Civamide topical (zucapsaicin topical) / Winston Pharma - LARVOL DELTA

Civamide Nasal Solution for Cluster Headache (clinicaltrials.gov) - P3; N=180; Not yet recruiting; Sponsor: Winston Laboratories; Trial completion date: Feb 2024 ➔ Feb 2026; Trial primary completion date: Nov 2023 ➔ Nov 2025

Clinical • Trial completion date • Trial primary completion date • Pain

Civamide Nasal Solution for Cluster Headache (clinicaltrials.gov) - P3; N=180; Not yet recruiting; Sponsor: Winston Laboratories; Trial primary completion date: Apr 2016 ->Apr 2017

Trial primary completion date • Biosimilar

Probing capsaicin-TRPA1 interactions with computational analysis (Neuroscience 2019) - "When docking was performed with a 100% exhaustive search with three replications, zucapsaicin emerged as the highest affinity ligand in the capsaicinoid family series. Results suggest that molecular simulation studies may help guide the selection and design of capsaicin derivatives for therapeutic purposes and will inform the design of experiments that evaluate TRPA1 responses to capsaicinoids in cells of the nervous system."

Civamide Nasal Solution for Cluster Headache (clinicaltrials.gov) - P3; N=180; Not yet recruiting; Sponsor: Winston Laboratories; Trial completion date: Feb 2022 ➔ Feb 2024; Trial primary completion date: Nov 2021 ➔ Nov 2023

Clinical • Trial completion date • Trial primary completion date