colchicine / Generic mfg. - LARVOL DELTA

CNS Inflammatory Lesions in a Patient with Behçet’s Disease: A Case of Neuro-Behçet’s versus Behçet’s Disease with Multiple Sclerosis (ACTRIMS Forum 2026) - "She was started on apremilast, hydroxychloroquine, colchicine, and prednisone... This case highlights the challenge in determining a diagnosis of NBD versus BD with MS. Our patient’s CNS lesions appear more consistent with MS. However, certain factors raise the possibility of a diagnosis of NBD and overlap syndrome: she had a higher degree of disease activity than expected for MS while on high potency B-cell therapy, she had multi-system involvement related to BD as seen in her cardiac and gastroenterological manifestations, and she developed migrainous headaches prior to starting BD treatment which are a common presentation of NBD."

Clinical • CNS Disorders • Dermatology • Migraine • Multiple Sclerosis • Ocular Inflammation • Ophthalmology • Optic Neuritis • Rare Diseases • Uveitis • Vasculitis

Colchicine's Unfinished Story in Cardiovascular Care. (PubMed, Am J Cardiol) - No abstract available

Journal • Cardiovascular

Inhibition of STING pathway attenuates experimental abdominal aortic aneurysm progression. (PubMed, Acta Pharmacol Sin) - "Colchicine could slow AAA formation in a partially STING-dependent manner in AAA mice. These findings suggest that STING might be a potential pharmacological target for the treatment of AAA."

Journal • Cardiovascular • Inflammation • APOE • ELANE • STING

Asthma as an Immune Network Disorder: Observational Evidence for Non-Th2 Therapeutic Targets (AAAAI 2026) - "JAK inhibitors and G-CSF stimulators showed no Conclusions Calcineurin inhibitors demonstrate a consistent protective effect against asthma exacerbations while colchicine, TNF-ɑ inhibitors, azithromycin, and methotrexate showed encouraging signals that may only affect select phenotypes. These findings suggest that immunomodulation outside the canonical Th2 pathway may influence asthma outcomes."

Asthma • Immunology • Respiratory Diseases

Effects of Intraperitoneal Colchicine on the Metabolic Consequences of High Fat Diet-Induced Obesity in Mice. (PubMed, Endocr Metab Immune Disord Drug Targets) - " Although this dose has been used in prior short-term mouse studies to suppress inflammation, chronic administration of 0.2 mg/kg intraperitoneal colchicine appears not suitable for metabolic studies. ."

Journal • Preclinical • Genetic Disorders • Inflammation • Metabolic Disorders • Obesity • NLRP3

Anti-citrullinated Protein Antibody-positive Arthralgia Associated with an L110P-E148Q Double Heterozygote: A Case-based Review. (PubMed, Intern Med) - "The patient was later diagnosed with RA and achieved remission with abatacept and colchicine. This case illustrates that ACPA-positive arthralgia evolves into RA through an autoinflammatory mechanism, thereby underscoring the diagnostic difficulties arising from the convergence of both autoimmune and autoinflammatory characteristics."

Journal • Genetic Disorders • Immunology • Inflammatory Arthritis • Musculoskeletal Pain • Rheumatoid Arthritis • Rheumatology

Colchicine as an Adjunct to Mechanical Thrombectomy: Targeting Neutrophil–Driven Thrombo–Inflammation in Ischemic Stroke (ISC 2026) - "Colchicine administered at reperfusion attenuates neutrophil-driven thrombo-inflammation, improving neurovascular outcomes in a murine MT-mimicking stroke model. These findings support colchicine as a potential adjunct to reperfusion therapy for AIS."

Cardiovascular • Hematological Disorders • Inflammation • Ischemic stroke • Reperfusion Injury • Thrombosis

Efficacy and Safety of an IL-1 Inhibitor in the Perioperative Period of Patients Undergoing Tophus Resection: A Single-Center, Prospective, Randomized, Positive-Controlled Study (ChiCTR) - P4 | N=54 | Not yet recruiting | Sponsor: The Fifth Hospital of Xi'an; The Fifth Hospital of Xi'an

New P4 trial • Immunology • Inflammatory Arthritis • Rheumatology

Coronary inflammation: Identification, clinical impact and possible therapeutical solutions. (PubMed, Int J Cardiol) - "Among patients with coronary artery disease, the use of colchicine has demonstrated significant risk reduction in adverse events, though with mixed results...In addition, GLP-1 receptor agonists, SGLT2 inhibitors, and PCSK9 inhibitors have been described to exhibit favourable vascular anti-inflammatory effects in experimental and in-vivo studies. In this comprehensive review, we provide an updated reappraisal of the available evidence unravelling how accurate identification of high-risk patients through multimodal imaging and biomarker profiling, combined with selective anti-inflammatory therapy, can represent a promising strategy for further reducing residual cardiovascular risk."

