fluvoxamine / Generic mfg. - LARVOL DELTA

Atypical onset of obsessive-compulsive disorder at age 50 following post-SARS-COV-2 syndrome: A case report. (PubMed, PCN Rep) - "The partial response to fluvoxamine and the need for risperidone suggest that SARS-COV-2-related OCD may involve complex neuroimmune changes beyond serotonin dysregulation. This case emphasizes the importance of recognizing neuropsychiatric complications in SARS-COV-2 survivors and underscores the need for further research into the mechanisms and management of SARS-COV-2-related neuropsychiatric symptoms, including OCD."

Journal • Infectious Disease • Inflammation • Mood Disorders • Novel Coronavirus Disease • Obsessive-Compulsive Disorder • Psychiatry • Respiratory Diseases

High-Frequency, At-Home Monitoring of Drug Safety and Tolerability in Clinical Trials: Results From Studies of Fluvoxamine for COVID-19 Treatment. (PubMed, Clin Transl Sci) - "With respect to tolerability, nausea was most frequent in the first 4-5 days, declining significantly thereafter, while anxiety and difficulty concentrating were uncommon with fluvoxamine compared to placebo. These findings show that remote assessment of safety and tolerability is feasible in clinical trials, and that frequent assessments can provide in-depth data on the timecourse of safety or tolerability signals."

Clinical • Journal • Infectious Disease • Mood Disorders • Novel Coronavirus Disease • Psychiatry

Environmental risk assessment of selective serotonin reuptake inhibitors (SSRIs) after COVID-19 pandemic: a systematic review. (PubMed, Chemosphere) - "One of the most commonly prescribed classes of antidepressants is selective serotonin reuptake inhibitors (SSRIs), such as citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. Given the elevated risks, it is crucial to implement preventive measures to limit the environmental concentrations of SSRIs. These should include upgrades to wastewater treatment technologies and the introduction of systematic micropollutant monitoring programs."

Journal • Review • CNS Disorders • Depression • Infectious Disease • Novel Coronavirus Disease • Psychiatry

Positive Protective Effects of Sigma-1 Receptor Stimulation with Fluvoxamine after Myocardial Ischemia and Reperfusion in Rats. (PubMed, Mol Imaging Biol) - "Sig-1R stimulation by fluvoxamine suppresses LV remodelling and enhances LVEF recovery post-ischemia, suggesting its potential as a novel cardioprotective strategy."

Journal • Preclinical • Cardiovascular • Fibrosis • Immunology • Myocardial Ischemia

Assessing neurological and cardiovascular effects caused by pharmaceuticals in river water: Insights from Daphnia magna and Danio rerio embryos. (PubMed, Chemosphere) - "Neuroactive drugs such as topiramate, rasagiline, citalopram, and fluvoxamine showed strong correlations with altered neurotransmitter levels in zebrafish, consistent with their known mechanisms. These findings support the utility of D. magna and zebrafish (D. rerio) embryos as sensitive and complementary biosentinels for monitoring pharmaceutical pollution and highlight zebrafish as a relevant model for studying environmentally driven neurotoxicity with potential human health implications."

Journal • Cardiovascular • CNS Disorders • Metabolic Disorders

SEVERE BRADYCARDIA AND HEMODYNAMIC INSTABILITY DUE TO FLUVOXAMINE-TIZANIDINE INTERACTION: A CASE OF RECURRENT SYNCOPE (CHEST 2025) - No abstract available

Clinical • Cardiovascular

Time-to-Onset Analysis of Rhabdomyolysis Associated With Selective Serotonin and Serotonin-Noradrenaline Reuptake Inhibitors Using the Japanese Pharmacovigilance Database. (PubMed, In Vivo) - "RM should be monitored in patients treated with SSRIs/SNRIs, particularly in the first few months of administration, and our results may be helpful for the safety management of such patients."

Adverse events • Journal

Fluvoxamine Attenuates Liver Injury in Lipopolysaccharide-Induced Sepsis: Via Nrf2/HO-1 Pathway. (PubMed, Fundam Clin Pharmacol) - "The decrease in serum aspartate aminotransferase (AST) and ALT was found to be significant only in the FLV group. Our findings therefore provide new evidence that FLV reduces LPS-induced liver injury."

