amphetamine/dextroamphetamine immediate release tablet / Generic mfg. - LARVOL DELTA

A Rare Case of Therapeutic Amphetamine-Dextroamphetamine-Induced Ischemic Colitis in a Middle-Aged Woman Without Traditional Vascular Risk Factors (ACG 2026) - "Amphetamine-dextroamphetamine (Adderall), commonly prescribed for ADHD, has rarely been implicated...Medications included amphetamine-dextroamphetamine ER 15 mg daily, semaglutide, escitalopram, clonidine, and rosuvastatin...The medication was discontinued, and the patient improved with IV fluids, ceftriaxone, and metronidazole...As prescription stimulant use increases, clinicians should remain aware of this rare adverse effect, as early recognition and discontinuation of the offending agent may prevent recurrent ischemia and complications. Figure: Ischemic-type changes characterized by hyalinization of the lamina propria (highlighted by the Sirius red stain), surface erosion, withering crypts and focal pseudomembranous exudates Figure: Segmental mucosal friability and ulcerative ischemic injury involving the sigmoid colon"

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Cognitive Disorders • Endometriosis • Gastroenterology • Gastrointestinal Disorder • Gynecology • Hematological Disorders • Immunology • Inflammation • Women's Health

Amphetamine-Associated Reversible Biventricular Cardiomyopathy Complicated by Acute Respiratory Failure: A Case Report. (PubMed, Cureus) - "A 26-year-old man presented approximately 33 hours after intentionally ingesting 25 20-mg extended-release mixed amphetamine salt tablets with lorazepam...At two-month follow-up, echocardiography showed complete recovery of biventricular function, with an ejection fraction of 55-60%. This case highlights profound but reversible biventricular cardiomyopathy following massive extended-release amphetamine overdose."

Journal • Acute Lung Injury • Cardiomyopathy • Cardiovascular • CNS Disorders • Congestive Heart Failure • Critical care • Depression • Heart Failure • Hypotension • Metabolic Disorders • Pain • Psychiatry • Pulmonary Embolism • Respiratory Diseases

Examining Increased Ritalin and Adderall Use Among Low-Income People Who Use Drugs: Mixed Methods Study. (PubMed, JMIR Form Res) - "Crack and methamphetamine are also frequently used in combination with opioids to offset the sedating effects of adulterants such as fentanyl and xylazine in the unregulated drug supply. The use of prescription stimulants appears to be increasingly common among new populations of people who use opioids, including those who report very low incomes and even homelessness. Additional research is warranted to examine how this type of polysubstance use may require different types of prevention strategies."

Journal • Addiction (Opioid and Alcohol) • Anesthesia

Incidence of Stimulant-Involved Fatal Overdoses Following the Stimulant Shortages in Rhode Island. (PubMed, Subst Use Misuse) - "In 2022, the Food and Drug Administration announced a shortage of immediate-release Adderall®...The number of stimulant-involved fatal overdoses has decreased. This data also suggests that there was not a significant increase in stimulant-involved fatal overdoses among individuals in stimulant treatment during the shortage, alleviating some concern that the shortage is driving stimulant-involved deaths."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

A Descriptive Survey of Student RN Anesthetists' Use of Cognitive Enhancers. (PubMed, J Nurs Educ) - "Adderall was the most commonly used CE, and 7% of the SRNAs (n = 8/114) reported taking CE without a prescription. These results provide a foundation for future research on the development of interventions to reduce SRNAs' CE use by promoting safer coping mechanisms."

Journal • Anesthesia

SMP: Effects of Stimulant Medications in PTSD (clinicaltrials.gov) - P1 | N=40 | Not yet recruiting | Sponsor: University of Chicago

New P1 trial • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

Let's Google It: Assessing the Readability ADHD-Related Terms Google Searches (APA 2026) - " The first 20 Google searches were analyzed for each: "ADHD," "ADD", "attention-deficit/hyperactivity disorder," "attention deficit disorder," "Ritalin," "Concerta," and "Adderall." Texts were evaluated for word count, complex words, syllables per word, and letters per word using the Good Calculators Flesch Kincaid Calculator. ADHD-related content is significantly more difficult to read than information about ADD or medications. The lower readability of medication-related content compared to diagnostic content may prioritize pharmacological treatments over understanding ADHD or considering other interventions. This readability gap presents an opportunity to enhance accessibility and health decision-making."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

ASCEND001: Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes (clinicaltrials.gov) - P=N/A | N=60 | Enrolling by invitation | Sponsor: Enhanced Emirates Limited

New trial • Real-world evidence

Crystal Clear: Purity of consumer-level methamphetamine samples and methamphetamine-adulteration of other drugs in Los Angeles, 2023-2025. (PubMed, medRxiv) - "As an unexpected component, the mean methamphetamine purity was 17.8% (SD 32.3%), and was mostly commonly found in samples expected to be fentanyl, heroin, MDMA, other amphetamines (e.g., counterfeit Adderall), and 2C-B. Future research should expand methamphetamine surveillance techniques and investigate how variability in illicit markets may impact health outcomes. Samples expected to contain methamphetamine had a mean purity of 72% (SD 24%).For 90% of samples expected to be meth, no other active compounds were detected.Meth was a substantial adulterant in other drugs, e.g. opioids (mean purity 17%)."

