nifedipine immediate release / Generic mfg. - LARVOL DELTA

Danggui Buxue Decoction and Its Active Constituents Inhibit Drug-Induced Uterine Contractions via L-Type Calcium Channels and the IP3/Ca2+ Pathway. (PubMed, Pharmaceuticals (Basel)) - "Ca2+-dependent experiments, intracellular calcium release assays, and inhibitor treatments (Nifedipine, 2-APB) were performed to evaluate the involvement of L-type calcium channels and the IP3R pathway... DBD and its active component Quercetin promote uterine relaxation by lowering Ca2+ levels, which is achieved through suppression of L-type calcium channels and the IP3/Ca2+ pathway. This contributes to their therapeutic action against primary dysmenorrhea."

Journal • Gynecology • Inflammation • Pain • Women's Health

A CASE OF HYPERTENSIVE EMERGENCY AND FOCAL SEGMENTAL GLOMERULOSCLEROSIS ASSOCIATED WITH LOW BIRTH WEIGHT (ISN-WCN 2026) - "Intravenous nicardipine was administered, followed by oral nifedipine, amlodipine, and methyldopa...Indicators of renal function, neurological function, and endothelial damage were improved after successful management of blood pressure. The patient was discharged to a rehabilitation facility on day 49 in stable condition.Download: Download high-res image (825KB)Download: Download full-size imageDownload: Download high-res image (679KB)Download: Download full-size imageConclusion Our case reinforces LBW as a critical risk factor of hypertension and kidney disease."

Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Hematological Disorders • Hypertension • Ophthalmology • HP

A WOMAN 38-YEAR-OLD LUPUS NEPHRITIS WITH RO-60 AND SCL-70 POSITIVE DURING PREGNANCY (ISN-WCN 2026) - "The patient received therapy with aspirin 80 mg once a day, folic acid 400 mcg twice a day, ferrous sulfate twice a day, calc once a day, nifedipine 10 mg 3 times a day, azathioprine 50 mg twice a day, hydroxychloroquine 200 mg once a day, methylprednisolone 16 mg twice a day.Results Pregnant women with LN are at increased risk for complications like pre-eclampsia, intrauterine growth restriction, stillbirth, and preterm delivery. During pregnancy, LN patients are managed by a multidisciplinary team (rheumatology, gynecology, obstetrics, and neonatology). Routine assessment involving close clinical and laboratory monitoring every 4-6 weeks to detect early signs of disease activity."

Clinical • Amyloidosis • ANCA Vasculitis • Cardiovascular • Glomerulonephritis • Gynecology • Hypertension • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Monoclonal Gammopathy • Nephrology • Obstetrics • Vasculitis

Identification of cellular ion channels that facilitate Hazara nairovirus infection enables selection of clinically approved compounds with anti-nairoviral properties. (PubMed, Sci Rep) - "Consistent with this, we showed that clinically-approved K+ channel blockers quinidine, quinine and dronedarone and clinically-approved Ca2+ channel blockers tetrandrine and nifedipine significantly reduced HAZV activities. Biochemical experiments showed K+ expanded the pH range that promoted entry, potentially allowing endosome escape deeper within the endolysosomal network. These results show clinically-approved channel blockers effectively inhibit HAZV replication, suggesting repurposing existing therapies may represent promising avenues to block nairovirus infection."

Journal • Infectious Disease

Guar gum-pullulan films produced by semisolid extrusion 3D printing for sublingual nifedipine administration. (PubMed, Int J Pharm) - "Despite this controlled release, the polymeric vehicle did not obstruct/hinder the passage of nifedipine through the sublingual mucosa, indicating that the drug can reach the bloodstream. These findings indicate that films designed for sublingual administration could serve as a promising new method for delivering nifedipine."

Journal • Cardiovascular • Hematological Disorders • Hypertension

Brain penetrant calcium channel blockers do not reduce alcohol consumption: Converging results from two large independent cohort studies using electronic health records. (PubMed, medRxiv) - "New users of BP-LTCCBs (nifedipine or felodipine) were compared with new users of a non-BP-LTCCB (amlodipine) and with unexposed patients sampled from the same clinics, following a 180-day washout and requiring at least 60 days' supply...In two large, preregistered EHR-based cohorts with rigorous confounding control, BP-LTCCBs were not associated with reduced drinking relative to comparators. Despite compelling genetic and preclinical evidence, these results do not support repurposing BP-LTCCBs for AUD, highlighting the need to prioritize alternative pharmacologic targets, potentially within etiologically informed subgroups."

