Fraxiparine (nadroparin) / Aspen Pharma - LARVOL DELTA

perioperative anticoagulation study (ChiCTR) - P=N/A | N=400 | Not yet recruiting | Sponsor: Fudan University Shanghai Cancer Center; Fudan University Shanghai Cancer Center

New trial • Cholangiocarcinoma • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor

Formation and Development of Deep Vein Thrombosis in Hip Fracture Patients With and Without Anticoagulation. (PubMed, Clin Appl Thromb Hemost) - "The anticoagulation group received nadroparin calcium (Fraxiparine, 3800 IU/0.4 mL subcutaneously once daily) plus mechanical thromboprophylaxis with an intermittent plantar pressure pump...Selective screening guided by symptoms or high-risk features may offer a more clinically appropriate strategy. Future studies should determine whether early DVT detection in this population translates into improved patient-important outcomes."

Clinical • Journal • Cardiovascular • Hematological Disorders • Musculoskeletal Diseases • Orthopedics • Pulmonary Embolism • Respiratory Diseases • Thrombosis • Venous Thromboembolism

Inhibitor-Regulated Cas12a Activation Enables Highly Sensitive and One-Pot Detection of Drug-Resistant Genes in River Water. (PubMed, Anal Chem) - "To overcome compatibility challenges between RPA and CRISPR systems, four glycosaminoglycans (heparin sodium, nadroparin calcium, dalteparin sodium, and chondroitin sulfate A sodium salt) with different molecular weights or negative charge density were evaluated as Cas-enzyme activity modulators. This assay achieved high sensitivity and specificity when it was applied to river samples, matching the performance of qPCR. The developed assay is simple to operate, has high sensitivity, and is widely adaptable, providing a robust tool for rapid antimicrobial resistance surveillance and exhibiting promise for public health management applications."

Journal

Explosive Multiterritorial Arterial Thrombosis Following Brief Heparin Exposure: A Diagnostic Pitfall in the Cath Lab. (PubMed, Case Rep Cardiol) - "This followed a brief nadroparin exposure 8 days prior...Management involved non-heparin anticoagulation (danaparoid sodium) and thrombectomies...The immediate "anaphylactoid-like" reaction following a heparin bolus is often misidentified as contrast allergy, delaying life-saving intervention. Suspect HIT in acute systemic reactions or multifocal thrombosis after heparin exposure, regardless of initial platelet counts."

Journal • Allergy • Cardiovascular • Hematological Disorders • Immunology • Myocardial Infarction • Thrombocytopenia • Thrombosis

The PARTUM Trial: Postpartum Aspirin to Reduce Thromboembolism Undue Morbidity (clinicaltrials.gov) - P3 | N=8805 | Recruiting | Sponsor: University of Calgary | Not yet recruiting ➔ Recruiting

Enrollment open • Cardiovascular • Venous Thromboembolism

Analysis of risk factors and prognostic differences in hospital-acquired thrombosis between very preterm infants and moderate to late preterm infants. (PubMed, Front Pediatr) - "A total of 40% of patients received pharmacotherapy (mainly nadroparin calcium, supplemented with rt-PA), with 5% discontinuing medication due to active bleeding...Individualised pharmacotherapy based on clinical manifestations and thrombus characteristics is associated with a favourable short-term prognosis, and timely adjustment of an abnormal catheter position is crucial for reducing thrombosis risk. Long-term follow-up is still needed for preterm infants with venous thrombosis to monitor for late adverse outcomes."

Journal • Cardiovascular • Critical care • Hematological Disorders • Pediatrics • Thrombosis

Dalteparin vs Nadroparin: A Retrospective Cohort Study of LMWH Therapy–Related Clinical Outcomes and Pain in Neonates and Young Infants (ISTH 2026) - "No clear drug-specific differences in pain were observed. DOI*10.1016/j.rpth.2026.105042"

Clinical data • Retrospective data • Cardiovascular • Hematological Disorders • Pain • Thrombosis

Maternal and Newborn Outcomes Following Inadvertent First-Trimester Exposure to Direct Oral Anticoagulants: A Retrospective Case Series. (ISTH 2026) - "Patients received rivaroxaban (n=9, 75.0%), or apixaban (n=3, 25.0%). Ten patients received enoxaparin and two nadroparin...Table or Figure Upload (1) Table 1. General characteristics and main results of 12 women who received DOACs during the first trimester of pregnancy Page 2 DOI*10.1016/j.rpth.2026.104735"

Retrospective data • Cardiovascular • Hematological Disorders • Thrombosis

Twice-Weekly Incremental Hemodialysis in a Real-World Cohort (ERA 2026) - "Intradialytic anticoagulation was provided with trisodium citrate in 11 patients, while the others received unfractionated heparin or nadroparin. Most patients maintained stable biochemical parameters during incremental treatment, and residual diuresis was supported with high-dose furosemide in approximately three-quarters of patients...Dialysis adequacy and biochemical control, including anemia and secondary hyperparathyroidism management, remained stable, while residual diuresis was preserved in the majority of patients. These findings support twice-weekly incremental hemodialysis as a viable treatment option in carefully selected patients in routine clinical practice."