Journal • Cardiovascular • Psychiatry

Polysubstance use during pregnancy and preterm birth (PAS 2026) - "The three most prevalent substances used during pregnancy were alcohol (9.35%), cigarettes (7.11%), and marijuana (4.84%). The highly correlated substance combinations were cigarettes and e-cigarettes (correlation coefficient r=0.600), cigarettes and marijuana (r=0.553), cigarettes and amphetamines (r=0.595), cigarettes and methadone (r=0.620), e-cigarettes and methadone (r=.518), marijuana and amphetamines (r=0.635), Adderall and amphetamines (r=.636), and amphetamines and methadone (r=.689). The use of cigarettes and marijuana (confounder-adjusted odds ratio or aOR=1.59 [95% confidence intervention or CI, 1.29-1.95]; p-value < 0.001) as well as the use of cigarettes and amphetamines (aOR=1.71 [95% CI, 1.18-2.48]; p-value=0.005) was associated with increased odds of preterm birth compared to non-users."

Prematurity

College students' conceptualization of substance use by peers and themselves: a pilot vignette-based experiment. (PubMed, J Am Coll Health) - "College students might need additional information regarding SUDs to provide peer support and seek treatment themselves."

Journal • Mood Disorders • Psychiatry

Spontaneous Proximal Middle Cerebral Artery Dissection due to Stimulant-associated Vascular Injury (AAN 2026) - "Given the severity of her deficits, she received IV Tenecteplase and was transferred for thrombectomy...She was treated with IV eptifibatide and transitioned to aspirin 81 mg daily...Given her use of bupropion and Adderall, stimulant-associated vascular injury was considered...In our unique case, a potential cause may have been stimulant-associated vascular injury, as amphetamine derivatives have been linked to vasculopathy, vasospasm, and vessel wall injury. This case highlights IAD as a rare but important cause of stroke in the young and raises stimulant-associated vascular injury as a possible contributor."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • General Anxiety Disorder • Giant Cell Arteritis • Hematological Malignancies • Immunology • Ischemic stroke • Thrombosis

Which Medication Improves Fatigue in Patients With Multiple Sclerosis (MS)?: A Systematic Review and Network Meta-analysis (AAN 2026) - "Objective we designed this systematic review and network meta-analysis to compare the efficacy of Amantadine, Adderall, modafinil, and methylphenidate in treating MS-related fatigue, and improving processing speed in patients with MS. For processing speed, none of the medications outperformed placebo, and methylphenidate was associated with a significant negative effect on the SDMT (Symbol Digit Modalities Test) score. Conclusions Among the prescribed medications for managing MS-related fatigue, only amantadine was found to be superior to placebo in improving the impact of fatigue on patients’ lives."

Retrospective data • Review • CNS Disorders • Fatigue • Multiple Sclerosis

Assessing the AOU Database for Vascular Complications of Prescribed Stimulants (AAN 2026) - "Design/Methods A cohort of patients prescribed Adderall, methylphenidate, and atomoxetine was selected in the AOU. This study displays an elevated risk profile compared to the literature-reported incidence. We recommend further investigation of the effect of prescription stimulants on arterial dissection."

40-Year-Old Male with Medial Gastrocnemius Tear after Adderall (Amphetamine/Dextroamphetamine) Use: A Case Report. (PubMed, J Orthop Case Rep) - "Adderall was discontinued, and he was treated conservatively with full resolution of symptoms. The case highlights the potential for Adderall (amphetamine/dextroamphetamine) to predispose patients to musculoskeletal injuries such as gastrocnemius tears, a phenomenon not previously described in the literature."

Journal • Cardiovascular • Hematological Disorders • Musculoskeletal Diseases • Pain • Thrombosis

Prescribing Practices, Motivations, and Behaviors Contributing to Prescription Stimulant Misuse Among Medical Students at an Allopathic Medical School: Cross-Sectional Survey Study. (PubMed, Cureus) - "Efforts should be taken to increase provider counseling on the medical risks of use and the implications of diversion. Mitigating the perceived normalcy of stimulant misuse may be an effective strategy for reducing misuse among medical students."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Gynecology • Obstetrics • Psychiatry • Urology

A Sharp Mind, a Failing Heart: Cardiomyopathy From Chronic Adderall Use (SCCM 2026) - "Introduction: Stimulants like Adderall and Ritalin are widely prescribed for attention-deficit/hyperactivity disorder (ADHD). In this patient, severe global hypokinesis and reduced EF were disproportionate to an isolated LAD lesion and, in the absence of other causes, supported a diagnosis of Adderall-induced cardiomyopathy. Clinicians should maintain high suspicion in patients with unexplained LV dysfunction and a history of chronic stimulant use."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiomyopathy • Cardiovascular • CNS Disorders • Heart Failure • Hypertension • Immunology • Mood Disorders • Movement Disorders • Osteoarthritis • Pulmonary Disease • Respiratory Diseases • Restless Legs Syndrome • Sleep Disorder

