desogestrel/ethinylestradiol / Generic mfg. - LARVOL DELTA

Eccdna-encoded LIPIN1 drives DGAT1-dependent lipid droplet biogenesis to promote Acute Myeloid Leukemia progression and chemoresistance (ASH 2025) - "This study provides preclinical evidence that eccDNA plays a critical role in AML progressionand chemoresistance by encoding LIPIN1. Mechanistically, ecc-LIPIN1 promotes lipid droplet formationand ER stress via DGAT1, ultimately driving chemoresistance. These findings identify ecc-LIPIN1 as a noveloncogenic factor in AML and highlight its potential as a therapeutic target."

Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Metabolic Disorders • ATF4 • LPIN1

Lactate promotes DLBCL progression via NAT10/ldha axis and immune suppression (ASH 2025) - "This study provides preclinical evidence that tumor-intrinsic lactate plays a pivotal role inDLBCL progression and immunosuppression through protein lactylation. Mechanistically, lactateincreases NAT10 protein levels via lactylation, and NAT10, in turn, promotes LDHA expression throughmRNA acetylation. LDHA further enhances lactate production, forming a positive feedback loop thatdrives tumor progression and suppresses antitumor immunity."

IO biomarker • B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • CD8 • IFNG • LDHA • NAT10

Insights in the management of older adults with mantle cell lymphoma amidst a changing therapeutic landscape: Lessons from a 25-year institutional experience (ASH 2025) - "Historically,chemoimmunotherapy (CIT) with bendamustine and rituximab (BR) +/- R maintenance was the preferredfrontline (1L) treatment option in 'transplant ineligible' patients, however, this paradigm has beenchallenged with the Introduction of BTK inhibitors (BTKi). In OA, the ECHO study showed improvedprogression-free survival (PFS) of acalabrutinib-BR over BR, with acalabrutinib being continuedindefinitely till progression. More recently, the ENRICH study showed an improved PFS for ibrutinib-rituximab (IR) over R-CHOP, with similar PFS as BR in OA...PFS and OS were estimated using theKaplan-Meier method, comparisons were made using log-rank test and associations between outcomes,clinical, and tx characteristics were evaluated with Fischer exact test.ResultsIn 419 OA with MCL, median age was 72y (range 65-102y), age ≥80y 19%, male 73%, Stage 4 82%, MIPIlow/intermediate/high 6%/47%/47%, blastoid/pleiomorphic 14%, Ki67 <30%/30-49%/≥50% 49%/25%/26%,p53..."

Clinical • IO biomarker • Hematological Malignancies • Lymphoma • Mantle Cell Lymphoma • TP53

An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian Origin (clinicaltrials.gov) - P1 | N=24 | Recruiting | Sponsor: Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany

New P1 trial

Comparison of the short-term effects of dienogest and oral contraceptives on pain and quality of life in women with endometriosis: a systematic review and meta-analysis. (PubMed, BMC Womens Health) - "Dienogest is superior to OCPs in improving pain and QoL in patients with endometriosis, but not as effective as OCPs in pelvic pain and dyspareunia, and the safety was similar between the two types of drugs."

Clinical • HEOR • Journal • Retrospective data • Review • Back Pain • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Incidence of spontaneous ultrasonographic regression of the corpus luteum in pregnant embryo recipients and broodmares: a field study. (PubMed, Theriogenology) - "Progesterone or altrenogest supplementation was administered in 34 % (18/53) of cases with spontaneous luteolysis of which 44.4 % (8/18) maintained their pregnancy by Day 42. The findings highlight that spontaneous luteolysis is more prevalent than previously reported and may occur even with apparently morphologically normal embryos, suggesting that MRP failure is multifactorial and not solely linked to embryonic development. These results emphasize the need for earlier and more accurate diagnostics to identify at-risk pregnancies and guide treatment, especially in IVP derived pregnancies, which have the highest incidence of luteolysis."