Clinical • Real-world • Real-world evidence • Cardiovascular • Diabetes • Endocrine Disorders • Hematological Disorders • Metabolic Disorders • Nephrology • Secondary Hyperparathyroidism • Type 2 Diabetes Mellitus

Treatment of a patient diagnosed with cerebral hemorrhage complicated by atypical pulmonary embolism in the rehabilitation department: Case report and anatomical factors analysis. (PubMed, Neuro Endocrinol Lett) - "Intracerebral hemorrhage complicated by atypical PE is a relatively uncommon occurrence in the rehabilitation ward. In this case, conservative low-dose nadroparin calcium anticoagulation was associated with marked biochemical improvement and complete bilateral pulmonary artery clearance on follow-up CTA, without recurrent intracranial hemorrhage. Although no domestic or international guidelines currently address intracerebral hemorrhage complicated by atypical PE, our experience suggests that early prevention, timely diagnosis, individualized anticoagulation, and multidisciplinary collaboration can enable safe and effective management in carefully selected patients."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Pulmonary Embolism • Respiratory Diseases

Symptomatic upper-extremity deep vein thrombosis induced by reverse S-shaped distortion of a peripherally inserted central catheter due to post-craniotomy epilepsy following traumatic brain injury: a case report. (PubMed, Front Med (Lausanne)) - "A cautious anticoagulation strategy was adopted, starting with nadroparin calcium at 4,100 IU once daily, then twice daily, and later switched to enoxaparin at 6,000 IU twice daily. Upon recanalization of the thrombus, the regimen was sequentially transitioned to rivaroxaban 20 mg once daily and maintained until discharge...Epilepsy after traumatic brain injury can cause unexpected PICC distortion, markedly increasing UEDVT risk. If the catheter is still required and keeps patent, maintaining it in situ with carefully escalated anticoagulation may be a safe management strategy."

Journal • Cardiovascular • CNS Disorders • Epilepsy • Hematological Disorders • Thrombosis • Vascular Neurology • Venous Thromboembolism

Monitoring anti-Xa levels and thromboelastography in puerperal venous thromboembolism: a prospective cohort study. (PubMed, Front Med (Lausanne)) - P=N/A | "This prospective cohort study included postpartum VTE patients treated with nadroparin at Shanghai First Maternity and Infant Hospital (September 2021-July 2022)...Anti-Xa levels and TEG correlations may enhance individualized anticoagulation monitoring strategies. https://www.chictr.org.cn/bin/project/edit?pid=132010, ChiCTR2100051002."

Journal • Cardiovascular • Hematological Disorders • Thrombocytopenia • Venous Thromboembolism

Observation of the Clinical Efficacy of Enoxaparin Sodium and Nadroparin Calcium in Preventing Lower Limb DVT after ACLR. (PubMed, Indian J Orthop) - "Prophylactic use of LMWH during ACLR surgery is a feasible measure for preventing lower limb deep vein thrombosis. Among LMWH options, nadroparin calcium seems to have better efficacy in reducing the incidence of lower limb DVT and improving coagulation indices compared to enoxaparin sodium."

Journal • Cardiovascular • Hematological Disorders • Thrombosis

Improving Outcome in Subarachnoid Hemorrhage wIth Nadroparine (clinicaltrials.gov) - P2 | N=100 | Recruiting | Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Not yet recruiting ➔ Recruiting

Enrollment open • Hematological Disorders • Subarachnoid Hemorrhage

The Intensive Care Platform Trial (INCEPT) (clinicaltrialsregister.eu) - P4 | N=40000 | Recruiting | Sponsor: Rigshospitalet

New P4 trial • Critical care

Hepatic arterial infusion chemotherapy combined with targeted immunotherapy and anticoagulation for hepatocellular carcinoma with right atrial tumor thrombus: a case report. (PubMed, Transl Gastroenterol Hepatol) - "He was treated with a combination of HAIC (FOLFOX), lenvatinib, pembrolizumab, and nadroparin anticoagulation...He was subsequently treated with seven cycles of HAIC (FOLFOX) combined with sintilimab, bevacizumab, and peri-procedural anticoagulation...Multimodal therapy integrating HAIC with targeted immunotherapy and anticoagulation achieved exceptional tumor control in these HCC-RATT cases. This approach warrants further investigation to optimize protocols and improve outcomes in this difficult-to-treat population."

Journal • Hepatitis B • Hepatocellular Cancer • Infectious Disease • Liver Cancer • Oncology • Solid Tumor • Thrombosis

Extended thrombotic prophylaxis in COVID-19 early discharge: A retrospective cohort study. (PubMed, PLoS One) - "For the future, thrombotic prophylaxis for COVID-19 home monitoring might not be indicated and reconsidered for different home monitoring programmes."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease

Discovery of a Piperazine-Based Quaternary Ammonium Macrocycle as a Universal Reversal Agent for Heparin Anticoagulants. (PubMed, J Med Chem) - "Here, we report that a piperazine-derived tetracationic macrocycle can efficiently neutralize both UFH and LMWHs, including dalteparin, enoxaparin, and nadroparin. In vitro and in vivo assays reveal that the compound outperforms protamine, exhibiting significantly improved neutralization activity, a broad therapeutic window for all heparins, and high biocompatibility, which is confirmed by its very low coagulation and hemolysis effect, as well as a high therapeutic index (20.5), defined as the ratio of the maximum tolerated dose to the effective therapeutic dose. Molecular dynamics simulations indicate that binding may occur through interlocked threading and direct contact patterns, which are stabilized by intermolecular hydrogen bonding and ion-pair electrostatic attraction."

