measles vaccine / Generic mfg. - LARVOL DELTA

Co-detection of measles virus vaccine strain and seasonal coronavirus in an immunocompromised patient with pneumonia. (PubMed, ASM Case Rep) - "We describe a 76-year-old patient with stage 3 multiple myeloma who had undergone autologous HSCT and received multiple therapies, including chimeric antigen receptor T-cell therapy and recent daratumumab treatment...This case highlights the rare but severe complication of measles vaccine-associated pneumonia in an immunocompromised host...Healthcare providers should exercise caution when considering live-attenuated vaccines in HSCT recipients with recent immunosuppressive therapy. Further research is needed to refine vaccination guidelines for this vulnerable population."

Journal • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Malignancies • Immunology • Infectious Disease • Measles • Multiple Myeloma • Mumps • Novel Coronavirus Disease • Oncology • Pneumonia • Respiratory Diseases • Rubella • Transplantation

Safety of Inadvertent Live Vaccine Administration in Patients With Inflammatory Bowel Disease on Immune-Modifying Therapy (ACG 2026) - "The exposed cohort comprised IBD patients who received a live vaccine (measles, mumps, and rubella (MMR), varicella, measles, mumps, rubella, and varicella (MMRV)...Inclusion required a vaccine CPT code, â¥12 months of continuous enrollment prior to index date, an IBD diagnosis (â¥2 IBD-related outpatient visits), and a prescription for an immune-modifying therapy (anti-tumor necrosis factor (TNF), vedolizumab, ustekinumab, tofacitinib, upadacitinib, risankizumab, guselkumab, or mirikizumab) < 90 days of the index date...³Anti-TNF agents: infliximab, adalimumab, certolizumab, golimumab...6Immunomodulators: methotrexate, azathioprine, 6-mercaptopurine... 220 IBD patients met inclusion criteria for the live vaccine cohort (132 MMR, 73 varicella, 15 MMRV); 170 (77%) were on anti-TNF therapy and 30 (14%) on vedolizumab (Figure). The comparator group comprised 2,204 PCV13 recipients Table for baseline demographics. All-cause hospitalization or ED..."

Clinical • Gastroenterology • Gastrointestinal Disorder • Herpes Zoster • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Measles • Mumps • Pneumococcal Infections • Rubella • Varicella Zoster • IL23A

Cellular Immune Response to Measles Vaccine in a Cohort of Pediatric Solid Organ Transplant Recipients (IDWeek 2026) - No abstract available

Clinical • Infectious Disease • Measles

Cellular Immune Response to Measles Vaccine in a Cohort of Pediatric Solid Organ Transplant Recipients (IDWeek 2026) - No abstract available

Clinical • Infectious Disease • Measles

Fever and rash after international travel: two cases of vaccine failure (PubMed, Inn Med (Heidelb)) - "Two returning travelers with measles vaccine failure are reported: a 49-year-old male with primary vaccine failure after single-dose vaccination who developed severe measles pneumonitis, and a 22-year-old male with secondary vaccine failure in the context of suspected immunodeficiency who presented with a mild course and atypical exanthem. Measles remains a relevant differential diagnosis even in vaccinated individuals, and travel medicine consultations should routinely include an assessment of measles vaccination status."

Journal • Infectious Disease • Inflammation • Measles • Pneumonia

Intranasal administration of spike-specific mRNA-LNP confers more protection than the intramuscular route against SARS-CoV-2. (PubMed, Iran J Basic Med Sci) - "I.N-vaccinated hamsters were completely protected from weight loss, whereas I.M-vaccinated animals showed mild weight reduction (~1%). Intranasal mRNA-LNP administration elicits potent mucosal and systemic immunity and provides superior protection against SARS-CoV-2 challenge compared to I.M vaccination, underscoring its promise as a transformative strategy for respiratory virus vaccines."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFNG

Impaired clinical, biological, and cytokine patterns in HIV-1 exposed uninfected newborns in Yaoundé: A comparative study of neonatal immune vulnerability. (PubMed, Afr J Lab Med) - "It provides initial information on pertinent but not yet described pro-inflammatory cytokines impairment in Cameroonian HEU newborns. Unlike previous research that has focused on their KIR-21 gene expression and responsiveness to measles vaccine, this study introduces their immunological responses through their umbilical cord blood analysis, a previously unexamined specimen."

Journal • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Measles • Neutropenia • IL1B • IL5 • IL6 • TGFB1

Anti-cancer efficacy of combined vaccine-strain measles and mumps viruses against colorectal cancer: an experimental study. (PubMed, Mol Biol Rep) - "The MM demonstrated synergistic and superior oncolytic efficacy against HT-29 colorectal cancer cells compared with single-virus therapies in both in vitro and in vivo xenograft models."

Journal • Colorectal Cancer • Infectious Disease • Measles • Mumps • Oncology • Solid Tumor

Characterizing measles healthcare facility exposures-December 2023-September 2025-New York City. (PubMed, Clin Infect Dis) - "Most contacts exposed to measles in NYC healthcare facilities had presumptive immunity or were adults with unknown immunity. No transmission occurred among 2,122 exposed contacts, including non-immune contacts. Given no secondary transmission and resource-intensive control measures, relying solely on time-based measles exposure definitions may be overly broad. Incorporating strategies like facility air exchange data might better assess transmission risk."

