ivermectin oral / Generic mfg. - LARVOL DELTA

Efficacy and safety of albendazole 400 mg for 30 days compared to single dose of ivermectin in adult patients with low Loa loa microfilaremia: A non-inferiority randomized controlled trial. (PubMed, PLoS Negl Trop Dis) - "Albendazole demonstrated microfilaricidal activity in individuals with low Loa loa microfilaremia following a 30-day treatment. The monitoring of parasite density 3-10 months post-treatment is needed to complete the present findings."

Head-to-Head • Journal • Infectious Disease

Antimalarial compounds exhibit variant- and cell-type-specific activity against SARS-CoV-2 isolated in Panama. (PubMed, Front Pharmacol) - "In Calu-3 cells, a wider variety of compounds, including chloroquine (CQ), amodiaquine (AQ), artesunate (AS), lumefantrine (LUM), and hydroxychloroquine (HCQ), were found to be effective against the Delta variant...Time-of-addition experiments suggested that CQ and primaquine (PQ) were ineffective during the viral adsorption phase but showed a dose-dependent antiviral effect against the A2.5 variant in the early replication phase, whereas the Delta variant showed resistance. This study underscores the critical role of selecting appropriate cell models for SARS-CoV-2 research, as drug efficacy varies between viral variants and host cell types."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Serpiginous Travels: A Case of Cutaneous Larva Migrans. (PubMed, Cureus) - "She returned to the Infectious Disease clinic three weeks later for follow-up with near resolution of the rash. In our case, we highlight the importance of obtaining a thorough social history when encountering cutaneous lesions as well as key differences in the treatment of hookworm compared to other parasitic infections."

Journal • Infectious Disease

Strongyloides stercoralis hyperinfection with shock and thrombosis. (PubMed, Infez Med) - "Ivermectin and albendazole were started with full-dose anticoagulation for the thrombotic event...This case emphasizes the importance of early diagnosis and timely management to avoid life-threatening complications. It also highlights the need for surveillance in endemic regions and the appropriate use of evidence-based therapeutic strategies."

Journal • Cardiovascular • Cough • Hematological Disorders • Infectious Disease • Pain • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Thrombosis • Venous Thromboembolism

An Epidemiological Cross-sectional Study of Post-COVID-19 Syndrome in Patients of Anand District. (PubMed, Indian J Community Med) - "Looking at current prevalence of PCS, well-sensitized healthcare system is needed to be established. Further research is required to explore more risk factors leading to PCS and various treatment options for PCS."

Journal • Observational data • Infectious Disease • Novel Coronavirus Disease

A blending-based therapeutic strategy using diaryl dichalcogenides and ivermectin against gastrointestinal nematodes of small ruminants. (PubMed, Vet Parasitol) - "Blending IVM with organochalcogen compounds (OCs) showed an additive effect of up to 34 %, contributing to developing novel blending-based therapeutic strategies. A distinctive mechanism of action of the OCs can also be an advantage in controlling multidrug-resistant parasites of ruminants."

Journal • Infectious Disease

From genome to drug targets: computational subtractive genomics reveals novel anti-filarial targets in Wuchereria bancrofti and identifies plant-based inhibitors of β-1,4-mannosyltransferase, a high-priority target. (PubMed, Mol Divers) - "The drugs albendazole (ALB), ivermectin (IVM), and diethylcarbamazine (DEC) are currently used to treat LF, but they are not effective against microfilariae and are known to have an inability to reverse chronic conditions, produce adverse reactions, and have developed drug resistance due to prolonged use...Further, structure-based virtual screening identified five potent phytochemicals (IMPPAT ID: 9,896,047, 49,777,225, 13,888,122, 89,483-03-4, and 14,605,093) having a better affinity with WbEGH. Furthermore, experimental validation of these identified phytochemicals would lead towards an effective method for controlling Lymphatic Filariasis."

Journal • Infectious Disease

Intranasal Delivery of Ivermectin Nanosystems as an Antitumor Agent: Focusing on Glioma Suppression. (PubMed, ACS Biomater Sci Eng) - "This study marks the first exploration of IVM delivery to the brain. In summary, nasal administration of nanoencapsulated IVM via nanocapsules presents a promising avenue for targeted therapy against glioblastoma, with potential implications for clinical translation."

Journal • Brain Cancer • Glioblastoma • Glioma • Hematological Disorders • Infectious Disease • Oncology • Solid Tumor

Ivermectin and COVID-19. (PubMed, J Infect) - No abstract available

Journal • Infectious Disease • Novel Coronavirus Disease

Strong-HD-VIE - Prevalence of Strongyloides stercoralis infection in hemodialysis patients in Vienna, Austria (ERA 2025) - "With globalization, migration, and climate change facilitating the spread of helminth infections, the prevalence of S. stercoralis in Austria is increasing. As one of ten dialysis patients tested positive for S. stercoralis, pre-transplant screening should be considered."