Acute Cardiovascular Responses to Amphetamine/Dextroamphetamine Salts (Adderall) in Adderall-Naïve Young Adults: A Randomized Clinical Trial. (PubMed, Mayo Clin Proc) - P4 | "Healthy Adderall-naïve participants consuming a single dose of Adderall manifest striking increases in BP, HR, and sympathetic activation, even at rest. These findings may have important mechanistic implications for understanding acute cardiovascular events associated with illicit Adderall use."

Clinical • Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Psychiatry

What Harm Can a Single Pill Do? Risks Associated With a Single Dose of Adderall. (PubMed, Mayo Clin Proc) - No abstract available

Journal

Stiff Person Syndrome: A Case Report. (PubMed, Cureus) - "Treatment for this patient included 10 mg Adderall daily, frequent ambulation, and appropriate sleep hygiene to improve wakefulness...This report aims to highlight the impact of early recognition on the initiation of therapy to minimize the progression of the disease. It stresses the importance of a multidisciplinary approach to treatment for the best clinical outcomes."

Journal • CNS Disorders • Excessive Daytime Sleepiness • Fatigue • Immunology • Mood Disorders • Movement Disorders • Muscle Spasticity • Musculoskeletal Pain • Narcolepsy • Obstructive Sleep Apnea • Pain • Psychiatry • Respiratory Diseases • Sleep Disorder

Durable Remission After Triple Therapy in New-Onset HFrEF: Implications for a Strategy of "Personalized GDMT". (PubMed, JACC Case Rep) - "Durable remission from new-onset HFrEF can be achieved with fewer drugs than quadruple GDMT. Diagnostic tools are needed to identify such patients."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

To choose or not to choose: Examining the influence of choice on elicitation of subjective and objective prescription stimulant placebo effects in the laboratory. (PubMed, Exp Clin Psychopharmacol) - "College students (N = 183; Mage = 19.48, 92.9% White non-Hispanic, 77.0% female) were randomized into choice (n = 95; ability to choose to ingest 10 mg Adderall [actually placebo]) or no-choice (n = 88; randomly assigned to receive drug [actually placebo] or no drug) conditions before completing subjective effect measures and cognitive tasks...These results provide further evidence of medium-large placebo effects for subjective, but not objective, outcomes following expected prescription stimulant use. Considerations surrounding methodological alterations to laboratory procedures which improve ecological validity are recommended to better understand the influence of both choice and prescription stimulant placebo effects."

Journal

Restricted Supply, Rising Demand: Reimagining Prescription Stimulant Regulation Amid A National Shortage. (PubMed, J Law Med Ethics) - "This paper examines the prescription stimulant shortage in the United States, a crisis that has intensified since the FDA's 2022 announcement of an Adderall shortage...These reforms aim to balance the dual imperatives of preventing misuse and ensuring equitable access to medications for patients with legitimate medical needs. By offering a comprehensive analysis of the prescription stimulant shortage and actionable policy recommendations, this paper seeks to inform regulatory reform, foster a more adaptive, patient-centered approach to ADHD care, and provide a roadmap for addressing one of the most pressing healthcare challenges of our time."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Chronic Lithium Use Need Not Always Be "Chronic" (KIDNEY WEEK 2025) - "She was also taking low dose Adderall for ADHD...The rate of decline in eGFR is reported to be around 0.92 ml/min/1.73m2 per year of lithium treatment. While rapid decline in renal function with lithium levels being maintained in therapeutic range is rare, our case signifies the importance of maintaining high clinical suspicion and early diagnosis to prevent further decline in renal function."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Bipolar Disorder • Chronic Kidney Disease • CNS Disorders • Mood Disorders • Nephrology • Psychiatry • Renal Disease • Suicidal Ideation

Running into Trouble: A Case of Acute Liver Failure From Severe Rhabdomyolysis After a Marathon (ACG 2025) - "We present the case of a healthy young adult who developed acute fulminant liver failure and renal failure following marathon-associated heat stroke and rhabdomyolysis, possibly exacerbated by Adderall use.Case Description/ A 21-year-old male with a history of ADHD on Adderall presented with altered mental status during a marathon after reportedly ingesting Adderall mid-race...The patient was treated with N-acetylcysteine, hemodialysis, lactulose, and supportive ICU care...While rhabdomyolysis is typically associated with renal complications, this case underscores its potential to precipitate acute liver failure. Prompt recognition, early ICU intervention, and multidisciplinary management can lead to full recovery even in fulminant presentations.Figure: Figure 1: Pathology image showing hepatic fibrosis."

Clinical • Acute Kidney Injury • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Cardiovascular • CNS Disorders • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Liver Failure • Nephrology • Psychiatry • Renal Disease