nifedipine immediate release / Generic mfg. - LARVOL DELTA

Non-Genomic Actions of Testosterone Metabolites on Uterine Contractility in Rats. (PubMed, Pharmaceutics) - "The actions of DHTs (10-4 M) and nifedipine (10-7 M) were also examined in contractions stimulated by KCl (40 mM) with a cumulative addition of CaCl2 (3-120 mM). Their single doses (30/100/300 mg/kg) elicited a flutamide-resistant uterine relaxing effect in vivo. DHTs or their analogs are candidates for further studies in the human uterus to establish their potential to treat conditions associated with uterine hyperactivity."

Journal • Preclinical

Simotang oral liquid alleviates functional dyspepsia-related motility dysfunction through Ca2+-dependent smooth muscle contraction and Nrf2/NF-κB modulation. (PubMed, J Food Drug Anal) - "In mice, SMT increased intestinal transit, acetylcholine-induced smooth muscle tension, Cav1.2 abundance, calmodulin fluorescence, and p-MLCK/p-MLC signaling, while nifedipine reduced the SMT-associated phosphorylation changes. Transcriptomic analyses showed enrichment of smooth muscle contraction, calcium signaling, oxidative stress response, and Nrf2-related antioxidant pathways, while protein analyses showed reduced canonical NF-κB activation markers. The data are consistent with Ca2+-dependent smooth muscle contraction as the central motor pathway associated with SMT- related functional improvement in FD, with Nrf2/NF-κB modulation as a microenvironmental regulatory component."

Journal • CNS Disorders • Dyspepsia • Gastrointestinal Disorder • Oncology • GAST • IL6 • MYLK • TNFA

Hypercontractile Esophagus in Immune Checkpoint Inhibitor-Induced Myasthenia Gravis-Myositis-Myocarditis Overlap Syndrome (ACG 2026) - "Case Description/ An 89-year-old man with metastatic renal cell carcinoma was treated with nivolumab and cabozantinib...He was treated with immunosuppression, including IVIG, plasma exchange, corticosteroids, rituximab, and infliximab, with improvement in swallowing...Nifedipine therapy was initiated...This case expands the spectrum of GI manifestations of ICI-related neuromuscular toxicity and highlights the importance of motility evaluation in patients with persistent dysphagia despite neurologic recovery. Figure: High-resolution esophageal manometry demonstrating a hypercontractile swallow with peak distal contractile integral (DCI) of 26,047 mmHg·s·cm, consistent with hypercontractile esophagus."

Checkpoint inhibition • Cardiovascular • CNS Disorders • Gastrointestinal Disorder • Genito-urinary Cancer • Immunology • Inflammation • Myasthenia Gravis • Myositis • Oncology • Pulmonary Disease • Rare Diseases • Renal Cell Carcinoma • Solid Tumor

Preeclampsia-Induced Pancreatitis Four Weeks Postpartum: A Case Report (ACG 2026) - "She was prescribed hydralazine for her gestational hypertension, but she did not take the medication...She was started on intravenous fluids, intravenous magnesium, and nifedipine...This case portrays a unique case of preeclampsia developing four weeks postpartum that induced acute pancreatitis. We believe that this case report will raise awareness of this topic, leading to more prompt diagnosis and timely treatment in future clinical cases."

Case report • Clinical • Cardiovascular • Gastroenterology • Genetic Disorders • Gynecology • Hypertension • Obesity • Pancreatitis • Renal Disease

Coexisting HELLP Syndrome and Acute Fatty Liver of Pregnancy: A Guatemalan Diagnostic Reasoning With the Swansea Criteria (ACG 2026) - "Preeclampsia with severe features was treated with nifedipine and magnesium sulfate, and she delivered vaginally...The case adds rare Latin American, adolescent, and resource-limited data to a literature dominated by high-income centers, and shows that prompt delivery with aggressive supportive care can achieve maternal survival without transplantation. Greater awareness of overlap, and of sepsis as a confounder, may reduce delays that drive high maternal mortality in low-resource regions."

Cardiovascular • Gynecology • Hematological Disorders • Hypertension • Hypoglycemia • Infectious Disease • Septic Shock

Rapid Effects of Finerenone on Pulmonary and Venous Hemodynamics in Rabbits after Its Intravenous Administration in Experiment. (PubMed, Bull Exp Biol Med) - "Concurrently, blood flow in the caudal vena cava increased to a greater extent than after nifedipine administration. The increased cranial and caudal vena cava flows after intravenous injection of finerenone were a result of vasodilatation of arterial vessels in the respective regions."