Clinical • Dermatology • Infectious Disease • Inflammation • Nephrology • Pruritus • Renal Disease • Septic Shock • Solid Organ Transplantation

First identification of a patent pentastomid pulmonary (Raillietiella orientalis) infection in a captive Meller's chameleon (Trioceros melleri) in Germany. (PubMed, Int J Parasitol Parasites Wildl) - "This is the first report, to the best of our knowledge, on a patent pulmonary R. orientalis infection in a captive chameleon. We call for further investigations on neglected pentastomid infections in chameleons and lizards kept as pets to better understand implications of this new host record and its possible role in transmission of emerging pentastomiasis."

Journal • Dental Disorders • Infectious Disease

A retrospective perspective on epidemiology, clinicopathological and therapeutic aspects of microfilariosis in buffaloes of West Godavari District, Andhra Pradesh. (PubMed, J Parasit Dis) - "Supportive therapy aided in the correction of anemia and speedy recovery. Recurrence of microfileremia was not observed after two months of periodic post therapeutic evaluation and follow-up."

Journal • Retrospective data • Hematological Disorders • Infectious Disease

A fatal post-COVID-19 sino-orbital mucormycosis in an adult patient with diabetes mellitus: a case report and review of the literature. (PubMed, J Infect Dev Ctries) - "Early diagnosis, prompt antifungal therapy, and appropriate surgical intervention are critical for improving mucormycosis outcomes, especially in COVID-19 patients."

Journal • Review • Diabetes • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Pain • Pulmonary Disease

The Deadly Itch: A Rare but Fatal Case of Norwegian Scabies. (PubMed, Cureus) - "Despite receiving aggressive treatment with oral ivermectin, topical permethrin, and IV antibiotics, the patient deteriorated and succumbed to sepsis. This case highlights the importance of early diagnosis, aggressive management, and strict infection control to prevent adverse outcomes."

Journal • CNS Disorders • Diabetes • Epilepsy • Infectious Disease • Metabolic Disorders • Septic Shock

Sarcoptic Mange in Reintroduced Red Foxes (Vulpes vulpes) in South Korea: Case Histories, Clinical Assessments, Treatments, and Pathological Findings. (PubMed, Animals (Basel)) - "Necropsy of the deceased animals (n = 12) revealed characteristic skin lesions, such as alopecia, hyperkeratosis, epidermal hyperplasia, and dermatitis. The study findings highlight the importance of long-term monitoring and active, continuous treatment of sarcoptic mange, a major threat, for the stable re-establishment of reintroduced foxes in South Korea."

Journal • Alopecia • Dermatitis • Dermatology • Hematological Disorders • Immunology • Infectious Disease

Small-Lungworm (Protostrongylidae) Infections in Relation to Meat Sheep Breeds, Mediterranean Climates, and Anthelmintic Regimens. (PubMed, Vet Sci) - "The anthelmintic regimen (ivermectin, levamisole, and albendazole) directly targets gastrointestinal nematodes and indirectly protostrongylids. The use of effective drugs targeting protostrongylids at key moments may provide more effective control."

Journal • Infectious Disease

Repurposing Anthelmintic Drugs for COVID-19 Treatment: A Comprehensive Meta-Analysis of Randomized Clinical Trials on Ivermectin and Mebendazole. (PubMed, Antibiotics (Basel)) - "With well-established safety profiles, immunomodulatory effects, and affordability, these drugs present strong candidates for further exploration. Advancing research through well-designed, large-scale RCTs will help unlock their full therapeutic potential and expand treatment options in the fight against COVID-19."

Clinical • Journal • Retrospective data • Review • Infectious Disease • Inflammation • Novel Coronavirus Disease

The molecular basis of scabies itch (SID 2025) - "Despite its prevalence, current treatments, such as topical (permethrin) and oral (ivermectin), have limitations, including resistance, side effects, and incomplete efficacy...Furthermore, our data suggest that PAR1 is linked downstream to TRPV1, as evidenced by global knockout mice studies. Our findings reveal a novel signaling pathway (Sar s 1c/ PAR1/TRPV1) associated with scabies itch, providing a potential therapeutic target for the development of more effective treatments."

Late-breaking abstract • Infectious Disease • TRPV1

Atypical mycobacterium arising in the setting of postscabetic pruritus (SID 2025) - "At the time of presentation to dermatology, the patient was being treated with oral clindamycin and oral metronidazole due to persistent pruritus...The patient was started on oral doxycycline and topical mupirocin 2% ointment mixed with Medihoney twice daily to skin ulcers...Infectious disease consultation confirmed that doxycycline was effectively managing the atypical mycobacterial infection. This case underscores the importance of considering atypical mycobacterial infections in patients with postscabetic pruritus."