Journal • Review • Acute Coronary Syndrome • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Inflammation • CRP • IL6

Paediatric colchicine poisoning in the UK: a 10-year retrospective case series from the National Poisons Information Service. (PubMed, Arch Dis Child) - "Colchicine overdose in children is infrequent but can be fatal. Colchicine poisoning in children can present asymptomatically and progress to systemic toxicity. Paediatricians should be aware of the potential severity of toxicity from colchicine overdose."

Journal • Retrospective data • Acute Coronary Syndrome • Cardiovascular • Coronary Artery Disease • Gastrointestinal Disorder • Genetic Disorders • Gout • Immunology • Inflammatory Arthritis • Pediatrics • Rheumatology

FeM-ID: A biotin labeling-based approach for the dissection of female meiotic chromosome behavior in Arabidopsis thaliana. (PubMed, Plant Cell) - "Our approach enabled us to analyze female meiotic chromosome behavior, including bivalent and univalent frequencies, minimum chiasma numbers and chromosome segregation, in various ecotypes (Col-0, Ler-0 and Ws-2), colchicine-induced tetraploids (Col-4x) and selected meiotic mutants (sporulation 11-1 (spo11-1), meiotic recombination 11 (mre11), and mutL homolog 3 (mlh3)), facilitating cytological studies of heterochiasmy (sex-specific differences in recombination rates or patterns). FeM-ID is compatible with other cytological techniques, such as immunolocalization and fluorescence in situ hybridization (FISH), which allowed us, for instance, to assess homologous chromosome pairing or to track individual chromosomes in female meiotic cells. In conclusion, FeM-ID represents an approach that fills a long-standing gap in the dissection of female meiotic chromosome behavior in Arabidopsis and holds the potential for application in other plant species."

Journal • MRE11A

Colchicine therapy in transcatheter aortic valve replacement: Modulating inflammation and outcomes. (PubMed, Int J Cardiol Cardiovasc Risk Prev) - "However, current evidence is preliminary, with only two post-TAVR intervention studies available. Larger trials are needed to determine whether colchicine can translate mechanistic advantages into clinically meaningful improvements in post-TAVR outcomes."

Journal • Review • Atrial Fibrillation • Cardiovascular • Hematological Disorders • Inflammation • Thrombosis

Right ventricular outflow tract aneurysm as an incidental finding in a patient with acute pericarditis: A case report. (PubMed, Radiol Case Rep) - "Conservative management with aspirin and colchicine led to symptom resolution; at 6-month follow-up, the patient was asymptomatic with stable imaging. This incidental finding underscores MDCT's utility in detecting coexisting structural anomalies in patients presenting with pericarditis. Conservative management is appropriate for asymptomatic cases without obstruction."

Journal • Cardiovascular • Heart Failure • Pain • Pulmonary Embolism • CRP

Genetic, and clinical features in Italian and lebanese subjects with familial mediterranean fever (FMF). (PubMed, Eur J Intern Med) - "Colchicine was first-line treatment, while biological drug use was higher in Italians...In conclusion, FMF presentation differed by country, with Italians showing milder symptoms and better treatment response, while Lebanese showed severe symptoms linked to pathogenic MEFV variants. Gene-environment interactions require further studies."

Journal • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Inflammation • Pediatrics

Si-Miao-Yong-An decoction restores macrophage efferocytosis and modulates vascular inflammation via PPAR-γ/MerTK pathway to treat atherosclerosis. (PubMed, Fitoterapia) - "This study, combining in vivo and in vitro experiments with network pharmacology, elucidates that SMYAD restores macrophage efferocytosis and mitigates vascular inflammation via the PPAR-γ/MerTK signaling pathway, offering potential therapeutic benefits for AS."

Journal • Atherosclerosis • Cardiovascular • Dyslipidemia • Inflammation • APOE • MERTK

Timing and absolute benefit in updated colchicine meta-analysis for coronary artery disease. Author's reply. (PubMed, Eur J Intern Med) - No abstract available

Journal • Retrospective data • Acute Coronary Syndrome • Cardiovascular • Coronary Artery Disease

From Idiopathic Pericardial Hemorrhage to Mycotic Aortic Aneurysm: A Case Report. (PubMed, Cureus) - "She was subsequently started on aspirin and colchicine therapy. Patients symptoms then resolved, and an improved small pericardial effusion was seen on repeat TTE. However, the surgical specimen grew S. capitis, a rare and slow-growing organism with scarce literature as it pertains to mycotic aortic aneurysms. The patient ultimately recovered from surgery and was discharged on appropriate antibiotics."