Journal

Cost-effectiveness of dienogest compared to gonadotropin releasing hormone agonists for the management of endometriosis in Vietnam. (PubMed, Cost Eff Resour Alloc) - "Dienogest is a cost-effective alternative to GnRH-a drugs for treating dysmenorrhea and pelvic pain in Vietnam, offering improved health outcomes at a lower cost. These findings support its broader adoption in clinical practice and healthcare policy."

HEOR • Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Effect of the new fixed-time artificial insemination technology based on novel hormone preparations in gilts. (PubMed, Anim Reprod Sci) - "Control gilts received oral altrenogest solution (20 mg/day) for 18 days, followed by 1000 IU equine chorionic gonadotropin (eCG) administered 42 h post-treatment and 100 μg GnRH 80 h later...Notably, the new treatment group exhibited superior litter productivity with significantly increased total born (13.81 vs. 11.80, P < 0.05) and live-born piglets (11.81 vs. 10.39, P < 0.05). These findings suggest that the new FTAI protocol achieves comparable synchronization efficacy while enhancing litter productivity compared to traditional regimens, supporting its use as an effective alternative for gilts reproductive management."

Journal

Multi center efficacy and safety of desogestrel ethinylestradiol tablets in the treatment of polycystic ovary syndrome (PCOS) Real world clinical research (ChiCTR) - P4 | N=600 | Not yet recruiting | Sponsor: Sichuan Provincial Maternal and Child Health Hospital; Sichuan Provincial Maternal and Child Health Hospital

New P4 trial • Real-world evidence • Polycystic Ovary Syndrome

SGLT2 INHIBITORS: FROM GLYCEMIC CONTROL TO CARDIO-RENAL PROTECTION EVLOEV KHARON KH1*, SNITSA DANIIL V2, PANKOV DANIL S2, GASPARYAN MARIYA A1, ZAYCEV MATVEY V3, KOIFMAN NATALYA A1, BUGLO ELENA A4, ZEFIROVA MARGARITA S2, RACHKOVA TAMARA A2, GURTIEV DMITRII A1, ZASEEVA VICTORIA V1, TOLMASOV JALOLIDDIN M1. 1NORTH-WESTERN STATE MEDICAL UNIVERSITY NAMED AFTER I.I. MECHNIKOV, SAINT-PETERSBURG,... (PubMed, Georgian Med News) - "We discuss landmark cardiovascular and renal outcome trials, evaluate the physiological and molecular mechanisms, including hemodynamic modulation, anti-inflammatory and antifibrotic effects, and improvements in myocardial and renal energetics, and assess the role of SGLT2 inhibitors in heart failure with reduced and preserved ejection fraction, as well as in chronic kidney disease with and without diabetes. The translation of these findings into clinical guidelines has reshaped therapeutic strategies in both endocrinology and cardiology, underscoring the importance of SGLT2 inhibitors as a cornerstone in cardiorenal protection."

Clinical guideline • Journal • Review • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Diabetes • Endocrine Disorders • Heart Failure • Metabolic Disorders • Nephrology • Pediatrics • Renal Disease • Type 2 Diabetes Mellitus

Hormonal imbalance-mediated immune inflammation in endometrial decidualization disorder. (PubMed, Placenta) - "Dienogest suppresses aromatase/cyclooxygenase-2 (COX-2)-mediated oestrogen synthesis and restores progesterone sensitivity via PR-B upregulation. Immunomodulatory approaches, including corticosteroids and tumour necrosis factor-α inhibitors, improve pregnancy outcomes in endometriosis-associated infertility. Future research, leveraging state-of-the-art technologies, should prioritise elucidating the molecular interactions within the oestrogen-progesterone-immune axis and translating these insights into personalised therapies to optimise the management of decidualization-related disorders."