Journal • Preclinical

d-Xylose oxetane copolymers as bioderived and tuneable polyesters for amorphous solid dispersions. (PubMed, RSC Appl Polym) - "The ring-opening copolymerisation of cyclic anhydrides with an oxetane derived from natural monosaccharide d-xylose has been used to synthesise fully biobased water soluble polyesters, which are able to stabilise the amorphous phases of nifedipine and mefenamic acid, enhancing their apparent solubility in water up to 918 and 142% respectively. Finally, drug dissolution studies demonstrated the effectiveness of the polymers in improving the drugs' apparent solubility in water. These results showcase the potential of synthetic carbohydrate polymers as excipient for tailored drug formulations."

Journal

Oral antihypertensive agents in hypertensive pregnancies and adverse maternal and perinatal outcomes: study protocol for a target trial emulation using Dutch electronic health record data. (PubMed, BMJ Open) - "International guidelines vary in their treatment recommendations and preferences for methyldopa, labetalol and nifedipine. The Medical Research Ethics Committee of the University Medical Centre Utrecht (NedMec, 23-092/DB) confirmed that formal ethical approval was not required. Study findings will be disseminated through publication in peer-reviewed scientific journals."

Clinical protocol • Journal • Acute Kidney Injury • Cardiovascular • Critical care • Gynecology • Hematological Disorders • Hypertension • Hypoglycemia • Nephrology • Obstetrics • Renal Disease • Small for Gestational Age

Bioengineered Amphiphilic Chitosan Nanocarriers for Improved Oral Absorption of Poorly Soluble Antihypertensive Agents. (PubMed, Recent Adv Drug Deliv Formul) - "For BCS Class II and IV medications like telmisartan, amlodipine, nifedipine, and carvedilol, these restrictions are especially important and call for creative delivery methods. This review carefully scrutinizes the chemistry and self-assembly processes, formulation strategies, pharmacokinetic advantages, safety-related issues, and potential uses of amphiphilic chitosan-based nanocarriers. All things considered, these technologies represent an interesting emerging delivery approach that may improve the oral bioavailability and therapeutic efficacy of poorly soluble antihypertensive drugs."

Journal • Cardiovascular • Hypertension

Comparison of oral enalapril-hydrochlorothiazide and oral nifedipine in treating postpartum hypertension: An open label randomised controlled trial. (PubMed, Am J Obstet Gynecol MFM) - "Enalapril-hydrochlorothiazide provided greater blood pressure reduction and reduced the need for additional antihypertensive therapy compared with nifedipine in the management of postpartum hypertension."

Journal • Cardiovascular • Hypertension

Drugs for prevention of migraine. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • CNS Disorders • Migraine • Pain

Eucommia ulmoides Leaf Polyphenols Alleviate Hypertension and Modulate Gut Microbiota and Metabolic Profiles in Spontaneously Hypertensive Rats. (PubMed, Foods) - "In this study, male Wistar rats served as the normal control, while spontaneously hypertensive rats were randomized into model, positive control (nifedipine, 6.0 mg/kg/d), and low-, medium-, and high-dose groups receiving 1.25, 2.50, and 3.75 mL/kg/d of the polyphenol extract (n = 8/group) via intragastric gavage for 4 weeks...Integrated metabolomics analysis further demonstrated that it modulated multiple metabolic pathways, particularly arachidonic acid and tryptophan metabolism, which are closely linked to vascular homeostasis, inflammation, and oxidative stress. Collectively, these findings indicate that the antihypertensive effects of the polyphenol extract are potentially linked to the regulation of the gut microbiota-metabolite axis, highlighting its promising application as a functional food ingredient for cardiovascular health."

Journal • Preclinical • Cardiovascular • Dyslipidemia • Hypertension • Inflammation • Metabolic Disorders

Nifedipine-associated maternal oxygen desaturation in an IVF twin pregnancy complicated by preterm premature rupture of membranes: a case report. (PubMed, AJOG Glob Rep) - "This case, strengthened by two positive rechallenges occurring without concurrent magnesium sulfate, provides compelling temporal evidence for nifedipine-associated respiratory compromise in an IVF twin pregnancy with PPROM. The pattern of desaturation without radiographic alveolar pulmonary edema, elevated BNP, and resolution without diuresis suggests subclinical hemodynamic perturbation as the underlying mechanism. Clinicians should maintain heightened vigilance for unexplained oxygen desaturation during nifedipine tocolysis in this patient population."

