nifedipine immediate release / Generic mfg. - LARVOL DELTA

Effect of plantamajoside on the pharmacokinetics of nifedipine in rats and the underlying mechanisms. (PubMed, Xenobiotica) - "The increased nifedipine exposure in rats could be attributed to the inhibition of CYP3A-mediated metabolism by plantamajoside. Given the role of orthologous CYP3A4 in humans, this interaction may enhance antihypertensive efficacy but could also increase the risk of severe hypotension clinically."

Journal • PK/PD data • Preclinical • Hypotension • CYP3A4

Prehospital Blood Pressure Lowering in Likely Intracerebral Hemorrhage Patients Is a Cost-Effective Treatment Strategy in Both US and China (ISC 2026) - "The objective of this study was to investigate if this treatment strategy would also be cost-effective.Methods Modeling inputs were: 1) age- and sex-specific life expectancies from US and China actuarial tables; 2) mRS disability weights and disability-level specific mortality hazard ratios for ICH and IS; 3) 3m mRS outcomes for ICH and IS patients from INTERACT 4; and 4) costs of prehospital BP medication in the US (nifedipine) and China (urapidil)...The average quality-adjusted life year gained for each treated female patient was 0.6y.Conclusion Prehospital BP-lowering treatment in hyperacute stroke patients assessed as likely having ICH would be highly cost-effective at positive predictive values attainable by currently available ICH diagnostic scales and point-of-care tests. These findings support pivotal trial testing of this promising treatment approach."

Clinical • Cost effectiveness • HEOR • Cardiovascular • Cerebral Hemorrhage • Hematological Disorders • Ischemic stroke • GFAP

Hypertensive Crisis in Labor: Believe it and Treat it (ISC 2026) - "As leaders in Women's Services, our initiative focused on implementing best practices for identifying and treating hypertensive crises in laboring patients.A comprehensive literature review using key terms such as "first-line antihypertensives in labor," "hypertensive crisis in labor," and "intrapartum blood pressure management" revealed three gold-standard practices endorsed by regulatory bodies and professional organizations: (1) prompt identification and provider notification of hypertensive crisis (defined as SBP >160 mmHg or DBP >110 mmHg on two readings within 15 minutes), (2) initiation of treatment within 60 minutes of the second elevated reading, and (3) use of standard first-line medications—IV labetalol, IV hydralazine, or oral nifedipine.Baseline chart audits showed minimal compliance with these standards. Post-implementation audits demonstrated a significant improvement, achieving over 80% compliance with all three..."

Cardiovascular • Hypertension • Infectious Disease

Efficacy of pharmacological agents for management of post-partum hypertension: A systematic review and network meta-analysis. (PubMed, J Hum Hypertens) - "Compared with labetalol, risk ratios for blood pressure control were 1.01 for nifedipine, 1.03 for hydralazine, and 1.31 for hydrochlorothiazide-lisinopril. Calcium channel blockers appear most effective for rapid reduction of blood pressure after childbirth, while labetalol is most reliable for sustained control within the first postpartum week. These findings provide a comparative framework for treatment selection and emphasize the need for larger, rigorously designed postpartum hypertension trials.PROSPERO Registration Number: CRD420251104693."

Journal • Retrospective data • Review • Cardiovascular • Hypertension

Retraction Note: Efficient administration of a combination of Nifedipine and sildenafil citrate versus only Nifedipine on clinical outcomes in women with threatened preterm labor: a systematic review and meta-analysis. (PubMed, BMC Pediatr) - No abstract available

Clinical data • Journal • Retrospective data

An individual participant data network meta-analysis of the APOSTEL trials on the effect of tocolysis in threatened preterm birth between 30-33+6 weeks of gestation in twin pregnancies. (PubMed, Eur J Obstet Gynecol Reprod Biol) - "No clear benefit of nifedipine or atosiban over placebo on neonatal outcomes in twin pregnancies with threatened preterm birth between 30+0 and 33+6 weeks was found."

Journal • Retrospective data

Outcome of lateral internal sphincterotomy for anal fissure in a retrospective cohort of patients. (PubMed, Updates Surg) - "The surgical treatment of chronic anal fissure by means of lateral internal sphincterotomy gives excellent results with prompt resolution of anal pain. A standardized approach, surgeon's experience and high volume of cases may represent contributing factors for a good outcome, minimizing complications and recurrence. Normal bowel function contributes to improve and preserve results of surgical treatment."