Journal • Review • Endometriosis • Gynecology • Infertility • Inflammation • Oncology • Sexual Disorders • Women's Health • IL10 • PGR

CalTrig: A GUI-based Machine Learning Approach for Decoding Neuronal Calcium Transients in Freely Moving Rodents. (PubMed, eNeuro) - "Tools such as MiniAN and CalmAn have been developed to convert Ca 2+ visual signals to numerical data, collectively referred to as CalV2N...This tool's adaptability and computational efficiency support diverse research applications, from behavioral neuroscience to translational studies. In brief, CalTrig enhances the precision and scalability of Ca2+ transient analysis, paving the way for deeper exploration of neuronal dynamics and facilitating advancements in neuroscience research."

Journal • Preclinical • CNS Disorders

Deeply Infiltrating Endometriosis (DIE) No More: Dienogest as a Game Changer in Rectovaginal Endometriosis. (PubMed, Cureus) - "This is the first reported case of Dienogest successfully shrinking rectovaginal deeply infiltrating endometriosis from 3 cm to undetectable on ultrasound and vaginal examination. This case demonstrates the success of Dienogest as a therapeutic modality for rectovaginal endometriosis, highlighting its promising potential as a standard treatment approach in the long-term management of the relapsing, chronic, and debilitating nature of endometriosis."

Journal • Endometriosis • Gynecology • Women's Health

EFFICACY AND SAFETY OF EFBEMALENOGRASTIM ALFA IN THE TREATMENT OF NEUTROPENIA INDUCED BY RCHOP-LIKE REGIMENS IN NEWLY DIAGNOSED NON-HODGKIN'S LYMPHOMA PATIENTS: A RANDOMIZED CONTROLLED MULTICENTER CLINICAL STUDY (EHA 2025) - P4 | "Efbemalenograstim a is anovelong-acting G-CSF approved by FDA in 2023, but there have been no reported data on its use in newly diagnosed non-Hodgkin's lymphoma patients to date. Using efbemalenograstim alfa for the primary prophylaxis of neutropenia induced by R-CHOP-like treatment regimens in patients with newly diagnosed non-Hodgkin's lymphoma is effective and safe."

Clinical • Back Pain • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Lymphoma • Musculoskeletal Pain • Neutropenia • Non-Hodgkin’s Lymphoma • Oncology • Pain

The effect of pregnancy, heat stress and altrenogest supplementation on the porcine mid-luteal phase corpus luteum proteome. (PubMed, Theriogenology) - "These included proteins involved in oxidoreductase activity (SOD1), translation and ribosomal activity, and metal ion binding (PGMRC1 and CYCS). An understanding of these effects could help improve reproductive performance in swine production."

Journal • Preclinical • MRC1

Minimally Invasive Mitral Valve Surgery Using the FlexCrown Retractor: A Safe and Effective New Self-Expandable Left Atrial Exposure Device. (PubMed, Innovations (Phila)) - "The FlexCrown self-expandable left atrial retractor by Geister allows excellent and safe exposure of the mitral valve with fast deployment and removal during MIMVS. The use of this innovative retractor may represent a helpful alternative to conventional left atrial retractors."

Journal • Cardiovascular

Medical treatment for adenomyosis: long term use of progestins. (PubMed, Gynecol Endocrinol) - "The treatment groups included dienogest (2 mg, n = 71), levonorgestrel-releasing intrauterine device (52 mg, n = 25), desogestrel (75 mcg, n = 20), and drospirenone (4 mg, n = 24)...Dienogest significantly reduced dysmenorrhea, dyspareunia, and HMB, with efficacy maintained over three years in most patients...Norethisterone acetate was used as a second-line treatment in cases of intolerance or inadequate response. Progestins are effective for the long-term management of adenomyosis symptoms. The flexibility in switching between different progestins or routes of administration may help in optimizing outcomes."

Journal • Endometriosis • Long-acting Reversible Contraceptives • Pain • Women's Health

Add-on effect of curcumin to dienogest in patients with endometriosis: a randomized, double-blind, controlled trial. (PubMed, Phytomedicine) - "The combination of curcumin and dienogest significantly reduced pain and improved QOL and sexual function in women with endometriosis, suggesting curcumin as an effective adjunct therapy."