Journal • Critical care • Respiratory Diseases

Systematic Review of Pharmacologic Treatment for Migraine Prevention in Adults: Report of the AAN Guidelines Subcommittee and the American Headache Society. (PubMed, Headache) - "This SR provides a comprehensive synthesis of evidence on pharmacologic migraine prevention in adults. High- and moderate-confidence findings confirm the efficacy of several established and newer preventive therapies and demonstrate improvements in patient-reported outcomes across multiple validated measures. These conclusions informed the development of evidence-based recommendations, presented in a companion publication, to guide clinicians in selecting preventive medications for adults with episodic and chronic migraine."

Journal • CNS Disorders • Migraine • Pain

Systematic Review of Pharmacologic Treatment for Migraine Prevention in Adults: Report of the AAN Guidelines Subcommittee and the American Headache Society. (PubMed, Neurology) - "This SR provides a comprehensive synthesis of evidence on pharmacologic migraine prevention in adults. High- and moderate-confidence findings confirm the efficacy of several established and newer preventive therapies and demonstrate improvements in patient-reported outcomes across multiple validated measures. These conclusions informed the development of evidence-based recommendations, presented in a companion publication, to guide clinicians in selecting preventive medications for adults with episodic and chronic migraine."

Journal • Review • CNS Disorders • Migraine • Pain

The role of integrated radiology in diagnosis and treatment of renal artery stenosis: a case report. (PubMed, Int J Surg Case Rep) - "A 16-year-old male presented with a 6-month history of dizziness and refractory hypertension, with peak readings above 190/100 mm Hg despite aggressive antihypertensive therapy (amlodipine, nifedipine, and spironolactone). Integrated imaging is essential for diagnosis, lesion characterization, and procedural planning in RAS patients. Endovascular revascularization is an effective treatment with early technical and clinical success."

Journal • Atherosclerosis • Cardiovascular • Hypertension • Renal Disease

Ufasomal Nanocarriers for Enhanced Cardiac Delivery of Nifedipine: A Novel Strategy to Mitigate Doxorubicin-Induced Cardiotoxicity in Breast Cancer Therapy. (PubMed, J Drug Target) - "Furthermore, the nasal NLU spray exhibited superior cardioprotective and antioxidant performance over the oral NFP. In conclusion, these findings establish the nasal NLU formulation as a promising therapeutic platform to mitigate doxorubicin-induced cardiotoxicity."

Journal • Breast Cancer • Cardiovascular • Oncology • Solid Tumor

Topical Sirolimus for Refractory Cutis Marmorata Telangiectatica Congenita in Adulthood: A Case Report. (PubMed, J Drugs Dermatol) - "Multiple therapies targeting vasospasm and microvascular flow (including sildenafil, pentoxifylline, diosmiplex, nifedipine, and aspirin) failed to improve symptoms. Initiation of once-daily topical sirolimus (1 mg/mL) resulted in marked pain reduction within four weeks and cessation of new ulcerations, with visible improvement and healed erosions by two months. This case supports topical sirolimus as a promising off-label option for adult CMTC with chronic ulcerative disease."

Journal • Cardiovascular • Gastroenterology • Immunology • Inflammatory Bowel Disease • Pain • Rheumatology • Ulcerative Colitis • Vasculitis

Revolutionizing physiology: advances in organ-on-a-chip technology (PubMed, Nihon Yakurigaku Zasshi) - "The system demonstrated superior physiological reproducibility compared to conventional methods in evaluating drug responses (e.g., nifedipine) and detecting fatal side effects like QT prolongation. In addition to the heart, applications are advancing across diverse organ and disease models, including the construction of ischemia-reperfusion injury models using kidney chips and pulmonary fibrosis models using lung chips, the evaluation of barrier functions via blood-brain barrier (BBB) chips, and the analysis of interactions between cancer cells and immune cells using cancer chips. It is concluded that these technologies enable high-precision in vitro reproduction of human physiology and pathology, thereby improving the efficiency of drug screening, reducing economic losses, and accelerating the paradigm shift toward the 3Rs (Replacement, Reduction, and Refinement) in animal experimentation."

