nifedipine immediate release / Generic mfg. - LARVOL DELTA

DS27 Checking blood pressure of patients having Mohs surgery: a survey of practice of UK- and Australasia-based Mohs surgeons. (PubMed, Br J Dermatol) - "'Other' open comment themes included determining signs of malignant hypertension, checking what their baseline BP was with the patient and/or general practitioner, refer to an emergency department or give a benzodiazepine (e.g. low-dose sublingual diazepam 2 mg)...From ANZ, glyceryl trinitrate, ramipril and sublingual nifedipine were given as antihypertensives...The results confirm a range of practice and no consensus. Further discussion and an evidence-based guideline would be helpful to develop more consistent practice."

Journal • Cardiovascular • Hypertension

Isolated trigeminal sensory neuropathy in a patient with mixed connective tissue disease: A diagnostic challenge (EHF-EHC 2025) - "Chronic medication included gabapentin 100mg three times daily, prednisolone 10mg, hydroxychloroquine 400mg, aspirin 150mg, pentoxifylline 400mg, nifedipine 20mg, furosemide, tadalafil and ambrisentan. This case highlights the importance of considering autoimmune mechanisms in isolated trigeminal neuropathies, especially in patients with systemic connective tissue disease. EMG may assist in detecting trigeminal dysfunction, and intrathecal autoantibodies, even without structural lesions, support an immune-mediated process and underscore the value of CSF analysis in atypical neurological presentations."

Clinical • Cardiovascular • Immunology • Melanoma • Pain • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Rheumatology • Solid Tumor

TOCOPROM: Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation (clinicaltrials.gov) - P3 | N=850 | Recruiting | Sponsor: Assistance Publique - Hôpitaux de Paris | Trial completion date: Nov 2030 ➔ Nov 2031 | Trial primary completion date: Nov 2025 ➔ Nov 2026

Trial completion date • Trial primary completion date

Targeted Therapy or Tension: A Case of Tyrosine Kinase Inhibitor-Mediated Hypertensive Crisis in a Patient with Advanced Renal Cell Carcinoma (KIDNEY WEEK 2025) - "Case Description A 71-year-old woman with well-controlled hypertension on lisinopril 20 mg daily and prior RCC treated by radical nephrectomy and short-lived pembrolizumab (stopped for immune polyarthritis) began cabozantinib 40 mg daily for progression...Twelve weeks after stopping cabozantinib, she remained markedly hypertensive despite four agents (lisinopril 40 mg qd, nifedipine 120 mg qd, chlorthalidone 25 mg qd, spironolactone 25 mg qd)...Since then, she has been receiving Belzutifan (HIF-2α inhibitor) without adverse effects. ( Ref Fig1 ) Discussion Grade 1-3 HTN was observed in about 37% of patients in the METEOR Trial (Cabozantinib versus Everolimus in Advanced Renal-Cell Carcinoma), but frank hypertensive crisis (grade 4) and true resistant hypertension are very uncommon (<1 %). Presentation with hypertensive crisis prompts discontinuation of the TKI therapy."

Clinical • Metastases • Cardiovascular • Genito-urinary Cancer • Hypertension • Immunology • Oncology • Renal Cell Carcinoma • Renal Disease • Solid Tumor • EPAS1

Mechanical and Electrical Phenotype of hiPSC-Cardiomyocytes on Fibronectin-Based Hydrogels. (PubMed, Adv Healthc Mater) - "Drug testing with known cardioactive compounds, including isoproterenol and nifedipine, revealed distinct differences in drug responses between hydrogel and glass cultures, suggesting that hydrogels provide a more physiologically relevant platform for assessing drug effects. This work highlights the potential of engineered hydrogel substrates to enhance the functional maturity and predictive accuracy of hiPSC-CMs for cardiac research and drug development."

