NanO2 (perflenapent) / NuvOx Pharma - LARVOL DELTA

Shared-private multimodal fusion of near-infrared diffuse-reflectance and UV-Vis chromogenic spectra for geographical authentication of Meconopsis integrifolia. (PubMed, Talanta) - "In this study, a shared-private multimodal fusion (SPMF) framework was developed for origin discrimination of M. integrifolia using paired near-infrared (NIR) diffuse-reflectance spectra and ultraviolet-visible (UV-Vis) absorption spectra of the NaNO2-Al(NO3)3-NaOH chromogenic system...Under the current experimental realization, the complete SPMF model matched or exceeded the performance of the reduced ablation variants. However, the component-specific effects remain preliminary, and because all samples were collected in 2019 and no external validation across collection years, batches, independent collection campaigns or analytical instruments was performed, the reported performance should be interpreted as discrimination within the current dataset rather than as established real-world generalizability."

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Microbiome-metabolome interaction reveals rhizosphere ecological, bioactive, and antioxidant responses of Paeonia lactiflora Pall. to intercropping and harvest timing. (PubMed, Front Microbiol) - "We measured paeoniflorin by high-performance liquid chromatography (HPLC), total phenolic content by the Folin-Ciocalteu method, total flavonoid content by the NaNO2-Al(NO3)3 method, and antioxidant activity by DPPH, ABTS, hydroxyl radical scavenging, and FRAP assays...Under intercropping, mid-stage harvest (TZ-2/TZ-3), with adjustments based on annual climatic conditions, is recommended to balance quality and ecological benefits. Collectively, these findings reveal differences in P. lactiflora across planting systems and harvest periods, providing a theoretical basis for the optimization of cultivation strategies."

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Oximophosphinothiolation of Alkenes with Sodium Nitrite, Elemental Sulfur, and Secondary Arylphosphines. (PubMed, J Org Chem) - "This transformation can be carried out under mild and additive-free conditions, employing NaNO2 and S8 as the NO source and sulfur source, respectively. A wide variety of α-dithiophosphinate oximes could be accessed via this method in moderate to good yields, and the reaction showed good tolerance to diverse functional groups."

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Fast-Food Component-Induced Epigenetic Modifications Modulate Immunotherapy in Metastatic Breast Cancer. (PubMed, ACS Omega) - "In this study, we investigated the effects of selected fast-food components monosodium glutamate (MSG), acrylamide (AA), sodium sorbate (SS), and sodium nitrite (NaNO2) on the expression of the epigenetic enzymes histone deacetylase 8 (HDAC8) and protein arginine methyltransferase 5 (PRMT5), and their role in suppressing immunotherapeutic responses in MDA-MB-231 triple-negative breast cancer (TNBC) cells...Interestingly, our studies revealed that the combined presence of CD47 and HDAC8 inhibitors enhanced macrophage-mediated phagocytosis, thereby enabling immune cells to engulf cancer cells, improved the therapeutic response in TNBC, and promoted anticancer activities. These findings emphasize the importance of personalized dietary strategies for improving the efficacy of cancer immunotherapy and support the integration of specific epigenetic inhibitors with immune checkpoint inhibitors to amplify the therapeutic outcomes."

IO biomarker • Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • HDAC8 • PD-L1 • PRMT5

Sustainable non-ionic surfactants from epoxidised linseed oil: synthesis, interfacial properties, foaming behaviour, and emulsification performance. (PubMed, RSC Adv) - "Cloud point increased systematically with ethylene oxide content and decreased slightly in the presence of inorganic salts in the order Na2SO4 > NaCl > NaNO2, consistent with Hofmeister effects. These findings demonstrate that PEG-functionalised epoxidised linseed oil is a versatile renewable platform for producing high-performance non-ionic surfactants with tunable interfacial properties for detergency, emulsification, coatings, personal care formulations and other sustainable industrial applications."

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Nitrite stress acclimation of Pediococcus pentosaceus improves nitrite degradation in fermented sausages: from phenotype to transcriptomic mechanism. (PubMed, Meat Sci) - "Results showed that the acclimated strains of Pediococcus pentosaceus exhibited markedly improved nitrite removal efficiency, achieving near-complete elimination (99.2% removal of 50 mg/L NaNO2) within 24 h in vitro and significantly accelerated nitrite reduction (77.4% removal of 150 mg/kg NaNO2 at 7th day) during sausage fermentation compared with the original strains...These findings demonstrated that adaptive evolution effectively enhances microbial functionality through coordinated metabolic regulation. This work not only provides mechanistic insights into microbial nitrite metabolism but also offers a feasible strategy for developing safer and more sustainable fermented meat products with reduced additive reliance."

