pentoxifylline / Generic mfg. - LARVOL DELTA

Adjuvant Treatment with Pentoxifyline in Patients with CIMDL: Experience in a Rhinology Service (AAO-HNSF 2026) - "Pentoxifylline was well tolerated and may contribute to improved postoperative clinical outcomes in CIMDL, particularly regarding crusting control and infection reduction. Although limited by small sample size, these results support further controlled clinical studies to establish the role of pentoxifylline in standardized treatment protocols for CIMDL."

Clinical • Cardiovascular • Immunology • Infectious Disease • Inflammation • Otorhinolaryngology

Evidence-based Management of Osteoradionecrosis and Medication Related Osteonecrosis of the Head and Neck (AAO-HNSF 2026) - "We discuss evidence-based medical management of the disease including pentoxifylline and tocopherol...Expound on novel techniques involving vascularized tissue to reverse progression of ORN and MRON while utilizing bony reconstruction for more advanced cases • 3. Review classifications systems and propose a novel classification system that pairs extent of disease with escalating management"

Cognitive Disorders

Temporal Trends in Treatment Modalities for Osteoradionecrosis in Head and Neck Cancer (AAO-HNSF 2026) - "This analysis suggests management of ORN is shifting away from HBOT and towards increased medical management with pentoxifylline and vitamin E, but without a notable reduction in the need for surgical intervention. These analyses highlight the multi-modal treatment modalities for ORN."

Head and Neck Cancer • Oncology • Solid Tumor

Phosphodiesterase Inhibitors, Pentoxifylline, as Adjunctive Therapy in Patients With Ulcerative Colitis. (clinicaltrials.gov) - P2 | N=60 | Completed | Sponsor: Tanta University | Recruiting ➔ Completed | N=44 ➔ 60

Enrollment change • Trial completion • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Ulcerative Colitis

Exacerbation of focal hepatotoxicity with Axitinib after Stereotactic Body Radiotherapy (SBRT) to malignant Renal mass in close proximity to Liver and resolution after short term drug holiday: Possible radio-sensitization effect. (PubMed, Pract Radiat Oncol) - "To our knowledge, this is the first reported case of TKI-exaggerated radiation hepato necrosis following SBRT. Exaggerated hepatotoxicity resolving on withholding Axitinib, highlights the susceptibility of normal liver volume to this type of interaction. Close monitoring with empirical initiation of vascular-protective agents (pentoxifylline + vitamin E) can be considered once such changes are evident radiologically, avoiding invasive biopsies."

Journal • Genito-urinary Cancer • Hepatology • Kidney Cancer • Oncology • Pain • Renal Cell Carcinoma • Solid Tumor

How to Prepare Patients Receiving Antiresorptive Therapy for Tooth Extraction: A Narrative Review. (PubMed, Int J Mol Sci) - "Bisphosphonates (BPs) and Denosumab (DMB) are antiresorptive agents (AA) commonly used in treatment of osteoporosis, multiple myeloma (8.0%), breast cancer (3.3%), prostate cancer (2.9%) and other malignancies (0.7%), bone metastases, and cancer-induced hypercalcemia...Patients from a high-risk group of MRONJ, demonstrating cancer, who were administered intravenous antiresorptive agents for longer than three years or zoledronic acid, or those with a history of jawbone necrosis or inflammation require prolonged antibiotic therapy (started before the procedure and continued up to 14 days after the procedure)...Pentoxifylline with tocopherol and low-level laser therapy (LLLT) are recognized as potentially useful non-invasive preventions...AA therapy suspension prior to the surgical procedure must always be consulted with the attending physician. A multidisciplinary approach along with well-planned pre- and postoperative care is essential for safe tooth extraction in..."

Journal • Review • Breast Cancer • Endocrine Disorders • Genito-urinary Cancer • Hematological Malignancies • Metabolic Disorders • Multiple Myeloma • Oncology • Prostate Cancer • Rheumatology • Solid Tumor

EFFECTS OF PENTOXIFYLLINE IN ANIMALS WITH CHRONIC CHAGAS CARDIOMYOPATHY: A SYSTEMATIC REVIEW AND META-ANALYSIS (CHEST 2026) - No abstract available

Retrospective data • Review • Cardiomyopathy • Cardiovascular

Multimodal Abdominal Contouring Combining Injectable Lipolysis, Ultrasonic Cavitation, and Neuromuscular Electrical Stimulation: A Retrospective Case Series. (PubMed, Clin Cosmet Investig Dermatol) - "The first phase combined injectable lipolysis using sodium deoxycholate, pentoxifylline, and L-carnitine with ultrasonic cavitation (Mesolipo)...Nevertheless, the findings provide preliminary, descriptive, and hypothesis-generating observations regarding the feasibility of a multimodal approach to abdominal contouring. Prospective controlled studies with larger samples are needed to evaluate efficacy and determine the contribution of individual therapeutic components."

