TC-2429 / Gyre Therapeutics - LARVOL DELTA

Short- and Long-Term Effects of Cocaine on Enteric Neuronal Functions. (PubMed, Cells) - "Key results obtained are that cocaine (1) exhibits a stimulating, non-neuronal effect on gastric antrum motility, (2) acutely (but not chronically) diminishes responses of primary cultured enteric neurons to nicotinic and serotonergic stimulation and (3) reversibly attenuates neuronal-mediated intestinal mucosal secretion. It can be concluded that cocaine, among its central effects, also alters enteric neuronal functions, providing potential explanations for the coexistence of cocaine abuse and gastrointestinal complaints."

Journal • Gastrointestinal Disorder • Tobacco Addiction