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Bioinspired Nitrite Reduction to Ammonia by Molecular Nickel Polypyridine-Quinoline Complex. (PubMed, J Am Chem Soc) - "Moreover, the 1-ONO complex shows electrocatalytic nitrite reduction to ammonia in nonaqueous and aqueous media with excellent Faradaic efficiencies of 86% and 98%, using tetra-butyl ammonium nitrite (TBAN) and sodium nitrite (NaNO2) respectively...The presence of a redox-active, sterically demanding quinoline moiety in the primary coordination sphere of the 1-ONO complex facilitates stepwise nitrite reduction, involving the key intermediates NO, NO-, HNO, and NH2OH, to ammonia (NH3) through proton-coupled electron transfer pathways. A comprehensive computational study outlines the reaction energy profile and elucidates the ligand-controlled product selectivity."

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RESTORE: A Study of NanO2 Combined With Radiation and Temozolomide in Patients With Newly Diagnosed GBM (clinicaltrials.gov) - P2 | N=87 | Active, not recruiting | Sponsor: NuvOx LLC | Trial completion date: Sep 2026 ➔ Sep 2027 | Trial primary completion date: Jun 2026 ➔ Jun 2027

Trial completion date • Trial primary completion date • Brain Cancer • Glioblastoma • Oncology • Solid Tumor

NuvOx Expanded Access (clinicaltrials.gov) - P=N/A | N=0 | Available | Sponsor: NuvOx LLC

New trial • Acute Respiratory Distress Syndrome • Brain Cancer • Cardiovascular • Glioblastoma • Ischemic stroke • Oncology • Solid Tumor

Metal-defect pairs for near-stoichiometric electrocatalytic C-N coupling. (PubMed, Natl Sci Rev) - "Furthermore, we developed an innovative cathodic oxime-alkali process, where high concentration NaNO2 and CYC can be electrochemically converted to high-purity products including NaOH and CHO. This work showcases the enormous potential of M-D GSCs in achieving near-stoichiometric conversion for ERCR reactions."

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Liver-Derived, Circulating Xanthine Oxidoreductase Drives Vascular Impairment Associated with Inhalation of Ultrafine Particulates. (PubMed, Free Radic Biol Med) - "Drinking water supplemented with the XOR inhibitor febuxostat or nitrite (NaNO2-) partially prevented nTiO2-induced impairment of vascular reactivity. Together these findings demonstrate that circulating XOR is a key contributor to endothelial dysfunction caused by UFP exposure. However, the impairment is not acute in nature and might involve epigenetic-mediated alterations in gene expression."

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Interfacial microdomain engineering using Zn-halloysite nanotubes for advanced electrochemical sensing of nitrite in food matrices. (PubMed, Anal Chim Acta) - "The Zn NP@HNT/GCE displayed remarkable electrocatalytic activity for sodium nitrite (NaNO2) detection, which can be ascribed to the cooperative effect of Zn NPs and the HNT framework that enhanced charge transfer and analyte interaction. The fabricated electrode delivered a broad linear response range with a low detection limit of 0.1888 μM, together with excellent stability, reproducibility, and resistance to interference. These attributes highlight Zn NP@HNT/GCE as a cost-efficient, robust, and reliable sensing platform with strong potential for applications in food safety, environmental monitoring, and biomedical analysis."

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The Effects of Nitrate and Nitrite Supplementation on Mitochondrial Respiration in Permeabilized Muscle Fibres in Young Healthy Adults. (PubMed, Nitric Oxide) - "However, the leak control ratio, reflecting the degree of uncoupling of mitochondrial respiration, was significantly higher with 3.0 μM NaNO2 administration (0.12±0.05) compared to 0 μM NaNO2 administration (0.09±0.04, P=0.03). These findings, involving both in vivo and in vitro administration approaches, albeit in the presence of relatively high oxygen concentrations, suggest that neither NO3- nor NO2- improves mitochondrial respiration, at least in young healthy adults."

