bisacodyl / Generic mfg. - LARVOL DELTA

Unveiling potential diagnostic biomarkers for rheumatoid arthritis through integrated gene expression analysis. (PubMed, Front Immunol) - "Additionally, potential therapeutic drugs targeting these key genes, including (+)-chelidonine, daunorubicin, and bisacodyl, were predicted. GABARAPL1, FKBP5, PCDH9, and SLAMF8 are identified as potential biomarkers for RA, offering insights into future therapeutic strategies."

Biomarker • Journal • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology • FKBP5 • GABARAPL1 • PCDH9 • SLAMF8

Optimization of Postoperative Bowel Habits (clinicaltrials.gov) - P=N/A | N=88 | Recruiting | Sponsor: Wake Forest University Health Sciences | Trial completion date: Jun 2026 ➔ May 2027 | Trial primary completion date: May 2026 ➔ May 2027

Trial completion date • Trial primary completion date • Constipation • Gastroenterology • Gastrointestinal Disorder

A novel oxidation strategy using a palladium nanocatalyst for stabilizing bisacodyl in polyethylene glycol suppositories. (PubMed, Sci Rep) - No abstract available

Journal

BODY SURFACE COLONIC MAPPING CORRELATES WITH HIGH RESOLUTION COLONIC MANOMETRY IN DETECTING BISACODYL RESPONSES IN CHILDREN WITH CHRONIC CONSTIPATION (DDW 2026) - No abstract available

Clinical • Constipation • Gastroenterology • Gastrointestinal Disorder

Antiulcer and laxative potential of polysaccharides from the ripe seed pulp of Delonix regia: A preliminary study. (PubMed, Int J Biol Macromol) - "Antiulcer activity was evaluated in ethanol- and ibuprofen-induced rat models by measuring the gastric content, acidity, ulcer index, and histopathology. Laxative activity was studied in a loperamide-induced constipation model and validated using a charcoal meal gastrointestinal transit test...In constipated animals, DRSP improved laxation by enhancing moist fecal weight and gastrointestinal transit ratio, with efficacy comparable to that of bisacodyl. These findings demonstrate that DRSP possesses dual antiulcer and laxative effects, likely mediated through antioxidant and cytoprotective mechanisms, supporting its potential as a natural therapeutic agent."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Oncology • Peptic Ulcer

Comparing various bowel preparation regimens in constipated patients undergoing colonoscopy: A systematic review and network meta-analysis of randomised controlled trials. (PubMed, Colorectal Dis) - "The 14d-probiotics + NaP and 3 L PEG + 3d-Lin may be among the more effective and tolerable bowel preparation regimens. While adverse events were similar, the observed reduction in abdominal pain with 3 L PEG + 3d-Lin may suggest improved patient comfort and adherence."

Clinical • Journal • Retrospective data • Review • Colorectal Cancer • Constipation • Gastroenterology • Gastrointestinal Disorder • Oncology • Pain • Solid Tumor

Quality of Bowel Preparation in the General Population. (PubMed, Medicina (Kaunas)) - "Enema (β = -0.20, p < 0.001), bisacodyl (β = -0.16, p < 0.001), and senna solution (β = -0.03, p = 0.012) were linked to poorer bowel preparation quality in comparison with polyethylene glycol... Age, gender, season, medications, withdrawal time, and the type of colorectal lesions influence bowel preparation quality. Personalized approaches, including patient education and targeted interventions, might contribute to improved bowel preparation, especially in older patients, and should be evaluated in future studies."