Journal • Cardiovascular • Hematological Disorders • Immunology • Infectious Disease • Pain • Vasculitis

Comment on "Risk of Pericarditis Recurrence Associated With Rilonacept and NSAID/Colchicine Therapy After Initial Pericarditis Presentation: A Retrospective Real-World Comparative Risk Analysis With TriNetX". (PubMed, Am J Ther) - No abstract available

Journal • Real-world evidence • Retrospective data • Cardiovascular

Idiopathic pericarditis in 2025: Advances in diagnosis and therapeutic strategies. (PubMed, Autoimmun Rev) - "Initial treatment combines non-steroidal anti-inflammatory drugs or aspirin and colchicine; in case of intolerance or resistance, second-line options include systemic corticosteroids or pharmacological blockade of IL-1...Individualized, risk-adapted management and prolonged follow-up are therefore recommended. This review summarizes contemporary data on the pathophysiology, diagnosis, management, and outcomes of idiopathic pericarditis, with a focus on autoinflammatory mechanisms and IL-1-targeted therapies."

Journal • Review • Cardiovascular • CRP

A case of intestinal Behçet disease in a deceased donor kidney transplantation recipient. (PubMed, Clin Transplant Res) - "The patient's symptoms improved after 2 weeks of therapy with colchicine, mesalazine, and mercaptopurine. This case highlights the rare, de novo development of intestinal BD years after kidney transplantation. Intestinal BD should be considered in transplant recipients presenting with unexplained abdominal pain or diarrhea."

Journal • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Pain • Transplantation

When Sweet's Syndrome Reveals Paucibacillary Pulmonary Tuberculosis: A Diagnostic and Therapeutic Pitfall (IWLH 2026) - "Corticosteroids are the first-line therapy but may mask or worsen unrecognized infections; alternatives such as colchicine or dapsone are used in selected cases (1,2)...Given the extensive cutaneous involvement, systemic corticosteroids (prednisone) were promptly started, with rapid improvement... Sweet's syndrome may exceptionally present as active tuberculosis, even in asymptomatic, low-risk patients.  Always include infectious causes such as TB in SS differential diagnosis.  Corticosteroids, though standard therapy (1,2), require caution until infection is excluded."

Dermatology • Infectious Disease • Respiratory Diseases • Solid Tumor • Tuberculosis • CRP

Downhill Running Blocks the Mitophagic Flux and Autophagosome-Lysosome Fusion in Rat Soleus Muscle. (PubMed, Med Sci Sports Exerc) - "A bout of downhill running may block mitophagic flux by impairing mitophagosome-lysosome fusion, which is accompanied by increased recruitment of STX17 and SNAP29 to autophagosome and reduced co-localizations of STX17 and SNAP29 with lysosomal VAMP8."

Journal • Preclinical • CTSD • LAMP2 • MAP1LC3B • VAMP8

Impact of MEFV gene variants on clinical presentation in Familial Mediterranean Fever: A focus on Exon 2 mutations. (PubMed, Reumatol Clin (Engl Ed)) - "Exon 2 mutations are associated with atypical presentations in FMF. Arthralgia and myalgia presentations are mostly indicative of Exon 2 variant, while a family history and earlier age of symptom onset are characteristic of Exon 10 variant. Clinicians should recognize the complex nature of FMF and adopt a personalized approach."

Journal • Retrospective data • Amyloidosis • Genetic Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Pain

Mistaking Gloriosa Tubers for Ginger: Moderate Symptoms after Accidental Ingestion of a Potentially Life-Threatening Amount of Colchicine. (PubMed, Klin Padiatr) - No abstract available

Journal

Colchicine reduces inflammatory cytokines and improves symptoms in HFpEF: an observational pilot study. (PubMed, Front Med (Lausanne)) - P=N/A | "After 1 month of treatment, significant improvements were observed in anxiety, depression, and quality of life. These findings support colchicine's potential as a therapeutic option for managing inflammation and improving outcomes in patients with HFpEF."

Clinical • Journal • Cardiovascular • CNS Disorders • Congestive Heart Failure • Depression • Heart Failure • Inflammation • Mood Disorders • Psychiatry • CXCL8 • IL6 • TNFA