pentoxifylline / Generic mfg. - LARVOL DELTA

Sickle cell disease presenting with chronic lower extremity ulcers (ASH 2025) - "Additionally, therapies for SCD, like hydroxyurea, can lead to ulcers by causing epidermal toxicity, altering microcirculation, and inducing tissue anoxia...Newer modalities of treatment, like glycosaminoglycans, growth factors, skin grafting, zinc, L-carnitine, and pentoxifylline, are mostly anecdotal and lack robust evidence...Conclusions Managing LEU in patients with SCD requires a multidisciplinary approach with meticulous wound care, appropriate pharmacotherapy, and addressing comorbid conditions to prevent recurrence, delayed wound healing, and profound impact on quality of life. Further research is necessary to establish more effective treatment protocols and reduce the burden of this debilitating complication."

Cardiovascular • Complement-mediated Rare Disorders • Diabetes • Genetic Disorders • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Metabolic Disorders • Mood Disorders • Peripheral Arterial Disease • Peripheral Neuropathic Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Retinal Disorders • Sickle Cell Disease • Vasculitis • BMP6 • HP

Pentoxifylline vaginal gel improves sperm motility and vitality in asthenozoospermic males: A randomized, blinded, in vitro study. (PubMed, Front Pharmacol) - "The PKB171 4% gel significantly improves progressive motility and preserves sperm vitality in sperm samples from asthenozoospermic males. These promising in vitro findings require further clinical investigation to confirm the potential benefits in infertile couples with male infertility."

Journal • Preclinical • Infertility • Sexual Disorders

P048 Lenalidomide use in recalcitrant inflammatory dermatoses: a trio of successes. (PubMed, Br J Dermatol) - "A 36-year-old woman with recurrent aphthous stomatitis had not responded to treatment with colchicine, pentoxifylline, azathioprine, dapsone or mycophenolate mofetil...A 49-year-old woman with severe recalcitrant cutaneous discoid lupus erythematosus (CDLE), systemic lupus and Raynaud phenomenon with chilblains had not responded to, had intolerance to or had adverse side-effects with multiple systemic agents including hydroxychloroquine, mepacrine, dapsone, rituximab biosimilar, mycophenolate mofetil, fumaric acid esters, acitretin, ciclosporin, thalidomide (tremor/loss of concentration), belimumab and methotrexate...Baseline and renal function monitoring is required for dose adjustment, and strict adherence to pregnancy prevention programmes is necessitated due to teratogenicity. Our three cases demonstrate lenalidomide to be a clinically beneficial, fast-acting and well-tolerated alternative off-label option for recalcitrant inflammatory dermatoses."

Journal • Cardiovascular • Cataract • Dental Disorders • Dermatology • Discoid Lupus Erythematosus • Hematological Disorders • Hematological Malignancies • Immunology • Inflammatory Arthritis • Lupus • Lymphoma • Movement Disorders • Multiple Myeloma • Myelodysplastic Syndrome • Neutropenia • Oncology • Ophthalmology • Pain • Peripheral Neuropathic Pain • Rheumatology • Stomatitis • Systemic Lupus Erythematosus • Thrombocytopenia • IL12A • IL6

Role of brain-gut axis in mechanism of gastrointestinal defense. (PubMed, J Physiol Pharmacol) - "Pharmacological agents, affecting mucosal blood flow, such as cyclooxygenase (COX) products, COX inhibitors and pentoxifylline, are also able to modify functions of the brain-gut axis. We conclude that brain-gut axis plays a particularly important role in maintaining of mucosal barrier in GI-tract and alteration in its functions is implicated in pathogenesis of various diseases of the gut."

Journal • Review • Gastrointestinal Disorder • Oncology

Development and validation of UPLC-MS/MS method for detecting nootropic misuse in oral fluids: A step towards combating doping in Esports. (PubMed, Anal Chim Acta) - "This study establishes a robust and practical analytical method utilising oral fluid for the detection of nootropics relevant to doping control in Esports. The approach enables rapid, non-invasive sample collection and reliable quantification, offering the potential for routine pre-game and in-competition monitoring. While the method is validated, further investigation is warranted to define drug excretion profiles and detection windows in oral fluid under real-use conditions."

