NanO2 (perflenapent) / NuvOx Pharma - LARVOL DELTA

Prickly Pear and Pomegranate Peel Extracts as Natural Antioxidants: Effects on Colour, Lipid, and Protein Oxidation in Refrigerated Cooked Chicken Models. (PubMed, Foods) - "Cooked chicken samples were formulated with different concentrations of PPE or HPE and compared to sodium nitrite (NaNO2) treatment...These findings suggest that PPE, particularly at 300 mg/kg, is a promising natural alternative to synthetic antioxidants for improving oxidative stability and shelf life in meat products. Further research should explore sensory attributes and consumer acceptance to facilitate industrial applications."

Journal

Staphylococcus aureus persisters exhibit increased tolerance to oxygen and nitrogen species (IMMUNOLOGY 2025) - "Similarly, following lethal challenge with NaNO2 (96mM) and paraquat (10mM), fumC::NΣ exhibited a 1 log increase in survival compared to the wild type. These data suggest persisters have a survival advantage to compounds within macrophages.Keywords: Cells Monocytes/Macrophages; Infections Bacterial"

Infectious Disease

High-Efficiency Electrocatalytic Conversion of Nitrite to Ammonia Using Nickel Phthalocyanine. (PubMed, Chem Asian J) - "-1 at -1.0 V versus RHE in 0.1 M Na2SO4 containing 0.1 M NaNO2 solution. Furthermore, the catalyst exhibits exceptional long-term stability during chronoamperometry tests. These findings boost the future ammonia production from nitrite reduction for sustainable development."

Journal

Extending 17O transverse relaxation measurement to satellite transitions as a direct probe of molecular dynamics in solids. (PubMed, Solid State Nucl Magn Reson) - "Experimental 17O R2 data recorded for both CT and ST from 17O-labeled NaNO2 over a large temperature range are used to verify the theoretical predictions...The advantages of the ST R2 approach are discussed. This ST R2 approach adds a new dimension to the currently available CT-based solid-state NMR techniques for probing molecular motion in solids."

Journal

Practical Electrochemical Hydroxynitration and Chloronitration Bifunctionalization of Alkenes with NaNO2. (PubMed, Chemistry) - "Besides, the EIS and CV results provided deeper insights into the reaction mechanism. Further extensions of the method have also confirmed the practicality of the strategy developed."

Journal

Tricetin, a Dietary Flavonoid, Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer's Disease by Regulating the PI3K/Akt/mTOR Signaling Pathway. (PubMed, J Agric Food Chem) - "This study investigated the antineuroinflammatory and autophagic protective effects of TRN in lipopolysaccharide (LPS)-induced BV2 cells and D-galactose/sodium nitrite/aluminum chloride (D-gal/NaNO2/AlCl3)-induced AD mice...In conclusion, TRN demonstrated robust neuroprotective effects in vitro and in vivo AD models by regulating the PI3K/Akt/mTOR signaling pathway. These findings highlight its potential as a promising therapeutic agent for treating AD."

Journal • Alzheimer's Disease • CNS Disorders • Inflammation • Oncology

Rapid and Efficient Polymer/Contaminant Removal from Single-Layer Graphene via Aqueous Sodium Nitrite Rinsing for Enhanced Electronic Applications. (PubMed, Polymers (Basel)) - "This study presents a rapid and efficient surface treatment method that relies on an aqueous sodium nitrite (NaNO2) solution to remove such contaminants effectively...This effective rinsing process enhances the reproducibility and performance of SLG, enabling its integration into advanced electronic devices such as organic light-emitting diodes (OLEDs), photovoltaic (PV) cells, and transistors. Furthermore, the technique is broadly applicable to other two-dimensional (2D) materials, paving the way for next-generation (opto)electronic technologies."

Journal

Sodium nitrite prevents impaired postnatal alveolar development. (PubMed, Am J Physiol Lung Cell Mol Physiol) - "Treatment with NaNO2 increased S-nitrosylation of nine lung proteins; none were increased by iNO. These observations provide a biological rationale for superior efficacy of NaNO2 in preventing experimental BPD."

Journal • Bronchopulmonary Dysplasia • Cardiovascular • Hypertension • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Cu-Catalyzed Synthesis of Symmetric Diarylamines from Organoboronic Acids Using NaNO2 as the Amino Source. (PubMed, J Org Chem) - "Under a simple ligand- and base-free copper catalytic system (CuCl as the sole catalyst), a wide range of symmetric diarylamines could be obtained in moderate to good yields. Notably, the use of Na15NO2 could produce 15N-labeled diarylamines, which would otherwise be difficult to prepare by the known methods."

