MB-110 / Microbio, National Health Research Institutes - LARVOL DELTA

[VIRTUAL] MBP110 - Resolving the Known Unknowns: The Quest for Gene Function (WMF 2021) - "This session will highlight approaches to assign functions to genes, such as through genetic screens, improved phenotyping, and computational analyses. Upon completion of this In-depth Symposium, the participant should be able to: Describe the challenges of homology-based functional annotation Illustrate new methods for functional gene annotation Compare experimental and computational approaches for assigning gene function"

Collaborative Cross Mice Yield Genetic Modifiers for Pseudomonas aeruginosa Infection in Human Lung Disease. (PubMed, mBio) - "Based on major changes in the survival times, a quantitative-trait locus (QTL) was mapped on murine chromosome 3 to the genomic interval of Mb 110.4 to 120.5...Our study employed novel approaches and improved mouse disease models to identify genetic modifiers that affect the severity of P. aeruginosa lung infection. We identified candidate genes to enhance our understanding of P. aeruginosa infection in humans and provide a proof of concept that could be exploited for other human pathologies mediated by bacterial infection."

Journal

A versatile diamond anvil cell for X-ray inelastic, diffraction and imaging studies at synchrotron facilities. (PubMed, Rev Sci Instrum) - "An even larger opening of 150° can be manufactured enabling X-ray imaging tomography. We report data obtained with the mBX110 on different beamlines with single-crystal diffraction of stishovite up to 55 GPa, X-ray powder diffraction of rutile-GeO and tungsten to 25 GPa and 280 GPa, respectively, X-Ray Raman spectra of the Si L-edge in silica to 95 GPa, and Fe Kβ X-ray emission spectra on a basalt glass to 17 GPa."

Journal