible and to use the data obtained to evaluate the possibilities for introducing new PCVs in the Czech Republic."

Journal • Infectious Disease • Novel Coronavirus Disease • Pneumococcal Infections • Pneumonia

Determining the dose-response relationship for pneumococcal conjugate vaccines: a nested analysis of the fractional dose PCV trial. (PubMed, Vaccine) - P4 | "Our findings suggest that available PCV10/13 could be reformulated to optimize protective responses."

Clinical • Journal • Infectious Disease • Pneumococcal Infections

Nasopharyngeal pneumococcal carriage in Indian children following 10-valent PCV (PNEUMOSIL®) introduction through India's universal immunization program: A post licensure cross-sectional study. (PubMed, Vaccine) - "The observed reduction in VT-carriage amongst Indian children was comparable to that observed with other PCVs that have demonstrated marked declines in disease transmission. These results suggest PNEUMOSIL® could be an effective public health tool in decreasing pneumococcal disease."

Journal • Observational data • Infectious Disease • Pneumococcal Infections • Pneumonia

Long-Term Impact of Pneumococcal Conjugate Vaccines on the Burden of Pneumococcal Meningitis in Mozambique, 2013-2023. (PubMed, Vaccines (Basel)) - "Since the introduction of PCVs in Mozambique, the burden of pneumococcal meningitis and deaths in children under 5 years of age has substantially decreased, as well as the prevalence of PCV13-serotypes. Higher valency PCVs are needed due to the increased prevalence of non-PCV10/13-serotypes."

Journal • CNS Disorders • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

OPTIMAL: Opportunistic Pneumococcal Immunisation Trial in MALnutrition (clinicaltrials.gov) - P4 | N=214 | Not yet recruiting | Sponsor: Nick Fancourt | Initiation date: Apr 2025 ➔ Jan 2026 | Trial primary completion date: Dec 2027 ➔ Mar 2028

Trial initiation date • Trial primary completion date • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Serotypes, antibiotic susceptibility and whole-genome characterization of Streptococcus pneumoniae in Sichuan Province, China in 2023. (PubMed, J Med Microbiol) - "Vaccine coverage rates were 45.71% for PCV7/PCV10, 64.76% for PCV13, 69.52% for PCV20 and 70.48% for PPV23. All isolates were susceptible to linezolid and vancomycin, but high resistance was observed to erythromycin (92.38%), clindamycin (82.86%), tetracycline (86.87%) and trimethoprim/sulfamethoxazole (60.95%)...Our study provides reliable information, including the prevalence, molecular characterization and antimicrobial resistance of S. pneumoniae isolates in Sichuan Province of China in 2023. The high MDR rate and predominance of vaccine-covered serotypes highlight the urgent need for enhanced surveillance, rational antibiotic use and broader implementation of pneumococcal vaccines, including the potential introduction of PCV20."

Journal • CNS Disorders • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Pneumococcal vaccines: A dose of change. Vaccine failures and breakthrough infections in Belgian children during the PCV13 era (2019-2024). (PubMed, Vaccine) - "These findings provide the first national baseline of vaccine failures, offering a reference point for evaluating PCV20 introduction. Continued monitoring will be essential to assess the real-world impact of higher-valent pneumococcal vaccines and to guide evidence-based vaccination policy."

Journal • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Pneumococcal Vaccination of Adults in Italy: What Strategies? (PubMed, J Prev Med Hyg) - "In 2010, the 13-valent pneumococcal vaccine (PCV13) and 10-valent pneumococcal vaccine (PCV10) were approved...Regarding compliance, all possible strategies must be activated in order to raise public awareness of the risks of pneumococcal disease and the benefits of vaccination, so as to increase coverage rates. A thorough analysis of epidemiological and clinical data, combined with an assessment of the economic and social impact, is crucial to guiding vaccination policies and supporting efficient decision-making in order to protect the health of the entire population."

Journal • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia

Evolution of pneumococcal serotype 19A in children in Bangladesh: insights from genomic analysis. (PubMed, BMC Microbiol) - "This study presents the first comprehensive genomic analysis of the serotype 19A population in Bangladesh, supporting the decision to introduce PCV10 in Bangladesh based on local pneumococcal serotype burden data. However, the rapid evolution within the local 19A population highlights the need for continuous epidemiological and genomic surveillance to support effective vaccination programs."

Journal • Infectious Disease • Otorhinolaryngology • Pneumococcal Infections • Pneumonia

Safety and coverage of Pneumosil pneumococcal polysaccharide conjugate vaccine (10-valent PCV) in a camp for internally displaced persons in Somaliland. (PubMed, Vaccine) - P4 | "Vaccination of children PCV10-SII resulted in a small number of AEFIs. Campaign coverage suggests high acceptability of a newly introduced vaccine amongst IDPs in Somaliland."