Journal • Addiction (Opioid and Alcohol)

REFRACTORY DIGITAL ULCERS AND CHRONIC OSTEOMYELITIS COMPLICATING DIFFUSE SYSTEMIC SCLEROSIS: A REAL-LIFE CASE (SSWC 2026) - "Digital ulcers were refractory to nifedipine 60 mg/day, prompting escalation to alprostadil in 2013 and iloprost in 2016, both initially effective...Sildenafil (up to 150 mg/day, 2024–2025) proved ineffective. Bosentan, initiated in January 2025, was discontinued after re-hospitalization in August 2025 for multiple ulcers and chronic osteomyelitis of the right fifth digit...Osteomyelitis developed in the right second digit in 2019, requiring multiple antibiotic courses (flucloxacillin, amoxicillin–clavula- nate, clindamycin, trimethoprim–sulfamethoxazole) following Staphylococcus aureus isolation, with relapse in 2020 managed with ciprofloxacin...Mycophenolate mofetil (2017–2019) was used for progressive skin fibrosis and NSIP but discontinued due to recurrent osteomyeli- tis. Nintedanib (2021–2024) was initiated for progressive pulmonary fibrosis but withdrawn due to severe diarrhea and weight loss... This case illustrates the complex therapeutic challenges in SSc..."

Clinical • Cardiovascular • Fibrosis • Hepatology • Hypotension • Immunology • Infectious Disease • Inflammation • Interstitial Lung Disease • Musculoskeletal Diseases • Orthopedics • Pneumonia • Primary Biliary Cholangitis • Pulmonary Disease • Respiratory Diseases • Scleroderma • Systemic Sclerosis • Venous Ulcer

DELAYED SEROCONVERSION AND PULMONARY INVOLVEMENT IN SLE-SYSTEMIC SCLEROSIS OVERLAP SYNDROME: A CASE REPORT (SSWC 2026) - "The patient was diagnosed with SLE and started on hydroxychloroquine 400 mg/day, pentoxifylline 400 mg three times daily, and nifedipine 30 mg/day, achieving partial symptomatic improvement...Immunosuppressive therapy was initiated with mycophenolate mofetil, titrated to 1000 mg twice daily, alongside with nintedanib 100 mg twice daily, maintaining clinical stability... This case illustrates the diagnostic challenges of overlap syndromes. The delayed seropositivity of anti-Scl70 antibo- dies emphasizes that serology alone may underestimate disease evolution. Anti-Scl70 positivity is known to correlate with a higher risk of interstitial lung disease in SSc, consistent with this patient's pulmonary involvement."

Case report • Clinical • Cardiovascular • Fibrosis • Immunology • Infectious Disease • Inflammatory Arthritis • Interstitial Lung Disease • Lupus • Musculoskeletal Pain • Pneumonia • Pulmonary Disease • Respiratory Diseases • Scleroderma • Systemic Lupus Erythematosus • Systemic Sclerosis • CRP

Nicardipine Versus Nifedipine for Postpartum Hypertensive Emergencies in Severe Preeclampsia. (PubMed, J Vis Exp) - "Statistical analyses will use SPSS 32.0, with appropriate tests for between-group comparisons and covariance analysis to adjust for confounding. This protocol is intended to provide a standardized workflow for comparing the two agents in real-world clinical settings, to inform individualized PHE management-particularly regarding drug selection based on clinical context (e.g., venous access availability, monitoring resources)-and to support evidence-based decision-making for postpartum hypertensive crisis care."

Journal • Observational data • Retrospective data • Gynecology • NPPB

Comparative Effectiveness of Lidocaine- Versus Nifedipine-Based Multimodal Conservative Regimens for Acute Hemorrhoidal Disease: A Multicenter Cohort Study. (PubMed, J Clin Gastroenterol) - "In this multicentre retrospective cohort study, structured multimodal conservative therapy, particularly the lidocaine-based regimen, was associated with faster symptom relief, improved patient-reported quality of life, and a reduced need for urgent procedures compared with standard conservative care for AHD. These findings suggest the need for further prospective evaluation of lidocaine-centred multimodal protocols in the conservative management of AHD."