Clinical • Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Efficacy and safety of hormone therapies for treating adenomyosis-associated pelvic pain: a systematic review and network meta-analysis of randomized controlled trials. (PubMed, Front Endocrinol (Lausanne)) - "Dienogest seems to be the most effective HT for AAPP. However, although rare, it is also related to more adverse effects compared to other HTs. https://www.crd.york.ac.uk/prospero/, identifier CRD42024535472."

Clinical • Journal • Retrospective data • Review • Endometriosis • Gynecology • Long-acting Reversible Contraceptives • Musculoskeletal Pain • Pain • Women's Health

Marvelon suppresses MC38 tumor growth and promotes anti-tumor immunity. (PubMed, Mol Immunol) - "By further investigating the effects of Marvelon's primary components, Ethinylestradiol and Desogestrel, we reveal that Ethinylestradiol enhances IFN-γ production in Type 1 Cytotoxic T (Tc1) cells and significantly inhibits the viability of MC38 tumor cells, whereas Desogestrel exhibits minimal effects. This study not only redefines the role of oral contraceptives but also provides valuable insights for the development of novel immunotherapeutic strategies."

IO biomarker • Journal • Colorectal Cancer • Oncology • Solid Tumor • CD8 • IFNG

Dienogest treatment of symptomatic adenomyosis: An in-depth meta-analysis. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "Dienogest substantially alleviates dysmenorrhea in women with adenomyosis, particularly among those with severe baseline dysmenorrhea and extended treatment periods. However, variability in patient responses and the potential for adverse effects underscores the importance of individualized treatment strategies. Further large-scale, long-term comparative studies and randomized clinical trials are warranted to optimize treatment outcomes and better understand patient-specific factors."

Clinical • Journal • Retrospective data • Endometriosis • Gynecology • Women's Health

Injectable and In Situ Phospholipid-Based Phase Separation Gel for Sustained Delivery of Altrenogest. (PubMed, Gels) - "The pharmacokinetic results showed that the AUC (0-∞) of the altrenogest gel was almost double that of the altrenogest solution. The MRT (0-∞) was 40.92 ± 7.21 h and the t1/2 of the altrenogest gel was 80.03 ± 20.79 h. The altrenogest gel demonstrated excellent fluidity, ease of injectability, high drug-loading capacity, and appropriate sustained-release characteristics both in vitro and in vivo, making it a potential drug delivery system for swine production."

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Meta-analysis and network pharmacology studies of the clinical efficacy of Guizhi Fuling capsules/pills combined with dienogest in treating endometriosis. (PubMed, Medicine (Baltimore)) - "In conclusion, GZFL combination treatment could increase the clinical effectiveness rate of EMs patients, and reduce the serum level of carbohydrate antigen 125, estradiol, matrix metalloproteinases, pain scores, and the diameter of the ectopic cyst. The potential mechanism might be linked to the modulation of hormone receptors and inflammation."

Clinical • Journal • Retrospective data • Endometriosis • Gynecology • Oncology • Pain • Women's Health • EGFR • ER • IL6

A new genus and two new species of gelechiid moths (Lepidoptera, Gelechiidae, Gelechiinae) from the East Malaysia with unusual male secondary characters. (PubMed, Zootaxa) - "n., type species, and E. natalyae sp...Males of the new taxa possess unique metathoracic and abdominal androconial structures and wing-like structures on the metascutum. The taxonomic position of the new genus within the family Gelechiidae is discussed."

Journal

Effects of altrenogest supplementation in late lactation on reproductive performance of primiparous sows. (PubMed, Theriogenology) - "Interestingly, ALT sows showed higher number, but smaller endometrial glands (P < 0.05). Taken together, short-term altrenogest supplementation in the last week of lactation increased progesterone levels after estrus onset, improving uterine vascularization and endometrial glands hyperplasia in the pre-implantation period, which benefit embryo development, leading to a decrease in the proportion of low birthweight piglets."

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