Journal

Integrating drug effects on individual cardiac ionic currents and cardiac action potentials to understand nonclinical translation to clinical ECG changes. (PubMed, Front Pharmacol) - "The results showed that hERG block-mediated QTC prolongation with dofetilide was shortened by co-administration of lidocaine or mexiletine-drugs that inhibit INaL...Consistent with this interpretation, nifedipine, which preferentially inhibits ICaL over hERG (ICaL: 13.2 nM; hERG: 35 μM; ratio = 2,651) caused APD shortening without AP triangulation. Results from this study thus support the following: 1) diltiazem failed to reduce moxifloxacin-induced QTC prolongation due to its concomitant hERG block at clinical exposure levels; and 2) the importance of using physiologically relevant protocols to generate ion channel pharmacology and obtaining functional recordings from myocytes to provide a better understanding of nonclinical data translation to clinical ECG signals. Data used in this manuscript, including the original electrophysiology records, may be found at: https://osf.io/69ght/."

Journal

Conservative Management of Spontaneous Posterior Mediastinal Intercostal Artery Hemorrhage: A Case Report and Literature Review. (PubMed, J Emerg Med) - "Blood pressure was initially controlled with intravenous nicardipine, followed by oral sacubitril/valsartan and nifedipine administration. Conservative management may be feasible in hemodynamically stable patients with natural tamponade; however, careful patient selection and close monitoring are crucial. Awareness of this condition can help avoid unnecessary invasive procedures."

Journal • Back Pain • Cardiovascular • Genetic Disorders • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Mood Disorders • Musculoskeletal Pain • Neurofibromatosis • Pain • Peripheral Arterial Disease • Solid Tumor • Systemic Lupus Erythematosus

Prevalence, associated factors, and pharmacotherapy of hypertensive disorders among parturients in Bono Region of Ghana: An analytical cross-sectional study. (PubMed, Afr J Reprod Health) - "Oral nifedipine and intravenous hydralazine were the primary antihypertensive therapies. Magnesium sulfate was universally administered using the Pritchard regimen, though product concentrations for intramuscular use varied slightly. Findings highlight the need to standardize magnesium sulfate formulations to optimize intramuscular dosing and enhance treatment consistency in lower-level facilities managing HDPs."

Journal • Observational data • Cardiovascular • Gynecology • Hypertension

Quadruple parametric optical mapping to measure cardiac metabolism-excitation-contraction coupling. (PubMed, Commun Biol) - "Using this technique, we demonstrate known and novel cardiac responses to nifedipine and flecainide. We determine chronological changes in MECC with FCCP and ischemia/reperfusion to understand the interplay between electrical, mechanical, and metabolic functions in the heart and mechanisms underlying arrhythmogenesis."

Journal • Cardiovascular • Reperfusion Injury

Potentially inappropriate medication use and associated factors among older adults in Ethiopia: a systematic review and meta-analysis. (PubMed, J Pharm Policy Pract) - "The most common drug used inappropriately among older adults in Ethiopia was Nifedipine 230 (13.6%)...The pooled prevalence of potentially inappropriate medication among older adults in Ethiopia is high indicating two out of five older adults used inappropriate medication. This review is crucial to MOH of Ethiopia, healthcare professionals and researchers."

Journal • Retrospective data • Review

Role of S1P- and Rho-kinase signalling in age-related myogenic tone deficiency in murine resistance arteries. (PubMed, Exp Physiol) - "The P2Y-receptor blocker suramin inhibited MT, whereas PPADS and apyrase did not...High-resolution microangiography confirmed that infusion of JTE-013 or KD025 (a Rho-kinase 2 inhibitor) preferentially dilated small (distal) CAs, and infusion of nifedipine (an L-type channel inhibitor) dilated all CAs in all mice, independent of age. SK and S1P2-R are crucially involved in pressure sensing in MT. RhoA/Rho-kinase signalling might be involved in age-related MT deficiency."

Journal • Preclinical • Alzheimer's Disease • Cardiovascular • CNS Disorders • RHOA

Treatment of Hypertensive Crisis in Primary Care Health Facilities in Peru, 2019-2024. (PubMed, High Blood Press Cardiovasc Prev) - "Short-acting antihypertensives and other agents remain common in Peruvian primary care hypertensive crises. Targeted strategies are needed to align practice with evidence-based recommendations."

