ELND006 / Perrigo Company - LARVOL DELTA

[VIRTUAL] AAV-C99 MICE: A NEW AD MODEL WITH LYSOSOMAL AND MITOCHONDRIAL ALTERATIONS (ADPD 2021) - "To discriminate between C99 and Abeta toxicity, we treated mice with the gammasecretase inhibitor ELND006 (D6) that blocks Abeta production and enhances C99 accumulation... Overall, we developed a new AD mouse model for studying specifically the amyloidogenic pathway. The AAV-C99 mice display C99 accumulation, lysosomal/autophagic dysfunction, mitochondrial and mitophagic alterations, Abeta production and plaques formation. Thus C99 could contribute to early stage of AD pathology while Abeta could be involved at later stages of disease progression."

Alzheimer's Disease • CNS Disorders