ProcCluster / inflamed pharma - LARVOL DELTA

The Procaine-Based ProcCluster® Impedes the Second Envelopment Process of Herpes Simplex Virus Type 1. (PubMed, Int J Mol Sci) - "Established antiviral drugs, such as acyclovir (ACV), have been successfully used over the past decades. The combination of PC with ACV resulted in an enhanced antiviral effect. Based on these results, PC alone, as well as in combination with ACV, appears to be a promising substance with antiviral potential against HSV-1 infections."

Journal • Herpes Simplex • Infectious Disease

ProcCluster® and procaine hydrochloride inhibit the growth of Aspergillus species and exert antimicrobial properties during coinfection with influenza A viruses and A. fumigatus in vitro. (PubMed, Front Cell Infect Microbiol) - "Finally, the combination of ProcCluster® with the antiviral drug favipiravir exhibited increased antipathogenic activity, particularly against IAV replication. This research highlights ProcCluster® and procaine HCl as substances with anti-infective properties against various pathogens."

Journal • Preclinical • Anesthesia • Infectious Disease • Influenza • Pulmonary Disease • Respiratory Diseases

ProcCluster® and procaine hydrochloride inhibit the replication of influenza A virus in vitro. (PubMed, Front Microbiol) - "We demonstrate that ProcCluster® and procaine hydrochloride inhibit phospholipase A2 (PLA2) enzymes from A549 but not MDCK cells and confirm that specific inhibition of calcium independent PLA2 but not cytosolic PLA2 has antiviral effects. We show that ProcCluster® and procaine hydrochloride inhibit influenza A virus infection at several stages of the replication cycle and have potential as antiviral substances."

Journal • Preclinical • Anesthesia • Infectious Disease • Influenza • Respiratory Diseases

The Local Anaesthetic Procaine Prodrugs ProcCluster and Procaine Hydrochloride Impair SARS-CoV-2 Replication and Egress In Vitro. (PubMed, Int J Mol Sci) - "The addition of procaine during the early stages of the SARS-CoV-2 replication cycle in a cell culture first limits the production of subgenomic RNA transcripts, and later affects the replication of the viral genomic RNA. Interestingly, procaine additionally exerts a prominent effect on SARS-CoV-2 progeny virus release when added late during the replication cycle, when viral RNA production and protein production are already largely completed."

Journal • Preclinical • Anesthesia • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases