BI 653048 / Boehringer Ingelheim - LARVOL DELTA

Biased regulation of glucocorticoid receptors signaling. (PubMed, Biomed Pharmacother) - "Based on the bias regulation of GR, selective GR agonists and modulators (SEGRAMs) were developed to bias therapeutic outcomes toward expected outcomes (e.g., anti-inflammation and immunoregulation) by influencing GR-mediated gene expression. This paper provides a review of the bias regulation and mechanism of GR and the research progress of drugs."

Journal • Review • Immune Modulation • Inflammation