Journal • Review • Cardiovascular • Immunology • Oncology • Pulmonary Disease • Reperfusion Injury • Respiratory Diseases

Computational modeling of timothy syndrome using a human induced pluripotent stem cell-derived ventricular cardiomyocyte model with improved Ca²⁺current dynamics (ESC 2026) - "Validation included: (a) simulation of dose-dependent ICaL blockade with nifedipine; (b) induction of Ca²⁺ overload to assess delayed afterdepolarizations (DADs); (c) implementation of the p.G406R CACNA1C mutation to reproduce the TS phenotype without additional parameter fitting...Conclusions This novel Markovian hiPSC-CM model provides an improved mechanistic representation of ICaL and Ca²⁺ handling, enabling accurate simulation of pharmacological modulation, Ca²⁺-dependent arrhythmogenesis, and Timothy Syndrome. This robust framework allows mechanistic investigation of Ca²⁺-related arrhythmias and represents a potent platform for translational and personalized medicine applications."

Cardiovascular

Comparison of Oral and Intravenous Nitroglycerin in the Treatment of Acute Postpartum Hypertension After Cesarean Delivery for Preeclampsia. (PubMed, Niger J Clin Pract) - "Oral-only therapy provides 24-hour blood pressure control and short-term outcomes comparable with resource-intensive IV nitroglycerin regimens. In stable postpartum patients, oral therapy can be used as first-line management."

Clinical • Journal • Retrospective data • Cardiovascular • Gynecology • Hypertension

Melatonin exerts dual, concentration-dependent effects on intestinal pacemaker networks via MT2 receptor activation and redox pathways. (PubMed, Br J Pharmacol) - "Melatonin modulates ICC networks in a concentration-dependent manner: stimulation via MT2 signalling at functionally relevant levels and inhibition via antioxidant pathways at supraphysiological levels. These findings indicate that ICC networks contribute to melatonin responses and reveal distinct receptor-dependent and redox-dependent mechanisms regulating gastrointestinal pacemaker networks."

Journal

Postpartum Thrombotic Thrombocytopenic Purpura With Coexisting Preeclampsia With Severe Features (ASA 2026) - "Initial treatment included labetalol, nifedipine, and magnesium. She was treated with plasma exchange, high-dose corticosteroids, rituximab, and caplacizumab with platelet recovery after 7 days. This case highlights TTP as a critical diagnostic consideration in postpartum patients with apparent preeclampsia."

Gynecology • Hematological Disorders • Hypertension • Thrombocytopenia • Thrombocytopenic Purpura • HP

POPS or POP02: Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS) (clinicaltrials.gov) - P=N/A | N=5000 | Recruiting | Sponsor: Duke University | Trial completion date: Jul 2027 ➔ Dec 2026 | Trial primary completion date: Mar 2027 ➔ Nov 2026

Trial completion date • Trial primary completion date • ADHD (Impulsive Aggression) • Asthma • Attention Deficit Hyperactivity Disorder • Bronchopulmonary Dysplasia • Cardiovascular • CNS Disorders • Dermatology • Developmental Disorders • Endocrine Disorders • Genetic Disorders • Gynecology • Heart Failure • Hematological Disorders • Hemophilia • Hypertension • Immunology • Infectious Disease • Insomnia • Metabolic Disorders • Nephrology • Novel Coronavirus Disease • Pain • Pneumonia • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Rare Diseases • Renal Disease • Respiratory Diseases • Sleep Disorder

A novel CACNA1S variant associated with diltiazem-related worsening of hypokalemic periodic paralysis: a case report. (PubMed, Neurol Sci) - "The p.(Met1366Arg) variant is located in the S6 segment of CaV1.1, outside the canonical S4 arginine residues implicated in most cases of CACNA1S-related HypoPP; nevertheless, strong intrafamilial segregation evidence supports its pathogenicity. Furthermore, its proximity to the diltiazem-binding site raises the possibility of altered drug-channel interactions. The observed diltiazem-associated worsening of HypoPP may be variant-specific rather than a class effect of LTCCBs. Nevertheless, careful monitoring may be warranted when prescribing these agents to patients with HypoPP."

Journal • Cardiovascular • CACNA1S • CAV1