amphetamine/dextroamphetamine immediate release tablet / Generic mfg. - LARVOL DELTA

A Sharp Mind, a Failing Heart: Cardiomyopathy From Chronic Adderall Use (SCCM 2026) - "Introduction: Stimulants like Adderall and Ritalin are widely prescribed for attention-deficit/hyperactivity disorder (ADHD). In this patient, severe global hypokinesis and reduced EF were disproportionate to an isolated LAD lesion and, in the absence of other causes, supported a diagnosis of Adderall-induced cardiomyopathy. Clinicians should maintain high suspicion in patients with unexplained LV dysfunction and a history of chronic stimulant use."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiomyopathy • Cardiovascular • CNS Disorders • Heart Failure • Hypertension • Immunology • Mood Disorders • Movement Disorders • Osteoarthritis • Pulmonary Disease • Respiratory Diseases • Restless Legs Syndrome • Sleep Disorder

Spontaneous Proximal Middle Cerebral Artery Dissection due to Stimulant-associated Vascular Injury (AAN 2026) - "Given the severity of her deficits, she received IV Tenecteplase and was transferred for thrombectomy...She was treated with IV eptifibatide and transitioned to aspirin 81 mg daily...Given her use of bupropion and Adderall, stimulant-associated vascular injury was considered... Intracranial arterial dissection (IAD) is a rare cause of stroke in the young that frequently requires angiography for diagnosis. Management remains unstandardized and necessitates broad differential consideration for underlying etiology. In our unique case, a potential cause may have been stimulant-associated vascular injury, as amphetamine derivatives have been linked to vasculopathy, vasospasm, and vessel wall injury."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • General Anxiety Disorder • Giant Cell Arteritis • Hematological Malignancies • Immunology • Ischemic stroke • Thrombosis

Assessing the AOU Database for Vascular Complications of Prescribed Stimulants (AAN 2026) - "Objective: To assess the All of Us (AOU) Database for Vascular Dissections occurring in patients prescribed amphetamine, dextroamphetamine, atomoxetine, and methylphenidate.Background: Greater than 5% of the American population use prescribed stimulants, including Adderall. Limited conclusions can be assessed without further controlling for other prescriptions, co-morbidities, and risk factors for dissection. This study displays an elevated risk profile compared to the literature-reported incidence. We recommend further investigation of the effect of prescription stimulants on arterial dissection."

Which Medication Improves Fatigue in Patients With Multiple Sclerosis (MS)?: A Systematic Review and Network Meta-analysis (AAN 2026) - "Objective: we designed this systematic review and network meta-analysis to compare the efficacy of Amantadine, Adderall, modafinil, and methylphenidate in treating MS-related fatigue, and improving processing speed in patients with MS.Background: Fatigue is a disabling symptom of multiple sclerosis (MS) with an unknown etiology. Among the prescribed medications for managing MS-related fatigue, only amantadine was found to be superior to placebo in improving the impact of fatigue on patients' lives."

Retrospective data • Review • CNS Disorders • Fatigue • Multiple Sclerosis

Acute Cardiovascular Responses to Amphetamine/Dextroamphetamine Salts (Adderall) in Adderall-Naïve Young Adults: A Randomized Clinical Trial. (PubMed, Mayo Clin Proc) - P4 | "Healthy Adderall-naïve participants consuming a single dose of Adderall manifest striking increases in BP, HR, and sympathetic activation, even at rest. These findings may have important mechanistic implications for understanding acute cardiovascular events associated with illicit Adderall use."

Clinical • Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Psychiatry

What Harm Can a Single Pill Do? Risks Associated With a Single Dose of Adderall. (PubMed, Mayo Clin Proc) - No abstract available

Journal

Stiff Person Syndrome: A Case Report. (PubMed, Cureus) - "Treatment for this patient included 10 mg Adderall daily, frequent ambulation, and appropriate sleep hygiene to improve wakefulness...This report aims to highlight the impact of early recognition on the initiation of therapy to minimize the progression of the disease. It stresses the importance of a multidisciplinary approach to treatment for the best clinical outcomes."