HEOR • Journal • Gastroenterology • Gastrointestinal Disorder • Pain

EARLY-ONSET, ASYMPTOMATIC NIFEDIPINE HEPATOTOXICITY: EXPANDING THE SPECTRUM OF CALCIUM CHANNEL BLOCKER LIVER INJURY (ACC 2026) - "He was started on intravenous nicardipine, later transitioned to oral nifedipine 90 mg daily plus losartan...Nifedipine was discontinued, replaced with hydrochlorothiazide, and liver enzymes normalized within 90 days... This case demonstrates that nifedipine can cause early, asymptomatic hepatocellular injury even in young, otherwise healthy individuals. Clinicians should maintain vigilance for unexplained transaminase elevations soon after initiation, and promptly discontinue the drug to prevent progression."

Hepatology • Immunology • Liver Failure

NIFEDIPINE VERSUS LABETALOL FOR HYPERTENSION IN PREGNANCY: A META-ANALYSIS IN 2,570 PATIENTS (ACC 2026) - "Nifedipine appeared more effective in hypertensive crises and, in matched analyses, was associated with lower risks of preeclampsia and preterm birth. While these findings highlight potential advantages of nifedipine, both drugs remain acceptable options, and further high-quality trials are needed to confirm differential benefits."

Retrospective data • Cardiovascular • Gynecology • Hypertension

SPONTANEOUS CORONARY ARTERY DISSECTION IN LATE POST-PARTUM PERIOD (ACC 2026) - "She received aspirin, heparin, and nifedipine for afterload reduction. This patient's presentation underscores that SCAD may occur beyond the early postpartum period, especially in women with hypertensive and vascular risk factors. Clinical vigilance, tailored conservative therapy, and ongoing monitoring remain essential to optimize patient outcomes in complex SCAD cases."

Acute Coronary Syndrome • Coronary Artery Disease • Genetic Disorders • Gynecology • Hypertension • Obesity

A RARE CASE OF CLUSTERED RECURRENCE OF SPONTANEOUS CORONARY ARTERY DISSECTION (ACC 2026) - "The patient was medically managed with DAPT, nifedipine, and labetalol. This case highlights the therapeutic challenges of SCAD, marked by rapid recurrence and the need for clinical awareness, as it often occurs without conventional cardiovascular risk factors."

Clinical • Coronary Artery Disease • Gynecology • Hypertension • Myocardial Infarction

A COMPARATIVE ANALYSIS OF NIFEDIPINE AND LABETALOL IN HYPERTENSIVE DISORDERS OF PREGNANCY: COMPARING OUTCOMES WITH 10 YEARS OF DATA FROM THE UNITED STATES (ACC 2026) - "In this real-world retrospective cohort of patients treated for HDP, nifedipine was linked to significantly lower three-year rates of postpartum HF, chronic hypertension, hypertensive heart disease, and cardiomyopathy compared with labetalol. These findings suggest clinically meaningful, differential long-term effects among agents commonly used in pregnancy. Given the elevated lifetime cardiovascular risk after HDP, prospective studies—including randomized trials—are needed to confirm these associations and guide antihypertensive selection with a focus on lifelong cardiovascular health."

Cardiomyopathy • Congestive Heart Failure • Heart Failure • Hypertension • Obstetrics

IDENTIFYING A NOVEL SIGNALING MECHANISM FOR ENDOTHELIN-1-INDUCED CONSTRICTION OF CORONARY ARTERIOLES GUIDES DRUG DEVELOPMENT FOR THE CLASSIFICATION AND THERAPY OF CORONARY MICROVASCULAR DYSFUNCTION (ACC 2026) - P2, P3 | "L-type calcium channel blocker nifedipine (1 μM) prevented and reversed vasoconstriction to PDBu but not to ET-1. A clinical level of ET-1 caused profound and long-lasting narrowing of porcine coronary arterioles and was reversed by blockade of ROCK but not PKC, ETA receptors, or L-type calcium channels. Thus, the current data may explain why zibotentan or diltiazem failed to show clinical benefit for CMD. A new druggable target, i.e., ROCK, might be a solution for managing CMD."