Journal

Hydrogen bond-mediated surface microenvironment regulation of folic acid-functionalized carbon dots for pentoxifylline drug sensing. (PubMed, Talanta) - "This work represents the first example of a fluorescence sensor for PTX detection and provides a promising candidate for practical applications in the field of medicine. The hydrogen bond-mediated surface microenvironment regulation strategy offers an innovative approach for probe design in future."

Journal • CNS Disorders • Vascular Neurology

Machine learning-based prediction of drug response in ischemia reperfusion animal model. (PubMed, Sci Rep) - "The models incorporated molecular and biochemical features to evaluate three drugs: trans-Anethole (TNA), pentoxifylline (PTX), and cyanidin-3-O-glucoside (Cy3G)...Feature selection identified one molecular marker (SOX5) and two biochemical markers (dP/dtmax and cTnT) as significant predictors of drug response. This integrative approach has the potential to enhance personalized therapy for myocardial ischemia by enabling precise drug response predictions and guiding the development of targeted treatment strategies."

Journal • Preclinical • Cardiovascular • Myocardial Ischemia • Reperfusion Injury

Isolated trigeminal sensory neuropathy in a patient with mixed connective tissue disease: A diagnostic challenge (EHF-EHC 2025) - "Chronic medication included gabapentin 100mg three times daily, prednisolone 10mg, hydroxychloroquine 400mg, aspirin 150mg, pentoxifylline 400mg, nifedipine 20mg, furosemide, tadalafil and ambrisentan. This case highlights the importance of considering autoimmune mechanisms in isolated trigeminal neuropathies, especially in patients with systemic connective tissue disease. EMG may assist in detecting trigeminal dysfunction, and intrathecal autoantibodies, even without structural lesions, support an immune-mediated process and underscore the value of CSF analysis in atypical neurological presentations."

Clinical • Cardiovascular • Immunology • Melanoma • Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Rheumatology • Solid Tumor

Efficacy of Oral and Intralesional Pentoxifylline in Grade II and Grade III Oral Submucous Fibrosis: a Systematic Review. (PubMed, J Maxillofac Oral Surg) - "Among these, oral pentoxifylline in combination with intralesional injections of dexamethasone and hyaluronidase have shown promising results. The therapeutic benefits of oral pentoxifylline are unclear in terms of patient compliance as well as the side effects that may result due to its route of administration as compared to intralesional pentoxifylline combined with other intralesional steroids, where the effect will be seen in local tissues with nil or minimal side effects. Hereby proves beneficial in improving the symptoms of the disease."

Journal • Review • Fibrosis • Immune Modulation • Immunology • Pain

Effect of Pentoxifylline + CoQ10 vs CoQ10 Alone on Sperm Motility in Subfertile Men With Asthenozoospermia (clinicaltrials.gov) - P=N/A | N=56 | Recruiting | Sponsor: Mst.Sumyara Khatun

New trial

Exploring the role of pentoxifylline as a renal protector in diabetic kidney disease: a comprehensive review. (PubMed, BMC Nephrol) - "Studies indicate that pentoxifylline can reduce proteinuria, improve glomerular filtration rate, and protect against kidney fibrosis in DKD, offering a multifaceted approach to disease management. By addressing several key pathways in DKD progression, pentoxifylline may provide an essential addition to existing therapeutic strategies, especially in patients with advanced disease."

Journal • Review • Chronic Kidney Disease • Diabetic Nephropathy • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX-trial). (PubMed, Br J Clin Pharmacol) - "In this dose-finding trial for PTX in preterm neonates, our findings reveal no discernible clinical advantage associated with either increasing or decreasing the PTX dosage. The relatively high variability in sepsis severity and patients' post-natal ages increase the uncertainty of our findings, but the standardly used dosage of 30 mg/kg/day (5 mg/kg/h for 6 h) has consistently demonstrated safe tolerability without any reported severe adverse events."