Journal • CNS Disorders • Excessive Daytime Sleepiness • Fatigue • Immunology • Mood Disorders • Movement Disorders • Muscle Spasticity • Musculoskeletal Pain • Narcolepsy • Obstructive Sleep Apnea • Pain • Psychiatry • Respiratory Diseases • Sleep Disorder

Durable Remission After Triple Therapy in New-Onset HFrEF: Implications for a Strategy of "Personalized GDMT". (PubMed, JACC Case Rep) - "Durable remission from new-onset HFrEF can be achieved with fewer drugs than quadruple GDMT. Diagnostic tools are needed to identify such patients."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

To choose or not to choose: Examining the influence of choice on elicitation of subjective and objective prescription stimulant placebo effects in the laboratory. (PubMed, Exp Clin Psychopharmacol) - "College students (N = 183; Mage = 19.48, 92.9% White non-Hispanic, 77.0% female) were randomized into choice (n = 95; ability to choose to ingest 10 mg Adderall [actually placebo]) or no-choice (n = 88; randomly assigned to receive drug [actually placebo] or no drug) conditions before completing subjective effect measures and cognitive tasks...These results provide further evidence of medium-large placebo effects for subjective, but not objective, outcomes following expected prescription stimulant use. Considerations surrounding methodological alterations to laboratory procedures which improve ecological validity are recommended to better understand the influence of both choice and prescription stimulant placebo effects."

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Restricted Supply, Rising Demand: Reimagining Prescription Stimulant Regulation Amid A National Shortage. (PubMed, J Law Med Ethics) - "This paper examines the prescription stimulant shortage in the United States, a crisis that has intensified since the FDA's 2022 announcement of an Adderall shortage...These reforms aim to balance the dual imperatives of preventing misuse and ensuring equitable access to medications for patients with legitimate medical needs. By offering a comprehensive analysis of the prescription stimulant shortage and actionable policy recommendations, this paper seeks to inform regulatory reform, foster a more adaptive, patient-centered approach to ADHD care, and provide a roadmap for addressing one of the most pressing healthcare challenges of our time."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Chronic Lithium Use Need Not Always Be "Chronic" (KIDNEY WEEK 2025) - "She was also taking low dose Adderall for ADHD...The rate of decline in eGFR is reported to be around 0.92 ml/min/1.73m2 per year of lithium treatment. While rapid decline in renal function with lithium levels being maintained in therapeutic range is rare, our case signifies the importance of maintaining high clinical suspicion and early diagnosis to prevent further decline in renal function."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Bipolar Disorder • Chronic Kidney Disease • CNS Disorders • Mood Disorders • Nephrology • Psychiatry • Renal Disease • Suicidal Ideation

Running into Trouble: A Case of Acute Liver Failure From Severe Rhabdomyolysis After a Marathon (ACG 2025) - "We present the case of a healthy young adult who developed acute fulminant liver failure and renal failure following marathon-associated heat stroke and rhabdomyolysis, possibly exacerbated by Adderall use.Case Description/ A 21-year-old male with a history of ADHD on Adderall presented with altered mental status during a marathon after reportedly ingesting Adderall mid-race...The patient was treated with N-acetylcysteine, hemodialysis, lactulose, and supportive ICU care...While rhabdomyolysis is typically associated with renal complications, this case underscores its potential to precipitate acute liver failure. Prompt recognition, early ICU intervention, and multidisciplinary management can lead to full recovery even in fulminant presentations.Figure: Figure 1: Pathology image showing hepatic fibrosis."

Clinical • Acute Kidney Injury • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Liver Failure • Nephrology • Psychiatry • Renal Disease

Stimulant-Induced Ischemic Colitis (ACG 2025) - "Of note, she had transitioned from lisdexamfetamine (Vyvanse) to amphetamine-dextroamphetamine (Adderall) one month prior for management of ADHD. Figure: Coronal image from a CT of the abdomen and pelvis with IV contrast that demonstrates circumferential wall thickening of the colon at the splenic flexure with associated mild peri-colonic fat stranding. Not captured on this single slice image is that these findings involve a longer segment of the colon including an entirety of the splenic flexure."