Journal • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Oncology • Solid Tumor • Ulcerative Colitis

BOLD: Bisacodyl Oral for Lowering Dysfunction (of Tenckhoff Catheter) (clinicaltrials.gov) - P4 | N=398 | Not yet recruiting | Sponsor: Chinese University of Hong Kong

New P4 trial • Chronic Kidney Disease • Renal Disease

A PRELIMINARY REPORT ON ACCESSIBILITY, AFFORDABILITY, AND AVAILABILITY OF MEDICINES FOR PARKINSON (ADPD 2026) - "The most available medicines were for autonomic symptoms such as omeprazole (98.28%), sildenafil (89.7%), bisacodyl (84.5%), tadalafil (60.3%), and for psychiatric symptoms such as haloperidol (50%) and fluoxetine (48.3%). Among dopaminergic medicines, carbidopa/levodopa was always available in 19% of pharmacies, dopamine agonists in 13.8% (bromocriptine), 6.9% (cabergoline), and 1.7% (ropinirole), and monoamine oxidase B inhibitors in 1.72%...Affordable medicines were those always available in the reference public hospital pharmacy, such as the antipsychotics haloperidol and risperidone, the anticholinergic trihexyphenidyl, and the antidepressant fluoxetine... Similar to other low-income countries, there is poor access to PD medicines in Malawi`s pharmacies due to regulatory, supply chain, and financial barriers."

CNS Disorders • Movement Disorders • Parkinson's Disease • COMT

4-L Split-dose Polyethylene Glycol and Bisacodyl and Docusate Sodium Regimen Versus 2-L Split-dose Polyethylene Glycol Plus Oral Simethicone Regimen for Bowel Preparation Before Colonoscopy (clinicaltrials.gov) - P=N/A | N=450 | Recruiting | Sponsor: Tanta University

New trial

Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis. (PubMed, Nat Commun) - "Here, we show the TRPM4 channel as a direct target of bisacodyl (BIC), a widely used clinical drug for chronic constipation management, and its active metabolite, deacetyl bisacodyl (DAB)...Additionally, we delineate a signaling axis, TRPM4 → VGCC/NCX → ANO1, that governs ion homeostasis in the epithelium. Together, these findings establish TRPM4 as a key regulator of intestinal fluid balance and reveal its noncanonical calcium-independent activation as a therapeutic strategy for constipation."

Journal • Constipation • Gastroenterology • Gastrointestinal Disorder • Inflammation • ANO1

Effect of Linaclotide on Colonic Motility Assessed With Intraluminal Colonic High-Resolution Manometry in Healthy Subjects. An Acute, Open Label, Randomized, Crossover, Reader-Blinded Study. (PubMed, Neurogastroenterol Motil) - "In healthy controls, acute administration of linaclotide increases the total number of long-distance propagating sequences and the pre-prandial pancolonic pressurizations."

Journal • Colorectal Cancer • Constipation • Gastroenterology • Gastrointestinal Disorder

Effects of Constipation Treatment in Chronic Kidney Disease: A Pilot Feasibility Trial (clinicaltrials.gov) - P=N/A | N=14 | Completed | Sponsor: University of Tennessee | Recruiting ➔ Completed | N=40 ➔ 14

Enrollment change • Trial completion • Chronic Kidney Disease • Constipation • Gastroenterology • Gastrointestinal Disorder • Nephrology • Renal Disease

Effects of Constipation Treatment in Chronic Kidney Disease: A Pilot Feasibility Trial (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: University of Tennessee | Trial primary completion date: Jun 2025 ➔ Nov 2025 | Trial completion date: Jul 2025 ➔ Nov 2025

Trial completion date • Trial primary completion date • Chronic Kidney Disease • Constipation • Gastroenterology • Gastrointestinal Disorder • Nephrology • Renal Disease

G Protein-Coupled Receptor 35 Holds Potential as a Beacon of Hope for Treating Chondrosarcoma. (PubMed, Balkan J Med Genet) - "G protein-coupled receptors are widely known targets for cancer treatment. Here, we showed that bisacodyl can be a potential therapeutic agent in chondrosarcoma cell lines."