Journal • Anesthesia • Hepatology • Infectious Disease • Inflammation • Liver Failure • Septic Shock • HMOX1 • KEAP1 • NFE2L2 • SPP1 • TNFA

Effect of Exercise on Tapering Antipsychotics in Patients With Psycho-cardiological Disease(EXTRA-study) (clinicaltrials.gov) - P=N/A | N=106 | Recruiting | Sponsor: Guangdong Provincial People's Hospital

New trial • Cardiovascular • CNS Disorders • Congestive Heart Failure • Depression • Mood Disorders • Psychiatry

When Standard Is Not Enough: A Narrative Review of Supratherapeutic SSRI Doses in Resistant Obsessive Compulsive Disorder. (PubMed, J Clin Med) - "Studies were included if they reported on the use of high-dose SSRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline) in patients with OCD and provided efficacy and/or tolerability data. However, careful patient selection, regular monitoring, and further controlled studies are necessary to better define its long-term safety and effectiveness. In this context, increasingly advanced technologies-such as therapeutic drug monitoring and pharmacogenetic testing for relevant polymorphisms-may support more individualized and safer treatment strategies."

Journal • Review • CNS Disorders • Mental Retardation • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry

Dissecting the pro-neurogenic effects of monoaminergic medications used to treat depression: a systematic review and meta-analysis. (PubMed, J Psychopharmacol) - "The available number of studies was also insufficient to yield definitive evidence for compounds acting as selective serotonin reuptake inhibitors (citalopram, escitalopram, fluvoxamine), serotonin-norepinephrine reuptake inhibitors (desvenlafaxine, duloxetine, venlafaxine), multimodal monoaminergic modulators (imipramine, desipramine), melatonergic compound (agomelatine), or norepinephrine-serotonin disinhibitory (mirtazapine). Subsequent updates of these reviews appear necessary to establish robust evidence regarding these compounds. Evidence was firm in favor of a robust pro-neurogenic effect of selective serotonin reuptake inhibitor fluoxetine, in both species, making updates of this review probably redundant."

Journal • Retrospective data • Review • CNS Disorders • Depression • Mood Disorders • Psychiatry

Prescription pattern and medical expenses in executive psychiatric clinic - RSUD Dr. Chasbullah Abdulmadjid (Type B government hospital) Bekasi City Indonesia - period March – November 2024 (CINP-AsCNP 2025) - "The most commonly prescribed medications were antidepressants (Vortioxetine, Escitalopram, Fluvoxamine, Mirtazapine, Duloxetine), antipsychotics (Brexpiprazole, Cariprazine, Aripiprazole, Quetiapine IR, Sulpiride) and non-benzodiazepines (Lemborexant). The coverage expenses for Psychiatric Clinic Type B Hospital with Indonesian national health insurance using Indonesia Case Base Groups (INA-CBGs) per month is 196.100 IDR / 12 USD / 20 AUD for consultation and medications (7 days to hospital) and the rest 23 days is fee for service. In comparison, the expenses at Executive Psychiatric Clinic Type B Government Hospital Bekasi City Indonesia are five times higher than national health insurance could cover to the hospital. And indeed each payment system has its own advantages and disadvantages."

Clinical • CNS Disorders • Depression • Insomnia • Mood Disorders • Psychiatry • Schizophrenia • Sleep Disorder

The current state of PGx (gene-drug pairs) implementation in youth mental health. (CINP-AsCNP 2025) - "Sertraline (18%), fluvoxamine (9%), risperidone (8%), aripiprazole (7%), and atomoxetine (6%) were the most frequently prescribed psychotropic medications with a PGx-based dosing guideline...Our findings to date have: (1) demonstrated that delivery of PGx testing improves symptoms, reduces adverse drug effects, and decreased healthcare utilization; (2) identified novel associations between CYP2D6 genetic variation and the efficacy of fluoxetine and amphetamine treatment; and (3) estimated, for the first time, a high prevalence (46%) of phenoconversion in youth receiving pharmacotherapy for mental health conditions. Our findings suggest prescribing of psychotropic medications with available PGx-based guidelines is common among youth and approximately one in every 10 youth are taking psychotropic medications that are incongruent with their PGx profile. These results are facilitating the integration of Canada's first evidence-based genetic testing service to improve..."

