AB1000 / Alveolus Bio - LARVOL DELTA

Pulmonary Live Biotherapeutic Product Reduces Neutrophilic Inflammation in Bronchopulmonary Dysplasia Through miR129-MMP-9 Pathway (ATS 2023) - "Administration of live biotherapeutic AB1000 to the lungs of mouse pups reduced the neutrophilic inflammatory response in BPD through the mir129-MMP9 pathway. This suggests a role for LBPs as interventions for preterm infants with chronic lung injury."

Bronchopulmonary Dysplasia • Inflammation • Pulmonary Disease • Respiratory Diseases • IL6 • MIR129 • MIR29A • MMP9

Live Biotherapeutic Performs at Par With Steroids in Reducing Neutrophilic Inflammation in Models of COPD (ATS 2023) - "We hypothesized that live biotherapeutic AB1000 would reduce neutrophilic inflammation comparably to the steroid fluticasone furoate in models of COPD. 1. Neutrophilic inflammation in models of COPD can be mitigated by the administration of live biotherapeutic AB1000. Live bacteria strains delivered to the lungs may have a direct therapeutic benefit potential in high inflammation COPD."

Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • ELANE • MMP9

Lactobacillus Based Live Biotherapeutic Product Downregulates Profibrotic Markers in Models of Pulmonary Fibrosis (ATS 2023) - "PMA-differentiated THP1 monocytes were exposed to bleomycin and treated with AB1000. Key biomarkers like TGFβ1, COL1A1, COL1A2, ɑ-SMA and fibronectin were attenuated by AB1515 treatment, suggesting potential beneficial effect in IPF development."

Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases • COL1A1 • COL1A2 • GLI2 • IL6 • TGFB1 • TNFA

A Live Biotherapeutic Product Reduces Neutrophilic Inflammation in Bronchopulmonary Dysplasia through miR129-MMP9 Pathway (PAS 2023) - "Markers of neutrophilic inflammation were significantly reduced, lung structure and function significantly improved in AB1000-treated as compared to controls in all models. Decreased miR-129 was associated with increased MMP-9 in BPD infants, in vitro cell lines, and BPD mouse model. miR-129 overexpression downregulated MMP-9 levels and miR-129 inhibition upregulated MMP-9 levels in a dose-dependent manner."

Bronchopulmonary Dysplasia • Inflammation • Pulmonary Disease • Respiratory Diseases • IL6 • MIR129 • MIR29A • MMP9