Journal • Oncology • Osteosarcoma • Sarcoma • Solid Tumor • CHEK2

Myxedema Ileus: A Rarely Reported Colonic Manifestation of Myxedema Coma (ACG 2025) - "The patient was started on levothyroxine, liothyronine, and hydrocortisone. Due to concern for ileus, the patient was started on a bowel regimen including docusate-senna, bisacodyl, and polyethylene glycol without resolution of his ileus...In this case, myxedema ileus resolved with treatment of myxedema coma following administration of levothyroxine and liothyronine, as well as treatment with laxatives and gastrografin enema. Myxedema coma has a high patient mortality and early recognition of manifestations such as myxedema ileus is important to prevent further complications.Figure: Distended bowel loops throughout the abdomen noted on x-ray, suggestive of ileus."

Cardiovascular • CNS Disorders • Endocrine Disorders • Heart Failure • Hypoglycemia • Mood Disorders

Comparing Safety and Efficacy of Different Bowel Preparation Regimens in Constipated Patients Undergoing Colonoscopy: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials (ACG 2025) - "Fifteen RCTs were included in this network meta-analysis. Compared to 4L PEG (polyethylene glycol), 3L PEG + 3d-Lin (3 days-Linaclotide) (RR=1.29; 95%CI:[1.12,1.47], p=0.0002), 4L PEG + 1d-Lin (RR=1.25; 95%CI:[1.04,1.51], p=0.02), NaP (sodium phosphate) + bisacodyl (RR=1.52; 95%CI:[1.09,2.10], p=0.01) and Probiotic 14d + NaP (RR= 3.59; 95%CI:[1.83,7.04], p=0.0002) arms significantly increased the adequate bowel preparation with Probiotic 14d + NaP group ranked highest and Senna + MgSO4 (Magnesium sulphate) ranked lowest regarding this outcome. The risk of all other adverse effects, including nausea, vomiting, and bloating, was comparable between different regimens, except abdominal pain, which was significantly reduced in the 3L PEG + 3d-Lin arm (RR=0.18; 95%CI:[0.04,0.88], p=0.03) compared to 4L PEG. In constipated patients, Probiotic 14d + NaP showed the highest efficacy for adequate bowel preparation, while Senna + MgSO4 was least effective."

Retrospective data • Review • Constipation • Gastroenterology • Gastrointestinal Disorder

Preventing Inadequate Colonoscopy Bowel Preparation With the Targeted Addition of Adjuncts: A Quality Improvement Study (ACG 2025) - "This study evaluates the impact of using an alternative enhanced prep regimen consisting of combining 15 mg bisacodyl to 4L PEG-3350 on a split schedule for patients at risk for inadequate prep. This was a quality improvement project... Of 2027 outpatient colonoscopies performed during the study period, 446 high risk patients were identified (102 patients with prior inadequate prep and 344 with risk factors) and prescribed the enhanced regimen. 86.8% were males. Average age was 64."

Addiction (Opioid and Alcohol) • Constipation • Diabetes • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Metabolic Disorders • Obesity

Hypertensive Emergency: Moving Fast to Correct Slow Transit Constipation (ACG 2025) - "Despite treatment with oral antihypertensive therapy and intravenous morphine, his symptoms persisted with worsening systolic pressures greater than 200 mmHg...For his severe constipation, polyethylene glycol, senna, lactulose, and bisacodyl suppositories were administered...In cases such as this, it is important to consider this mechanism to provide timely management and attempt to reduce the morbidity and mortality associated with hypertensive emergencies.Figure: Figure 1.A. Portable Upright Abdominal X-ray B. Portable Supine Abdominal X-ray"

Cardiovascular • Colorectal Cancer • Constipation • Diabetes • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Hypertension • Metabolic Disorders

Bisacodyl-Induced Ischemic Colitis Following Colonoscopy Preparation in a 58-Year-Old Female: A Case Report (ACG 2025) - "Further studies are warranted to clarify the incidence and risk factors for stimulant laxative-induced ischemic colitis. Figure: Friable mucosa in splenic flexure Figure: Friable, erythematous mucosa in the descending colon"

Case report • Clinical • Asthma • Cardiovascular • Colonic Polyps • Dermatology • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Immunology • Metabolic Disorders • Respiratory Diseases

