colchicine / Generic mfg. - LARVOL DELTA

Sociodemographic and Clinical Determinants of Colchicine Adherence in Adults with Familial Mediterranean Fever: A Cross-Sectional Study. (PubMed, Rheumatol Ther) - "Nearly one-third of adult patients with FMF exhibit low adherence to colchicine. Younger age and low household income were associated with low adherence. Routine adherence assessment and targeted support for potentially vulnerable subgroups may help optimize long-term outcomes. Graphical Abstract available for this article."

Journal • Observational data • Amyloidosis • Genetic Disorders • Inflammation

Screening for inflammation and treatment with colchicine in adults with known cardiovascular disease: an analysis of 13.5 million patients. (PubMed, Front Med (Lausanne)) - "The evidence on inflammation and its role in ASCVD is substantial. Screening for inflammation and treatment of the inflammation pathway in patients with ASCVD is very low and not consistent with evidence-based practice."

Journal • Atherosclerosis • Cardiovascular • Inflammation

Gastric Behçet's Disease With Contained Perforation, Intra-Abdominal Abscess, and Enterocutaneous Fistula: A Case Report (ACG 2026) - "She was restarted on azathioprine and colchicine, with biologic therapy planned outpatient. (A) Large cutaneous ulcer of the right lower face with raised, erythematous-violaceous borders and a fibrinopurulent base. (B) Perioral crusted erosions and an aphthous ulcer of the left ventrolateral tongue."

Case report • Clinical • Infectious Disease • Peptic Ulcer • Rare Diseases • Septic Shock • Vasculitis

A Diagnosis Delayed: IBD Mimicking Connective Tissue Disease (ACG 2026) - "She was prescribed hydroxychloroquine with PRN colchicine for mouth sores...Patient was started on 60 mg IV methylprednisolone daily...ANA positivity often occurs in patients with IBD and should not be used in isolation as an indicator of rheumatologic disease vs IBD. Figure: Figure 1: Representative colonoscopy image of sigmoid colon"

Dental Disorders • Hematological Disorders • Inflammation • Inflammatory Arthritis • Inflammatory Bowel Disease • Rheumatology

Targeting the Tumor, Tripping the Liver: A Rare Case of Neladalkib-Induced DILI (ACG 2026) - "Neladalkib was held and LFTs peaked (AST 6,594; ALT >5,000)...She received N-acetylcysteine (NAC) infusion and hemodiafiltration...The absence of viral markers and unremarkable liver imaging strongly point toward a drug-induced etiology; concurrent medications of colchicine and sertraline were likely non-contributors...Figure: Figure 1. DILI Resolution timeline by ALT, AST, Ammonia, and INRx10"

Clinical • Hepatology • Immunology • Infectious Disease • Liver Failure • Lung Cancer • Nephrology • Oncology • Septic Shock • Solid Tumor • ALK

Mesalamine-Induced Perimyocarditis in Newly Diagnosed Ulcerative Colitis (ACG 2026) - "Repeat echocardiogram showed normalization of EF, and he was discharged on prednisone and colchicine. Early recognition is essential to prevent severe cardiac complications. AI was used solely for proofreading."

Cardiovascular • Colorectal Cancer • Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Heart Failure • Immunology • Inflammation • Inflammatory Bowel Disease • Musculoskeletal Pain • Ulcerative Colitis

Anti-TNF-Induced Lupus Myopericarditis in a Pregnant Patient With Ulcerative Colitis: A Case Report (ACG 2026) - "Case Description/ A 29-year-old woman at 27 weeks gestation with longstanding UC in endoscopic remission (Mayo score 0) on infliximab (IFX) 5 mg/kg every 8 weeks and sulfasalazine presented two days after a scheduled infusion with acute pleuritic chest pain, exertional dyspnea, and palpitations...The patient was treated with intravenous methylprednisolone 60 mg daily and colchicine 0.5 mg twice daily, with subsequent transition to oral prednisolone on a structured taper...Figure: Transthoracic echocardiography revealed a large circumferential pericardial effusion (maximal posterior dimension 2.4 cm) without echocardiographic evidence of tamponade physiology, accompanied by an associated pleural effusion and a dilated inferior vena cava measuring 2.2 cm. Left ventricular systolic function was preserved with an estimated ejection fraction exceeding 55%, and no regional wall motion abnormalities were identified."

Case report • Clinical • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Arthritis • Inflammatory Bowel Disease • Lupus • Musculoskeletal Diseases • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Ulcerative Colitis

Acute Myopericarditis After Esophagogastroduodenoscopy (ACG 2026) - "He was treated with liquid ibuprofen 600 mg three times daily and colchicine 0.6 mg twice daily...Figure: Figure 2. Chest computed tomographic angiography showing circumferential pericardial thickening and enhancement with pericardial effusion."

