SERPIN1 / SERPINx - LARVOL DELTA

"A nice review: Alpha-1 antitrypsin deficiency: a re-surfacing adult liver disorder https://t.co/wCdTNFiUOI" (@KowdleyMd)

Review • Alpha-1 Antitrypsin Deficiency • Genetic Disorders • Hepatology • Pulmonary Disease • Respiratory Diseases

"The heart is super affected. It's been a while but fairly certain trypsin fibres start forming in the chest, making it look like congestive heart failure. Serpina1 is one beautiful protein, one ruff disease." (@NucleotideSoup)

Cardiovascular • Congestive Heart Failure • Heart Failure • SERPINA1

"Placental HTRA1 cleaves α1-antitrypsin to generate a NET-inhibitory peptide https://t.co/BIpKGsb6H7" (@BloodJournal)

AAT • HTRA1

"Mysteries of Alpha-1 Antitrypsin Deficiency Unraveling https://t.co/lCV5ZwHSur via @CleClinicMD" (@goldenflower44)

Alpha-1 Antitrypsin Deficiency • Genetic Disorders • Hepatology • Respiratory Diseases • AAT

Deregulated expression of Elastin Microfibril Interfacer 2 (EMILIN2) in gastric cancer affects tumor growth and angiogenesis. (PubMed, Matrix Biol Plus) - "Furthermore, we found that EMILIN2 had a dual effect on gastric carcinoma cells: on one hand, it decreased tumor cell proliferation by triggering apoptosis, and on the other hand, it evoked the production of a number of cytokines involved in angiogenesis and inflammation, such as IL-8. Collectively, our findings posit EMILIN2 as an important onco-regulator exerting pleiotropic effects on the gastric cancer microenvironment."

Journal • Gastric Cancer • Gastrointestinal Cancer • Immune Modulation • Immunology • Inflammation • Oncology • Solid Tumor • CXCL8

"Perhaps some alpha-1 antitrypsin globules?" (@Teclis82)

AAT

Carrier frequencies of antithrombin, protein C, and protein S deficiency variants estimated using a public database and expression experiments. (PubMed, Res Pract Thromb Haemost) - "In total, 133, 157, and 221 variants of SERPIN1 (encoding AT), PROC (PC), and PROS1 (PS), respectively, were registered as missense and putative loss-of-function variants in the ExAC database...All 33 PS variants showed normal or mildly reduced secretion, and 4 showed reduced total activity. Based on allele frequencies in the ExAC database, we calculated the frequencies of AT, PC, and PS genetic deficiency as 0.36%, 0.63%, and 0.39%, respectively."

Journal • Cardiovascular • Hematological Disorders • Venous Thromboembolism • PROS1

Use of dopamine agonists to target angiogenesis in women with endometriosis. (PubMed, Hum Reprod) - "In experimental models of endometriosis, DAs (bromocriptine, cabergoline, quinagolide) downregulate proangiogenic and upregulate antiangiogenic pathways in inflammatory, endothelial and endometrial cells, blocking cellular proliferation and reducing lesion size...Moreover, a 20-fold downregulation of Serpin-1, the gene that encodes for plasminogen activator inhibitor 1 (PAI-1), has been observed after DAs treatment...Thus, the data support the use of DAs in the medical management of endometriosis to reduce lesion size and pain while maintaining ovulation. A combined approach of DAs and pentoxifylline is perhaps a smart way of targeting the disease from a completely different angle than current medical treatments."

Clinical • Journal • Endometriosis • Gynecology • Immunology • Inflammation • Pain

Detection and in vitro studies of Cucurbita maxima phloem serpin-1 RNA-binding properties. (PubMed, Biochimie) - "Mutational analysis demonstrates that the CmPS1 N-terminal region is not involved in RNA binding. Since antithrombin-III, the human protease inhibitor of serpin family most closely sequence-related to CmPS1, is found to be unable to bind RNA, one can suggest that, in its evolution, CmPS1 has gained the RNA binding capability as an additional function likely relevant to its specific activities in the plant phloem."

Journal • Preclinical

Phloem transport of structured RNAs: A widening repertoire of trafficking signals and protein factors. (PubMed, Plant Sci) - "Here, three distinct types of such RNAs are discussed, along with the proteins that may specifically interact with these structures in the phloem. Three-dimensional (3D) motifs, which are characteristic of imperfect RNA duplexes, are discussed as elements of phloem-mobile structured RNAs specifically recognized by proteins involved in phloem transport, thus serving as PTSs."

Journal • Review

[VIRTUAL] Thrombophilia and Myocardial Infarction with Non-Obstructive Coronary Arteries (ISTH 2020) - "Previous results of our work indicate influence of Factor V Leiden G1691A on the risk of MINOCA, especially in young person."

Cardiovascular • Coronary Artery Disease • Hematological Disorders • Myocardial Infarction • F2 • MTHFR

Investigation of the influence of thrombophilic genes polymorphism, including serpin 1 (pai-i), fii, prothrombin and itgb3-˩ integrin, on the frequency of stroke in association with controllable risk factors for its occurrence. (PubMed, Wiad Lek) - "Identification of biochemical or genetic markers of thrombophilic conditions, including polymorphism of the hemostasis system genes, will significantly increase the possibility of adequate pathogenetic treatment and timely prevention of acute cerebrovascular disorders, especially persons of working age, which has great medical and social importance."

Clinical • Journal • Atrial Fibrillation • Cardiovascular • Diabetes • Genetic Disorders • Hematological Disorders • Metabolic Disorders • Obesity

Serpin7 controls egg diapause of migratory locust (Locusta migratoria) by regulating polyphenol oxidase. (PubMed, FEBS Open Bio) - "A total of seven non-redundant serpin genes (named serpin1-serpin7) of Locusta migratoria were obtained through transcriptomic analysis...Furthermore knock down of the serpin7 gene resulted in a significant upregulation of the activity of polyphenol oxidase (PPO). We therefore propose that the observed serpin7 gene plays a crucial role in diapause, suggesting that control of energy metabolism may have potential as a future strategy for the reproductive control of insect pests."

Journal

Transcriptomic Analysis of Mecp2 Mutant Mice Reveals Differentially Expressed Genes and Altered Mechanisms in Both Blood and Brain. (PubMed, Front Psychiatry) - "...This is the case for the gene Ube2v1, linked to ubiquitination system, and Serpin1, involved in complement and coagulation cascades...Some mechanisms are enriched in both preparations, such as lipid metabolism and response to stress. These results suggest that analysis of peripheral blood can reveal ubiquitous altered molecular mechanisms of Rett and have applications in diagnosis and treatments' assessments."

Journal

Reduced-Dose Statin Therapy Complemented With Nutraceuticals Alters HDL Proteomics (ATVB-PVD-GPM 2019) - "...A trend towards a reduction in ApoA1, ApoF and Alpha-1-antitrypsin (SERPIN1) was also observed. Our results suggest that combining lower statin dose and specific dietary compounds is not only effective for responders to nutraceuticals, but may also modulate HDL proteomics, especially decreasing pro-oxidative and acute-phase proteins. Whether these changes in HDL cargo affect its anti-inflammatory properties remains to be determined."