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Linking Local Water Electrostatic Potentials to Measured Hydrogen Evolution Onset in Aqueous Electrolytes. (PubMed, J Phys Chem Lett) - "Here, we combine voltammetric measurements of the HER onset in aqueous NaNO2 with molecular dynamics to show that water reduction is controlled by the local electrostatic potential at the water oxygen atoms (VOW)...Unlike the density functional theory or ab initio molecular dynamics, the UHER prediction needs only classical sampling and a few measured potentials. The approach is extensible to other salts and gives a molecular handle on the electrochemical stability window of aqueous electrolytes used in batteries, gas capture, and waste processing."

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Sublethal effects and bioaccumulation of "smart" anti-corrosion nanoadditives spiked in sediment in the ragworm Hediste diversicolor. (PubMed, Aquat Toxicol) - "This study evaluated the toxicity of CIs (MBT, BTA, bio-based sodium gluconate, and sodium nitrite, NaNO2), their nanostructured forms (LDH-MBT, LDH-BTA, LDH-Gluconate, LDHNO2), and the base nanomaterial (LDHNO3)...Biochemical biomarkers indicated neurotoxicity induced by MBT, LDH-MBT, LDH-BTA, and LDHNO3, with a decrease in AChE activity, despite no significant bioaccumulation. In contrast, the bio-based LDH-Gluconate and the bio-inspired LDHNO2 exhibited no significant toxicity, representing promising eco-friendly options for marine anticorrosive applications."

Journal • Pain

A phase 2 double-blind, randomized, prospective, placebo-controlled study of NanO₂ combined with radiation and temozolomide in patients with newly diagnosed glioblastoma: RESTORE. (ASCO 2026) - P2 | "The RESTORE trial (NCT03862430) is the first randomized, prospective, placebo-controlled study of NanO₂ (2% w/v dodecafluoropentane emulsion) in GBM, a fluorocarbon-based oxygen therapeutic hypothesized to reoxygenate hypoxic GBM tissue, with the goal of enhancing the efficacy of chemoradiation. In this blinded, pooled safety analysis of a randomized phase 2 trial in newly diagnosed GBM, the study treatment was well tolerated and no new safety signals were identified. Treatment allocation remains blinded. Efficacy outcomes and arm-specific safety analyses will be reported after completion of the primary endpoint analysis."

Clinical • P2 data • Brain Cancer • Cardiovascular • CNS Disorders • Epilepsy • Glioblastoma • Hematological Disorders • Pulmonary Embolism • Respiratory Diseases • Solid Tumor

Influence of acid structure and acidity strength on thermochemical, in-situ nitrogen generation. (PubMed, Sci Rep) - "In this work, the effects of five acids-acetic, citric, monochloroacetic, dichloroacetic, and trichloroacetic acids-on thermochemicals were studied, and the impact of several parameters on sodium nitrite (NaNO2) and ammonium chloride (NH4Cl) was examined, such as concentration, temperature, and pH...Due to its optimal molecular structure and catalytic properties, Acetic acid enhances the efficiency of N2 generation, making it promising for oilfield operations and reservoir enhancement. The study also highlights that the acid's strength and structure play important roles in the reaction, with the structure being a key factor as a catalyst."

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Environmental risk and mobilization of uranium and potentially toxic elements during leaching of the sandstone-type uranium ore. (PubMed, J Hazard Mater) - "Six lixiviants (NaNO2, FeCl3, citric acid (CA), oxalic acid (OA), HEDP, and EDDS) were employed in columnar static experiments to systematically investigate the release and migration of uranium and potential toxic elements (PTEs) in sandstone-type deposits and evaluate their associated ecological risks...Leaching significantly enhanced sample permeability but resulted in limited porosity increases, indicating simultaneous occurrence of mineral dissolution and secondary precipitation during water-rock reactions. This phenomenon significantly impacts the elemental migration pathways and subsequent environmental risks."