Journal • Cardiovascular • Hypertension

Effects of antihypertensives on the degradation behavior of AZ31 alloy in in-vitro environment. (PubMed, Sci Rep) - "Effects of seven antihypertensives of Losartan Kalicum(LK), Atenolol(ATEN), Nifedipine(NF), Hydrochlorothiazide(HCTZ), Valsartan(VLA), Furosemide(FUR) and Captopril(CAP) have been investigated on the degradation behavior of AZ31 alloy in simulated body fluid (Hank's solution). The surface analysis reveals that the addition of LK, NF and HCTZ can reduce degradation rate by promoting the growth of hydroxyapatite, increasing the protection effect of corrosion film formed. The present results may enhance the corrosion resistance of Mg-based orthopedic implants."

Journal • Preclinical • Orthopedics

A disproportionality analysis of nifedipine in the overall population and in pregnant women using the FDA Adverse Event Reporting System (FAERS) database. (PubMed, Medicine (Baltimore)) - "This study identified unexpected AE signals associated with nifedipine use during pregnancy. The findings offer valuable insights to guide clinical decision-making and promote safer use of nifedipine in pregnant populations."

Adverse events • Journal • Cardiovascular • Hypertension • Respiratory Diseases

Ischemic Necrosis of Bilateral Second Toes in the Absence of Macrovascular Disease or Primary Vasculitis: A Unique Case of Systemic Sclerosis Sine Scleroderma (ssSSc). (PubMed, Cureus) - "The patient was treated conservatively with aspirin, nifedipine, and local wound care, resulting in complete epithelialization within eight weeks. This case highlights the importance of considering ssSSc in the differential diagnosis of unexplained digital ischemia - particularly in the lower extremities - and underscores the value of multidisciplinary collaboration in identifying rare autoimmune vascular syndromes presenting with limb-threatening ischemia."

Journal • Cardiovascular • Diabetes • Immunology • Metabolic Disorders • Rheumatology • Scleroderma • Systemic Sclerosis • Vasculitis

Fetal Cardiac Effects of Tocolytic Nifedipine and Magnesium Sulfate (clinicaltrials.gov) - P=N/A | N=100 | Active, not recruiting | Sponsor: Sanliurfa Education and Research Hospital | Trial completion date: Aug 2025 ➔ Nov 2025

Trial completion date

A Clinical Analysis of the Association Between Nifedipine and Insulin Usage and the Increased Incidence of Colonic Polyps. (PubMed, JGH Open) - "(2) Significant differences were found between nifedipine, metformin, and insulin when comparing the single benign colonic polyps to multiple polyps (p < 0.05). The use of nifedipine, insulin, and metformin was associated with an increased risk of developing colonic polyps, whereas statin therapy was linked to a decreased risk."

Journal • Colon Cancer • Colonic Polyps • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Oncology • Solid Tumor

Anal Fissures. (PubMed, Surg Clin North Am) - "Lateral internal sphincterotomy is the gold standard surgical management. Special considerations exist for certain patient populations."

Journal • Review • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Oncology • Pain

Divergent Effects of Calcium Channel Modulators on H-Reflex Excitability in Fatigued Rat Muscle. (PubMed, Int J Mol Sci) - "Using the Hoffmann reflex (H-reflex) as an indicator of motoneuron excitability, we evaluated the effects of Ca2+ channel blockers (Amiloride, Nifedipine) and an activator ((-)-Bay K8644) on the reflex responses of the plantar muscle before and after fatigue induction. These findings demonstrate that pharmacological modulation of Ca2+ channels has distinct and divergent effects on spinal excitability during fatigue. These results highlight the close interaction between intramuscular Ca2+ regulation and reflex pathways and suggest potential strategies for enhancing muscle performance through targeted Ca2+ channel modulation."

Journal • Preclinical • Fatigue

Red Is Not Always Bad: Vin Rosé Urine in a Kidney Transplant Patient with Sickle Cell Crisis (KIDNEY WEEK 2025) - "His treatment included Tacrolimus ER, Cellcept, Prednisone, Hydroxyurea, Deferiprone, Apixaban, Pregabalin, Nifedipine and Methadone. However, as urinalysis experts nephrologists should be aware of it. Figure 1: Vin rosé urine"

Clinical • Anemia • Chronic Kidney Disease • CNS Disorders • Epilepsy • Genetic Disorders • Glomerulonephritis • Infectious Disease • Lupus Nephritis • Nephrology • Renal Calculi • Renal Disease • Sickle Cell Disease • Transplantation

