SB-002 / Solid BioSci - LARVOL DELTA

Targeting therapeutic against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis. (PubMed, J Clin Periodontol) - "The association between C3b/C4b and periodontitis may provide a basis for the development of novel therapeutic strategies for periodontitis and other inflammatory diseases."

Journal • Dental Disorders • Immunology • Inflammation • Osteoporosis • Periodontitis

Metabolomics-Guided Hypothesis Generation for Mechanisms of Intestinal Protection by Live Biotherapeutic Products. (PubMed, Biomolecules) - "Our lab developed two bioengineered LBPs (SBT001/BioPersist and SBT002/BioColoniz) modified to enhance colonization or persistence in the inflamed intestine...In comparison to BioColoniz, BioPersist increased serotonin and antioxidant production, limited bile acid accumulation, and enhanced tissue restoration via activated purine and pyrimidine metabolism. These data generated several novel hypotheses for the beneficial roles that LBPs may play during colitis."

Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease

Variability in the immunogenic preS region of Pakistani hepatitis B virus isolates. (PubMed, Virusdisease) - "Sequencing results showed that eight samples (SBS002-SBS008) have a deletion of 33 nucleotides at N-terminal that is characteristics of genotype D while SBS001 belongs to genotype C. Silent mutations and amino acid changes were also searched in this highly variable region of genome. Based upon this study it was concluded that genotype D is the most common genotype in Pakistan."

Journal