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Visible-Light-Promoted Continuous-Flow Iodination of Primary C(sp3)-H Bonds: An Undirected and Regioselective Approach. (PubMed, J Am Chem Soc) - "Here, we report a practical continuous-flow protocol for the regioselective iodination of primary C(sp3)-H bonds in alkanes, employing inexpensive, readily available iodine, NaNO2 and aqueous HCl in carbon tetrachloride solvent under visible-light irradiation...These resulting alkyl iodides serve as versatile intermediates for late-stage transformations, thereby providing indirect access to otherwise difficult C(sp3)-H functionalization. Mechanistic investigations indicate that the reaction proceeds through a reversible and nonselective C-H activation to generate a mixture of alkyl radicals, followed by a kinetically controlled iodination that selectively traps the primary radical species."

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The ComEA/ComEC Operon is Critical for Nitrosative Stress Tolerance by an Oral Commensal. (PubMed, Mol Oral Microbiol) - "Transcriptomics analysis revealed that the DNA uptake gene, comEA was upregulated during growth on 2 mM NaNO2. Further, loss of the ComEA/ComEC DNA uptake locus resulted in increased sensitivity to peroxynitrite and a decrease in biofilm development, intracellular nitrite transport, H2O2 production, and was defective for colonization in a Drosophila melanogaster colonization model. In summary, our data show that the ComEA/EC DNA uptake operon is critical for key aspects of S. parasanguinis physiology and potentially impacts S. parasanguinis's ability to colonize and modulate homeostasis in the oral cavity."

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AceE affects the optimum growth and biofilm formation of Mycobacterium tuberculosis via cell wall lipid remodeling. (PubMed, mSystems) - "Mtb ΔaceE exhibited markedly slower planktonic growth, smooth colony morphology, impaired biofilm formation, and was more sensitive to acid, NaNO2, and some commonly used antibiotics...The aceE gene not only aids in the bacteria's energy metabolism but also promotes lipid synthesis, forming a thicker cell wall that helps Mtb resist various intracellular stresses, further favoring its survival within the host cells. During in vivo survival, the increased expression of the aceE gene in the virulent Mtb H37Rv strain may enhance the conversion of pyruvate into acetyl-CoA, thereby providing more precursor materials for the synthesis of lipids and amino acids."

Journal • Infectious Disease • Metabolic Disorders • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Reduced Nitrates/Nitrites and Natural Additives in Organic Fermented Dry-Cured Sausages: Effects on Microbiological Safety, Quality, and Consumer Acceptance. (PubMed, J Food Sci) - "Five treatments were produced: C1 (80 mg/kg KNO3), HXT100 (40 mg/kg KNO3 + 100 mg/kg HXT), HXT300 (40 mg/kg KNO3 + 300 mg/kg HXT), C2 (80 mg/kg NaNO2), and HXT200 (40 mg/kg KNO2 + 200 mg/kg HXT)...These findings may support the development of cleaner label products with fewer additives and greater health appeal. Nonetheless, consumer sensory evaluations favored traditional formulations in terms of taste, texture, and overall quality."

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O. fragrans flower ameliorates compound 48/80-induced pseudo-allergic reactions in vitro and in vivo. (PubMed, Int Arch Allergy Immunol) - "This study indicates, for the first time, that OFE is a mast cell stabilizer. It decreases Ca2+[c] to suppress mast cell degranulation by directly enhancing mitochondrial Ca2+ uptake. These findings may unveil a potential medicinal value of O. fragrans flower as a promising candidate for relieving mast cell activation-related diseases."

Journal • Preclinical • Allergy • RHOD

Hybrid Oxygen-Sensing Bio-Scaffolds for 3D Micro-Tissue Models. (PubMed, Biosensors (Basel)) - "The results show superiority of the Matrigel hybrids with NanO2 and Nano-IR probes. Demonstration experiments were conducted with HCT116 cells and individual spheroids derived from these cells, culturing them in the Matrigel-NP hybrid scaffolds and monitoring oxygenation and local O2 gradients on a time-resolved fluorescence plate reader and by phosphorescence lifetime imaging microscopy (PLIM)."

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Hydration and transport properties of cesium hydroxide and mixed cesium hydroxide-sodium nitrite aqueous solutions. (PubMed, J Chem Phys) - "This study explores the hydration and transport properties of aqueous cesium hydroxide (CsOH) solution, with or without 1 molar (M) sodium nitrite (NaNO2)...Nonetheless, ion-pairing or obstructions did result in more sluggish transport properties as electrolyte concentrations increased. Overall, the research enhances the understanding of the complexities underlying ion interactions in multicomponent solutions."

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