Pediatrics • Psychiatry

Validation of a large volume-solid phase extraction methodology for biotoxicity assessment of pharmaceuticals in aquatic organisms. (PubMed, Environ Pollut) - "This method proved effective extraction and preconcentration of significant amounts of water, with recoveries between 19% and 109% in spiked wastewaters (except for fluvoxamine, remdesivir, tamoxifen and tetracycline, with recoveries <10%). Bioassays conducted with Daphnia magna juveniles and Danio rerio embryos validated the method's applicability regarding optimized exposure conditions, the absence of adverse effects from SPE blanks or solvent controls and sensitivity in detecting effects across field samples. Overall, the LV-SPE approach enhances sensitivity and reliability for evaluating pharmaceutical mixtures' risks under realistic conditions."

Journal

Risk of Thrombocytopenia by SSRIs or SNRIs in Patients With Depression Based on MID-NET: A Cohort Study in Japan. (PubMed, Clin Transl Sci) - "The exposure group was categorized as each drug of SSRIs/SNRIs, SSRIs group (escitalopram, sertraline, fluvoxamine), SNRIs group (duloxetine, venlafaxine, milnacipran), or vortioxetine. The results suggest that the risk of thrombocytopenia by sertraline or fluvoxamine was comparable to that by paroxetine, known as having the risk of thrombocytopenia, leading to the revision of the sertraline package insert as a regulatory safety measure. Prescribers and clinicians may need to be vigilant to the possibility of sertraline-induced thrombocytopenia in clinical practice."

Clinical • Journal • Observational data • CNS Disorders • Depression • Hematological Disorders • Mood Disorders • Psychiatry • Thrombocytopenia

A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11. (PubMed, Biochem J) - "The studies with Fluvoxamine and Epalrestat, specific inhibitors of CYP1A2 and CYP4A11, respectively, showed that despite the activity of recombinant CYP1A2 with MONACRA, it does not take part in its metabolism in HLM. We developed a robust and sensitive automated fluorimetric assay of MONACRA demethylation and used it to compare the substrate saturation profiles (SSP) in seven pooled HLM preparations with the known composition of the P450 pool. These studies demonstrated a close correlation between the of the main kinetic phase of MONACRA metabolism and the fractional content of CYP4A11 in the P450 pool."

Journal

Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders. (PubMed, Pharmaceuticals (Basel)) - "Interestingly, several medications, including fluvoxamine (an antidepressant), dextromethorphan (a cough suppressant), and amantadine (an antiviral), which were initially developed for unrelated indications, have shown encouraging results in neurodegenerative therapy through S1R activation. Furthermore, as a synergistic benefit, combining S1R-targeting drugs with other therapeutic agents may also improve treatment efficacy. In this review, we highlight key repurposed drugs targeting S1R and explore their mechanisms of action, shedding light on their emerging therapeutic potential in the fight against neurodegeneration."

Journal • Review • Alzheimer's Disease • CNS Disorders • Cough • Huntington's Disease • Movement Disorders • Parkinson's Disease • Respiratory Diseases

An Overview of the Systematic Reviews About the Efficacy of Fluvoxamine on Depression. (PubMed, Pharmaceuticals (Basel)) - "Comparisons with imipramine, clomipramine, amitriptyline, dothiepin, paroxetine, fluoxetine, citalopram, mianserin, nortriptyline, and moclobemide generally revealed no significant differences in efficacy. However, some reviews indicated that venlafaxine and mirtazapine were superior to fluvoxamine in certain outcomes, while fluvoxamine demonstrated greater efficacy than desipramine in one review. Sertraline and milnacipran showed mixed or review-quality-dependent results, with one low-quality review favoring milnacipran...While no single antidepressant was universally superior, fluvoxamine's unique pharmacological profile and favourable safety characteristics support its clinical utility. Further research is needed to explore its role in personalized treatment strategies and emerging therapeutic contexts, such as comorbid anxiety and post-traumatic stress disorder."