Dermatology • Immunology • Infectious Disease • Mood Disorders • Prurigo Nodularis • Pruritus

A Rare Case of Disseminated Strongyloidiasis Presenting as Polymicrobial Sepsis in a Patient With Lupus: A Diagnostic Conundrum (ATS 2025) - "He was started on systemic ivermectin and albendazole...Given the delay in diagnosis and associated higher mortality rates, screening for Strongyloides infection using stool studies before initiating immunosuppressive therapy should be considered, especially for people in endemic areas. This can help prevent fatal complications through early case detection."

Clinical • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Pulmonary Disease • Respiratory Diseases • Septic Shock

Eosinophilic Fasciitis With Pulmonary Granulomas: A Mimicker of Sarcoidosis (ATS 2025) - "She subsequently developed associated persistent, peripheral eosinophilia, concerning for parasitic infection, and was diagnosed and treated for Strongyloides infection with ivermectin and albendazole...She was treated with low-dose prednisone, as she could not tolerate higher doses, and Cellcept...Raynaud's phenomenon, dysphagia, positive ANA, and systemic sclerosis-specific autoantibodies are not generally present in EF. This case highlights the challenge of differentiating EF from other disorders, such as SS and Sarcoidosis, as it may impact therapeutic management."

Cardiovascular • Eosinophilia • Eosinophilic Granulomatosis With Polyangiitis • Fibrosis • Gastrointestinal Disorder • Hematological Malignancies • Herpes Zoster • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Langerhans Cell Histiocytosis • Monoclonal Gammopathy • Musculoskeletal Pain • Novel Coronavirus Disease • Oncology • Pain • Rare Diseases • Rheumatology • Sarcoidosis • Scleroderma • Systemic Sclerosis • Varicella Zoster • Vasculitis

As Many Diseases as They Please: A Case of Respiratory Failure Due to Overlap of Differentiation Syndrome and Staphylococcal Pneumonia (ATS 2025) - "This abstract is funded by: None Introduction: Differentiation syndrome (DS) is a life-threatening complication of acute promyelocytic leukemia (APL) treated with all-trans retinoic acid (ATRA) and/or arsenic trioxide (ATO)...She had been on prophylactic prednisone for DS which was switched to dexamethasone, and chemotherapy was held...She received vancomycin and cefepime, and was transferred to the ICU...However, the presence of another condition, such as a pneumonia, does not rule out a diagnosis of DS. All patients in the right setting (known malignancy and medication associated with DS) should receive empiric treatment with steroids."

Clinical • Acute Promyelocytic Leukemia • Cardiovascular • Congestive Heart Failure • Heart Failure • Hematological Malignancies • Infectious Disease • Leukemia • Oncology • Pneumonia • Respiratory Diseases

The Intoxicated Patient Who Cried Wolf: A Concealed Case of Obstructive Hydrocephalus From Cryptococcal Meningoencephalitis in Alcoholic Cirrhosis (ATS 2025) - "Treatment was initiated with liposomal amphotericin B and flucytosine followed by consolidation and maintenance with fluconazole...Cerebral dysfunction from alcoholic cirrhosis and intoxication may confound identification of common symptoms like confusion or headache encountered with cryptococcal CNS infection. This case highlights the need for a high index of suspicion for opportunistic infections as a cause for encephalopathy in patients with cirrhosis."

Clinical • Addiction (Opioid and Alcohol) • CNS Disorders • Epilepsy • Fibrosis • Hepatic Encephalopathy • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Liver Failure • Pain • Ventriculomegaly

Diagnostic Challenge: Unmasking a Dual Lung Infection (ATS 2025) - "Despite aggressive fluid resuscitation, vasopressor support, and broad-spectrum antibiotics (vancomycin, meropenem), his hemodynamic status remained unstable, prompting endotracheal intubation followed by bronchoscopy with bronchoalveolar lavage (BAL)...The patient was started on targeted antifungal therapy with itraconazole for histoplasmosis and ivermectin for strongyloidiasis, along with continued supportive care, including mechanical ventilation and renal replacement therapy...Routine diagnostic tests, such as blood cultures, may not always identify the causative organisms, necessitating more invasive procedures like bronchoscopy with BAL. Dual infections with Histoplasma capsulatum and Strongyloides stercoralis, although rare, can complicate the clinical course and require early and aggressive management, which is key to improving patient outcomes in such complex scenarios."

Acute Myelogenous Leukemia • Anemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology • Respiratory Diseases • Septic Shock • Thrombocytopenia • CRP

OFF-LABEL USE OF ORAL IVERMECTIN FOR PERSISTENT SCABIES IN INFANTS: A CASE SERIES (ESPID 2025) - "Adverse effects are usually mild and transient, including worsening itching, fever, skin reactions, respiratory distress, dizziness, diarrhea, nausea and eosinophilia. Further studies are needed to refine dosing and safety in children under 15 kg."

Clinical • Human Immunodeficiency Virus • Infectious Disease