Cardiovascular • Coronary Artery Disease • Gastroenterology • Gastrointestinal Disorder • Obstructive Sleep Apnea • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • Sleep Apnea • Sleep Disorder • CRP

A Case of 5-Aminosalicylic Acid-Induced Pleuropericarditis in a Patient With Ulcerative Colitis (ACG 2026) - "He was treated with Tamiflu for Influenza B. Despite treatment, symptoms worsened prompting reevaluation...5-ASA was discontinued and the patient was prescribed a course of steroids and colchicine for pericarditis...Figure: Figure1: Top Row (Lung View), Bottom Row (Mediastinal View): Left: CT Chest, PE Protocol (ED presentation one month after starting therapy); Right: CT Chest, PE Protocol (ED presentation two months after starting therapy) showing large bilateral pleural effusions, large pericardial effusion. Figure: Figure 2: Echocardiogram showing a moderate circumferential pericardial effusion."

Clinical • Cardiovascular • Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Influenza • Respiratory Diseases • Ulcerative Colitis

Heartburn of a Different Kind: Mesalamine-Induced Myopericarditis in Ulcerative Colitis (ACG 2026) - "He was started on colchicine and prednisone with improvement...He was discharged on colchicine, ibuprofen, budesonide, and omeprazole, with outpatient gastroenterology follow-up to discuss alternative UC therapy...Management centers on drug discontinuation, with NSAIDs and colchicine as adjuncts. Clinicians should suspect 5-ASA cardiotoxicity in any IBD patient with new cardiac symptoms shortly after initiation."

Cardiovascular • CNS Disorders • Depression • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Influenza • Musculoskeletal Pain • Novel Coronavirus Disease • Respiratory Diseases • Ulcerative Colitis • CRP

A Rash Decision: Diagnostic and Therapeutic Management of DRESS With DILI (ACG 2026) - "Case Description/ A 66 year old female with CKD3 presented with progressive fatigue and pruritic urticarial rash spreading from feet to the back after two weeks after starting colchicine and allopurinol for gout. Figure: Punch Biopsy of rash on patient's right leg, H&E 100x. Hyperkeratotic acanthotic epidermis with rare keratinocyte necrosis (arrows), papillary dermal edema, and perivascular to lichenoid superficial dermal inflammatory infiltrate of neutrophils with karyorrhexis, lymphocytes, and rare eosinophils Figure: Zone 3 hepatocyte necrosis with repair and mild associated inflammation"

Cardiovascular • Eosinophilia • Gout • Heart Failure • Hepatology • Immunology • Inflammatory Arthritis • Liver Failure • Nephrology • Renal Disease • Urticaria

Effect of Low-Dose Colchicine on Major Adverse Cardiovascular Events in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Real-World Cohort Analysis (ACG 2026) - "After PSM, each cohort comprised 1,644 patients. Mean age was approximately 60 years; 56% were female. The racial distribution was similar between groups, with White patients representing the majority (~73â75%)."

Adverse events • Clinical • Real-world • Real-world evidence • Atherosclerosis • Atrial Fibrillation • Cardiovascular • Chronic Kidney Disease • Congestive Heart Failure • Heart Failure • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Myocardial Infarction • Nephrology • Renal Disease • Solid Organ Transplantation • Venous Thromboembolism

Idiopathic Complex Aphthosis With Diffuse Gastrointestinal (GI) Ulceration (ACG 2026) - "Recurrent oral ulcers responded to iron supplementation and colchicine...Figure: Ulceration of the lateral tongue (A), oropharynx (B), arytenoid cartilages (C), and esophagus (D). Figure: Ulceration of the terminal ileum (A, B), cecum (C), and perianal region (D)."

Crohn's disease • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Rare Diseases

Long-Term Clinical Outcomes After Procedural Hemopericardium Requiring Pericardiocentesis During Atrial Fibrillation Ablation. (PubMed, J Cardiovasc Dev Dis) - "In patients with procedural hemopericardium during AF ablation, prompt pericardial drainage was associated with favorable clinical outcomes and absence of long-term pericardial sequelae. Adjunctive colchicine therapy was not associated with a significant reduction in arrhythmia recurrence; however, given the small sample size and limited number of events, a clinically meaningful treatment effect cannot be excluded."

Clinical data • Journal • Atrial Fibrillation • Cardiovascular • CRP

Targeting the Snail1-ATGL-Ferroptosis-EMT Axis via AKT-GSK3β Signaling: Low-Dose Colchicine Attenuates Idiopathic Pulmonary Fibrosis. (PubMed, Eur J Pharmacol) - "These findings identify ATGL as an epithelial checkpoint that modulates ferroptosis susceptibility and EMT under fibrotic stress and reveal Snail1-dependent regulation of ferroptosis as a previously unappreciated noncanonical mechanism of EMT regulation. This study provides novel mechanistic insight into the actions of low-dose COL, supporting its translational relevance in IPF."