Preparing for Success: Enhanced Bowel Preparation Protocol Significantly Reduces Inadequate Colonoscopy Preparation, a Retrospective Study of 1,850 Patients (ACG 2025) - "Variables assessed included demographic characteristics (age, gender, BMI), comorbidities (e.g., diabetes, cirrhosis, stroke, dementia, IBD, constipation), prior abdominal surgery, ASA class, functional status, incarceration status, substance use (alcohol, tobacco, marijuana), and medication use (narcotics, benzodiazepines, methadone, tricyclic antidepressants [TCAs], other antidepressants, anticholinergics, antipsychotics, laxatives). Factors independently associated with poor bowel preparation included anticholinergic use (OR 1.4, p = 0.007), baseline laxative use (OR 1.77, p = 0.008), higher ASA class (OR 1.77, p < 0.001), and marijuana use (OR 1.9, p = 0.018). TCA use demonstrated a trend toward significance (OR 1.8, p = 0.072). Following implementation of the updated protocol, "excellent" preparation rates improved from 35.51% to 42.49%, and "poor" preparation rates decreased from 3.78% to 1.62% (χ² = 11.65, p = 0.009)."

Retrospective data • Addiction (Opioid and Alcohol) • Alzheimer's Disease • Cardiovascular • CNS Disorders • Constipation • Dementia • Diabetes • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hepatology • Immunology • Metabolic Disorders

Prevalence and Prescription Patterns of IBS Treatments Across Demographic and Socioeconomic Factors (ACG 2025) - "The most commonly prescribed IBS-D medication was loperamide (4%), with prescription IBS-D drugs also used in only 2%...Black patients were more likely to be prescribed stimulant laxatives, particularly bisacodyl (10% vs. 4% in White and 2% in Asian patients)... Among 390,202 individuals in the database, 3.9% (n=14,897) were diagnosed with IBS. The majority (57%) were diagnosed between 36 and 65 years of age, were White (73%) and female (78%). The most commonly used medications for IBS-C were osmotic laxatives (18%), stimulant laxatives (9%), and fiber (6%)."

CNS Disorders • Gastrointestinal Disorder

Bowel Regimen Gone Rogue: A Rare Case of Anaphylaxis Secondary to Over-the-Counter Polyethylene Glycol 3350 (ACG 2025) - "He was given IV methylprednisolone sodium succinate 125mg, IV famotidine 20mg, IV diphenhydramine 25mg and started on an epinephrine infusion...Options without polyethylene glycols or polysorbates include sodium picosulfate, magnesium oxide, anhydrous citric acid; sodium phosphate tablets; oral sulfate solution/tablets; magnesium citrate; bisacodyl; and off label lactulose2.Citations: (1) Stone et al...April 2025. DOI: 10.1053/j.gastro.2025.02.002."

Clinical • Colorectal Cancer • Constipation • Dermatology • Diabetes • Gastroenterology • Gastrointestinal Disorder • Hypotension • Immunology • Metabolic Disorders • Pruritus • Solid Tumor

A Case of Polyethylene Glycol-Induced Ischemic Colitis (ACG 2025) - "Prior case reports have described bisacodyl and PEG with bisacodyl-associated ischemic colitis; however, no prior case reports describe ischemic colitis with PEG alone. While PEG is considered highly safe and efficacious, this case is suggestive of an infrequent episode of PEG-induced ischemic colitis.Figure: Localized erythema and shallow ulcerations of the splenic flexure.Figure: Erythema and ulceration of the sigmoid colon."

Clinical • Atherosclerosis • Colorectal Cancer • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Metabolic Disorders • Osteoarthritis • Rheumatology • Solid Tumor • CRP

Defecation Patterns in Constipated Patients (clinicaltrials.gov) - P=N/A | N=130 | Recruiting | Sponsor: The California Medical Innovations Institute, Inc. | Suspended ➔ Recruiting | Trial completion date: Mar 2026 ➔ Dec 2026 | Trial primary completion date: Mar 2025 ➔ Dec 2026

Enrollment open • Trial completion date • Trial primary completion date • Constipation • Gastroenterology • Gastrointestinal Disorder