Journal • Review • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

Removal of psychopharmaceuticals from WWTP effluent by an algae-mussel trophic cascade: a potential nature-based solution? (PubMed, Environ Sci (Camb)) - "The compounds fell into 3 categories: positive removal (citalopram, lamotrigine, and venlafaxine), negative removal (carbamazepine, gabapentin, and pregabalin), and no significant changes in concentration (amitriptyline, quetiapine, tramadol, fluvoxamine, lidocaine, and ibuprofen). Pregabalin and gabapentin also increased in risk, but did, however, not significantly change the overall risk from the analysed compounds due to their low concentrations. Since the presently designed nature-based treatment could not negate risk, it is not suitable for the removal of psychopharmaceuticals."

Journal

Resolving Catatonia After IV Steroids in Multiple Sclerosis (APA 2025) - "Initially treated with haloperidol for wandering and agitation...Fluvoxamine was added for anti-inflammatory properties, titrated to 100mg with plan to continue on inpatient psych...IV methylprednisolone was started...Lorazepam has shown outstanding, rapid relieve of symptoms... Alternative treatments for catatonia have been described including NMDA modulators, Na+ channel blockers and atypical antipsychotics like clozapine. [4] More recent cases describe response to IV steroids. This case demonstrates additional evidence that steroids may be helpful in resolving catatonia associated with neuroinflammatory condition."

CNS Disorders • Hematological Disorders • Immunology • Mental Retardation • Multiple Sclerosis • Oncology • Psychiatry • Schizophrenia

Vitamin E as a Potential Treatment for Antidepressant-Induced Excessive Sweating (ADIES) (APA 2025) - "While specific antidepressants have not been identified to be more likely to cause hyperhidrosis, when compared to others, bupropion, fluvoxamine, and vortioxetine may have a decreased risk of causing hyperhidrosis. In patients complaining of ADIES who are at risk for medication nonadherence or where there is a concern for polypharmacy, Vitamin E can be used as an efficacious over-the-counter supplement to treat ADIES. Shared decision-making is paramount while recommending this as an option. With further studies that are necessary to draw final conclusions, Vitamin E can become a superior option in addressing ADIES."

Dermatology

Evaluating the Evidence for CYP2C19 Inhibitor Classifications: A Scoping Review. (PubMed, Clin Pharmacol Ther) - "Discrepancies between listed and literature-reported classifications led to the following recommendations: (1) upgrade fluoxetine from moderate to strong in the Flockhart Table™, (2) upgrade fluconazole from moderate to strong in the Flockhart Table™, (3) downgrade omeprazole (and esomeprazole) from moderate to weak in the Flockhart Table™, and (4) include footnotes describing dose-dependent inhibition for fluvoxamine and fluconazole in both tables. These recommendations aim to improve the accuracy of CYP2C19 inhibitor classifications and the clinical utility of these tables."

Journal • CYP2C19

Selective serotonin reuptake inhibitors (SSRIs) suppress Na+- dependent Mg2+ efflux in rat ventricular myocytes. (PubMed, J Physiol Sci) - "Other SSRIs, namely paroxetine and fluvoxamine, were less effective than sertraline. In conclusion, sertraline inhibited Na+/Mg2+ exchange transport more effectively than any previously reported inhibitors of Na+/Mg2+ exchanger. Sertraline could be used as a tool to characterize the functions of Na+/Mg2+ exchanger."

Journal • Preclinical

Fluvoxamine, an inhibitor of CYP1A2, improves CS-induced pulmonary inflammation through estrogen deficiency. (PubMed, Toxicol Appl Pharmacol) - "WB and ELISA assay also demonstrated a significant decrease in CYP1A2 and estrogen levels following treatment with fluvoxamine or tamoxifen. This study positions fluvoxamine as a novel COPD treatment candidate, particularly for women, targeting hormonal and inflammatory pathways. Further research is needed to validate clinical translation."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases

Pragmatic Trial of Obsessive-compulsive Disorder (clinicaltrials.gov) - P2 | N=1600 | Recruiting | Sponsor: Shanghai Mental Health Center | Trial completion date: Dec 2024 ➔ Dec 2028 | Trial primary completion date: Jun 2024 ➔ Jun 2027

Trial completion date • Trial primary completion date • Mood Disorders • Obsessive-Compulsive Disorder • Psychiatry