Journal • Infectious Disease • Septic Shock

Adaptive Phase 2/3 Study for PCS499 (499) in Patients with FSGS (KIDNEY WEEK 2025) - "499 Background: Pentoxifylline (PTX) (FDA approved but not for PGD) has 7 active metabolites including its major metabolite, the S isomer of lisophylline (S-M1). ● What dosage regimen provides an approvable safety-efficacy profile? Results Phase 2-3 programs evaluated: ● Phase 2 study followed by a standard Phase 3 study with an interim analysis to evaluate sample size re-estimation ● Seamless Phase 2/3 study with interim analysis to evaluate safety, drop (or add) a dose, and/or sample size re-estimation Conclusion PCSA will share different Phase 2-3 programs that may improve the efficiency of clinically evaluating 499 in FSGS."

Clinical • P2/3 data • Chronic Kidney Disease • Diabetic Nephropathy • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Lupus Nephritis • Nephrology • Renal Disease

Recurrent Martorell ulcer in a patient with hypertension: a therapeutic success with pentoxifylline. (PubMed, Wounds) - "This unique case highlights pentoxifylline as a potentially effective alternative treatment for Martorell ulcer in patients who are unable to undergo first-line treatments. The reproducibility of healing on recurrence in this case further supports consideration of this medication in select patients."

Journal • Cardiovascular • Hypertension

Medical Treatments and Outcomes in Acute Alcohol-Related Hepatitis. (PubMed, Clin Liver Dis) - "This review provides an overview of outcomes across the spectrum of disease severity in AH. We discuss current treatments available for AH, and how they apply to contemporary medical practice."

Journal • Review • Hepatology • Inflammation • Transplantation

Buerger's Disease: Successful Management of Acute Cutaneous Features and Achieving Disease Remission With Pentoxifylline. (PubMed, Australas J Dermatol) - "We describe a 46-year-old man with Buerger's disease, who achieved regression of acute ulceration of his lower limbs and remission of his disease with pentoxifylline. Usually thought to just improve pain-free walking distance, this is the first case that demonstrates pentoxifylline may in fact improve the acute cutaneous features and progression of Buerger's disease."

Journal • Inflammation • Pain

Malignant Atrophic Papulosis: A Manageable Death Sentence? (ASH 2024) - "Her ANA titer was positive.The patient was initially started on hydroxychloroquine, with improvement in her joint pains...However, she continued to develop skin lesions and migraines, for which she was prescribed nortriptyline.Three years after her initial onset of symptoms, she presented acutely to her local hospital with two months of worsening abdominal pain...Antiplatelet drugs such as aspirin, clopidogrel and pentoxifylline have been known to help but failed to halt the disease progression in this case...In our case, the patient noted significant improvement in her abdominal pain and overall condition after the very first infusion of eculizumab. This case emphasizes the importance of further research to manage patients with the malignant/systemic form of this disease and understand how it progresses. Further work should be done to assess the benefits of expedited use of eculizimab, and to identify the benefits of screening for systemic disease in patients with..."

CNS Disorders • Gastrointestinal Disorder • Infectious Disease • Migraine • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Thrombosis

Purine Derivatives in the Management of Antiresorptive Drug-Related Osteonecrosis of the Jaw. (PubMed, Curr Health Sci J) - "A study group of 23 consecutive patients was selected to receive adjunctive therapy with pentoxifylline (800 mg/day) and vitamin E (1000 IU/day) for six months, while the remaining 137 patients who were not eligible for pentoxifylline tretament formed the control group...Post-hoc power analysis showed that the study was strongly powered to detect the observed differences, supporting the reliability of the results. Treatment with purine derivatives demonstrates significant therapeutic potential in the management of antiresorptive drug-related osteonecrosis of the jaw and should be considered as complementary to the standard therapy, particularly in advanced stages of the disease."