ADHD (Impulsive Aggression) • Atherosclerosis • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Dermatology • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Psychiatry • CRP

Local Data, National Crisis: Pediatric ADHD Treatment Disruptions Amid 2024 Stimulant Shortages (AACAP 2025) - "All data used were deidentified. Of 51 total encounters, the most commonly affected medication was Vyvanse (n = 20, 39.2%), followed by Concerta (n = 14, 27.5%), Focalin XR (n = 10, 19.6%), Ritalin (n = 4, 7.8%), and Adderall (n = 3, 5.9%). These findings provide a real-time clinical snapshot of how stimulant shortages disrupted ADHD care among vulnerable pediatric populations. Even when prescriptions were ultimately filled, the process introduced delays, suboptimal substitutions, and increased burdens on families and providers. These disruptions risk exacerbating symptoms such as impulsivity, inattention, and emotional dysregulation in youth."

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Pediatrics • Psychiatry

Perceived Risk and Prescription Amphetamine Misuse Among US High School Seniors: A Cross-Sectional Analysis. (PubMed, Subst Use Misuse) - "Perceived risk of occasional Adderall use was self-reported, with responses ranging from "No Risk" to "Great Risk." Weighted modified Poisson regression models with robust standard errors assessed the cross-sectional association between perceived risk of Adderall use and past 30-day prescription amphetamine misuse, adjusting for demographic covariates...Findings support the role of perceived risk as protective and underscore its relevance for early intervention strategies. Future longitudinal studies are needed to clarify the directionality and temporality of this association."

Journal

Intraoperative Hypotension in a Patient on Chronic Amphetamines: Anesthetic Challenges in Catecholamine-Depleted States [WITHDRAWN] (ASA 2025) - "A 40-year-old man with hypogonadal hypogonadism and ADHD on chronic Adderall therapy presented for excision of a buccal mucosal lesion and sialoadenectomy with ductal dilation...He was successfully extubated with stable vitals. This case underscores the anesthetic challenges posed by catecholamine-depleted patients on chronic amphetamine therapy."

Clinical • ADHD (Impulsive Aggression) • Anesthesia • Attention Deficit Hyperactivity Disorder • CNS Disorders • Endocrine Disorders • Hypotension • Psychiatry

Double Trouble: A Hemodynamic and Therapeutic Challenge (HFSA 2025) - "Based on initial RHC hemodynamics (Table 1) she was started on inhaled nitric oxide (iNO) for RV afterload reduction to improve PA-RV coupling that led to marked hemodynamic improvement.The patient was cautiously transitioned to sildenafil and macitentan...With resting gradients persistently >50 mm Hg despite high dose BB therapy, disopyramide was initiated. The RHC hemodynamics diagnosed severe pre-capillary PH suspected to be due to Group 1 disease given history of chronic adderall use... This case highlights the challenging pathophysiology of concomitant pre-capillary PH and LVOTO, where treatment for one may exacerbate the other. A cautious, hemodynamically guided approach is necessary for management with balanced medical therapy in such patients.Table 1: Right Heart Catheterization HemodynamicsRA Pressure22 mmHgRV Pressures71/10 mmHgPA Pressures67/31 (47) mmHgPCWP23 mmHgCO/CI (Fick)1.58 / 1.15 TPG24 mmHgPVR16.8 WuSVI17 mL/m2"

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiomyopathy • Cardiovascular • CNS Disorders • Hypertrophic Cardiomyopathy • Obstructive Hypertrophic Cardiomyopathy • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Understanding Path to Diagnosis, HCP Relationships, and Treatment Regimens Among People Living With Narcolepsy (WSS 2025) - "Current medications for narcolepsy most commonly included traditional stimulants (56%; [Adderall®, Ritalin®, etc.]) and antidepressants (38%). These findings highlight the challenges PWN face, emphasizing the need for expedited diagnosis and access to specialized healthcare. Despite greater satisfaction with care from sleep medicine specialists, there is a shortage in this field. This gap underscores the necessity for improved treatment regimens and enhanced discussions between PWN and HCPs to address mental health support and long-term planning."

