bisacodyl / Generic mfg. - LARVOL DELTA

Time Comparison of Interventions on Bowel Programs in Spinal Cord Injury (clinicaltrials.gov) - P=N/A | N=30 | Not yet recruiting | Sponsor: Casa Colina Hospital and Centers for Healthcare

New trial • CNS Disorders • Orthopedics

Colon Cancer Screening in Cystic Fibrosis: Lessons Learned from a Multiphase Quality Improvement Project (NACFC 2026) - "The optimal balance of preparation quality and tolerance may be achieved among individuals using CFTR modulators, following a clear liquid diet on the day before the procedure, and using either one-day or two-day regimen with PEG mixed into a sports drink with bisacodyl. Our adenoma prevalence was consistent with prior literature, reaffirming that PwCF are at higher risk for colorectal cancer and merit more intensive screening and surveillance. Future studies could consider randomizing to different preparation duration (1 vs 2 day) as well as low residue versus clear liquid diet."

Colon Cancer • Cystic Fibrosis • Genetic Disorders • Immunology • Oncology • Respiratory Diseases • Solid Tumor

First Reported Case of MRI Performed on a Patient With Multiple Vibrant Vibrating Capsules In Situ (ACG 2026) - "She experienced ineffective responses or side-effects to multiple pharmacologic therapies including polyethylene glycol, senna, bisacodyl (oral and rectal), glycerin suppositories, magnesium salts, linaclotide, plecanatide, lubiprostone, prucalopride, and tenapanor. This report also highlights the need for improved screening for ingestible electronic devices prior to MRI. Figure: X-ray Showing 5 Vibrant Vibrating Capsules In Situ 1 Day After MRI"

Clinical • Constipation • Endocrine Disorders • Fibromyalgia • Gastroenterology • Gastrointestinal Disorder • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics

Adjunctive Use of Vibrating Capsule for Refractory Constipation in Autosomal Dominant Polycystic Kidney Disease With Severe Organomegaly (ACG 2026) - "He had failed or inadequately responded to lactulose, polyethylene glycol, magnesium citrate, bisacodyl, senna, mineral oil, enemas, suppositories, lubiprostone, prucalopride, fiber, linaclotide alone, plecanatide alone, and pelvic floor physical therapy. Figure: Figure 1b. Sagittal T2-weighted MRI demonstrates renomegaly along with stool-filled colon."

Autism Spectrum Disorder • Autosomal Dominant Polycystic Kidney Disease • Chronic Kidney Disease • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Muscular Dystrophy • Myotonic Dystrophy • Nephrology • Pancreatic Cancer • Polycystic Kidney Disease • Renal Disease

The Contemporary "Balloon Man" Phenotype: A Giant Fecaloma in a Patient on Chronic Antipsychotics (ACG 2026) - "Psychiatry transitioned him from clozapine and olanzapine to haloperidol without breakthrough psychosis. He was discharged on prucalopride, polyethylene glycol, bisacodyl, and lactulose...Figure: Fig 2. Prior flexible sigmoidoscopy showing 2-3 cm clean-based rectosigmoid ulcers, consistent with chronic stercoral pressure injury from recurrent fecal loading."

Clinical • Acute Kidney Injury • CNS Disorders • Constipation • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Mental Retardation • Nephrology • Renal Disease • Schizophrenia

Randomized Trial of Two Over-the-Counter Laxatives to Treat GLP-1 Constipation (ACG 2026) - " Participants prescribed GLP-1 therapy were randomized to liquid glycerin suppository (LGS) or oral bisacodyl tablets (BIS) for emergent constipation... Sixty-nine participants reporting constipation were enrolled in the study (LGS=34, 32 F, mean age 49.5 yrs.; BIS=35, 31 F, 51.5 yrs.). The number of participants achieving 1st BM within labeling was 55.9% for LGS and 57.1% for BIS ( p =0.916, Chi-square test). Table 1 shows median time to 1st BM for LGS was 00:45 (00:30 - 13:14) and for BIS was 11:30 (07:45 - 27:16)."