Cardiovascular • Myocardial Ischemia • EDN1

Prevent from Home: Young person and buddies’ cardiovascuLar heaLth Improvement feasibility Study (PHYLLIS) (UKKW 2026) - "PHYLLIS will be delivered in two phases: Part A where 108 individuals, with pregnancies complicated by HdP, following informed consent will be randomised (1:1) immediately postpartum to receive enalapril or nifedipine for 16 weeks with transthoracic echocardiogram (TTE) and retinal imaging performed at baseline and final visit and Part B for 162 individuals, who have completed breastfeeding, provided informed consent and had pregnancies complicated by HdP and/or GDM who will be randomised (1:1:1) to tirzepatide, dapagliflozin or standard care for 26 weeks with a further 26 weeks of follow-up, with TTE and retinal exam performed at baseline, 26 weeks and final visit...(Ref:24/LO/0902). Preliminary results will be presented, including feasibility of a randomised study of SGLT2i and GLP-1/GIP agonists in postpartum individuals with risk factors for CVD."

Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Diabetic Retinopathy • Gestational Diabetes • Hypertension • Metabolic Disorders • Nephrology • Renal Disease • Retinal Disorders • Type 2 Diabetes Mellitus

EARLY MYOCARDIAL INVOLVEMENT IN PATIENTS WITH SYSTEMIC SCLEROSIS (SSWC 2026) - "Material and Case 1: A 29-year-old woman with overlap syndrome of SSc and polymyositis (diagnosed in 2019, with positive anti-SCL70 and anti-PM/SCL100 antibodies) presented with diffuse cutaneous, articular, vascular, gastrointestinal, and muscular involvement, treated with nifedipine 30mg per day and methotrexate 20mg per week...Myocardial involvement secondary to SSc was assumed, and she was treated with intravenous cyclophosphamide (cumulative 6 g), followed by mycophenolate mofetil (2 g/day), leading to initial clinical and laboratory improvement... Myocardial involvement in SSc may occur early and requires a high index of suspicion. Prompt recognition and aggres- sive immunosuppressive treatment can favorably alter disease trajectory. Nonetheless, cardiac disease in SSc remains associated with poor outcomes, underscoring the need for close monitoring and multidisciplinary management."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Immunology • Inflammation • Myositis • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Scleroderma • Systemic Sclerosis

When Therapy Turns Toxic: Thrombotic Microangiopathy Following Bevacizumab Administration (NKF-SCM 2026) - "METHODS/CASE SUMMARY A 69-year-old female with recurrent, platinum-sensitive ovarian cancer—treated with carboplatin/paclitaxel, cytoreductive surgery, and carboplatin/doxorubicin—was started on bevacizumab maintenance...Her blood pressure was controlled with nifedipine, so maintenance bevacizumab was started...When biopsy is high-risk, early consideration of complement inhibition with eculizumab may lead to hematologic and renal stabilization. Further study is needed to define optimal management strategies for VEGF inhibitor-associated TMA."

Acute Kidney Injury • Cognitive Disorders • Hypertension • Nephrology • Ovarian Cancer • Renal Disease • Solid Tumor • Thrombocytopenia • HP

Rational development of a drug-delivery device based on MOF UiO-66 for calcium-channel-blocker drugs. (PubMed, Dalton Trans) - "The administration of drugs with low solubility or absorption, such as the calcium-channel-blocker (CCB) drugs amlodipine, nifedipine, and nimodipine, affects the management of complicated health conditions related to cardiovascular diseases. Finally, the effect on the biological activity of the drugs was evaluated using human microvascular endothelial cells, demonstrating that the material can improve the bioavailability of each drug, allowing a 90% reduction in the doses needed to attain a physiological effect. These results support the potential of UiO-66 as a central component in the development of a versatile drug-delivery system aimed at improving the treatment of patients with cardiovascular diseases."