Journal

Nitrites in Meat Products in Serbia: Harmful or Safe? (PubMed, Foods) - "The average nitrite content, expressed as sodium nitrite (NaNO2), was found to be 61.5 mg/kg in finely chopped sausages, 57.6 mg/kg in coarsely chopped sausages, 48.4 mg/kg in canned meat, and 41.8 mg/kg in smoked meat. The results collectively demonstrate nitrite concentrations within regulatory limits. In conclusion, the nitrite concentrations in all tested products were below the maximum allowable limits as per national and European regulations, ensuring compliance with safety standards while highlighting the importance of continuous monitoring to mitigate public health risks."

Journal

NanO2 in Large VessEL Occlusion Stroke (NOVEL) (clinicaltrials.gov) - P2 | N=172 | Not yet recruiting | Sponsor: NHS Greater Glasgow and Clyde

New P2 trial • Cardiovascular • Ischemic stroke

Technical Feasibility and Protocol Compliance in the Second Stroke Pre-Clinical Assessment Network (ISC 2025) - "The Interventions, also selected through an NIH peer review process, included NanO2 (NuvOx) an oxygen delivery emulsion, tatCN19o (Neurexis) a CaM-kinase II inhibitor, GSK2256098 (GlaxoSmithKline/ETSU) a focal adhesion kinase inhibitor, GSK2256294 (GlaxoSmithKline/OHSU) a soluble epoxide hydrolase inhibitor, and BPN-27332 (Loxagen/MGH) a lipoxygenase inhibitor. The feasibility and protocol compliance seen in SPAN 1 have been replicated in stage 1 of the second trial, SPAN 2.1. Mortality resembles previous experience, with an improved survival in aged mice. SPAN 2 has advanced to Stage 2 where improved dose timing is implemented."

Compliance • Preclinical • Cardiovascular • Obesity

Total flavonoid content revised: an overview of past, present, and future determinations in phytochemical analysis. (PubMed, Anal Biochem) - "The AlCl3 assay, with or without NaNO2 addition, is the most used method in the present, although less frequently used methods (using 2,4-dinitrophenylhydrazine, dimethylamino-cinnamaldehyde, or diethylene glycol) show potential for complementary and specific determinations...The focal point of this review is to serve as a basis for laboratory protocol reorganization regarding TFC determination, as a powerful tool before mass spectrometry, as well as to present a potential complementary analysis protocol applicable to biological samples. Among the methods found in the literature, SBC was the only assay providing accurate determinations of TFC."

Journal • Review

EXTEND-1b: A Dose Escalation Study of NanO2 in Patients with Mild Respiratory Distress (clinicaltrials.gov) - P1 | N=18 | Not yet recruiting | Sponsor: NuvOx LLC | Initiation date: Oct 2024 ➔ Feb 2025

Trial initiation date

Unraveling compound curing agent on protein characteristics and proteome changes of Nuodeng ham by TMT-labeled quantitative proteomics. (PubMed, Food Chem) - "To understand the effects of compound curing agent (60 % NaCl+40 % KCl + 90 mg/kg NaNO2) on the protein characteristics and proteome of Nuodeng ham, the protein structure, oxidation, degradation, and proteomic changes of Nuodeng ham were analyzed...GO functional annotation and protein-protein interaction analysis showed that I3LQ79, Q4PS85, I3LUD1, and A0A2C9F3F0 were important differentially expressed proteins in Nuodeng ham. These results elucidate the intrinsic mechanism of action of the compound curing agent from the perspective of protein changes, providing a scientific theoretical basis for the development and utilization of the compound curing agent."

Journal

Suicide by sodium nitrite: Autopsy case report. (PubMed, Leg Med (Tokyo)) - "Cases of the fatal SNP may present a significant challenge in forensic practice due to their rarity and nonspecific presentation. Without any information about the circumstances of the case, it is often unrecognizable."

Journal

Sodium nitrite orchestrates macrophage mimicry of tongue squamous carcinoma cells to drive lymphatic metastasis. (PubMed, Br J Cancer) - "Our findings highlight the role of NaNO2 in enabling macrophage mimicry in TSCC cells through the CREB1-CD68 signaling pathway, which promotes lymphatic metastasis. Shedding light on drivers of lymphatic metastasis in TSCC and providing a new perspective on dietary strategies to improve outcomes of patients with TSCC."