Journal • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • GSK3B • HDAC1 • HDAC2 • SNAI1 • TGFB1

Col-DM: Colchicine for Primary Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes (clinicaltrials.gov) - P2 | N=300 | Recruiting | Sponsor: Tan Tock Seng Hospital

New P2 trial • Atherosclerosis • Cardiovascular • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus • ICAM1

Nanoparticle Co-delivery of Microtubule Inhibitors and Cisplatin Overcomes DNA Repair-Mediated Resistance in Head and Neck Cancer. (PubMed, Mol Cancer Ther) - "Through a combined screen of DNA crosslink repair and cisplatin sensitivity modulators, our current study identifies a strong synergy between cisplatin and microtubule-targeting agents (MTAs), including taxanes and colchicine. Indeed, in syngeneic HNSCC models, nanoparticle co-delivery of paclitaxel and cisplatin prodrug produced markedly superior antitumor efficacy compared to the free drug combination. Collectively, our findings define a mechanism-guided, nanoparticle-enabled therapeutic approach for sensitizing HNSCC to platinum-based chemotherapy through selective disruption of DNA damage responses."

Journal • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck • ERCC1 • RAD51 • RPA2

Late-onset familial Mediterranean fever: A case series of missed diagnoses in pleural effusions. (PubMed, Sage Open Chronic Dis) - "In all cases, MEFV (Mediterranean fever) gene analysis revealed R202Q mutations, which guided the initiation of colchicine therapy with favorable outcomes. This study highlights the diagnostic challenges posed by atypical FMF presentations and underscores the importance of considering FMF in recurrent serositis, even without systemic inflammation. Early genetic testing and appropriate treatment may reduce unnecessary interventions and improve patient outcomes."

Journal • Pleural effusion • Genetic Disorders • Inflammation • Respiratory Diseases

Genotype-phenotype divergence in pediatric familial Mediterranean fever across two closely related populations: a Türkiye-Azerbaijan comparison. (PubMed, Turk J Pediatr) - "This first systematic Türkiye-Azerbaijan comparison reveals distinct genotype-phenotype correlations in pediatric FMF, with Turkish patients showing a higher burden of confirmatory exon 10 genotypes and more severe disease, highlighting the need for center- and population-aware management strategies."

Clinical • Journal • Retrospective data • Genetic Disorders • Immunology • Inflammation • Musculoskeletal Pain • Pain • Pediatrics • Rheumatology • CRP

Psychosocial burden in pediatric familial mediterranean fever: A study of quality of life, sleep habits, maternal mental health, and clinical correlates. (PubMed, BMC Psychol) - "In this cohort of clinically stable, attack-free children with FMF, parent-reported health-related quality of life was lower in children with two pathogenic MEFV exon 10 variants and in girls, whereas child-reported health-related quality of life did not differ according to mutation burden, age, or sex. Maternal anxiety and depressive symptom scores and children's sleep habit scores were also similar across these subgroups. These findings highlight the importance of considering both child and caregiver perspectives when evaluating psychosocial outcomes in pediatric FMF."

Clinical • HEOR • Journal • Tumor mutational burden • CNS Disorders • Depression • Genetic Disorders • Inflammation • Mood Disorders • Pediatrics • Psychiatry • Rheumatology • TMB

NOD2 Variants in a Pediatric Population: Genotype-Phenotype Patterns and a Comparison to Adult Yao Syndrome (ACR Convergence 2026) - "Ten patients (43.5%) received no treatment, while corticosteroids and colchicine were each used in seven cases (30.4%)... In this cohort, pediatric patients with NOD2 VUS exhibited a broad and overlapping range of inflammatory phenotypes rather than a single uniform clinical entity. A proportion of patients met proposed adult Yao syndrome criteria, but many had alternate diagnoses. Compared with published adult Yao syndrome cohorts, the pediatric cohort exhibited more frequent oral ulcers, but less arthritis and rash."

Clinical • Crohn's disease • Gastroenterology • Immunology • Inflammation • Inflammatory Bowel Disease • Musculoskeletal Pain • Pediatrics • NLRC5

Real-world safety of concomitant colchicine and statin therapy (ACR Convergence 2026) - "Although colchicine-statin concomitant therapy was associated with higher rates of laboratory and clinical adverse events, the additional risk beyond statin monotherapy was small, supporting their use when clinically indicated."

Clinical • Real-world • Real-world evidence • Cardiovascular • Genetic Disorders • Gout • Hepatology • Inflammatory Arthritis • Myositis

MEFV Zygosity Predicts Colchicine Drug Survival with a Resistance Profile Distinct from Mediterranean Cohorts: the Largest Chinese FMF Longitudinal Study (ACR Convergence 2026) - No abstract available

Longitudinal study • Observational data

Completed suicide with colchicine in familial Mediterranean fever: demographic, clinical, and post-mortem features (ACR Convergence 2026) - No abstract available

Clinical • Genetic Disorders

Colchicine Resistance and Comorbidities in Biologic Selection for Familial Mediterranean Fever (ACR Convergence 2026) - No abstract available

Genetic Disorders