Journal • Hematological Disorders

Low dose AAV8-FVIII gene therapy on Chinese severe Hemophilia A patients with sustainable efficacy and safety (ASH 2025) - P=N/A | "An investigator-initiated trial (IIT) (NCT04728841) and a phase Ⅰ/Ⅱ trial (CTR20231730) of GS1191-0445 have beenconducted in Chinese patients with severe Hemophilia A to evaluate long-term efficacy and safety.Nineteen adults with severe Hemophilia A (factor Ⅷ level ≤1%) have been recruited and injected with asingle treatment of AAV8-hFⅧ infusion...Twoimmunosuppressive regimens, prophylactic prednisone or prednisone plus tacrolimus, can be selectedto control the potential AAV capsid immune response from the 7-day prior to study drug infusion to atleast 12 weeks post study drug administration...One of themuses Nadroparin calcium injection and Aspirin enteric-coated tablets to prevent blood clots...Gene therapy with AAV8-hFVIII vector in Chinese patients with Hemophilia A demonstrated a good safetyprofile and sustained, clinically relevant benefit, as measured by a substantial reduction in annualizedrates of bleeding events and complete cessation of prophylactic..."

Clinical • Gene therapy • Cardiovascular • Gene Therapies • Hematological Disorders • Hemophilia • Hemophilia A • Rare Diseases • Thrombosis

Exploring anti-Xa activity and its correlation with C-Reactive Protein in Intensive Care Unit patients receiving a therapeutic dosage of nadroparin. (PubMed, Thromb Res) - No abstract available

Journal • Critical care • Renal Disease • CRP

Updated Meta-Analysis of Randomized Controlled Trials on Primary Outpatient Thromboprophylaxis (POTP) in Patients with Lung Cancer Receiving Chemotherapy (ASH 2023) - "The prophylactic doses of bemiparin, certoparin, dalteparin, nadroparin, semuloparin and tinzaparin, intermediate dose of enoxaparin and prophylactic dose of rivaroxaban and apixaban were used in the studies. In our subgroup meta-analysis of POTP with DOACs, there was no statistically significant difference in reduction of VTE in LC patients with Khorana Score ≥2. Hence, the selection of appropriate patients who are high risk for VTE is crucial and further studies are required to define high risk subsets of LC patients receiving chemotherapy who may benefit from POTP."

Retrospective data • Cardiovascular • Lung Cancer • Oncology • Solid Tumor • Venous Thromboembolism

Atypical Presentation of Toxic Shock Syndrome in a Patient With Postpartum Necrotizing Endometritis. (PubMed, Cureus) - "Although she had been prescribed prophylactic nadroparin during pregnancy, anticoagulation was discontinued upon discharge following the cesarean section...Skin lesions gradually stabilized with desquamation and partial healing by day 14. This case highlights an unusual dermatologic manifestation of TSS and underscores the potential contribution of MTHFR C677T/A1298C polymorphisms to thromboinflammatory complications in the postpartum period."

Journal • Acute Kidney Injury • Cardiovascular • Endometriosis • Gynecology • Hematological Disorders • Hypotension • Infectious Disease • Nephrology • Renal Disease • Septic Shock • Thrombosis • MTHFR

A multicenter randomized controlled trial of heparin therapy for patients with functional abnormalities in cardiac mechanical valves (ChiCTR) - P=N/A | N=134 | Recruiting | Sponsor: Northern Theater Command General Hospital of the Chinese People's Liberation Army; Northern Theater Command General Hospital

New trial

Early Massive Left Atrial Thrombosis Following Mitral Bioprosthetic Valve Replacement Due to Suboptimal Anticoagulation: A Case Report. (PubMed, Cureus) - "Anticoagulation therapy was intensified with warfarin and bridged with subcutaneous nadroparin. The thrombus decreased after three weeks and resolved completely by three months, and subsequent echocardiography showed valvular function was satisfactory. This case underscores the importance of strict INR monitoring for high-risk patients, highlighting that warfarin is an effective treatment option for left atrial thrombi following mitral valve replacement."

Journal • Atrial Fibrillation • Cardiovascular • Hematological Disorders • Thrombosis

Gaps and comparison in knowledge and management on venous thromboembolism in nephrotic syndrome: a national survey of pulmonologists and nephrologists (ERS 2025) - "This nationwide study revealed significant disparities in VTE risk perception and implementation of evidence-based guidelines among physicians between pulmonologists and nephrologists."

Cardiovascular • Glomerulonephritis • Nephrology • Renal Disease • Venous Thromboembolism