Journal • Head and Neck Cancer • Oncology • Oral Cancer • Solid Tumor • Squamous Cell Carcinoma • Tongue Carcinoma • CD68 • CREB1

Green fabricated bimetallic zinc ferrite nanoparticles mitigate oxidative stress-induced pathogenesis. (PubMed, Anal Biochem) - "Current study evaluates the beneficial role of bio-functionalized zinc ferrite nanoparticles fabricated from an aqueous extract of Decalepis hamiltonii leaves (DHLE.ZnFe2O4 NPs) on sodium nitrite (NaNO2) and Diclofenac (DFC) induced oxidative stress in RBCs and Sprague Dawley male rat models...Most importantly, DHLE.ZnFe2O4 NPs exhibited anti-inflammatory, anti-diabetic, anti-thrombotic activities and were non-toxic to RBCs. In conclusion, DHLE.ZnFe2O4 NPs through its anti-oxidant potential ameliorate oxidative stress induced pathogenesis such as, inflammation, tissue damage, diabetes and thrombosis."

Journal • Cardiovascular • Diabetes • Hematological Disorders • Inflammation • Metabolic Disorders • Thrombosis

The impact of sodium nitrite and intermittent fasting on neurofilament and tau protein phosphorylation, and spatial learning in rat hippocampus. (PubMed, Exp Brain Res) - "NaNO2 was found to induce hyperphosphorylation of hippocampal NF and tau proteins at the Ser396/404 sites, which was accompanied by a decline in spatial learning and memory abilities. Conversely, intermittent fasting ameliorated the NaNO2-induced hyperphosphorylation of hippocampal neurofilaments and the decline in learning and memory abilities, with no discernible effect on hippocampal tau protein hyperphosphorylation."

Journal • Preclinical • CNS Disorders

Investigating Flavor Enhancement Methods in NaCl-Reduced Chinese Bacon (Larou) by Focusing on Physicochemical Characteristics, Bacterial Diversity, and Volatiles. (PubMed, Foods) - "Increasing the TVB-N, TBARS, and moisture content, decreasing the pH and NaNO2 properly, and inoculating with Staphylococcus and Kocuria were effective methods to enhance the flavor of LT. Vital PCs and predominant bacteria are prioritized to meet most of the quality and the biosafety, although key VOCs may be sacrificed at this point."

Journal

Aqueous solution of biogenic carboxylic acids as sustainable catalysts and green reaction media for the high-yielding synthesis of Biginelli adducts, Hantzsch esters, and substituted pyridines. (PubMed, RSC Adv) - "Aqueous ammonia was successfully employed instead of ammonium salt to improve the atom economy of DHPs. Moreover, substituted pyridines were synthesized from DHPs in a one-pot, two-step process using NaNO2 as an oxidant in the GAAS medium."

Journal

Inflammatory mediators-induced DNA damage in liver and brain injury: Therapeutic approach of 5-Methoy-N-acetyltryptamine. (PubMed, Toxicol Rep) - "In conclusion, treatment with both QR and 5-MNAT revealed the most effective therapeutic index in improving NaNO2-induced liver and brain injury, confirming the effectiveness of this combination as a powerful treatment for brain hypoxia. Nevertheless, this was confirmed with histopathological investigation."

Journal • CNS Disorders • Inflammation • Vascular Neurology • CRP • IL6

Emulsification and pH Control for Sustainable Thermochemical Fluids Reactivity. (PubMed, Molecules) - "Thermochemical fluids (TCFs), such as NH4Cl and NaNO2 salts, have been utilized in various applications, including the oil and gas industry...The findings from this study can be utilized to optimize various downhole applications of TCFs, enhancing the efficiency of TCF reactions and success rates. This paper presents in detail the results obtained, and discusses the potential contributions of the examined TCFs' reactivity control techniques to sustainability."

Journal

Effect of Particle Size on Physical Properties, Dissolution, In Vitro Antioxidant Activity, and In Vivo Hepatoprotective Properties of Tetrastigma hemsleyanum Diels et Gilg Powders. (PubMed, Pharmaceutics) - "The content of the total flavonoids, total polysaccharides, kaempferol-3-O-rutinoside, and rutin of TDG powders were determined using the NaNO2-Al (NO3)3 colorimetric method, the sulphate-phenol colorimetric method, and HPLC, respectively... The particle size of TDG powders had a significant effect on the physical properties and in vivo bioactivity. TDG pulverized to a fine particle size or smaller is a promising approach for clinical applications with improved physicochemical and biological properties."

Journal • Preclinical • CAT

Optimization of Transcardiac Perfusion for More Accurately Evaluating Biodistribution of Large Molecules. (PubMed, Int J Mol Sci) - "Moreover, under Ketamine/Xylazine (Ket/Xyl) anesthesia, which reduced blood clot formation compared to CO2 euthanasia, 100 mM NaNO2 achieved the lowest hemoglobin levels in the brain. We have developed a method to efficiently evaluate blood-brain barrier integrity during transcardiac perfusion. The combination of Ket/Xyl anesthesia and 100 mM NaNO2 effectively removes residual blood from tissues without significantly affecting blood vessel permeability."

Journal • Anesthesia • Thrombosis