ivermectin oral / Generic mfg. - LARVOL DELTA

Palliative Management of Advanced Breast Carcinoma Complicated by Myiasis: First Case Report From Bangladesh. (PubMed, Clin Med Insights Case Rep) - "She was treated with morphine, flucloxacillin, ivermectin, and albendazole, which resulted in significant symptomatic relief...This report underscores the importance of early recognition and integrated management of malignant wound myiasis, particularly in resource-constrained environments. It also draws attention to the broader psychosocial impacts of such conditions and the essential role of end-of-life care in mitigating suffering."

Journal • Breast Cancer • HER2 Breast Cancer • HER2 Positive Breast Cancer • Infectious Disease • Oncology • Pain • Palliative care • Solid Tumor • HER-2

Effect of ivermectin on Toxocara canis larvae in vitro and in vivo at different migratory stages. (PubMed, Biomedica) - "Ivermectin is effective against T. canis larvae during early migratory stages but shows limited efficacy against late-stage larvae."

Journal • Preclinical • Infectious Disease • Inflammation

Critical role of P-Glycoprotein-9 in ivermectin tolerance in nematodes. (PubMed, PLoS Pathog) - "To explore drug dynamics, we developed a fluorescent IVM analog, which revealed reduced drug accumulation in IVR10, a phenotype reversed by pgp-9 deletion. Altogether, these findings show that nematode PGP-9 modulates IVM tolerance in IVR10 by controlling drug efflux and highlight it as a potential therapeutic target."

Journal • Infectious Disease

Ivermectin Combined With Immune Checkpoint Inhibition in Cancer (ICONIC) (clinicaltrials.gov) - P2 | N=80 | Not yet recruiting | Sponsor: University of Florida

Checkpoint inhibition • New P2 trial • Oncology • Solid Tumor

Ivermectin Therapy for Scabies Infection in Children Younger Than 5 Years of Age (ITCHY Study) (clinicaltrials.gov) - P2 | N=120 | Active, not recruiting | Sponsor: Murdoch Childrens Research Institute | Recruiting ➔ Active, not recruiting

Enrollment closed • Infectious Disease • Pruritus

A phase II double-blind randomised placebo-controlled trial to assess the efficacy of ivermectin in combination with favipiravir in mild-to-moderate COVID-19 adult patients (IFCOV) (ESCMID Global 2026) - No abstract available

Clinical • Combination therapy • P2 data • Infectious Disease • Novel Coronavirus Disease

A rare case of oral myiasis in a non-tropical region: the role of systemic vulnerability. (PubMed, Rev Inst Med Trop Sao Paulo) - "This case shows that oral myiasis may develop in non-tropical settings when systemic vulnerability exists. It highlights the importance of regular oral exams and mouth care for high-risk patients."

Journal • Cachexia • CNS Disorders • Critical care • Fibrosis • Immunology • Infectious Disease • Lung Cancer • Movement Disorders • Oncology • Parkinson's Disease • Psychiatry • Respiratory Diseases • Septic Shock • Solid Tumor

Dermatologic Care Solutions for Persons Experiencing Homelessness: Adapted Therapies to Access Models (AAD 2026) - "Examples of person-centered care include recommending oral ivermectin over topical permethrin for scabies when hygiene is limited, and tailoring skin and soft tissue infection management by assessing predisposing factors, obtaining cultures and empiric first-generation cephalosporins due to high prevalence of Group A Streptococci in PEH... Integrating person-centered therapies with innovative delivery models offers a path forward in reducing barriers for PEH, though challenges in sustainability, adoption and infrastructure must be addressed."

Atopic Dermatitis • CNS Disorders • Dermatitis • Genetic Disorders • Immunology • Infectious Disease • Psoriasis • Skin Cancer

Onchocerca volvulus infection prevalence and intensity in Logo and Nyarambe Health Zones in Ituri, Democratic Republic of the Congo in 2010 and in 2021-2023: results of screening for clinical trials of moxidectin versus ivermectin. (PubMed, Parasit Vectors) - "Given that the reduction in infection prevalence and intensity in Logo HZ cannot be attributed to ivermectin distribution, it has to be due to reduction in infective vector biting rates, possibly linked to a recently proposed change in vector species triggered by land-use changes. Because SmfD reflects transmission events approximately 2-15 years earlier, infective vector biting rate assessment is needed to determine current transmission rates. Reduced transmission shifts macrofilariae age distribution toward older macrofilariae with lower reproductive capacity. Comparison of the results from the Phase 3 and the ongoing efficacy study might help determine whether drug susceptibility changes significantly with macrofilariae age. Should that be the case, transmission models evaluating the impact of mass drug administrations could be adjusted."

