ribavirin / Nagoya University, Tech Manage Corp - LARVOL DELTA

Real-world treatment outcome with protease inhibitor direct-acting antiviral in advanced hepatitis C cirrhosis: a REAL-C study. (PubMed, Hepatol Int) - "Tolerability and treatment outcomes were not significantly different in advanced HCV cirrhosis treated with PI-based (vs. non-PI) DAA up to CTP-B or MELD score of 15. Safety of PI-based DAA in those with CTP-C or MELD beyond 15 awaits further data."

HEOR • Journal • Metastases • Real-world • Real-world evidence • Cardiovascular • Fibrosis • Gastrointestinal Cancer • Hepatitis C • Hepatocellular Cancer • Hepatology • Hypertension • Immunology • Infectious Disease • Inflammation • Liver Cancer • Nephrology • Oncology • Renal Disease • Solid Tumor

REAL-WORLD TREATMENT OUTCOME WITH PROTEASE INHIBITOR (PI) VERSUS NON-PI DIRECT ACTING ANTIVIRAL (DAA) IN DECOMPENSATED HEPATITIS C (HCV) CIRRHOSIS: A REAL-C STUDY WITH INVERSE PROBABILITY OF TREATMENT WEIGHTING (IPTW) ANALYSIS (AASLD 2022) - "IPTW on 13 variables (age, sex, history of clinical decompensating events, MELD score, platelet, albumin, Asia [vs. non-Asia], Asian [vs. non-Asian], hypertension, hemoglobin, genotype 1, HCC and ribavirin) yield 395 PI and 417 non-PI patients who were balanced in relevant characteristics... Treatment response and tolerability outcomes were similar in mild decompensated HCV cirrhosis treated with PI vs. non-PI-based DAA. However, data in CTP class C and MELD >15 require further validation in future studies with large sample size for these populations."

Clinical • HEOR • Real-world evidence • Cardiovascular • CNS Disorders • Fibrosis • Hepatic Encephalopathy • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammation

Independent evolution of multi-dominant viral genome species observed in a hepatitis C virus carrier. (PubMed, Biochem Biophys Rep) - "From phylogenetic analysis, these dominant species evolved independently. Our study demonstrated that multiple dominant species co-existed in patient sera and evolved independently."

Journal • Hepatitis C • Hepatology • Infectious Disease • Inflammation