Journal • Retrospective data • Constipation • Gastroenterology • Gastrointestinal Disorder • Pain

Chronic Bilateral Distal Radial and Ulnar Artery Occlusion Presenting as Peripheral Neuropathy in a Young Adult. (PubMed, JACC Case Rep) - "Chronic bilateral distal radial and ulnar artery occlusion is a rare peripheral artery disease that may cause neuropathy owing to hypoperfusion, inflammation, and microvascular dysfunction. Diagnosis relies on clinical evaluation and duplex ultrasonography. Management centers on conservative therapy, including risk-factor control, antiplatelets, statins, and neuropathy treatment."

Journal • Cardiovascular • Dyslipidemia • Genetic Disorders • Hypertension • Inflammation • Metabolic Disorders • Mood Disorders • Obesity • Pain • Peripheral Arterial Disease • Vasculitis

Effects of GS-967, GS-6615 and ranolazine on the responses of the rabbit aorta to adrenergic nerve stimulation. (PubMed, Front Physiol) - "Electrical Field Stimulation (EFS) (2, 4 and 8 Hz) induced frequency-dependent contractions that were abolished by tetrodotoxin, prazosin, or guanethidine (10-6 M)...Concentration-response curves to GS-967, GS-6615 or RAN were constructed in rings precontracted with noradrenaline, endothelin-1 or KCl with or without specific inhibitors (L-NAME, nimesulide, SC-560, verapamil, nifedipine, apamin or charybdotoxin)...Taken together, our results indicate that GS-967, GS-6615 and RAN decrease vasoconstrictor responses due to both neural and noradrenaline-induced adrenergic stimuli. We can suggest that the use of GS-967, GS-6615 and Ranolazine may be interesting in clinical procedures involving hyperstimulation of the adrenergic nervous system."

Journal • Preclinical • EDN1

Successful term pregnancy after renal transplant in end-stage renal disease with complement factor H-related mutation: A case report. (PubMed, World J Transplant) - "High-risk complement-mediated TMA patients can achieve successful pregnancy post-transplant through individualized care without mandatory complement blockade."

Journal • Atypical Hemolytic Uremic Syndrome • Cardiovascular • Chronic Kidney Disease • Complement-mediated Rare Disorders • Hematological Disorders • Hypertension • Nephrology • Renal Disease • Transplantation • CFH • CFHR3

Double action of HPMCAS as a dry binder and precipitation inhibitor in ASD tablet formulations of nifedipine prepared by hot-melt extrusion. (PubMed, Int J Pharm X) - "The results from this study demonstrate, for the first time, the dual function of HPMCAS (AS-HF) as a dry binder and precipitation inhibitor in high ASD load tablets, independent of the carrier polymer. This can potentially reduce the pill burden and improve the drug bioavailability in ASD tablet formulations."

Journal

Histomorphometric and immunohistochemical evaluation of apoptosis in nifedipine-induced gingival overgrowth. (PubMed, BMC Oral Health) - No abstract available

Journal

Hypotensive Agents for Controlled Hypotension in Endoscopic Sinus Surgery: A Systematic Review and Network Meta-Analysis. (PubMed, JAMA Otolaryngol Head Neck Surg) - "Randomized clinical trials of patients undergoing ESS and receiving dexmedetomidine, clonidine, esmolol, labetalol, bisoprolol, metoprolol, diltiazem, nifedipine, or verapamil vs placebo. In this systematic review and network meta-analysis, controlled hypotension improved surgical field quality in ESS with comparable safety. Diltiazem, esmolol, dexmedetomidine, labetalol, and clonidine were effective; dexmedetomidine was associated with reduced MAP the most, and esmolol favored recovery."

Clinical • Journal • Retrospective data • Hypotension • Otorhinolaryngology

EARLY-ONSET, ASYMPTOMATIC NIFEDIPINE HEPATOTOXICITY: EXPANDING THE SPECTRUM OF CALCIUM CHANNEL BLOCKER LIVER INJURY (ACC 2026) - "Abstract is embargoed at this time."

Hepatology • Liver Failure

NIFEDIPINE VERSUS LABETALOL FOR HYPERTENSION IN PREGNANCY: A META-ANALYSIS IN 2,570 PATIENTS (ACC 2026) - "Abstract is embargoed at this time."

Retrospective data • Cardiovascular • Hypertension

A COMPARATIVE ANALYSIS OF NIFEDIPINE AND LABETALOL IN HYPERTENSIVE DISORDERS OF PREGNANCY: COMPARING OUTCOMES WITH 10 YEARS OF DATA FROM THE UNITED STATES (ACC 2026) - "Abstract is embargoed at this time."

Hypertension

NEPHRON: Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study (clinicaltrials.gov) - P=N/A | N=200 | Not yet recruiting | Sponsor: The Cleveland Clinic

New trial • Cardiovascular • Gynecology • Hypertension

Acute high-altitude illnesses - Definition, Prophylaxis, Therapy (PubMed, Ther Umsch) - "Prevention includes slow ascent, pre-acclimatization, and eventually acetazolamide or dexamethasone...Treatment requires descent, oxygen therapy, and possibly nifedipine or PDE-5-inhibitors. If untreated, HACE and HAPE progress rapidly and can be fatal. Prevention, early recognition and immediate treatment are crucial."

