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Effects of Three Anthelmintics on the Transcriptome of FHs 74 Int Enterocytes. (PubMed, Trop Med Infect Dis) - "In this study, the three commonly used anthelmintics albendazole, ivermectin, and praziquantel were investigated by transcriptome analysis for their effects on gene activity in the human intestinal cell line FHs 74 Int after 24-h exposure...Analysis of these genes showed that albendazole caused a modest upregulation of cell cycle related processes, especially mitotic spindle formation, and chromosome segregation. The cells showed a stronger response to ivermectin and the data suggested inhibition of cell proliferation through downregulated transcription factors and nuclear receptors and stimulation of cell growth and cell survival mechanisms through upregulated metabolic enzymes."

Journal • Infectious Disease

Circulating Leukocytes and Antibody Isotype Reactivity in Rats Experimentally Infected with Different Burdens of Strongyloides venezuelensis, Before and After Treatment with Ivermectin or Dexamethasone. (PubMed, Trop Med Infect Dis) - "IgA anti-ES/L3 (excretory and secretory larval antigens) reactivity significantly decreased in intestinal wash after parasitological cure. These data would help the development of more efficient immunodiagnostic alternatives for human strongyloidiasis based on antibody isotype reactivity."

Journal • Preclinical • Infectious Disease

Hidden risk: Corticosteroid exposure and severe outcomes in patients with latent Strongyloides stercoralis. (PubMed, J Helminthol) - "Prophylactic ivermectin was associated with a lower risk of a composite outcome (12.9% vs. 27.1%; OR 0.40, 95% CI 0.18-0.89). These findings support enhanced screening and preventive strategies in at-risk patients."

Journal • Retrospective data • Infectious Disease • Septic Shock

Comparison of topical 5% permethrin and oral ivermectin for treatment of childhood scabies: a randomized controlled trial. (PubMed, J Trop Pediatr) - "Oral ivermectin may be a cost-effective alternative treatment of childhood scabies. The trial was registered in the Clinical Trial Registry of India (Registration no.: CTRI/2023/07/055910, dated 31 July 2023)."

Clinical • Journal • Dermatology • Infectious Disease • Pediatrics

Navigating Therapeutic Frontiers: A Meta-review and Meta-analysis of COVID-19 Treatment Options. (PubMed, J Res Pharm Pract) - "285 reviews with 152 meta-analyses were included, The analysis of systematic reviews contents indicated that most reviewed drugs were as follows: chroquine/hydroxychloroquine (n = 48), tocilizumab (n = 39), remdesivir (n = 25), corticosteroids (n = 25), JAK inhibitors (n = 12), colchicine (n = 11), ivermectin (n = 8), anakinra (n = 7), favipravir (n = 7), lopinavir/ritonavir (n = 6), ACEI/ARB (n = 6), azithromycin (n = 4), sofosbuvir (n = 4), and Vitamin D (n = 4)...lower requirement for mechanical ventilation and intensive care unit admission and a shorter hospital length of stay was observed with the tocilizumab, JAKIs, anakinra, corticosteroids and sofosbuvir Only one third of the included reviews had 70% quality based on the AMSTAR scale assessment. The results of this study have the potential to be a useful tool for the translation of health evidence and for designing the decision support systems for evidence synthesis."

Journal • Retrospective data • Review • Critical care • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Real-World Comparison of 5% Permethrin Cream Alone versus Combination with Oral Ivermectin for the Treatment of Scabies: A Retrospective Study (EADV 2026) - No abstract available

Real-world • Real-world evidence • Retrospective data • Infectious Disease

Spectacular Response of Pediatric Palmar Scabies to Oral Ivermectin and Antibiotherapy: A Case Report (EADV 2026) - No abstract available

Case report • Clinical • Infectious Disease • Pediatrics

Strongyloides hyperinfection complicated by invasive aspergillosis and osmotic demyelination syndrome. (PubMed, Trop Doct) - "His course was complicated by multidrug-resistant Klebsiella pneumoniae bacteraemia, probable invasive pulmonary aspergillosis and osmotic demyelination syndrome related to severe electrolyte disturbances. He improved with ivermectin and supportive therapy, highlighting the importance of early recognition of strongyloidiasis in steroid-exposed patients in endemic regions."

Journal • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Modelling anti-Ov16 seroprevalence for the control and elimination of onchocerciasis. (PubMed, Nat Commun) - "The duration of antibody persistence remains uncertain. Our findings support the use of mechanistic transmission models to refine serological thresholds for start- and stop-treatment, and aid interpretation of post-treatment and post-elimination surveillance serological signals."

Journal • Infectious Disease

BEYOND HYPERINFECTION: A MAZZOTTI-LIKE REACTION WITH IVERMECTIN IN PULMONARY STRONGYLOIDIASIS (CHEST 2026) - No abstract available

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges. (PubMed, Neuroprotection) - "In this review, we critically examine the therapeutic potential of selected antimicrobial classes, including tetracyclines (e.g., minocycline), macrolides (e.g., azithromycin), antimalarial agents (e.g., chloroquine/hydroxychloroquine), sulfones (e.g., dapsone), and antiparasitic agents (e.g., ivermectin), in non-infectious neurological diseases...Despite the encouraging evidence, we must carefully manage challenges such as antimicrobial resistance, off-target effects, and regulatory considerations. Further well-designed clinical trials are essential to validate their long-term safety and efficacy in neurodegenerative and neuroinflammatory diseases."