Journal • Infectious Disease

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management. (PubMed, J Appl Toxicol) - "The COVID-19 pandemic amplified these risks through widespread off-label use, especially of veterinary formulations, resulting in a substantial increase in toxic exposures without demonstrated clinical benefit. Overall, ivermectin toxicity emerges as a predictable consequence of interactions between pharmacokinetics, transporter biology, exposure patterns, and host-specific factors rather than an inherent contradiction of its therapeutic value."

Journal • Review • CNS Disorders • Epilepsy • Infectious Disease • Novel Coronavirus Disease • ABCB1

EFFUSIVE-CONSTRICTIVE PERICARDITIS SECONDARY TO STRONGYLOIDIASIS (ACC 2026) - "Strongyloides stercoralis is a rare but significant cause of ECP that remains underreported in the literature. Travel history and consideration of parasitic infections are essential for prompt identification and treatment."

Cardiovascular • Eosinophilia • Fibrosis • Immunology • Infectious Disease • Inflammation • Respiratory Diseases

Crusted Scabies Beyond the Immunocompromised: A Case of Delayed Diagnosis (AAD 2026) - "Despite therapy with oral hydroxyzine and topical corticosteroids, pruritus persisted...The patient was promptly started on oral ivermectin...Delayed recognition may contribute to progression, dissemination, and risk of nosocomial outbreaks. Clinicians should maintain a high index of suspicion for atypical scabies presentations to ensure timely diagnosis and treatment."

Clinical • Contact Dermatitis • Dermatitis • Immunology • Infectious Disease • Nephrology • Pruritus

Elephantiasis Nostras Verrucosa Complicated by Cutaneous Myiasis: A Rare Case with Ivermectin Non-Response (AAD 2026) - "Mechanical debridement and wound care were subsequently performed. This case underscores three major messages: ENV should be considered in the differential diagnosis of chronic lymphedema with verrucous lesions; cutaneous myiasis represents a rare but severe complication requiring early recognition and multidisciplinary management; and ivermectin non-response underscores the need for multimodal therapeutic approaches, including mechanical debridement, occlusion, or surgical intervention."

Clinical • Infectious Disease

Microscopic clearance with ivermectin-permethrin combination versus permethrin alone in non-crusted scabies: a retrospective cohort study. (PubMed, Clin Exp Dermatol) - "In a real-world outpatient setting, ivermectin-permethrin combination therapy was associated with earlier microscopic clearance than permethrin monotherapy. These findings suggest that combination therapy may be considered in selected patients with heavier infestation or in settings where rapid parasitological clearance is a priority."

Journal • Retrospective data • Dermatology • Infectious Disease

Comparative effectiveness of permethrin and ivermectin on pruritus and psychological outcomes in scabies: a prospective cohort of 600 adults. (PubMed, Postgrad Med) - "Of these, 292 received oral ivermectin and 308 received topical permethrin...While both agents are effective, permethrin may confer greater short-term psychological benefit. These findings highlight the relevance of psychobehavioral mechanisms in scabies management beyond symptom control."

HEOR • Journal • CNS Disorders • Depression • Dermatology • Infectious Disease • Mood Disorders • Pruritus • Psychiatry

Fatal Disseminated Strongyloidiasis in a Lung Transplant Recipient: A Case Report (ISHLT 2026) - "Given his high immunologic risk, induction immunosuppression was initiated with alemtuzumab, followed by rituximab administration due to the development of de novo class II donor-specific antibodies...Prompt dual antiparasitic therapy with ivermectin and albendazole was initiated...Absence of eosinophilia does not exclude parasitic disease. Early recognition and treatment are critical to improve patient outcomes."