Journal • Infectious Disease • Pneumococcal Infections

Large Reductions in Invasive Pneumococcal Disease and Related Morbidities Among Children in New Zealand After Change from PCV10 to PCV13. (PubMed, J Infect Dis) - "The timely change in pneumococcal vaccine and subsequent incidence decreases underscores the importance of epidemiology-driven decisions."

Journal • Infectious Disease • Pediatrics • Pneumococcal Infections

Population snapshot of Streptococcus pneumoniae causing invasive disease among adults aged ≥18 years in South Africa before and after implementation of pneumococcal conjugate vaccines in 2005-2020. (PubMed, Microb Genom) - "All GPSC9/CC63 isolates sequenced from the pre-PCV period (n=3) expressed serotype 14; however, during the late-PCV13 period, nearly all (88.2%, 15/17) were serotype 15A. The emergence among non-PCV13 serotypes, of lineages usually associated with PCV13 serotypes (such as GPSC5/CC172 and GPSC9/CC63), warrants continued genomic surveillance in South Africa, more so as PCV10 (Pneumosil) replaced PCV13 in South Africa in 2024."

Journal • Infectious Disease • Pneumococcal Infections • Pneumonia

Evolving pneumococcal epidemiology and vaccine impact in the Netherlands, 2004-2024: carriage and invasive disease. (PubMed, J Infect) - "This study shows stabilized pneumococcal carriage from 2018-2023 with low invasive disease potential for common serotypes, except for serotype 19A. However, rising IPD incidence from other non-vaccine serotypes highlights the need for higher-valency vaccines. The newly introduced PCV15 covers 58% of IPD cases, while PCV20 could cover 73%."

Journal • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia

Pneumococcal meningitis in Mexico. Serotype distribution and antimicrobial resistance before and after the introduction of pneumococcal conjugate vaccines in pediatric patients. Results from the GIVEBPVac group. (PubMed, J Infect Public Health) - "PCVs significantly reduced the burden of pneumococcal meningitis in Mexican children. However, the emergence of non-vaccine serotypes and the persistence of serotype 19 A highlights the need for continued surveillance and evaluation of higher-valent vaccines to inform future immunization strategies."

Journal • CNS Disorders • Infectious Disease • Pediatrics • Pneumococcal Infections • Pneumonia

Effectiveness of Pneumococcal Vaccines in Preventing Otitis Media in Children: A Targeted Literature Review (ISPOR-EU 2025) - "Median (range) of point VE estimates against all-cause OM/AOM across these three studies was 14% (2─27%) for PCV13 and 18% (5─42%) for PCV10; VE against pneumococcal OM was 86% for PCV13... This review supports the effectiveness of PCVs in reducing OM/AOM, particularly pneumococcal OM/AOM. However, evidence from RCTs is limited. VE estimates from observational studies vary substantially, likely due to heterogeneity in methodologies."

Clinical • Pneumococcal vaccines • Review • Infectious Disease • Otorhinolaryngology • Pneumococcal Infections

Impact of early life malaria chemoprevention on immunogenicity of pneumococcal vaccination in childhood (ASTMH 2025) - P3 | "While intermittent preventive treatment in childhood (IPTc) reduces malaria burden, its impact on immune responses to vaccines such as the pneumococcal conjugate vaccine (PCV-10; given at 6, 10, and 14 weeks in Uganda) remains unclear...IgG concentrations to all serotypes increased from week 8 to week 24, and from week 24 to week 52, in most but not all participants, indicating successful vaccine priming and boosting. Preliminary analyses also suggest differences by malaria exposure history; unblinded analyses by study arms will be shared at the meeting."

Clinical • Pneumococcal vaccines • Infectious Disease • Malaria • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Pneumococcal Serotype Replacement in the Post-PCV Era: Implications for Vaccine Policy in Bangladesh (ASTMH 2025) - "Our findings show persistently low detection of PCV-10 serotypes even a decade after its introduction, while non-PCV-10 serotypes—particularly those covered by PCV-13 and PCV-20—continue to circulate widely in Bangladesh. This underscores the evolving pneumococcal serotype landscape and highlights the need for continuous surveillance to inform future vaccination strategies."

CNS Disorders • Infectious Disease • Pneumococcal Infections • Pneumonia • Respiratory Diseases • Septic Shock

Hospital-Based Surveillance of Pediatric Invasive Pneumococcal Diseases, 2016-2023 in Korea: Serotype Trends and Vaccination Policy. (PubMed, J Korean Med Sci) - "Given the approval of two new PCVs, the study results identified the substantial contribution of non-PCV13 serotypes to pediatric IPD and provide critical insights for optimal vaccination strategies to protect children against pneumococcal diseases."

Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Pneumococcal Infections • Pneumonia • Respiratory Diseases