Suvenyl (sodium hyaluronate) / Roche - LARVOL DELTA

A new hyaluronate gel spacer and injection technique for cervical cancer brachytherapy: a technical report. (PubMed, J Radiat Res) - "We introduce a new hyaluronate gel spacer with MEIJI (ADANT®) as an alternative to the previously used Suvenyl® and its injection technique for cervical cancer brachytherapy. MEIJI HGI facilitates a sufficient CTVHRD90% while keeping the rectal and bladder D2cc within dose constraints, even when the rectum and bladder are in close proximity to the CTVHR. In conclusion, the MEIJI spacer may help appropriately meet dose constraints, thereby potentially contributing to improving local control and/or reducing adverse events for patients receiving radiotherapy for cervical cancer."

Journal • Cervical Cancer • Oncology • Solid Tumor

THE EXPRESSION OF ADAMTS4, A MAJOR AGGRECANASE IN OSTEOARTHRITIC SYNOVIUM, IS SYNERGISTICALLY UP-REGULATED BY IL-1ALPHA, TNF-ALPHA AND TGF-BETA (OARSI 2019) - "The signaling pathways for downstream molecules of these cytokines were examined by using their inhibitors and effect of anti-arthritic drugs including high-molecular-weight hyaluronan (Suvenyl), Adalimumab (Humira) and Tocilizumab (Actemra) on the ADAMTS4 expression was also examined. Among the ADAMTS species examined, ADAMTS1, 4, 5, 9 and 16 were expressed in OA synovium and synovial fibroblasts. Our data demonstrate that ADAMTS4 is a major aggrecanase in OA synovium and synergistically up-regulated by IL-1α, TNF-α and TGF-β in OA synovial fibroblasts, and suggest that combined therapy with anti-TNF-α drug and signaling pathway inhibitor(s) may be a useful remedy for OA."