Journal • Review • Alzheimer's Disease • Cardiovascular • CNS Disorders • Epilepsy • Infectious Disease • Inflammation • Metabolic Disorders • Movement Disorders • Parkinson's Disease • Vascular Neurology

Evaluation of Dermatologists' Opinions in the Face of Increasing Scabies Cases: A Survey Study. (PubMed, Turkiye Parazitol Derg) - "Nearly 60% of dermatologists reported using oral ivermectin as a second-line therapy, while 20% prescribed it as a first-line therapy in appropriate cases...Scabies remains a growing healthcare problem in Türkiye. Strengthening primary care involvement, improving patient education, and reconsidering treatment strategies are essential for effective disease control."

Journal • Dermatology • Infectious Disease

Incidental Colonic Strongyloides stercoralis During Surveillance Colonoscopy in an Asymptomatic Patient Receiving Immunosuppressive Therapy (ACG 2026) - "Medications included methotrexate and TNF-α inhibitor adalimumab...Figure: Figure 1 - Cecum polyp shown between 2 white arrows. Figure: Figure 2 - H&E stain: Strongyloides stercoralis larvae (single arrow) with dense eosinophilic infiltrate (double arrows)."

Clinical • Cardiovascular • Diabetes • Dyslipidemia • Endocrine Disorders • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Glaucoma • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Inflammatory Bowel Disease • Metabolic Disorders • Obesity • Ophthalmology • Rheumatoid Arthritis

Sepsis Secondary to Crusted Scabies Following Iatrogenic Treatment for Hansen's Disease in an Indigenous Amazonian Patient: A Case Report. (PubMed, Case Rep Infect Dis) - "He was treated with oral ivermectin, topical 5% permethrin, and systemic antibiotics, with gradual tapering and discontinuation of corticosteroids. This case highlights the critical importance of early recognition of crusted scabies and the risks associated with misdiagnosis and inappropriate immunosuppressive therapy. Prompt diagnosis and treatment are essential to prevent severe complications such as sepsis, particularly in resource-limited and endemic settings."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Pruritus • Septic Shock

Declining Onchocerca volvulus transmission despite limited ivermectin delivery in the Kakoi-Koda focus, Ituri, Democratic Republic of the Congo: An epidemiological, entomological and landscape evidence synthesis. (PubMed, PLoS Negl Trop Dis) - "Parasitological, serological, entomological and geospatial evidence consistently indicates substantial declines in O. volvulus infection indicators across Kakoi-Koda, compatible with reduced transmission. Residual positive indicators were spatially circumscribed, including in Logo where no routine ivermectin was delivered. Whether the current simuliid species can sustain transmission above elimination thresholds remains uncertain. Standardised, representative surveys in the Muda/Kuda and Lebu River basins are warranted to guide decisions on starting and stopping ivermectin delivery."

Journal • Infectious Disease

Opening a Can of Worms: Incidental Strongyloides stercoralis in an Elderly Asymptomatic Male (ACG 2026) - "Figure: Figure 2. Histopathological findings showing (A) colonic mucosa with eosinophilia and a parasitic fragment consistent with Strongyloides stercoralis (yellow circle), and (B) colonic mucosal eosinophilia."

Clinical • Addiction (Opioid and Alcohol) • Colorectal Cancer • Eosinophilia • Gastrointestinal Disorder • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Substance Abuse

Hidden in the Crypts: Strongyloides Hyperinfection Syndrome Overshadowed by Concurrent H. pylori Gastritis (ACG 2026) - "Ivermectin and albendazole were initiated...Figure: (Histology, H&E 200x): Gastric biopsy demonstrating Strongyloides stercoralis larvae within gastric crypts (arrows), with marked active chronic inflammation and reactive epithelial changes. Figure: (EGD): Endoscopic view demonstrating diffuse severe gastritis with mucosal erythema, friability, erosions, and ulceration throughout the gastric body."

Cardiovascular • Diabetes • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Infectious Disease • Inflammation • Metabolic Disorders • Peptic Ulcer • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus

Gastric and Duodenal Strongyloidiasis Presenting as Acute Dysphagia in an Immunocompetent Patient (ACG 2026) - "Despite immigrating from Honduras 25-years earlier, our patient remained chronically infected. Clinicians should maintain suspicion for strongyloidiasis in patients from endemic areas presenting with unexplained gastrointestinal symptoms, even years after emigration."