Journal • Infectious Disease • Measles

Measles: A Narrative Review of Current Therapeutic Options and Implications for the Future. (PubMed, Viruses) - "Despite the availability of a safe and effective measles vaccine for several decades, measles remains a significant cause of morbidity and mortality worldwide, causing 95,000 deaths in 2024 alone...There are few reports indicating that repeated remdesivir courses, as well as intraventricular or intrathecal ribavirin or IFN, may temporarily stabilize the neurologic status of patients with subacute sclerosing panencephalitis...Overall, the development of antiviral agents against measles has been extremely slow. Therapeutic agents against measles are urgently needed."

Clinical • Journal • Review • CNS Disorders • Infectious Disease • Measles

HUMORAL VACCINE RESPONSES IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES FOLLOWING CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL THERAPY (EBMT 2025) - "Patients received the same vaccine protocol that is used after hematopoietic cell transplantation (HCT), with conjugate pneumococcal vaccines (both PCV7, PCV15 and PCV20 were used during the study), combination vaccine containing tetanus, full component diphtheria and pertussis (TDaP), inactivated polio vaccine (IPV), conjugated Haemophilus influenzae (Hib) type B vaccine, Hepatitis A and B, given either as monovalent or combination vaccines, recombinant zoster vaccine, and measles-mumps-rubella (MMR), when criteria for live vaccines were met... The CD19 group showed significantly better baseline protection against a majority of tested antigens. However, the vaccine responses did not differ significantly between the BCMA vs CD-19 groups. The pneumococcal conjugate response rate was particularly low in both groups, with a response rate of 33%."

Clinical • Hematological Disorders • Hematological Malignancies • Hepatitis B • Hepatology • Herpes Zoster • Infectious Disease • Inflammation • Influenza • Measles • Mumps • Oncology • Pertussis • Pneumococcal Infections • Respiratory Diseases • Rubella • Tetanus • Varicella Zoster

HUMORAL VACCINE RESPONSES IN PATIENTS WITH HEMATOLOGIC MALIGNANCIES FOLLOWING CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL THERAPY (EBMT 2025) - "Patients received the same vaccine protocol that is used after hematopoietic cell transplantation (HCT), with conjugate pneumococcal vaccines (both PCV7, PCV15 and PCV20 were used during the study), combination vaccine containing tetanus, full component diphtheria and pertussis (TDaP), inactivated polio vaccine (IPV), conjugated Haemophilus influenzae (Hib) type B vaccine, Hepatitis A and B, given either as monovalent or combination vaccines, recombinant zoster vaccine, and measles-mumps-rubella (MMR), when criteria for live vaccines were met... The CD19 group showed significantly better baseline protection against a majority of tested antigens. However, the vaccine responses did not differ significantly between the BCMA vs CD-19 groups. The pneumococcal conjugate response rate was particularly low in both groups, with a response rate of 33%."

Clinical • Hematological Disorders • Hematological Malignancies • Hepatitis B • Hepatology • Herpes Zoster • Infectious Disease • Inflammation • Influenza • Measles • Mumps • Oncology • Pertussis • Pneumococcal Infections • Respiratory Diseases • Rubella • Tetanus • Varicella Zoster

Ethiopia missed opportunities for vaccination study: Cluster-randomized evaluation of 5-dose measles vaccine vials and a flexible open-vial policy, 2021-2022. (PubMed, Vaccine) - "The combined 5-dose intervention improved MCV1 timeliness and MCV2 coverage and reduced wastage, addressing a key operational barrier and potentially supporting measles elimination in Ethiopia."

Journal • Infectious Disease • Measles

Estimating current susceptibility to measles in Australia following sustained measles elimination. (PubMed, Aust N Z J Public Health) - "Our estimates provide baseline data to inform vaccination activities to address immunity gaps in older age groups, particularly those likely to travel internationally."

Journal • Infectious Disease • Measles

Protective antibody response following two doses of measles vaccination and factors for non-response among children from tribal Odisha, India. (PubMed, Indian J Med Res) - "This study aimed to estimate the proportion of children developing protective antibody levels following two doses of measles vaccine in a tribal location and to identify potential risk factors associated with non-response...Interpretation and conclusion This study provides the first evidence of suboptimal measles antibody response among children from a tribal area of Odisha, India, despite high vaccination coverage. There is a need to understand the immune persistence among such a vulnerable population, where measles control remains a challenge."

Journal • Infectious Disease • Measles

Geographic Variation in Measles Vaccine Coverage Among Children Aged 7 Years in Northern California. (PubMed, JAMA Netw Open) - No abstract available

Journal • Infectious Disease • Measles

Softening of vero cells induced by measles vaccine virus. (PubMed, Micron) - "These findings suggested that MVV infection is associated to consistent remodelling of viscoelastic behaviour and actin organization. Overall, this study provides a quantitative biomechanical characterization of MVV associated cellular changes and establishes a descriptive framework for time resolved and mechanistic investigations of virus-host interactions."

