SER150 / Serodus, Evolva - LARVOL DELTA

Identification, characterization and molecular docking study of umami peptides from Spanish mackerel head enzymatic hydrolysate and Maillard reaction products. (PubMed, Int J Biol Macromol) - "Molecular docking analysis revealed that these peptides interact with the T1R1/T1R3 umami receptor through hydrogen bonding and hydrophobic interactions, with key binding residues identified as Ser150, Ser256, and Glu128. This study provides a novel methodology for screening umami peptides from seafood by-products and lays the groundwork for their application as natural umami enhancers in the food industry."

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SER150 vs Placebo in Diabetic Kidney Disease (clinicaltrials.gov) - P2/3 | N=20 | Completed | Sponsor: Serodus AS | Recruiting ➔ Completed | N=110 ➔ 20 | Trial completion date: Jan 2025 ➔ Jun 2024 | Trial primary completion date: Jan 2025 ➔ Jun 2024

Enrollment change • Trial completion • Trial completion date • Trial primary completion date • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

Nanostructures on Fluoropolymer Nanotextile Prepared Using a High-Energy Excimer Laser. (PubMed, Materials (Basel)) - "Samples coated with silver and further treated with the excimer laser 150 mJ/cm inhibited 100% of the bacterial strain E. coli...These properties can be used in different types of applications, mainly in tissue engineering and the medicinal industry, where water-repellent materials may play important roles. This synergy was achieved via the technique we proposed, and even when the Ag nanostructures were prepared, the high hydrophobicity of the system Ag-polytetrafluorethylene was maintained."

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Phosphorylation-Competent Metastable State of Escherichia coli Toxin HipA. (PubMed, Biochemistry) - "The Escherichia coli toxin HipA, which phosphorylates glutamyl-tRNA synthetase and triggers bacterial persistence under stress, becomes inactivated upon autophosphorylation of Ser150...Together, the data clearly identify the existence of a phosphorylation-competent metastable state of HipA. Our results not only suggest a mechanism of HipA autophosphorylation but also add to a number of recent reports on unrelated protein systems where the common proposed mechanism for phosphorylation of buried residues is their transient exposure even without phosphorylation."

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Molecular mechanism of LIP05 derived from Monascus purpureus YJX-8 for synthesizing fatty acid ethyl esters under aqueous phase. (PubMed, Front Microbiol) - "Protein structure modeling indicated LIP05 belonged to α/β fold hydrolase, contained a lid domain and a core catalytic pocket with conserved catalytic triad Ser150-His215-Asp202, and the oxyanion hole composed of Gly73 and Thr74...Residues Leu83, Ile204, Ile211 and Leu216 were involved in forming the hydrophobic substrate-binding pocket through steric hindrance and hydrophobic interaction. The catalytic mechanism for esterification in aqueous phase of LIP05 was proposed and provided a reference for clarifying the synthesis of fatty acid ethyl esters during the fermentation process of strong-flavor Baijiu."

Journal • CD20

SER150 vs Placebo in Diabetic Kidney Disease (clinicaltrials.gov) - P2/3 | N=110 | Recruiting | Sponsor: Serodus ASA | Trial completion date: Jun 2023 ➔ Jan 2025 | Trial primary completion date: Jun 2023 ➔ Jan 2025

Trial completion date • Trial primary completion date • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

The effect of different training modalities on resting hormonal level in active young males. (PubMed, J Appl Biomed) - "86 regularly active young males were assigned to one of six groups: Endurance constant running (ECR), Endurance interval running (EIR), Resistance training (RT), Explosive training (ET), Speed-endurance 50 m running (SER50) and Speed-endurance 150 m running (SER150) training...Except for SER50, each training program improved physical fitness. Our results suggest that endurance and resistance training modalities performed with a moderate to vigorous intensity may be a usable way to manage the resting cortisol level and enhance physical fitness in active young males."

Journal

SER150 vs Placebo in Diabetic Kidney Disease (clinicaltrials.gov) - P2/3; N=100; Recruiting; Sponsor: Serodus ASA; Not yet recruiting ➔ Recruiting

Clinical • Enrollment open • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus

SER150 vs Placebo in Diabetic Kidney Disease (clinicaltrials.gov) - P2/3; N=100; Not yet recruiting; Sponsor: Serodus ASA

Clinical • New P2/3 trial • Diabetes • Diabetic Nephropathy • Metabolic Disorders • Nephrology • Renal Disease • Type 2 Diabetes Mellitus • CST3

Pesticide application inhibit the microbial carbonic anhydrase-mediated carbon sequestration in a soil microcosm. (PubMed, Environ Sci Pollut Res Int) - "The inhibition was a mixed type and had significantly lowered the carbon reduction to about 2.38 ± 0.17% in a soil microcosm study. Based on the molecular docking, the inhibition was contributed due to weak H-bonding interaction with amino acid residues (Gly65, Gly95, Val147, Ser150 and Gly65, Ser146, and Ser150)."

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A molecular dynamics simulation study decodes the Zika virus NS5 methyltransferase bound to SAH and RNA analogue. (PubMed, Sci Rep) - "For the binding motif of Zika virus NS5 protein and SAH, we suggest that the four Zika NS5 substructures (residue orders: 101-112, 54-86, 127-136 and 146-161) and the residues (Ser56, Gly81, Arg84, Trp87, Thr104, Gly106, Gly107, His110, Asp146, Ile147, and Gly148) might be responsible for the selectivity of the new Zika virus drugs. For the binding motif of Zika NS5 protein and m7GTP, we suggest that the three Zika NS5 substructures (residue orders: 11-31, 146-161 and 207-218) and the residues (Asn17, Phe24, Lys28, Lys29, Ser150, Arg213, and Ser215) might be responsible for the selectivity of the new Zika virus drugs."

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Evaluating the suitability of RNA intervention mechanism exerted by some Flavonoid molecules against Dengue virus MTase RNA capping site: A Molecular docking, Molecular dynamics simulation and Binding free energy study. (PubMed, J Biomol Struct Dyn) - "Notably, QGN forms strong hydrogen bonding interactions with Asn18, Leu20 and Ser150 residues and π⋅⋅⋅π stacking interaction with Phe25 residue...The binding free energy calulation includes prediction of total binding free energy of ligand-protein complex and per-residue free energy decomposition. The QGN binding to NS5 MTase affects it's native motion, this result is found from Principal component analysis."

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