Journal • Retrospective data • Obesity

Advances in the prevention and management of bisphosphonate-related osteonecrosis of the jaw: A literature review. (PubMed, Stomatologija) - "Although emerging treatment methods show promising results, BRONJ continues to pose significant clinical challenges."

Journal • Review

Therapeutic Interventions for Radiation-Induced Fibrosis in Head and Neck Cancer Patients: A Systematic Review. (PubMed, Otolaryngol Head Neck Surg) - "Improvements in HNC fibrosis after current treatments ranged widely across studies; however, substantial heterogeneity in study design and outcome measurement limits definitive conclusions regarding comparative effectiveness."

Journal • Review • Aesthetic Medicine • Fibrosis • Head and Neck Cancer • Immunology • Oncology • Solid Tumor

PROTECT: Intravenous pentoxifylline as adjunct therapy to improve long-term disability in preterm infants (ANZCTR) - P3 | N=1300 | Active, not recruiting | Sponsor: University of Sydney | Recruiting ➔ Active, not recruiting

Enrollment closed • Gastrointestinal Disorder • Infectious Disease • Septic Shock

An Ascitic Mystery: Unmasking Sclerosing Mesenteritis (ACG 2026) - "Given the patientâs persistent symptoms and negative workup for malignancy or TB, empiric treatment for suspected SM was initiated with prednisone and tamoxifen...Alternative agents such as azathioprine, pentoxifylline, cyclophosphamide, and thalidomide have also been used with varying success. Obstructive symptoms need conservative therapy or surgical bypass if necessary. Figure: CT image depicting partially calcified sclerosing mesenteritis mass"

Cardiovascular • Fibrosis • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Neuroendocrine Tumor • Respiratory Diseases • Solid Tumor • Tuberculosis

Inflammation as a therapeutic target to improve kidney and cardiovascular outcomes. (PubMed, Nat Rev Nephrol) - "Investigational treatments that have targeted inflammation include inhibition of apoptosis signal-regulating kinase-1 (ASK1) by selonsertib, Janus kinase (JAK) 1/2 inhibition with baricitinib, protein kinase C-β (PKCβ) inhibition with ruboxistaurin, nuclear factor erythroid 2-related factor 2 (Nrf2) activation with bardoxolone, phosphodiesterase inhibition with pentoxifylline and monoclonal antibodies against IL-1β and IL-6. Furthermore, proven therapies for CKD, including renin-angiotensin-aldosterone system inhibitors, sodium-glucose cotransporter-2 inhibitors, glucagon-like peptide-1 receptor agonists and non-steroidal mineralocorticoid antagonists, possess anti-inflammatory properties that might contribute to their previously established clinical benefits."

Journal • Review • Atherosclerosis • Cardiovascular • Chronic Kidney Disease • Inflammation • Nephrology • Renal Disease • CRP • IL1B • IL6 • PRKCB

Fatal Radioembolization-Induced Liver Disease Following Y-90 Treatment for Hepatocellular Carcinoma (ACG 2026) - "He was treated with lactulose, prednisolone 60 mg daily, ursodiol 300 mg BID, pentoxifylline, and therapeutic enoxaparin for portal vein thrombosis. NCCN guidelines note increased REILD risk with bilirubin >2 mg/dL. This case underscores the need for rigorous pre-treatment liver reserve assessment, including ALBI scoring and volumetry, to minimize this fatal complication in cirrhotic patients"

Addiction (Opioid and Alcohol) • Alzheimer's Disease • Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • CNS Disorders • Dementia • Fibrosis • Hematological Disorders • Hepatocellular Cancer • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Oncology • Respiratory Diseases • Solid Tumor • Thrombocytopenia • Thrombosis

Topical Sirolimus for Refractory Cutis Marmorata Telangiectatica Congenita in Adulthood: A Case Report. (PubMed, J Drugs Dermatol) - "Multiple therapies targeting vasospasm and microvascular flow (including sildenafil, pentoxifylline, diosmiplex, nifedipine, and aspirin) failed to improve symptoms. Initiation of once-daily topical sirolimus (1 mg/mL) resulted in marked pain reduction within four weeks and cessation of new ulcerations, with visible improvement and healed erosions by two months. This case supports topical sirolimus as a promising off-label option for adult CMTC with chronic ulcerative disease."

Journal • Cardiovascular • Gastroenterology • Immunology • Inflammatory Bowel Disease • Pain • Rheumatology • Ulcerative Colitis • Vasculitis

Calcium ionophore supplementation for immature oocytes and pentoxifylline supplementation for immotile sperms: A study of embryo quality of difficult cases in in vitro fertilization in a mouse model. (PubMed, J Adv Pharm Technol Res) - "The quality of embryos after adding CaI and PTX (1st day - 58.3% and 3rd day - 33.3%) was significantly different from that without addition, although it was not different when compared to adding CaI alone or PTX alone. We conclude that in a mouse model, the addition of calcium for immature oocytes and PTX for immotile spermatozoa may assist in difficult cases in IVF practices, even though further research is needed, particularly in a clinical trial in human."