Narcolepsy • Sleep Disorder

Challenges in the Treatment of Narcolepsy and the Positive Impact of Acetyl-L-Carnitine: A Case-Based Review with 20-Year Follow-Up (WSS 2025) - "Initial pharmacologic management included antidepressants, Modafinil, Armodafinil, Adderall, Concerta, Jornay, Vyvanse, and sodium oxybate (Xyrem). This case highlights the multifaceted challenges in narcolepsy management and proposes acetyl-L-carnitine as a potential adjuvant therapy in refractory cases. Given its safety profile and observed benefit in this case, ALCAR warrants further investigation through controlled clinical trials."

Clinical • Review • Barrett Esophagus • Cataplexy • CNS Disorders • Excessive Daytime Sleepiness • Gastrointestinal Disorder • Mental Retardation • Metabolic Disorders • Mood Disorders • Narcolepsy • Psychiatry • Sleep Disorder

Drugs for ADHD. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Ischemic cardiomyopathy in a 43-year-old male with stroke during admission: the role of chronic amphetamine-dextroamphetamine use. (PubMed, Int J Physiol Pathophysiol Pharmacol) - "Cardiomyopathy associated with amphetamine-dextroamphetamine (Adderall) use is an emerging and under-recognized clinical concern, particularly in the context of chronic stimulant exposure...Unlike prior reports of reversible non-ischemic cardiomyopathy, this case required surgical revascularization, underscoring the irreversible nature of the damage in some patients. It uniquely highlights the synergistic contribution of stimulant-induced toxicity and underlying CAD to the development of severe cardiac dysfunction."

Journal • Acute Coronary Syndrome • Atherosclerosis • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Diabetes • Fibrosis • Heart Failure • Hypertension • Metabolic Disorders • Pulmonary Disease

United States trends in non-prescribed use of Adderall and Ritalin: Population Assessment of Tobacco and Health (PATH) Study estimates from 2013 to 2022. (PubMed, Addiction) - "Despite an increase in dispensing of prescription stimulant medications in the United States, the prevalence of nonprescribed Ritalin or Adderall use does not appear to have increased, as assessed in the nationally representative Population Assessment of Tobacco and Health (PATH) Study. The prevalence of nonprescribed Ritalin or Adderall use among young adults aged 18-24, the age group with the highest nonprescribed use prevalence, declined 2013 to 2022."

Journal

Examining College Students’ Exposure to Substance Use Disorders and Attitudes Toward Treatment (CPDD 2025) - " We recruited college students from introductory psychology courses to take a voluntary survey in which they were randomly presented a vignette where the protagonist met DSM-5 SUD criteria involving 1 of 7 substances (tobacco, alcohol, cannabis, Adderall, cocaine, Vicodin, and heroin)... Exposure to situations involving persons with SUDs appears to be common among college students. Participants’ generally positive beliefs about SUD treatment effectiveness 1 contrasted with the relatively high rates of perceived non-treatment seeking behaviors among their family or friends with SUD. Our findings support current research efforts to examine possible roles of students in assisting friends or family members with SUD to avail of treatment."

Navigating the Labyrinth: Rapid Cycling Bipolar Disorder With Comorbid ADHD and Substance Use Disorder (APA 2025) - "Initially hyperverbal and anxious, she was redirectable but admitted to noncompliance with her medications, including Adderall and Abilify...Due to persistent hyperverbal speech and decreased sleep, Abilify was switched to Seroquel, titrated to 200 mg at bedtime...This case underscores the importance of a tailored treatment approach when addressing rapid-cycling bipolar disorder with comorbid conditions. Future studies should explore alternative treatments that effectively manage ADHD in the context of bipolar disorder and substance use, with a focus on minimizing the risk of addiction and mood destabilization."

Addiction (Opioid and Alcohol) • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Bipolar Disorder • CNS Disorders • Depression • Grave’s Disease • Insomnia • Major Depressive Disorder • Mood Disorders • Psychiatry • Sleep Disorder

A qualitative systematic thematic review of motivations for medical use of prescription stimulants among adults with ADHD. (PubMed, J Affect Disord) - "Improving access to non-pharmacological interventions and updating treatment guidelines remain essential. A multi-modal approach is required to optimize outcomes for adults with ADHD."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry