PLN-1474 / Pliant Therapeutics - LARVOL DELTA

Screening and comparison of current clinical candidates in MASH using human 3D liver spheroids (EASL-ILC 2024) - "Examples of successful translational effect are the FASN inhibitor TVB2640 (Sagimet) showing a significant reduction of triglycerides and the alphav/beta1 integrin inhibitor (PLN-1474) demonstrating a strong reduction of PC-1 secreted levels. We show for the first time a screening platform that combines safety and MASH efficacy readouts. We show the translational capacity of this human in-vitro 3D platform by recapitulating the clinical effects of several drug candidates."

Clinical • Late-breaking abstract • Fibrosis • Hepatology • Immunology • Inflammation • Metabolic Dysfunction-Associated Steatohepatitis