Journal • Preclinical • Gynecology

Effects of semaglutide on walking distance, symptoms and rescue treatment by baseline medical therapy and LDL cholesterol levels: insights from the STRIDE trial (ESC 2026) - "Medications were categorized by class (anti-hypertensive [AHTN], anti-thrombotic [ATT], lipid lowering [LLT], and therapies for claudication ([cilostazol or pentoxifylline, CT]). Of the 792 randomized participants, medication use at baseline was 88% AHTN, 84% LLT, 77% ATT, 35% SGLT2i, 14% CT. The proportion with LDL-C < 1.8 mmol/L (<70 mg/dL) and <1.4 mmol/L (<55 mg/dL) were 45% and 26%, respectively. The primary and secondary endpoints of change in MWD and PFWD at 52 weeks (Figure Panel A) were significantly improved with semaglutide with consistent benefit regardless of baseline medications or LDL-C."

Cardiovascular • Dyslipidemia • Peripheral Arterial Disease

Radiation-Induced Liver Disease Following Y-90 Radioembolization for Metastatic Neuroendocrine Tumor: A Case Report (ACG 2026) - "He was started on ursodiol and intravenous methylprednisolone followed by a prednisone taper...There is some evidence for prophylactic ursodiol with steroids, and recent work suggests benefit of pentoxifylline with anticoagulation. Ultimately, prophylaxis and early recognition remain essential. Further research into the mechanisms of RILD is warranted to enable development of novel therapeutic agents and improve patient survival."

Case report • Clinical • Metastases • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Liver Failure • Neuroendocrine Tumor • Oncology • Solid Tumor

Unexpected Synthesis of a Furoxan Derivative from 3-Acetyl-2,4,6-Trimethylpyridine: Structural Characterization and Biological Evaluation. (PubMed, Molecules) - "Finally, in vitro evaluations using a blood hyperviscosity model confirmed significant hemorheological efficacy, as compound 5 effectively prevented the rise in blood viscosity, outperforming the reference drug pentoxifylline. The convergence of computational insights and experimental functional activity establishes this novel bis(nicotinoyl)furoxan framework as a promising candidate for further hemorheological and cardioprotective applications."

Journal • MMP9

The adverse effects of testicular hyperthermia on semen quality in stallions are attenuated by oral pentoxifylline treatment. (PubMed, J Equine Vet Sci) - "In conclusion, oral pentoxifylline attenuates heat-induced spermatogenic dysfunction in stallions by reducing oxidative stress and apoptosis, supporting its potential as a pharmacological strategy to enhance recovery of semen quality following testicular injury."

Adverse events • Journal • CASP3 • CASP7

Effectiveness of Pentoxifylline in Adult Patients with COVID-19: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (PubMed, Curr Med Chem) - "The results of the present study suggest that pentoxifylline may reduce systemic inflammation and improve oxygenation in hospitalized adults with COVID-19. It may also be associated with reduced ICU admission; however, its effects on mortality, mechanical ventilation requirement, and hospital length of stay remain uncertain. Larger, rigorously designed randomized trials are needed to confirm these findings."

Clinical • Journal • Retrospective data • Infectious Disease • Inflammation • Novel Coronavirus Disease

Pharmacological interventions targeting cognition and related clinical outcomes in vascular dementia: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Eur J Clin Pharmacol) - "Galantamine and memantine showed small short-term cognitive effects; EGb 761® suggested a fragile, very low-certainty signal; patient-important benefits remain uncertain."

Clinical • Clinical data • Journal • Retrospective data • Review • Alzheimer's Disease • CNS Disorders • Dementia

Effect of pentoxifylline on inflammatory markers in non-diabetic chronic kidney disease patients: A prospective, interventional, open label. (PubMed, World J Nephrol) - "In non-diabetic CKD patients, adjunctive treatment with PTX was associated with significant decreases in C-reactive protein levels and proteinuria. The reduction in proteinuria was mainly explained by changes in mean arterial pressure, followed by changes in TNF-α, indicating that hemodynamic factors may play a more prominent role than inflammatory modulation in mediating this effect."

Journal • Chronic Kidney Disease • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Oncology • Renal Disease • CRP • IL6 • TNFA

Retraction Note: Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-α inhibition. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - No abstract available

Journal

PTX-5FU-VIT: Comparative Study of Topical Pentoxifylline Versus Topical 5-Fluorouracil Combined With Microneedling and NB-UVB for Stable Vitiligo (clinicaltrials.gov) - P=N/A | N=42 | Completed | Sponsor: Tanta University

New trial • Dermatology • Immunology • Vitiligo