Journal • Cardiovascular

New Eruption of Bullous Pemphigoid Within Disseminated Superficial Porokeratosis Lesions: A Rare Case Report. (PubMed, Australas J Dermatol) - "Dermoscopic examination unveiled unique features, including the 'double-track sign', dilated capillaries and a central yellowish translucent area with haemorrhagic crusts, underscoring the diagnostic utility of dermoscopy in elucidating this rare co-presentation. This case highlights the diagnostic challenges and therapeutic considerations in managing concurrent DSP and BP, shedding light on potential exacerbating factors and treatment outcomes deserving further exploration in dermatological research."

Journal • Bullous Pemphigoid • Dermatology • Dermatopathology • Immunology

ANTIHYPERTENSIVE TREATMENT PATTERNS BEFORE AND DURING PREGNANCY AMONG WOMEN WITH CHRONIC HYPERTENSION: A REAL-WORLD EHR STUDY (ISPOR 2026) - "Antihypertensive medication use was assessed and compared using Pearson's Chi-square test during four periods: pre-conception, as well as the first, second, and third trimesters. Among 556 pregnant women with chronic hypertension, antihypertensive treatment before conception was dominated by calcium channel blockers and beta-blockers, with amlodipine (30.7%), nifedipine (24.4%), and labetalol (20.3%) being the most prescribed medications, while renin-angiotensin system inhibitors were still frequently prescribed (losartan: 2.8%). In this real-world cohort, a shift toward more guideline-recommended drugs in pregnancy (labetalol and nifedipine) happened between pre-conception and pregnancy. However, the use of other non-first-line drugs, such as amlodipine, and a low prevalence of the recommended drug methyldopa was observed."

Clinical • Real-world • Real-world evidence • Cardiovascular • Hypertension

Tizanidine withdrawal presenting as hypertensive emergency with recurrent acute kidney injury (NKF-SCM 2026) - "On day 3, she developed hypotension and lethargy requiring vasopressors, attributed to sedative and antihypertensive polypharmacy (tizanidine, clonidine, labetalol, gabapentin, methocarbamol)...A structured tizanidine taper was initiated with concurrent titration of nifedipine and metoprolol...In patients with refractory or labile hypertension and chronic tizanidine use, withdrawal should be included in the differential. Gradual tapering and careful medication reconciliation are essential to prevent recurrent adrenergic crises and end-organ injury"

Acute Kidney Injury • Back Pain • Cardiovascular • Hematological Disorders • Hypertension • Hypotension • Movement Disorders • Musculoskeletal Pain • Nephrology • Pulmonary Embolism • Renal Disease • Respiratory Diseases

To Deliver or Not to Deliver: Using the sFlt-1/PIGF ratio to Distinguish Preeclampsia from a Lupus Nephritis Flare (NKF-SCM 2026) - "Blood pressures remained persistently elevated despite nifedipine 90 mg daily, prompting the addition of labetalol 200 mg every 8 hours. In our clinical case, stable lupus disease markers argued against progressive lupus nephritis. In the absence of a kidney biopsy, the sFlt-1/PlGF assay provided valuable diagnostic support, guiding the decision to proceed with delivery in the context of preeclampsia."

Cardiovascular • Glomerulonephritis • Gynecology • Hypertension • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • FLT1

SEVERE CARDIAC INVOLVEMENT IN SYSTEMIC SCLEROSIS: TWO CASES OF SCLERODERMA CARDIAC CRISIS (SSWC 2026) - "Cardiac Magnetic resonance (CMR) showed myocardial fibrosis but despite immunosuppression (intravenous methylprednisolone and rituximab) and cardioprotective treatment she developed acute cardiogenic shock, necessitated ICU admission and vasopressor support but she did not respond and died. The second patient – aged 61- had a diagnosis of diffuse SSc for 16 months and was on treatment with low dose prednisolone, mycophenolate, tocilizumab and nifedipine with partial control of her disease... Scleroderma cardiac crisis is a devastating and often fatal complication of SSc. Early recognition, cardiac monitoring, and prompt initiation of immunosuppressive, cardio-protective and supportive therapy are essential, however no specific treatment has been proved to be effective in these patients."

Clinical • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Hypotension • Immunology • Inflammation • Pulmonary Disease • Scleroderma • Systemic Sclerosis