A Rare Case of ANCA-Associated Vasculitis (AAV) with Concurrent Immune Complex (IC) Deposition (KIDNEY WEEK 2025) - "Case Description A 74-year old male with past medical history of prostate cancer (CA), non-small cell lung CA, basal cell CA, rheumatoid arthritis (on abatacept) and hypertension presented to the hospital with complaint of flank pain. He reported consuming 1.6-2g/day of ibuprofen. Home medications included nifedipine and carvedilol...He received induction treatment with rituximab, steroids and avacopan...However, the deposition of both IgG and IgA co-dominant deposits is still rare. In spite of his aggressive RPGN, we elected not to use cyclophosphamide given his recent malignancies."

Clinical • ANCA Vasculitis • Genito-urinary Cancer • Glomerulonephritis • Hypertension • IgA Nephropathy • Immunology • Inflammatory Arthritis • Lung Cancer • Lupus Nephritis • Nephrology • Non Small Cell Lung Cancer • Prostate Cancer • Renal Disease • Rheumatoid Arthritis • Rheumatology • Solid Tumor • Thrombosis • Vasculitis • MPO

Complement-Mediated Thrombotic Microangiography Presenting as Hypertensive Emergency and Kidney Failure (KIDNEY WEEK 2025) - "He was discharged on Carvedilol, Hydralazine, Nifedipine and Spironolactone...He was started on ravulizumab-cwvz with improvement in his Cr and BP...CM-TMA tends to fall lower on the differential, however early diagnosis and treatment is essential for treatment and prevention of worsening renal failure. This case also highlights the importance of access to care and the financial burdens that may limit or delay treatment."

Acute Kidney Injury • Anemia • Atypical Hemolytic Uremic Syndrome • Cardiovascular • Complement-mediated Rare Disorders • Hematological Disorders • Hypertension • Immunology • Nephrology • Renal Disease • Thrombocytopenia • Thrombocytopenic Purpura

Reversible Calcium Channel Blocker-Induced Chylous Ascites in a Pediatric Patient on Peritoneal Dialysis: A Rare Complication (KIDNEY WEEK 2025) - "Case Description A 12-year-old male with ESRD on PD developed milky effluent (Figure 1) on CCB therapy (Nifedipine)...Rapid resolution on CCB withdrawal is a key learning point; prompt CCB discontinuation prevents unnecessary antibiotics, investigations, and PD cessation. Chylous effluent before discontinuation of CCB After stopping CCB"

Clinical • Chronic Kidney Disease • Dyslipidemia • Hypertriglyceridemia • Nephrology • Pediatrics • Renal Disease

Resistant Hypertension in ANCA-Associated Vasculitis: Role for Aliskiren? (KIDNEY WEEK 2025) - "Despite receiving cyclophosphamide and methylprednisolone, he remained dialysis-dependent and was referred for renal transplant. He had multiple hypertensive emergency admissions despite a multi-drug regimen with nifedipine, telmisartan, carvedilol, eplerenone, clonidine, and hydralazine, and dry weight optimization...Studies are warranted to compare DRI efficacy against standard antihypertensives in similar clinical scenarios. The views expressed in this abstract are those of the author(s) and do not necessarily reflect the official policy of the Department of Defense or the U.S. Government."

ANCA Vasculitis • Cardiovascular • Glomerulonephritis • Hypertension • Inflammation • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis • MPO

FSGS-Like Features and Proteinuria in an Adolescent with Unilateral Renal Artery Stenosis (KIDNEY WEEK 2025) - "He was transitioned to Procardia and discharged but re-admitted due to persistent AKI and worsening UPCR to 2.54.Biopsies showed glomerulomegaly, pseudocrescents,and mesangial hypercellularity in the right kidney concerning for secondary FSGS...He later underwent left renal artery recanalization and acheived normotension with improved UPCR to 0.15 and transitioned to lisinopril...The presence of bilateral podocyte effacement in this case of unilateral RAS remains unexplained. The patient’s proteinuria and HTN resolved with stabilized renal function post angioplasty suggesting attenuation of the injurious effects of circulating angiotensin II independent of blood pressure control."

Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Hypertension • Nephrology • Pediatrics • Renal Disease