Clinical • Constipation • Gastroenterology • Gastrointestinal Disorder • Obesity

A Rare Clue to a Common Cancer: Adult Colocolonic Intussusception Leading to the Diagnosis of Cecal Adenocarcinoma (ACG 2026) - "He reported initial constipation, followed by a dark liquid bowel movement after bisacodyl, with resolution of pain...Family screening remains critical components of comprehensive management in patients with colorectal cancer diagnosed at a relatively young age. Figure: Large colo-colonic intussusception involving the proximal colol Figure: Proximal cecal mass containing ulcerate adenocarcinoma"

Clinical • Colon Adenocarcinoma • Colon Cancer • Colorectal Cancer • Constipation • Gastroenterology • Gastrointestinal Disorder • Oncology • Solid Tumor • Thrombocytosis

Non-pharmacological dietary support for functional constipation in long-term care: A quasi-experimental pilot study of young barley leaf. (PubMed, Geriatr Nurs) - "In this pilot study, short-term YBL supplementation was feasible and was associated with favorable bowel-related changes among long-term care residents with functional constipation. Because this study used a one-group pretest-posttest design without a control group, the findings should be interpreted as preliminary and hypothesis-generating. Further controlled studies with larger samples and validated outcome measures are needed to confirm the potential role of YBL supplementation as a non-pharmacological dietary support strategy in long-term care."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder

Colonic Manometry and Contrast Enema Findings in Children With Ineffective Antegrade Continence Enema Therapy. (PubMed, J Pediatr Surg) - "Prolonged ACE use (≥36 months) demonstrated a higher prevalence of right colonic dilation and differences in selected colonic manometry parameters compared with those with shorter ACE duration."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder

Precision Network Pharmacology Revealed by High-throughput Blind Docking: Deciphering the Multitarget Synergy of Taohe Chengqi Decoction against Constipation. (PubMed, Curr Comput Aided Drug Des) - "The innovative integration of machine learning-driven high-throughput blind docking technology with network pharmacology establishes a novel paradigm for traditional Chinese medicine research, significantly enhancing target prediction reliability through advanced structural validation."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Inflammation • IL17A • MAPK3

CLEAR-CAP: A Pilot Study of Commercially Available Bowel Preparation Regimens Packaged and Ingested Via Vegan Capsules (clinicaltrials.gov) - P1 | N=80 | Not yet recruiting | Sponsor: Ottawa Hospital Research Institute

New P1 trial • Gastroenterology • Gastrointestinal Disorder

Management challenges in metachronous bilateral breast cancer with discordant receptor status: a case report. (PubMed, Front Oncol) - "The patient was initiated on neoadjuvant chemotherapy with the adriamycin and cyclophosphamide (AC) regimen and received supportive care, including ondansetron, morphine, and bisacodyl. Metachronous bilateral breast cancer with discordant molecular subtypes presents significant diagnostic and management challenges. Individualized, biology-driven treatment strategies are critical, emphasizing the importance of systemic therapy guided by the more aggressive tumor and careful post-chemotherapy surgical planning."

Journal • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • ER • HER-2 • PGR

Comparative Effects of Live and Heat-Killed Lacticaseibacillus paracasei HP7 on Intestinal Motility, Barrier-Related Markers, and Gut Microbiota in Delayed Transit Mice. (PubMed, J Microbiol Biotechnol) - "BALB/c mice were treated with live HP7 (HP7L), heat-killed HP7 (HP7K), or bisacodyl following loperamide administration. Predicted functional profiling suggested that both HP7L and HP7K were associated with shifts in carbohydrate metabolism-related pathways, with HP7K showing additional predicted enrichment of pathways related to redox-associated metabolism, lipid metabolism, and microbial substrate utilization. These findings suggest that heat-killed HP7 retains biological activity and has potential as a postbiotic candidate for regulating intestinal motility."