Journal • Infectious Disease • Measles

Parents' role as advocates for and against childhood vaccination: Findings from a nationally representative survey. (PubMed, PLoS One) - "Findings of our nationally representative study suggest that parents who encourage routine vaccination far outnumber those who discourage it. Given that encouragers often advocate for measles vaccine, future efforts to increase vaccination coverage should consider ways to partner with parent advocates to stem the alarming resurgence of this disease."

Journal • Infectious Disease • Measles • Novel Coronavirus Disease

Trends in Selective Childhood Measles-Mumps-Rubella (MMR) Vaccine Nonreceipt Surrounding the MMR-Autism Controversy: National Immunization Survey Analyses, 1996-2019. (PubMed, J Community Health) - "paper. Key demographic factors outlined herein provide an opportunity for targeted outreach to encourage increased MMR vaccination uptake."

Journal • Autism Spectrum Disorder • Genetic Disorders • Infectious Disease • Measles • Mumps • Rubella

Safety and Immunogenicity of Live-Attenuated Measles-Mumps-Rubella Vaccination After Pediatric Heart Transplantation. (PubMed, J Heart Lung Transplant) - "In carefully selected pediatric heart transplant recipients, MMR vaccination was safe and provided acceptable immunogenicity. These findings challenge the historical exclusion of this population from live vaccination and suggest current eligibility criteria may be overly restrictive."

Journal • Infectious Disease • Measles • Mumps • Pediatrics • Rubella • Transplantation

Seroprotection after Measles Vaccination in Children with Sickle Cell Anemia Receiving Hydroxyurea. (PubMed, Blood Adv) - P=N/A | "We conducted a retrospective cohort study of children with SCA enrolled on the TREAT trial (NCT02286154) to determine anti-measles seroprotection (IgG ≥ 200 IU/L via ELISA) after first (MV1) and second (MV2) measles vaccine. Hydroxyurea treatment at the time of vaccination did not reduce seroprotection; rather, earlier hydroxyurea initiation was associated with increased seroprotection (OR 4.4, p=0.02). The majority of children with SCA are adequately protected following measles vaccination, similar to the general population, and seroprotection is increased with timely vaccination and early hydroxyurea treatment."

Journal • Anemia • Genetic Disorders • Hematological Disorders • Infectious Disease • Measles • Sickle Cell Disease

Measles and rubella seropositivity among suspected measles cases in northwestern region of Nigeria. (PubMed, J Public Health Afr) - "This high measles seropositivity is concerning considering the ease of access to measles vaccines available at every primary, secondary and even tertiary health facilities spread across northwestern Nigeria. This study reveals that measles virus circulates with high endemicity in the region, with 50.3% serologically confirmed cases among samples from persons suspected to have measles sent for testing. Additionally, 10.3% of individuals suspected having measles but tested negative were found to test positive for rubella."

Journal • Infectious Disease • Measles • Rubella

Minor differences in the untranslated regions of measles vector additional transcription units are reflected by differential immunogenicity of encoded MERS-CoV Spike antigen. (PubMed, J Virol) - "Besides mRNA vaccines, also viral platform technologies, that is, the adenovirus-derived vaccines Vaxzevria and JCOVDEN, have proven to be of immense value during the COVID-19 pandemic...This knowledge allows the tailoring of vaccine vectors to fit specific target product profiles, for example, to build vectors which trigger an accentuated T cell or, alternatively, antibody response against an antigen of interest. Our study using the live-attenuated measles vaccine backbone as a promising example is therefore crucial in demonstrating that very minor differences in the vaccine backbone can alter the antigen expression profile of the vector-antigen system and impact the relative induction of T-cell or antibody responses against the added target antigen."

Journal • Infectious Disease • Measles • Novel Coronavirus Disease • Respiratory Diseases • IFNAR1

A Rise in Measles Reporting Two Years After the COVID-19 Pandemic: A Descriptive Analysis of Measles in Iraq in 2023 and Early 2024. (PubMed, Int J Environ Res Public Health) - "Clusters of high reporting were mainly in the middle of Iraq while clusters of low reporting were mainly in the north. We recommend continuing to study clusters of measles and vaccine coverage to direct prevention efforts."

Journal • Infectious Disease • Measles • Novel Coronavirus Disease

Community-Led Defaulter Tracking for Catch-Up Vaccination: Implementation Experience in Uganda, 2022 and 2024. (PubMed, Vaccines (Basel)) - "Community-led defaulter tracking was feasible and improved vaccination uptake in post-COVID-19 Uganda. Strengthening the quality and availability of health facility immunization data, along with targeted community engagement, caregiver reminders and integrated vaccination services would improve identification and follow-up of defaulters, reducing population immunity gaps."

Journal • Infectious Disease • Measles • Novel Coronavirus Disease • Pertussis • Respiratory Diseases • Rubella • Tetanus