Cogenzia (gentamicin) / Innocoll - LARVOL DELTA

COACT-2: Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers (clinicaltrials.gov) - P3; N=524; Completed; Sponsor: Innocoll; Active, not recruiting ➔ Completed

Clinical • Combination therapy • Trial completion • Diabetes • Infectious Disease • Metabolic Disorders

COACT-1: Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers (clinicaltrials.gov) - P3; N=612; Completed; Sponsor: Innocoll; Active, not recruiting ➔ Completed

Clinical • Combination therapy • Trial completion • Diabetes • Infectious Disease • Metabolic Disorders

Does routine topical antimicrobial administration prevent sternal wound infection after cardiac surgery? (PubMed, Interact Cardiovasc Thorac Surg) - "Lower evidence observational studies found benefit in the use of different regimes, including: combination of vancomycin paste and subcutaneous gentamycin; combined cefazoline and gentamicin spray; isolated cefazolin; bacitracin ointment; and rifampicin irrigation. The strongest evidence, derived from 2 meta-analyses, is related to the use of gentamicin-collagen sponges and topical vancomycin. Heterogeneity throughout studies regarding antibiotic agents, dosages, application protocols and SWI definition makes providing general recommendations challenging."

Journal • Cardiovascular

Study of a Topical Gentamicin-Collagen Sponge Along With Systemic Antibiotic in Infected Diabetic Foot Ulcers (clinicaltrials.gov) - P3; N=500; Recruiting; Sponsor: Innocoll; Not yet recruiting -> Recruiting

Enrollment open • Biosimilar • Diabetes • Immunology

Ultralow anterior resection with implantation of gentamicin-collagen sponge and no defunctioning stoma: anastomotic leakage and local cancer relapse. (PubMed, Radiol Oncol) - "It was highly significantly more common and developed earlier in patients who have had AL when compared with non-AL group: 80% vs. 9% (P = 0.00001) and 8.5 vs. 17 months (P = 0.014), respectively. Conclusions Anastomosis wrapping with GCS after anterior resection with TME is a safe procedure resulting in the low incidence of anastomotic leakage which may be also associated with decreased risk of local relapse."

Journal

A survey of practice and opinions on the use of topical antibiotics to prevent surgical site infection: more confusion than consensus. (PubMed, J Antimicrob Chemother) - "Most respondents did not use or recommend topical antibiotics to prevent SSI; of those that did, gentamicin collagen sponges were most commonly used (24/96 responses, 25%)...There are diverse opinions and practices among healthcare professionals about the use of topical antibiotics for the prevention of SSI. This considerable, and possibly inappropriate, variation in clinical practice needs to be addressed as part of antibiotic stewardship."

Journal

Can Gentamicin-collagen Sponges Prevent Seroma Formation Following Mastectomy? (PubMed, Clin Breast Cancer) - "Application of GC sponges significantly lowered the incidence of CSS. The incidence of SSI was halved, although this was not significant."

Journal

A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection. (PubMed, BMC Infect Dis) - P4; "The gentamicin-sponge was very well tolerated, but did not significantly influence overall cure."

Clinical • Combination therapy • Journal