Case report • Clinical • Cardiovascular • Eosinophilia • Infectious Disease • Pneumonia • Pulmonary Arterial Hypertension • Respiratory Diseases • Septic Shock • Transplantation • CRP

Ivermectin is making a post-pandemic comeback, among cancer patients (WYPR) - "'Those are the most heartbreaking because those are patients that we really have stuff that can help, that's tried and true, and they're kind of putting all their eggs in a basket that I don't think is going to be helpful for them,' Mizrahi says."

Media quote

First Molecular Confirmation of Canine Ocular Thelaziosis Caused by Thelazia callipaeda From India. (PubMed, Vet Ophthalmol) - "This report describes the first molecularly confirmed report of T. callipaeda infection from India, emphasizing the need for increased awareness and regional surveillance of this emerging zoonotic parasite."

Journal • Conjunctivitis • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Zydus Lifesciences Limited has received final approvals from the United States Food and Drug Administration (USFDA) for Ivermectin Tablets USP, 3 mg and Dapsone Tablets USP, 25 mg and 100 mg. (Indian Pharma Post) - "Ivermectin Tablets USP, 3 mg had annual sales of US$ 14.8 mn."

ANDA • Sales • Infectious Disease

Modelling of onchocerciasis-associated skin and ocular disease and the impact of ivermectin treatment. (PubMed, Commun Med (Lond)) - "Integrating morbidity outcomes into transmission dynamics modelling will help improve estimates of onchocerciasis disease burden and inform the effectiveness and cost-effectiveness of current and alternative interventions."

Journal • Dermatology • Infectious Disease • Ophthalmology

Exploring potential pathogenesis mechanisms of onchocerciasis-associated epilepsy through cerebrospinal fluid analysis of children with complex febrile seizures: a pilot study in Aketi, Democratic Republic of the Congo. (PubMed, BMJ Open) - "Study data will be stored in an open repository. Pan African Clinical Trials Registry (PACTR202507670131109)."

Journal • CNS Disorders • Epilepsy • Infectious Disease • Ophthalmology • Pediatrics

Point participation does not reflect long‑term treatment adherence: An evaluation of ivermectin MDA in the Kwanware‑Ottou persistent onchocerciasis transmission focus, Wenchi, Ghana. (PubMed, PLoS Negl Trop Dis) - "High point participation masks low effective participation and insufficient subdistrict geographical coverage. Conducting exhaustive CES in delineated foci is essential for evaluating CDTI performance, tailoring and strengthening CDTI, and informing alternative strategies to interrupt onchocerciasis transmission. This approach has contributed to effective, context-specific strategies to interrupt transmission in Wenchi and beyond."

Journal • Infectious Disease

Combinations of Favipiravir with Doxycycline, Azithromycin or Ivermectin Exert Synergistic Effects Against Influenza A H3N2 Virus Replication. (PubMed, Pathogens) - "Specific combinations of Favipiravir with Artesunate or Andrographolide revealed additive effects by inhibiting influenza virus titers by about 2 or 1.5 log10, respectively. Our findings indicate that specific drug combinations show promising efficacy and potential in the treatment of influenza and warrant further studies using influenza models of human cell, tissue and animal infection."

Journal • Infectious Disease • Influenza • Respiratory Diseases • IFNG • IL1B • IL6 • TNFA

Human strongyloidiasis in rural villages of South Kalimantan, Indonesia: A case series. (PubMed, Narra J) - "Urgent actions are needed, including community education and the provision of basic sanitation infrastructure such as latrines and access to clean water. These interventions are especially critical given that ivermectin-the first-line treatment for strongyloidiasis-is not currently available in Indonesia."

Journal • Infectious Disease

The impact of the termination of Lymphatic Filariasis mass drug administration on Soil-transmitted Helminth prevalence in school children in Malawi. (PubMed, PLoS Negl Trop Dis) - "An overall resurgence in A. lumbricoides infections after LF MDA was estimated in SAC, despite ongoing annual STH PC. This suggests STH PC could not sustain the prevalence levels achieved in SAC under community-wide LF MDA. The potential role of drug resistance in this resurgence calls for urgent investigation. Understanding how this resurgence corresponds to prevalence of moderate and heavy infections should be a priority for future research."

Journal • Infectious Disease