Journal

Cocaine and Pentoxifylline (BED IN 47) (clinicaltrials.gov) - P1 | N=30 | Recruiting | Sponsor: William Stoops | Not yet recruiting ➔ Recruiting

Enrollment open • Inflammation

Combined benznidazole and pentoxifylline therapy improves behavioral and cognitive changes in association with the regulation of systemic inflammatory profile in chronic experimental Chagas disease. (PubMed, PLoS One) - "Moreover, principal components analysis (PCA-2D and 3D projections) underlined the distinction between the noninfected and vehicle-treated infected groups, while Bz + PTX-treated infected mice were closer to noninfected controls. The combined Bz + PTX therapy reduced parasite load and regulated pivotal neurochemical changes in the brain and the systemic inflammatory profile, improving behavioral and cognitive changes in a model of Chagas disease."

Journal • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Oncology • Psychiatry • TNFA

The effects of antioxidant supplementation on pain, oxidative stress markers, and clinical pregnancy rate in women with endometriosis: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Front Med (Lausanne)) - "This systematic review and meta-analysis included 21 randomized controlled trials involving 1,626 participants and evaluated more than 10 types of antioxidant supplementation, including vitamins, pentoxifylline, melatonin, astaxanthin, fish oil, and silymarin...Further large-scale and high-quality randomized controlled trials are needed to validate these results and establish optimal antioxidant strategies for long-term management of endometriosis. PROSPERO CRD420251071723, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD420251071723."

Journal • Retrospective data • Review • Endometriosis • Gynecology • Infertility • Inflammation • Musculoskeletal Pain • Pain • Sexual Disorders • Women's Health

Gut-liver axis in metabolic dysfunction-associated steatotic liver disease and alcoholic liver disease (FFS-AIH 2025) - "Through different pathways, gut microbiota is strongly entangled in the pathogenesis and the progression of liver injury in both MASLD and ALD patients. The results of this research is supported by many other studies. However, few studies showed different data when decreased levels of Parabacteroides genus, Prevotella, and Clostridium, with higher values of Lactobacillus and Bifidobacterium were observed in ALD."

Alcoholic Fatty Liver Disease • Fibrosis • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Liver Failure • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Solid Tumor

Radiation-Induced Skin Injury: Mechanisms, Clinical Manifestations, and Management. (PubMed, Int J Dermatol) - "For established disease, antimicrobial dressings shorten ulcer healing by 20%-40%, while long-term therapies including pentoxifylline-tocopherol, vascular lasers, and autologous fat grafting improve tissue pliability, pigmentation, and function...A proactive, multidisciplinary approach anchored by dermatologic expertise and evidence-based strategies is essential to reducing morbidity, enhancing healing, and improving quality of life. Given the worldwide use of radiotherapy, these approaches are intended to be adaptable across diverse healthcare systems, supporting dermatologists globally in patient care."

Journal • Review • Aesthetic Medicine • Dermatitis • Dermatology • Fibrosis • Genetic Disorders • Immunology • Oncology • Skin Cancer

Anti-Inflammatory Drugs for Alcoholic Liver Disease: A Systematic Review on Survival and Adverse Events. (PubMed, Int J Hepatol) - "The interventions compared to corticosteroids included pentoxifylline, anakinra, metadoxine, S-adenosylmethionine (SAMe), granulocyte colony-stimulating factor (G-CSF), rifaximin, and fecal microbiota transplantation (FMT) as monotherapies or combination regimens. The evidence is limited by significant study heterogeneity and a lack of high-quality RCTs. These limitations underscore the critical need for well-powered, rigorous RCTs with standardized survival and safety outcomes."

Adverse events • Journal • Review • Hepatology • Inflammation • Transplantation

Early outcomes of Gamma Knife stereotactic radiosurgery for symptomatic intracranial meningiomas in octogenarians: technique analysis and rationale. (PubMed, J Neurooncol) - "In our experience, SRS in octogenarian patients with symptomatic intracranial meningiomas provided early tumor control and was associated with a low risk of transient radiosurgical morbidity."

Journal • Retrospective data • Brain Cancer • CNS Disorders • Epilepsy • Meningioma • Oncology • Pain • Solid Tumor