XEN D0103 / Servier, Xention - LARVOL DELTA

Novel insights into the electrophysiology of murine cardiac macrophages: relevance of voltage-gated potassium channels. (PubMed, Cardiovasc Res) - "Our results provide a first electrophysiological characterisation of cardiac resident MΦ, and a computational model to quantitatively explore their relevance in the heterocellular heart. Future work will be focussed at distinguishing electrophysiological effects of MΦ-CM coupling on both cell types during steady-state and in patho-physiological remodelling, when immune cells change their phenotype, proliferate, and/or invade from external sources."

Journal • Preclinical • Immunology

A double-blind, randomised, placebo-controlled, cross-over study assessing the use of XEN-D0103 in patients with paroxysmal atrial fibrillation and implanted pacemakers allowing continuous beat-to-beat monitoring of drug efficacy. (PubMed, J Interv Card Electrophysiol) - "XEN-D0103 did not reduce AF burden in patients with PAF and dual chamber pacemakers providing beat-to-beat monitoring. XEN-D0103 was well tolerated and did not have any apparent effect on heart rate. Although single-ion channel blockade with XEN-D0103 did not affect AF in this study, there might be a potential for this agent to be used in combination with other atrially specific drugs in the treatment of AF."

Clinical • Journal • Biosimilar • Cardiovascular • CNS Disorders • Multiple Sclerosis