pegylated endostatin (M2ES) / Protgen - LARVOL DELTA

An evaluation of the Africa-CORDEX regional climate model's performance in simulating air temperatures and precipitation in the Melka-Wakena catchment, southeast Ethiopia. (PubMed, Heliyon) - "This study finds that, top-3 ensemble (for temporal scale tasmin, monthly pr), top-7 ensemble (monthly and seasonal tasmax), average hybrid (top-1 with MME (daily pr and tasmax), HadGEM2ES_RACMO22T for seasonal and yearly pr), and HadGEM2ES_RCA4 for yearly tasmax) are preferable, with weighted scores of 0.29, 0.44, 0.22, 0.20, 0.35, 0.40, 0.39, 0.33, 0.45, 0.25, and 0.33, respectively...While ensemble approaches are generally more resilient and possible, single-best-performing model approaches can be quite effective for long-term periods. Finally, these studies have an important implication for improving climate change assessment, adaptation, and mitigation measures."

Journal

Large-area and few-layered 1T'-MoTe2 thin films grown by cold-wall chemical vapor deposition. (PubMed, Nanotechnology) - "Furthermore, Ti/Al bilayer metal contacts deposited on the few-layered 1T'-MoTe2films exhibit low specific contact resistances of approximately 1.0 × 10-4Ω-cm2estimated by the transfer length model. This finding suggests a viable approach for achieving low ohmic contact resistance using the 1T'-MoTe2intermediate layer between metallic electrodes and two-dimensional semiconductors."

Journal

"Sri Lanka shine in Super Over to seal T20 win over New Zealand https://t.co/im2EssWDlT" (@Reuters)

Pre-clinical Efficacy and Safety Pharmacology of PEGylated Recombinant Human Endostatin. (PubMed, Curr Mol Med) - "On the basis of the pre-clinical efficacy and safety pharmacology data of M2ES, M2ES can be authorized to carry out further clinical studies."

Journal • Preclinical • Gastric Cancer • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor

"Exceedingly powerful video about applying PRINCIPLES of airtravel safety to Healthcare by surgeon turned pilot @nialldowney https://t.co/bLatm2eSBa @Atul_Gawande @GaryLSculli @TheIHI" (@doctorcaldwell)

Clinical • Video

"Es gab ja mal den Ansatz über Mesothelin im Blut ein sehr einfaches Erstscreening zu machen. https://t.co/Hz2krqm2Es" (@DocPress)

MSLN

"Cannabisbruk kan öka risken för psykotiska störningar https://t.co/DMg6x2M2Es" (@CisionNews)

"Caduceus versus the Staff of Asclepius from Hektoen International Nice brief article at the link https://t.co/IhZM2eS2Bo" (@DrDanMO)

"F-Secure Becomes Cybersecurity Awareness Month 2021 Champion https://t.co/12NGm2espW" (@CisionNews)

Clinical efficacy of Qi Di laxative decoction in the treatment of functional constipation: A protocol for systematic review and meta-analysis. (PubMed, Medicine (Baltimore)) - "This proposed systematic review will evaluate the existing evidence on the clinical efficacy of Qi Di Laxative Decoction in treating FC."

Journal • Retrospective data • Review • Constipation • Gastroenterology • Gastrointestinal Disorder

"Właśnie przed chwiła znalazłam że to w Niemczech - gdzie myslałabym że by czytali... tylko jedna osoba pozostaje w szpitalu... https://t.co/fM2EsSqqBH" (@KJPiorkowska)

M2 macrophage-derived exosomes promote the c-KIT phenotype of vascular smooth muscle cells during vascular tissue repair after intravascular stent implantation. (PubMed, Theranostics) - "In addition, the isolated M2Es helped to promote VSMC dedifferentiation and softening. Furthermore, the M2Es enhanced vascular tissue repair potency by upregulation of VSMCs c-KIT expression via activation of the c-Jun/activator protein 1 (AP-1) signaling pathway. The findings of this study emphasize the prominent role of M2Es during VSMC dedifferentiation and vascular tissue repair via activation of the c-Jun/AP-1 signaling pathway, which has a profound impact on the therapeutic strategies of coronary stenting techniques."

Journal • IL13 • IL4 • KIT

Biophysical and Biological Characterization of PEGylated Recombinant Human Endostatin (M ES). (PubMed, Clin Exp Pharmacol Physiol) - "Notably, M ES retards endothelial cell migration and tumor growth when compared to control group. These biophysical and biological characterization study data contribute to the initiation of the ongoing clinical study."

Journal • Oncology • Prostate Cancer

Cost-effectiveness of adding Rh-endostatin to first-line chemotherapy in patients with advanced non-small-cell lung cancer in China (Clin Ther) - P=NA; N=NA; Treatment with rh-endostatin plus standard CT would increase OS by 0.63 years and 0.35 QALYs per patient compared with standard CT, at an additional cost of $8402.60; The ICER for adding rh-endostatin to chemotherapy was $24,454.25/QALY gained (at a 3% discounted rate); On 1-way sensitivity analysis, the utility value of progression-free survival was the most influential factor on the results, followed by the cost of rh-endostatin

Cost analysis • Non Small Cell Lung Cancer

"https://t.co/hs7Gm2esZV" (@LuigiFontana22)