Clinical • Eosinophilia • Gastrointestinal Disorder • Human Immunodeficiency Virus • Infectious Disease • Peptic Ulcer

Strongyloidiasis Presenting as Steroid-Refractory Colitis Years After Remote Travel to an Endemic Region (ACG 2026) - "She was treated with IV methylprednisolone and mesalamine for presumed IBD flare without improvement...Colonoscopy demonstrating (A) erythema and small superficial ulcerations in the terminal ileum and (B) diffusely irregular mucosa characterized by mucosal erythema, edema, friability, and ulceration in the transverse to splenic flexure region. Findings initially attributed to Crohn disease prior to diagnosis of Strongyloides stercoralis infection."

Crohn's disease • Diabetes • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Type 2 Diabetes Mellitus • Ulcerative Colitis

Pasta and Parasites: A Penne for Your Thoughts! (ACG 2026) - "Figure: Probable intestinal worms with multiple linear filling defects in the mid jejunum, some appear to contain positive oral contrast internally. Large conglomerate of the worms is causing a partial low-grade obstruction with proximal bowel dilated up to 3.3 cm and decompressed distal bowel."

Celiac Disease • Constipation • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease

Biopsy-Proven Pluvicto (Lutetium-177 Vipivotide Tetraxetan)-Induced Colitis in a Patient With Metastatic Prostate Cancer: A Case Report (ACG 2026) - "Case Description/ A 60-year-old man with stage IVB metastatic prostate adenocarcinoma (BRCA2-mutated), previously treated with radiotherapy and docetaxel, began lutetium-177 vipivotide tetraxetan therapy at an outside institution...Budesonide 9 mg daily led to rapid symptom improvement...No granulomas or viral cytopathic effect is identified Figure: Colonic mucosa demonstrates focally active chronic colitis with cryptitis, mixed inflammatory infiltrates in the lamina propria, and mild and focal crypt architectural distortion. No granulomas or viral cytopathic effect is identified"

Biopsy • Case report • Clinical • Metastases • Castration-Resistant Prostate Cancer • Gastroenterology • Gastrointestinal Disorder • Genito-urinary Cancer • Immunology • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor • BRCA2

Incidental Detection of Trichuris trichiura (Whipworm) During Screening Colonoscopy in an Asymptomatic Patient With HIV (ACG 2026) - "Albendazole and ivermectin are effective, and follow-up stool testing is recommended to confirm eradication...Parasitic infections should be considered during screening colonoscopy in patients with relevant epidemiologic risk factors. Figure: Whipworm visualized on colonoscopy Figure: Whipworm visualized on colonoscopy"

Clinical • Hematological Disorders • Hepatitis B • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Respiratory Diseases • Tuberculosis

Diffuse Colonic Ulcerations and Hematochezia Mimicking Ischemic Colitis in a Post-Hematopoietic Cell Transplant Patient With Strongyloides stercoralis Infection (ACG 2026) - "Case Description/ A 69-year-old male with IgA Kappa MM status post autologous HCT receiving daratumumab, pomalidomide, and dexamethasone presented with progressive weakness and failure to thrive over several months...Figure: Figure 1: Colonoscopy demonstrating erythema and ulceration at the hepatic flexure. Figure: Figure 2: Colonic biopsy demonstrating parasitic organisms (arrows) within the mucosa, with associated eosinophilic inflammation and giant cells involving the crypts and lamina propria."

Clinical • Atrial Fibrillation • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hypotension • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Multiple Myeloma • Transplantation

Refractory Pruritus and Eosinophilic Dermatitis as the Sole Presenting Manifestation of Hepatocellular Carcinoma Arising From Occult Hepatitis B Infection (ACG 2026) - "The symptoms were unresponsive despite dermatological treatment with topical steroids, antihistamines, ivermectin, fluconazole, and doxycycline...He was started on dual immunotherapy with tremelimumab and durvalumab. Tenofovir disoproxil fumarate was initiated for HBV prophylaxis prior to immunotherapy...This case also highlights the importance of evaluating occult HBV infection in anti-HBc-positive patients and adds to emerging evidence supporting consideration of occult hepatitis B infection in future HCC surveillance guidelines. Figure: Figure 1: Eroded crusted erythematous papules on erythematous base in anterior chest and erythematous pink lichenified papules coalescing into plaques in lower abdomen Figure: Figure 2: Triple phase CT abdomen and pelvis demonstrating a large hepatic mass (20.1 Ã 12.6 Ã 14.8 cm) involving both left and right lobes with hypervascularity ( Image A: arterial phase ) and washout ( Image B: portal venous phase and Image C: delayed..."

Acute Lymphocytic Leukemia • Dermatitis • Dermatology • Hematological Malignancies • Hepatitis B • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Lymphoblastic Lymphoma • Lymphoma • Oncology • Pruritus • Skin Cancer • Solid Tumor • AFP

Strongyloidiasis Presenting as Recurrent Eosinophilic Ascites, Pleural Effusion, and Severe Gastrointestinal Dysmotility: A Diagnostic Challenge (ACG 2026) - "Prolonged inflammation may have resulted in irreversible dysfunction. Serologic testing is most sensitive to diagnose chroni strongyloidiasis."

Pleural effusion • Constipation • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Leukopenia • Respiratory Diseases