Biomarker • Clinical • Journal • Preclinical • Metabolic Disorders • IL17A • IL6 • MUC2 • OCLN • SLC6A4 • TJP1

The laxative efficacy of a mixed extract of Cassia alata with Plantago major in rats. (PubMed, Open Vet J) - "Rats had constipation induced by an oral administration of loperamide (3 mg/kg BW) for 6 days, followed by three control groups assessment (normal, negative, positive which treated bisacodyl), and three treatment groups of the leaf extract of C. alata with P. major (50, 75, and 100 mg/kg BW) for 6 days. This combination at the minimum dosage of 50 mg/kg is more favorable, potentially due to a synergistic interaction between the two extracts. Further studies involving additional dose combinations are recommended."

Journal • Preclinical • Constipation • Gastroenterology • Gastrointestinal Disorder

DO REPEAT BISACODYL PROVOCATIONS MATTER? OUTCOMES IN CHILDREN FOLLOWING NORMAL COLONIC MANOMETRY (ESPGHAN 2026) - "A key marker of intact colonic integrity on CM is the presence of high-amplitude propagating contractions (HAPCs) throughout the colon, whether occurring spontaneously or provoked by bisacodyl. Conclusions Among children with normal CM, needing a second/higher bisacodyl provocation dose was not associated with worse outcomes, and higher total mg/kg correlated with more favorable medication outcomes. These findings challenge the "more is worse" assumption and support interpreting a normal CM as reassuring regardless of provocation threshold Contact e-mail address [email protected]"

Clinical • Gastroenterology • Gastrointestinal Disorder • Pediatrics

MANAGEMENT OF PAEDIATRIC FUNCTIONAL CONSTIPATION UNRESPONSIVE TO FIRST-LINE TREATMENT: A NATIONWIDE SURVEY ON BEHALF OF THE ITALIAN SOCIETY OF PAEDIATRIC GASTROENTEROLOGY, HEPATOLOGY AND NUTRITION (SIGENP) (ESPGHAN 2026) - "Eighty-five percent of respondents used other pharmacological options, such as rectal medications (71%), stimulant laxatives (68%), serotonin agonist (17%) and secretagogue (linaclotide, 4%)...The most commonly used stimulant laxative was bisacodyl (48%), followed by sodium picosulphate (36%), and senna (33%)...Limited clinician experience with second-line therapies, along with uncertainty regarding their efficacy, represents an unmet clinical need to be addressed through targeted educational programs. Contact e-mail address [email protected]"

Clinical • Constipation • Gastroenterology • Gastrointestinal Disorder • Hepatology • Pediatrics

A prospective, randomized, single-center trial: elobixibat/PEG vs. bisacodyl/PEG for bowel preparation (IDDF 2026) - "Crucially, Elobixibat, as an adjunct to PEG, is a viable alternative to the current standard of care (Bisacodyl/PEG), offering similar efficacy with better tolerability. These findings support the use of Elobixibat to optimize bowel preparation strategies, ultimately improving patient experience and comfort without compromising colonoscopy quality."

Clinical • CNS Disorders • Colorectal Cancer • Sleep Disorder • Solid Tumor

Effect of Simethicone on Colon Preparation During Water Exchange Colonoscopy (clinicaltrials.gov) - P=N/A | N=180 | Not yet recruiting | Sponsor: Dalin Tzu Chi General Hospital

New trial

CIRRHOPREP: Evaluation of a Modified Bowel Preparation Regimen in Cirrhotic Patients Undergoing Colonoscopy (clinicaltrials.gov) - P3 | N=252 | Not yet recruiting | Sponsor: Hospital do Divino Espírito Santo de Ponta Delgada

New P3 trial • Immunology • Liver Cirrhosis

Electrochemical Selective C2-H Hydroxymethylation of Pyridines via a Zinc Single-Atom Cathode and Anodic Iodide Relay-Mediated Strategy. (PubMed, J Am Chem Soc) - "Direct molecular modification of drugs is achieved, and gram-scale synthesis of Bisacodyl is demonstrated...Coupled with a relay sequence comprising adsorption, activation, electroreduction, coupling, and electrooxidation, this effect enables efficient formation of the target products. By integrating single-atom catalysis with relay paired electrolysis, this work provides a new framework for the electrocatalytic transformation of inert chemical bonds."