Journal • Review • Acute Respiratory Distress Syndrome • Ataxia • Cough • Fatigue • Movement Disorders • Pain • Pulmonary Disease • Respiratory Diseases

Therapeutic role of nifedipine in threatened preterm labor: Current evidence and future perspectives. (PubMed, Int J Gynaecol Obstet) - "Future studies should involve large and homogeneous populations, continuous assessment of maternal hemodynamics, and application of novel biomarkers to support individualized therapy. Accumulation of such evidence is expected to optimize the management of threatened preterm labor and ultimately improve outcomes for mothers and infants."

Journal • Review • Cardiovascular • CNS Disorders • Vascular Neurology

Use of Intravenous Clevidipine in the Management of Severe Preeclampsia: A Case Report. (PubMed, Cureus) - "First-line antihypertensives such as labetalol, hydralazine, and nifedipine are widely used; however, alternative agents may be considered in refractory cases. Additionally, its metabolism by blood and tissue esterases, independent of hepatic or renal function, makes clevidipine advantageous in preeclampsia, where hepatic and renal dysfunction are often part of the disease process. Its rapid titratability also allows prompt discontinuation following spinal anesthesia, preventing prolonged hypotension that may result from non-titratable agents."

Journal • Anesthesia • Critical care • Gynecology • Hypotension • Nephrology • Obstetrics • Renal Disease

Management of postpartum hypertension. (PubMed, Curr Opin Obstet Gynecol) - "Contrary to historical teaching, not all hypertensive disorders are cured by delivery. Hypertension requires close follow-up during the fourth trimester, and these patients may benefit from tighter BP control. Further research should be done to establish guideline-based treatment and monitoring throughout the lifetime."

Journal • Cardiovascular • Gynecology • Hypertension

Efficacy and Safety of Nifedipine as a Tocolytic Agent in Preterm Labor. (PubMed, J Pharm Bioallied Sci) - "Nifedipine effectively prolonged preterm labor in 84.78% of cases, with 94.93% delivering vaginally with minimal manageable side effects. Overall, nifedipine was a safe and effective tocolytic agent."

Journal • Cardiovascular • Hypotension • Pain

Conn Syndrome with Hyperthyroidism and Refractory Hypokalemia: A Case Report. (PubMed, Acta Med Indones) - "The patient had a history of hyperthyroidism for 10 years and routinely took anti-hypertension (Nifedipine), anti-thyroid, and potassium supplements...An anti-hypertension drug was then administered, particularly a mineralocorticoid antagonist receptor (Spironolactone)...Conn syndrome with hyperthyroidism can cause refractory hypokalemia, which transforms into a challenge in patient management. With early detection and management, the outcome of this case is manageable."

Journal • Cardiovascular • Endocrine Disorders • Hypertension

Using Physiologically Based Pharmacokinetic Modeling and Simulations to Predict Antihypertensive Drug Doses in Cirrhotic Patients. (PubMed, J Clin Pharmacol) - "The model predicted that the healthy doses of nifedipine 20 mg three times daily (TID), verapamil 80 mg TID, nebivolol 10 mg once daily, and diltiazem 60 mg TID should be adjusted to 44%, 41%, 49.8%, and 51% of these doses, respectively, in the mild cirrhosis population. Among the studied drugs, nifedipine was the most affected and diltiazem was the least affected by cirrhosis, highlighting variability in hepatic impact across antihypertensive drugs. In the absence of dedicated clinical trials in cirrhosis for these drugs, validated PBPK models offer evidence-based insights to support clinicians in evaluating antihypertensive dosing options."

Journal • PK/PD data • Cardiovascular • Fibrosis • Gastroenterology • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis

Comparison of Tocolytic Agents for Successful External Cephalic Version: A Bayesian Network Meta-Analysis of Sixteen Randomized Controlled Trials. (PubMed, Balkan Med J) - "Maternal adverse effects, including tachycardia, palpitations, hypotension, nausea, dizziness, and flushing, were more frequently reported with terbutaline, nifedipine, and nitroglycerin than with placebo. Terbutaline and ritodrine appear to offer superior efficacy in improving ECV success compared with alternative tocolytic agents, albeit with a higher incidence of maternal side effects. Consequently, clinical decision-making regarding tocolytic use should be informed by a comprehensive assessment of the associated benefits and potential risks."

Journal • Retrospective data • Cardiovascular • Hypotension