Journal

Investigating Immune Microenvironment of Inflammatory Bowel Disease and the Mitochondrial Metabolism-Related Molecular Mechanisms: Combining a Multiomics Approach and Experimental Validation. (PubMed, OMICS) - "Additionally, therapeutic drugs targeting key genes were predicted, including cimetidine, eugenol, chlortetracycline, vincristine, irinotecan, bisacodyl, and sulpiride, with molecular docking validating high affinity between these drugs and key targets. This study constructed a multiomics integrated analysis strategy and identified MRPL35 and MRPL39 as potential markers and therapeutic targets, providing new insights for the diagnosis and treatment of IBD."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • CD4 • CD74 • CXCR4 • ITGB2 • SDC1 • XIST

CHRONIC KIDNEY DISEASE AND ACUPUNCTURE: AN UNEXPECTED TURNAROUND (ERA 2026) - "The patient was able to discontinue all home medications (sodium bicarbonate, ebastine, pantoprazole, famotidine, macrogol, treoli, rizmoic, trimebutine, pyridostigmine, rifaximin/VSL, normast, bisacodyl, glycerin, senna, buprenorphine) retaining only clonazepam. Why this case is exeptional In summary, this case demonstrates that acupuncture may provide meaningful clinical benefits in patients with CKD who experience refractory symptoms, supporting its consideration as a complementary approach in nephrology care. Table Laboratory Parameters and Medications Changes in a patient treated with Acupuncture Baseline (March 2025) Session VII (July 2025) Follow-up (Jan 2026) sCreat (mg/dL) 2.19 1.68 1.96 Urea (mg/dL) 74 64 79 eGFR (mL/min) 25 35 28 Total sProtein (g/dL) 7.3 7.1 6.9 Uprot (mg/day) 675 693 800 UUrea (g/die) 10 14.4 13.2 Hb (g/dL) 13.4 13.6 13.1 HCO3 (mmol/L) 21 28 21 Total N. Medications 16 1 3 Image TE6 point needling for treating constipation"

Cardiovascular • Chronic Kidney Disease • Constipation • Endometriosis • Gastroenterology • Gastrointestinal Disorder • Gynecology • Inflammation • Metabolic Disorders • Movement Disorders • Musculoskeletal Pain • Nephrology • Renal Disease

The Diagnostic and Therapeutic Dilemma of Suspected Rectal Perforation in a Patient with Neurogenic Bowel Dysfunction after Quadriplegia: A caes report (ISPRM 2026) - "Rehabilitation was adapted to include abdominal massage, oral laxatives (Lactulose, Bisacodyl), and probiotics, avoiding rectal stimuli. For spinal cord injury patients with suspected rectal perforation, rehabilitation must prioritize safety, favoring conservative bowel management over invasive techniques. A multidisciplinary approach is essential to navigate the of promoting bowel function while minimizing the risk of life-threatening complications. This case underscores the need for tailored protocols and heightened vigilance in managing neurogenic bowel when compounded by potential structural compromise."

Clinical • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Inflammatory Bowel Disease • Orthopedics

Body surface colonic mapping detects meal and bisacodyl-induced colonic motility in patients with chronic constipation. (PubMed, Am J Gastroenterol) - "BSCM accurately detects meal and bisacodyl-induced increases in colonic motility with high fidelity to invasive HRM. BSCM could be applied in larger cohort studies to elucidate symptom-motility associations and guide personalized management in refractory chronic constipation."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Myositis • Pain

Comparing Three Rescue Bowel Preparation Regimens for Colonoscopy After Failed Cleansing: A Randomized Controlled Trial (clinicaltrials.gov) - P=N/A | N=220 | Recruiting | Sponsor: Ospedale San Pio

New trial